Q6ISE0 (Q6ISE0_HUMAN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
LMX1B protein EMBL AAH69588.1

Gene names

Name:

LMX1B EMBL AAH69588.1

Organism

Homo sapiens (Human) EMBL AAH69588.1

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	377 AA.
Sequence status	Fragment.
Protein existence	Evidence at transcript level

General annotation (Comments)

Subcellular location	Nucleus By similarity RuleBase RU000682.
Sequence similarities	Contains 1 homeobox DNA-binding domain. SAAS SAAS001781 Contains 2 LIM zinc-binding domains. RuleBase RU000350 SAAS SAAS001781

Ontologies

Keywords
Cellular component	Nucleus RuleBase RU000682 SAAS SAAS001781
Domain	Homeobox RuleBase RU000682 SAAS SAAS001781 LIM domain RuleBase RU000350 SAAS SAAS001781 Repeat SAAS SAAS001781
Ligand	DNA-binding SAAS SAAS001781 RuleBase RU000682 Metal-binding Zinc
Gene Ontology (GO)
Cellular_component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	sequence-specific DNA binding Inferred from electronic annotation. Source: InterPro sequence-specific DNA binding transcription factor activity Inferred from electronic annotation. Source: InterPro zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Experimental info
	Non-terminal residue	1	1	EMBL AAH69588.1

Sequences

	Sequence		Length	Mass (Da)
	Q6ISE0 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: 342C0EAD3206548A	FASTA	377	42,165
	10 20 30 40 50 60 DGIKMEEHAL RPGPATLGVL LGSDCPHPAV CEGCQRPISD RFLMRVNESS WHEECLQCAA 70 80 90 100 110 120 CQQALTTSCY FRDRKLYCKQ DYQQLFAAKC SGCMEKIAPT EFVMRALECV YHLGCFCCCV 130 140 150 160 170 180 CERQLRKGDE FVLKEGQLLC KGDYEKEKDL LSSVSPDESD SVKSEDEDGD MKPAKGQGSQ 190 200 210 220 230 240 SKGSGDDGKD PRRPKRPRTI LTTQQRRAFK ASFEVSSKPC RKVRETLAAE TGLSVRVVQV 250 260 270 280 290 300 WFQNQRAKMK KLARRHQQQQ EQQNSQRLGQ EVLSSRMEGM MASYTPLAPP QQQIVAMEQS 310 320 330 340 350 360 PYGSSDPFQQ GLTPPQMPGD HMNPYGNDSI FHDIDSDTSL TSLSDCFLGS SDVGSLQARV 370 GNPIDRLYSM QSSYFAS

References

[1]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M. , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J. Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: PCR rescued clones EMBL AAH69588.1.

+

Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC069588 mRNA. Translation: AAH69588.1.
IPI	IPI00030989.
RefSeq	NP_001167618.1. NM_001174147.1.
UniGene	Hs.129133.
3D structure databases
ProteinModelPortal	Q6ISE0.
ModBase	Search...
Protein-protein interaction databases
STRING	Q6ISE0.
Proteomic databases
PRIDE	Q6ISE0.
Protocols and materials databases
DNASU	4010.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4010.
KEGG	hsa:4010.
Organism-specific databases
CTD	4010.
PharmGKB	PA30417.
Phylogenomic databases
HOVERGEN	HBG052335.
KO	K09371.
Gene expression databases
ArrayExpress	Q6ISE0.
Bgee	Q6ISE0.
Family and domain databases
Gene3D	1.10.10.60. 1 hit. 2.10.110.10. 2 hits.
InterPro	IPR017970. Homeobox_CS. IPR001356. Homeodomain. IPR009057. Homeodomain-like. IPR001781. Znf_LIM. [Graphical view]
Pfam	PF00046. Homeobox. 1 hit. PF00412. LIM. 2 hits. [Graphical view]
SMART	SM00389. HOX. 1 hit. SM00132. LIM. 2 hits. [Graphical view]
SUPFAM	SSF46689. Homeodomain_like. 1 hit.
PROSITE	PS00027. HOMEOBOX_1. 1 hit. PS50071. HOMEOBOX_2. 1 hit. PS00478. LIM_DOMAIN_1. 2 hits. PS50023. LIM_DOMAIN_2. 2 hits. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	4010.
NextBio	15732.

Entry information

Entry name

Q6ISE0_HUMAN

Accession

Primary (citable) accession number: Q6ISE0

Entry history

Integrated into UniProtKB/TrEMBL:	July 5, 2004
Last sequence update:	July 5, 2004
Last modified:	April 3, 2013
This is version 79 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.