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Protein

Solute carrier family 25 member 47

Gene

Slc25a47

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Uncoupling protein which may catalyze the physiological 'proton leak' in liver.By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 25 member 47
Alternative name(s):
Hepatocellular carcinoma down-regulated mitochondrial carrier homolog
Gene namesi
Name:Slc25a47
Synonyms:Hdmcp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:2144766. Slc25a47.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei3 – 2321Helical; Name=1Sequence analysisAdd
BLAST
Transmembranei55 – 7521Helical; Name=2Sequence analysisAdd
BLAST
Transmembranei98 – 11417Helical; Name=3Sequence analysisAdd
BLAST
Transmembranei194 – 21017Helical; Name=4Sequence analysisAdd
BLAST
Transmembranei219 – 23921Helical; Name=5Sequence analysisAdd
BLAST
Transmembranei280 – 29819Helical; Name=6Sequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • mitochondrial inner membrane Source: UniProtKB-SubCell
  • mitochondrion Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 310310Solute carrier family 25 member 47PRO_0000291780Add
BLAST

Proteomic databases

PaxDbiQ6IS41.
PRIDEiQ6IS41.

PTM databases

iPTMnetiQ6IS41.
PhosphoSiteiQ6IS41.

Expressioni

Gene expression databases

BgeeiQ6IS41.
CleanExiMM_AI132487.
GenevisibleiQ6IS41. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000050329.

Structurei

3D structure databases

ProteinModelPortaliQ6IS41.
SMRiQ6IS41. Positions 89-280.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati1 – 8080Solcar 1Add
BLAST
Repeati93 – 208116Solcar 2Add
BLAST
Repeati217 – 30488Solcar 3Add
BLAST

Sequence similaritiesi

Contains 3 Solcar repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0762. Eukaryota.
ENOG410Z9ZS. LUCA.
GeneTreeiENSGT00700000104295.
HOVERGENiHBG003500.
InParanoidiQ6IS41.
KOiK15123.
OMAiHCLAHIC.
OrthoDBiEOG77DJ6R.
PhylomeDBiQ6IS41.
TreeFamiTF351739.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR002067. Mit_carrier.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 3 hits.
[Graphical view]
PRINTSiPR00926. MITOCARRIER.
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6IS41-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDFVAGAIGG VCGVAVGYPL DTVKVRIQTE AKYAGIWHCI RDTYRQERVW
60 70 80 90 100
GFYRGLSLPV CTVSLVSSVS FGTYHHCLAH ICRFRYGSTD AKPTKADITL
110 120 130 140 150
SGCASGLVRV FLTSPTEVAK VRLQTQTQAQ TQQRRSSASW TSGAPALCPT
160 170 180 190 200
PTACLEPRPK YSGPLHCLVT VAREEGLRGL YKGSSALLLR EGHSFATYFL
210 220 230 240 250
SYAMLCEWLT PAGHSQPDVL GVLVAGGCAG VLAWAVATPM DVIKSRLQAD
260 270 280 290 300
GQGQHRYRGL LHCVVTSVRE EGPRVLFKGL ALNCCRAFPV NMVVFVAYEA
310
VLRLTQSLLT
Length:310
Mass (Da):33,646
Last modified:April 17, 2007 - v2
Checksum:iF5571D9E0D9431F0
GO

Sequence cautioni

The sequence AAH55027.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti182 – 1821K → M in AAH89616 (PubMed:15489334).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK149369 mRNA. Translation: BAE28839.1.
BC055027 mRNA. Translation: AAH55027.1. Different initiation.
BC069939 mRNA. Translation: AAH69939.2.
BC089616 mRNA. Translation: AAH89616.1.
CCDSiCCDS26165.1.
RefSeqiNP_001012310.2. NM_001012310.2.
UniGeneiMm.202653.

Genome annotation databases

EnsembliENSMUST00000057026; ENSMUSP00000050329; ENSMUSG00000048856.
GeneIDi104910.
KEGGimmu:104910.
UCSCiuc007pae.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK149369 mRNA. Translation: BAE28839.1.
BC055027 mRNA. Translation: AAH55027.1. Different initiation.
BC069939 mRNA. Translation: AAH69939.2.
BC089616 mRNA. Translation: AAH89616.1.
CCDSiCCDS26165.1.
RefSeqiNP_001012310.2. NM_001012310.2.
UniGeneiMm.202653.

3D structure databases

ProteinModelPortaliQ6IS41.
SMRiQ6IS41. Positions 89-280.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000050329.

PTM databases

iPTMnetiQ6IS41.
PhosphoSiteiQ6IS41.

Proteomic databases

PaxDbiQ6IS41.
PRIDEiQ6IS41.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000057026; ENSMUSP00000050329; ENSMUSG00000048856.
GeneIDi104910.
KEGGimmu:104910.
UCSCiuc007pae.1. mouse.

Organism-specific databases

CTDi283600.
MGIiMGI:2144766. Slc25a47.

Phylogenomic databases

eggNOGiKOG0762. Eukaryota.
ENOG410Z9ZS. LUCA.
GeneTreeiENSGT00700000104295.
HOVERGENiHBG003500.
InParanoidiQ6IS41.
KOiK15123.
OMAiHCLAHIC.
OrthoDBiEOG77DJ6R.
PhylomeDBiQ6IS41.
TreeFamiTF351739.

Miscellaneous databases

PROiQ6IS41.
SOURCEiSearch...

Gene expression databases

BgeeiQ6IS41.
CleanExiMM_AI132487.
GenevisibleiQ6IS41. MM.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR002067. Mit_carrier.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 3 hits.
[Graphical view]
PRINTSiPR00926. MITOCARRIER.
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Liver.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Liver.

Entry informationi

Entry nameiS2547_MOUSE
AccessioniPrimary (citable) accession number: Q6IS41
Secondary accession number(s): Q3UES2, Q5FW58, Q7TPP3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: April 17, 2007
Last modified: June 8, 2016
This is version 90 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.