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Protein

Eukaryotic translation initiation factor 5A-1-like

Gene

EIF5AL1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

mRNA-binding protein involved in translation elongation. Has an important function at the level of mRNA turnover, probably acting downstream of decapping. Involved in actin dynamics and cell cycle progression, mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity. Functions as a regulator of apoptosis. Mediates effects of polyamines on neuronal process extension and survival. May play an important role in brain development and function, and in skeletal muscle stem cell differentiation (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Elongation factor

Keywords - Biological processi

mRNA transport, Protein biosynthesis, Protein transport, Translocation, Transport

Keywords - Ligandi

RNA-binding

Protein family/group databases

TCDBi1.I.1.1.3. the nuclear pore complex (npc) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Eukaryotic translation initiation factor 5A-1-like
Short name:
eIF-5A-1-like
Short name:
eIF-5A1-like
Alternative name(s):
Eukaryotic initiation factor 5A isoform 1-like
Gene namesi
Name:EIF5AL1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:17419. EIF5AL1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Endoplasmic reticulum, Membrane, Nuclear pore complex, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134920977.

Polymorphism and mutation databases

BioMutaiEIF5AL1.
DMDMi190359775.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 154153Eukaryotic translation initiation factor 5A-1-likePRO_0000340263Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei50 – 501HypusineBy similarity

Post-translational modificationi

eIF-5A seems to be the only eukaryotic protein to have a hypusine residue which is a post-translational modification of a lysine by the addition of a butylamino group (from spermidine).By similarity

Keywords - PTMi

Hypusine

Proteomic databases

EPDiQ6IS14.
PaxDbiQ6IS14.
PRIDEiQ6IS14.
TopDownProteomicsiQ6IS14.

PTM databases

iPTMnetiQ6IS14.
PhosphoSiteiQ6IS14.
SwissPalmiQ6IS14.

Expressioni

Gene expression databases

BgeeiQ6IS14.
CleanExiHS_EIF5AL1.
GenevisibleiQ6IS14. HS.

Interactioni

Protein-protein interaction databases

BioGridi126793. 7 interactions.
IntActiQ6IS14. 1 interaction.
STRINGi9606.ENSP00000430706.

Structurei

3D structure databases

ProteinModelPortaliQ6IS14.
SMRiQ6IS14. Positions 15-150.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the eIF-5A family.Curated

Phylogenomic databases

eggNOGiKOG3271. Eukaryota.
COG0231. LUCA.
GeneTreeiENSGT00390000003738.
HOVERGENiHBG001104.
InParanoidiQ6IS14.
OMAiAGEEMLI.
OrthoDBiEOG7KSXB7.
PhylomeDBiQ6IS14.
TreeFamiTF101534.

Family and domain databases

Gene3Di2.30.30.30. 1 hit.
2.40.50.140. 1 hit.
InterProiIPR012340. NA-bd_OB-fold.
IPR014722. Rib_L2_dom2.
IPR019769. Trans_elong_IF5A_hypusine_site.
IPR001884. Transl_elong_IF5A.
IPR020189. Transl_elong_IF5A_C.
IPR008991. Translation_prot_SH3-like.
[Graphical view]
PANTHERiPTHR11673. PTHR11673. 1 hit.
PfamiPF01287. eIF-5a. 1 hit.
[Graphical view]
PIRSFiPIRSF003025. eIF5A. 1 hit.
SMARTiSM01376. eIF-5a. 1 hit.
[Graphical view]
SUPFAMiSSF50104. SSF50104. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00037. eIF_5A. 1 hit.
PROSITEiPS00302. IF5A_HYPUSINE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6IS14-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADDLDFETG DAGASATFPM QCSALRKNGF VVLKGWPCKI VEMSASKTGK
60 70 80 90 100
HGHAKVHLVG IDIFTGKKYE DICPSTHNMD VPNIKRNDFQ LIGIQDGYLS
110 120 130 140 150
LLQDSGEVPE DLRLPEGDLG KEIEQKYDCG EEILITVLSA MTEEAAVAIK

AMAK
Length:154
Mass (Da):16,773
Last modified:June 10, 2008 - v2
Checksum:i6A0F0426D24980C0
GO

Sequence cautioni

The sequence AAH70048.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC070048 mRNA. Translation: AAH70048.1. Different initiation.
CCDSiCCDS53546.1.
RefSeqiNP_001093162.1. NM_001099692.1.
UniGeneiHs.104825.

Genome annotation databases

EnsembliENST00000520547; ENSP00000430706; ENSG00000253626.
GeneIDi143244.
KEGGihsa:143244.
UCSCiuc009xrx.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC070048 mRNA. Translation: AAH70048.1. Different initiation.
CCDSiCCDS53546.1.
RefSeqiNP_001093162.1. NM_001099692.1.
UniGeneiHs.104825.

3D structure databases

ProteinModelPortaliQ6IS14.
SMRiQ6IS14. Positions 15-150.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126793. 7 interactions.
IntActiQ6IS14. 1 interaction.
STRINGi9606.ENSP00000430706.

Protein family/group databases

TCDBi1.I.1.1.3. the nuclear pore complex (npc) family.

PTM databases

iPTMnetiQ6IS14.
PhosphoSiteiQ6IS14.
SwissPalmiQ6IS14.

Polymorphism and mutation databases

BioMutaiEIF5AL1.
DMDMi190359775.

Proteomic databases

EPDiQ6IS14.
PaxDbiQ6IS14.
PRIDEiQ6IS14.
TopDownProteomicsiQ6IS14.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000520547; ENSP00000430706; ENSG00000253626.
GeneIDi143244.
KEGGihsa:143244.
UCSCiuc009xrx.4. human.

Organism-specific databases

CTDi143244.
GeneCardsiEIF5AL1.
HGNCiHGNC:17419. EIF5AL1.
neXtProtiNX_Q6IS14.
PharmGKBiPA134920977.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3271. Eukaryota.
COG0231. LUCA.
GeneTreeiENSGT00390000003738.
HOVERGENiHBG001104.
InParanoidiQ6IS14.
OMAiAGEEMLI.
OrthoDBiEOG7KSXB7.
PhylomeDBiQ6IS14.
TreeFamiTF101534.

Miscellaneous databases

GeneWikiiEIF5AP1.
GenomeRNAii143244.
NextBioi84677.
PROiQ6IS14.

Gene expression databases

BgeeiQ6IS14.
CleanExiHS_EIF5AL1.
GenevisibleiQ6IS14. HS.

Family and domain databases

Gene3Di2.30.30.30. 1 hit.
2.40.50.140. 1 hit.
InterProiIPR012340. NA-bd_OB-fold.
IPR014722. Rib_L2_dom2.
IPR019769. Trans_elong_IF5A_hypusine_site.
IPR001884. Transl_elong_IF5A.
IPR020189. Transl_elong_IF5A_C.
IPR008991. Translation_prot_SH3-like.
[Graphical view]
PANTHERiPTHR11673. PTHR11673. 1 hit.
PfamiPF01287. eIF-5a. 1 hit.
[Graphical view]
PIRSFiPIRSF003025. eIF5A. 1 hit.
SMARTiSM01376. eIF-5a. 1 hit.
[Graphical view]
SUPFAMiSSF50104. SSF50104. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00037. eIF_5A. 1 hit.
PROSITEiPS00302. IF5A_HYPUSINE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.

Entry informationi

Entry nameiIF5AL_HUMAN
AccessioniPrimary (citable) accession number: Q6IS14
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: June 10, 2008
Last modified: May 11, 2016
This is version 101 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Translation initiation factors
    List of translation initiation factor entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.