Q6ISS4 (LAIR2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Leukocyte-associated immunoglobulin-like receptor 2
Short name=LAIR-2

Alternative name(s):
CD_antigen=CD306

Gene names

Name:	LAIR2
Synonyms:	CD306

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	152 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Subcellular location	Secreted.
Sequence similarities	Contains 1 Ig-like C2-type (immunoglobulin-like) domain.

Ontologies

Keywords
Cellular component	Secreted
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Immunoglobulin domain Signal
Molecular function	Receptor
PTM	Disulfide bond
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	receptor activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Note: Named isoforms=2.

Isoform 1 (identifier: Q6ISS4-1)

Also known as: LAIR-2a;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q6ISS4-2)

Also known as: LAIR-2b;

The sequence of this isoform differs from the canonical sequence as follows:
     122-138: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 21	21	Potential
	Chain	22 – 152	131	Leukocyte-associated immunoglobulin-like receptor 2		PRO_0000250685
Regions
	Domain	29 – 117	89	Ig-like C2-type
Amino acid modifications
	Disulfide bond	49 ↔ 101		By similarity
Natural variations
	Alternative sequence	122 – 138	17	Missing in isoform 2.		VSP_020720
	Natural variant	78	1	G → S. Corresponds to variant rs36121405 [ dbSNP | Ensembl ].		VAR_049882
	Natural variant	87	1	H → R. Corresponds to variant rs34423078 [ dbSNP | Ensembl ].		VAR_049883
	Natural variant	115	1	F → Y. Corresponds to variant rs34429135 [ dbSNP | Ensembl ].		VAR_049884

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (LAIR-2a) [UniParc]. Last modified July 5, 2004. Version 1. Checksum: 8097688A9DB42EC8	FASTA	152	16,280
	10 20 30 40 50 60 MSPHLTALLG LVLCLAQTIH TQEGALPRPS ISAEPGTVIS PGSHVTFMCR GPVGVQTFRL 70 80 90 100 110 120 EREDRAKYKD SYNVFRLGPS ESEARFHIDS VSEGNAGLYR CLYYKPPGWS EHSDFLELLV 130 140 150 KESSGGPDSP DTEPGSSAGT VPGTEASGFD AP
	Isoform 2 (LAIR-2b) [UniParc]. Checksum: 5053FD160CF31CC7	FASTA	135	14,722
	10 20 30 40 50 60 MSPHLTALLG LVLCLAQTIH TQEGALPRPS ISAEPGTVIS PGSHVTFMCR GPVGVQTFRL 70 80 90 100 110 120 EREDRAKYKD SYNVFRLGPS ESEARFHIDS VSEGNAGLYR CLYYKPPGWS EHSDFLELLV 130 KGTVPGTEAS GFDAP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"LAIR-1, a novel inhibitory receptor expressed on human mononuclear leukocytes." Meyaard L., Adema G.J., Chang C., Woollatt E., Sutherland G.R., Lanier L.L., Phillips J.H. Immunity 7:283-290(1997) [PubMed: 9285412] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
[2]	"Leukocyte-associated Ig-like receptor-1 functions as an inhibitory receptor on cytotoxic T cells." Meyaard L., Hurenkamp J., Clevers H., Lanier L.L., Phillips J.H. J. Immunol. 162:5800-5804(1999) [PubMed: 10229813] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF013250 mRNA. Translation: AAB69325.1. AA133246 mRNA. No translation available. BC069366 mRNA. Translation: AAH69366.1.
IPI	IPI00010137. IPI00032545.
RefSeq	NP_002279.2. NM_002288.4. NP_067154.1. NM_021270.3.
UniGene	Hs.43803.
3D structure databases
HSSP	HSSP built from PDB template 1VDG based on UniProtKB Q8NHL6.
ProteinModelPortal	Q6ISS4.
SMR	Q6ISS4. Positions 26-122.
ModBase	Search...
Protein-protein interaction databases
STRING	Q6ISS4.
Polymorphism databases
DMDM	74736630.
Proteomic databases
PRIDE	Q6ISS4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000301202; ENSP00000301202; ENSG00000167618.
GeneID	3904.
KEGG	hsa:3904.
UCSC	uc002qgc.1. human. uc002qgd.1. human.
Organism-specific databases
CTD	3904.
GeneCards	GC19P055009.
H-InvDB	HIX0039945.
HGNC	HGNC:6478. LAIR2.
MIM	602993. gene.
neXtProt	NX_Q6ISS4.
PharmGKB	PA30267.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG12108.
GeneTree	ENSGT00390000016673.
InParanoid	Q6ISS4.
OMA	FRLGPSE.
PhylomeDB	Q6ISS4.
Gene expression databases
ArrayExpress	Q6ISS4.
Bgee	Q6ISS4.
CleanEx	HS_LAIR2.
Genevestigator	Q6ISS4.
GermOnline	ENSG00000167618. Homo sapiens.
Family and domain databases
InterPro	IPR013783. Ig-like_fold. IPR003599. Ig_sub. [Graphical view]
Gene3D	G3DSA:2.60.40.10. Ig-like_fold. 1 hit.
KO	K06725.
SMART	SM00409. IG. 1 hit. [Graphical view]
PROSITE	PS50835. IG_LIKE. False negative. [Graphical view]
ProtoNet	Search...
Other
NextBio	15327.
SOURCE	Search...

Entry information

Entry name

LAIR2_HUMAN

Accession

Primary (citable) accession number: Q6ISS4
Secondary accession number(s): Q6PEZ4

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 3, 2006
Last sequence update:	July 5, 2004
Last modified:	January 25, 2012
This is version 64 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.