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Protein

Solute carrier family 25 member 47

Gene

Slc25a47

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Uncoupling protein which may catalyze the physiological 'proton leak' in liver.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processTransport

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 25 member 47
Alternative name(s):
Hepatocellular carcinoma down-regulated mitochondrial carrier homolog
Gene namesi
Name:Slc25a47
Synonyms:Hdmcp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi

Organism-specific databases

MGIiMGI:2144766 Slc25a47

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei3 – 23Helical; Name=1Sequence analysisAdd BLAST21
Transmembranei55 – 75Helical; Name=2Sequence analysisAdd BLAST21
Transmembranei98 – 114Helical; Name=3Sequence analysisAdd BLAST17
Transmembranei194 – 210Helical; Name=4Sequence analysisAdd BLAST17
Transmembranei219 – 239Helical; Name=5Sequence analysisAdd BLAST21
Transmembranei280 – 298Helical; Name=6Sequence analysisAdd BLAST19

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002917801 – 310Solute carrier family 25 member 47Add BLAST310

Proteomic databases

PaxDbiQ6IS41
PRIDEiQ6IS41

PTM databases

iPTMnetiQ6IS41
PhosphoSitePlusiQ6IS41

Expressioni

Gene expression databases

BgeeiENSMUSG00000048856
CleanExiMM_AI132487
ExpressionAtlasiQ6IS41 baseline and differential
GenevisibleiQ6IS41 MM

Structurei

3D structure databases

ProteinModelPortaliQ6IS41
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati1 – 80Solcar 1Add BLAST80
Repeati93 – 208Solcar 2Add BLAST116
Repeati217 – 304Solcar 3Add BLAST88

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0762 Eukaryota
ENOG410Z9ZS LUCA
GeneTreeiENSGT00700000104295
HOVERGENiHBG003500
InParanoidiQ6IS41
KOiK15123
OMAiHCLAHIC
OrthoDBiEOG091G0HVE
PhylomeDBiQ6IS41
TreeFamiTF351739

Family and domain databases

Gene3Di1.50.40.10, 1 hit
InterProiView protein in InterPro
IPR002067 Mit_carrier
IPR018108 Mitochondrial_sb/sol_carrier
IPR023395 Mt_carrier_dom_sf
PfamiView protein in Pfam
PF00153 Mito_carr, 3 hits
PRINTSiPR00926 MITOCARRIER
SUPFAMiSSF103506 SSF103506, 1 hit
PROSITEiView protein in PROSITE
PS50920 SOLCAR, 3 hits

Sequencei

Sequence statusi: Complete.

Q6IS41-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDFVAGAIGG VCGVAVGYPL DTVKVRIQTE AKYAGIWHCI RDTYRQERVW
60 70 80 90 100
GFYRGLSLPV CTVSLVSSVS FGTYHHCLAH ICRFRYGSTD AKPTKADITL
110 120 130 140 150
SGCASGLVRV FLTSPTEVAK VRLQTQTQAQ TQQRRSSASW TSGAPALCPT
160 170 180 190 200
PTACLEPRPK YSGPLHCLVT VAREEGLRGL YKGSSALLLR EGHSFATYFL
210 220 230 240 250
SYAMLCEWLT PAGHSQPDVL GVLVAGGCAG VLAWAVATPM DVIKSRLQAD
260 270 280 290 300
GQGQHRYRGL LHCVVTSVRE EGPRVLFKGL ALNCCRAFPV NMVVFVAYEA
310
VLRLTQSLLT
Length:310
Mass (Da):33,646
Last modified:April 17, 2007 - v2
Checksum:iF5571D9E0D9431F0
GO

Sequence cautioni

The sequence AAH55027 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti182K → M in AAH89616 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK149369 mRNA Translation: BAE28839.1
BC055027 mRNA Translation: AAH55027.1 Different initiation.
BC069939 mRNA Translation: AAH69939.2
BC089616 mRNA Translation: AAH89616.1
CCDSiCCDS26165.1
RefSeqiNP_001012310.2, NM_001012310.2
UniGeneiMm.202653

Genome annotation databases

EnsembliENSMUST00000057026; ENSMUSP00000050329; ENSMUSG00000048856
GeneIDi104910
KEGGimmu:104910
UCSCiuc007pae.1 mouse

Entry informationi

Entry nameiS2547_MOUSE
AccessioniPrimary (citable) accession number: Q6IS41
Secondary accession number(s): Q3UES2, Q5FW58, Q7TPP3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: April 17, 2007
Last modified: May 23, 2018
This is version 101 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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