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Protein

Leukocyte-associated immunoglobulin-like receptor 2

Gene

LAIR2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Receptor

Enzyme and pathway databases

ReactomeiR-HSA-198933. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.

Names & Taxonomyi

Protein namesi
Recommended name:
Leukocyte-associated immunoglobulin-like receptor 2
Short name:
LAIR-2
Alternative name(s):
CD_antigen: CD306
Gene namesi
Name:LAIR2
Synonyms:CD306
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:6478. LAIR2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30267.

Polymorphism and mutation databases

BioMutaiLAIR2.
DMDMi74736630.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121Sequence analysisAdd
BLAST
Chaini22 – 152131Leukocyte-associated immunoglobulin-like receptor 2PRO_0000250685Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi49 ↔ 101By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ6ISS4.
PeptideAtlasiQ6ISS4.
PRIDEiQ6ISS4.

PTM databases

iPTMnetiQ6ISS4.
PhosphoSiteiQ6ISS4.

Expressioni

Gene expression databases

BgeeiENSG00000167618.
CleanExiHS_LAIR2.
ExpressionAtlasiQ6ISS4. baseline and differential.
GenevisibleiQ6ISS4. HS.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
EMILIN1Q9Y6C23EBI-10250491,EBI-744586
SGTAO437653EBI-10250491,EBI-347996

Protein-protein interaction databases

BioGridi110099. 2 interactions.
IntActiQ6ISS4. 2 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ6ISS4.
SMRiQ6ISS4. Positions 26-122.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini29 – 11789Ig-like C2-typeAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Signal

Phylogenomic databases

eggNOGiENOG410J37Q. Eukaryota.
ENOG41119RI. LUCA.
GeneTreeiENSGT00720000108843.
HOGENOMiHOG000234395.
InParanoidiQ6ISS4.
KOiK06725.
OrthoDBiEOG091G0RAQ.
PhylomeDBiQ6ISS4.
TreeFamiTF336644.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
[Graphical view]
PfamiPF13895. Ig_2. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6ISS4-1) [UniParc]FASTAAdd to basket
Also known as: LAIR-2a

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSPHLTALLG LVLCLAQTIH TQEGALPRPS ISAEPGTVIS PGSHVTFMCR
60 70 80 90 100
GPVGVQTFRL EREDRAKYKD SYNVFRLGPS ESEARFHIDS VSEGNAGLYR
110 120 130 140 150
CLYYKPPGWS EHSDFLELLV KESSGGPDSP DTEPGSSAGT VPGTEASGFD

AP
Length:152
Mass (Da):16,280
Last modified:July 5, 2004 - v1
Checksum:i8097688A9DB42EC8
GO
Isoform 2 (identifier: Q6ISS4-2) [UniParc]FASTAAdd to basket
Also known as: LAIR-2b

The sequence of this isoform differs from the canonical sequence as follows:
     122-138: Missing.

Show »
Length:135
Mass (Da):14,722
Checksum:i5053FD160CF31CC7
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti78 – 781G → S.
Corresponds to variant rs36121405 [ dbSNP | Ensembl ].
VAR_049882
Natural varianti87 – 871H → R.
Corresponds to variant rs34423078 [ dbSNP | Ensembl ].
VAR_049883
Natural varianti115 – 1151F → Y.
Corresponds to variant rs34429135 [ dbSNP | Ensembl ].
VAR_049884

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei122 – 13817Missing in isoform 2. 1 PublicationVSP_020720Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF013250 mRNA. Translation: AAB69325.1.
AA133246 mRNA. No translation available.
BC069366 mRNA. Translation: AAH69366.1.
CCDSiCCDS12897.1. [Q6ISS4-1]
CCDS12898.1. [Q6ISS4-2]
RefSeqiNP_002279.2. NM_002288.5. [Q6ISS4-1]
NP_067154.1. NM_021270.4. [Q6ISS4-2]
UniGeneiHs.43803.

Genome annotation databases

EnsembliENST00000301202; ENSP00000301202; ENSG00000167618. [Q6ISS4-1]
ENST00000351841; ENSP00000301203; ENSG00000167618. [Q6ISS4-2]
ENST00000612901; ENSP00000478193; ENSG00000274084. [Q6ISS4-1]
ENST00000620256; ENSP00000477747; ENSG00000274084. [Q6ISS4-2]
ENST00000621280; ENSP00000480904; ENSG00000277335. [Q6ISS4-2]
ENST00000622556; ENSP00000477535; ENSG00000277335. [Q6ISS4-1]
GeneIDi3904.
KEGGihsa:3904.
UCSCiuc002qgc.4. human. [Q6ISS4-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF013250 mRNA. Translation: AAB69325.1.
AA133246 mRNA. No translation available.
BC069366 mRNA. Translation: AAH69366.1.
CCDSiCCDS12897.1. [Q6ISS4-1]
CCDS12898.1. [Q6ISS4-2]
RefSeqiNP_002279.2. NM_002288.5. [Q6ISS4-1]
NP_067154.1. NM_021270.4. [Q6ISS4-2]
UniGeneiHs.43803.

3D structure databases

ProteinModelPortaliQ6ISS4.
SMRiQ6ISS4. Positions 26-122.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110099. 2 interactions.
IntActiQ6ISS4. 2 interactions.

PTM databases

iPTMnetiQ6ISS4.
PhosphoSiteiQ6ISS4.

Polymorphism and mutation databases

BioMutaiLAIR2.
DMDMi74736630.

Proteomic databases

PaxDbiQ6ISS4.
PeptideAtlasiQ6ISS4.
PRIDEiQ6ISS4.

Protocols and materials databases

DNASUi3904.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000301202; ENSP00000301202; ENSG00000167618. [Q6ISS4-1]
ENST00000351841; ENSP00000301203; ENSG00000167618. [Q6ISS4-2]
ENST00000612901; ENSP00000478193; ENSG00000274084. [Q6ISS4-1]
ENST00000620256; ENSP00000477747; ENSG00000274084. [Q6ISS4-2]
ENST00000621280; ENSP00000480904; ENSG00000277335. [Q6ISS4-2]
ENST00000622556; ENSP00000477535; ENSG00000277335. [Q6ISS4-1]
GeneIDi3904.
KEGGihsa:3904.
UCSCiuc002qgc.4. human. [Q6ISS4-1]

Organism-specific databases

CTDi3904.
GeneCardsiLAIR2.
HGNCiHGNC:6478. LAIR2.
MIMi602993. gene.
neXtProtiNX_Q6ISS4.
PharmGKBiPA30267.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J37Q. Eukaryota.
ENOG41119RI. LUCA.
GeneTreeiENSGT00720000108843.
HOGENOMiHOG000234395.
InParanoidiQ6ISS4.
KOiK06725.
OrthoDBiEOG091G0RAQ.
PhylomeDBiQ6ISS4.
TreeFamiTF336644.

Enzyme and pathway databases

ReactomeiR-HSA-198933. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.

Miscellaneous databases

GeneWikiiLAIR2.
GenomeRNAii3904.
PROiQ6ISS4.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000167618.
CleanExiHS_LAIR2.
ExpressionAtlasiQ6ISS4. baseline and differential.
GenevisibleiQ6ISS4. HS.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
[Graphical view]
PfamiPF13895. Ig_2. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiLAIR2_HUMAN
AccessioniPrimary (citable) accession number: Q6ISS4
Secondary accession number(s): Q6PEZ4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: July 5, 2004
Last modified: September 7, 2016
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.