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Q6ISS4 (LAIR2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 85. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Leukocyte-associated immunoglobulin-like receptor 2

Short name=LAIR-2
Alternative name(s):
CD_antigen=CD306
Gene names
Name:LAIR2
Synonyms:CD306
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length152 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Subcellular location

Secreted.

Sequence similarities

Contains 1 Ig-like C2-type (immunoglobulin-like) domain.

Ontologies

Keywords
   Cellular componentSecreted
   Coding sequence diversityAlternative splicing
Polymorphism
   DomainImmunoglobulin domain
Signal
   Molecular functionReceptor
   PTMDisulfide bond
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Note: Named isoforms=2.
Isoform 1 (identifier: Q6ISS4-1)

Also known as: LAIR-2a;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q6ISS4-2)

Also known as: LAIR-2b;

The sequence of this isoform differs from the canonical sequence as follows:
     122-138: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2121 Potential
Chain22 – 152131Leukocyte-associated immunoglobulin-like receptor 2
PRO_0000250685

Regions

Domain29 – 11789Ig-like C2-type

Amino acid modifications

Disulfide bond49 ↔ 101 By similarity

Natural variations

Alternative sequence122 – 13817Missing in isoform 2.
VSP_020720
Natural variant781G → S.
Corresponds to variant rs36121405 [ dbSNP | Ensembl ].
VAR_049882
Natural variant871H → R.
Corresponds to variant rs34423078 [ dbSNP | Ensembl ].
VAR_049883
Natural variant1151F → Y.
Corresponds to variant rs34429135 [ dbSNP | Ensembl ].
VAR_049884

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 (LAIR-2a) [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: 8097688A9DB42EC8

FASTA15216,280
        10         20         30         40         50         60 
MSPHLTALLG LVLCLAQTIH TQEGALPRPS ISAEPGTVIS PGSHVTFMCR GPVGVQTFRL 

        70         80         90        100        110        120 
EREDRAKYKD SYNVFRLGPS ESEARFHIDS VSEGNAGLYR CLYYKPPGWS EHSDFLELLV 

       130        140        150 
KESSGGPDSP DTEPGSSAGT VPGTEASGFD AP 

« Hide

Isoform 2 (LAIR-2b) [UniParc].

Checksum: 5053FD160CF31CC7
Show »

FASTA13514,722

References

« Hide 'large scale' references
[1]"LAIR-1, a novel inhibitory receptor expressed on human mononuclear leukocytes."
Meyaard L., Adema G.J., Chang C., Woollatt E., Sutherland G.R., Lanier L.L., Phillips J.H.
Immunity 7:283-290(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
[2]"Leukocyte-associated Ig-like receptor-1 functions as an inhibitory receptor on cytotoxic T cells."
Meyaard L., Hurenkamp J., Clevers H., Lanier L.L., Phillips J.H.
J. Immunol. 162:5800-5804(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF013250 mRNA. Translation: AAB69325.1.
AA133246 mRNA. No translation available.
BC069366 mRNA. Translation: AAH69366.1.
RefSeqNP_002279.2. NM_002288.5.
NP_067154.1. NM_021270.4.
UniGeneHs.43803.

3D structure databases

ProteinModelPortalQ6ISS4.
SMRQ6ISS4. Positions 26-122.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000301202.

PTM databases

PhosphoSiteQ6ISS4.

Polymorphism databases

DMDM74736630.

Proteomic databases

PaxDbQ6ISS4.
PRIDEQ6ISS4.

Protocols and materials databases

DNASU3904.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000301202; ENSP00000301202; ENSG00000167618. [Q6ISS4-1]
ENST00000351841; ENSP00000301203; ENSG00000167618. [Q6ISS4-2]
ENST00000570730; ENSP00000460887; ENSG00000262317. [Q6ISS4-2]
ENST00000573611; ENSP00000461039; ENSG00000262317. [Q6ISS4-1]
ENST00000603315; ENSP00000473694; ENSG00000271116. [Q6ISS4-1]
ENST00000603569; ENSP00000474459; ENSG00000271116. [Q6ISS4-2]
GeneID3904.
KEGGhsa:3904.
UCSCuc002qgc.3. human. [Q6ISS4-1]
uc002qgd.3. human. [Q6ISS4-2]

Organism-specific databases

CTD3904.
GeneCardsGC19P055009.
HGNCHGNC:6478. LAIR2.
MIM602993. gene.
neXtProtNX_Q6ISS4.
PharmGKBPA30267.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG115686.
HOGENOMHOG000234395.
InParanoidQ6ISS4.
KOK06725.
OMAPGWSEHS.
PhylomeDBQ6ISS4.
TreeFamTF336644.

Gene expression databases

ArrayExpressQ6ISS4.
BgeeQ6ISS4.
CleanExHS_LAIR2.
GenevestigatorQ6ISS4.

Family and domain databases

Gene3D2.60.40.10. 1 hit.
InterProIPR013783. Ig-like_fold.
IPR003599. Ig_sub.
[Graphical view]
SMARTSM00409. IG. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiLAIR2.
GenomeRNAi3904.
NextBio15327.
PROQ6ISS4.
SOURCESearch...

Entry information

Entry nameLAIR2_HUMAN
AccessionPrimary (citable) accession number: Q6ISS4
Secondary accession number(s): Q6PEZ4
Entry history
Integrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: July 5, 2004
Last modified: March 19, 2014
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 19

Human chromosome 19: entries, gene names and cross-references to MIM

Human cell differentiation molecules

CD nomenclature of surface proteins of human leucocytes and list of entries