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Protein

Eukaryotic translation initiation factor 5A-1-like

Gene

EIF5AL1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

mRNA-binding protein involved in translation elongation. Has an important function at the level of mRNA turnover, probably acting downstream of decapping. Involved in actin dynamics and cell cycle progression, mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity. Functions as a regulator of apoptosis. Mediates effects of polyamines on neuronal process extension and survival. May play an important role in brain development and function, and in skeletal muscle stem cell differentiation (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionElongation factor, RNA-binding
Biological processmRNA transport, Protein biosynthesis, Protein transport, Translocation, Transport

Protein family/group databases

TCDBi1.I.1.1.3. the eukaryotic nuclear pore complex (e-npc) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Eukaryotic translation initiation factor 5A-1-like
Short name:
eIF-5A-1-like
Short name:
eIF-5A1-like
Alternative name(s):
Eukaryotic initiation factor 5A isoform 1-like
Gene namesi
Name:EIF5AL1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000253626.3.
HGNCiHGNC:17419. EIF5AL1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Endoplasmic reticulum, Membrane, Nuclear pore complex, Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000253626.
PharmGKBiPA134920977.

Polymorphism and mutation databases

BioMutaiEIF5AL1.
DMDMi190359775.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003402631 – 154Eukaryotic translation initiation factor 5A-1-likeAdd BLAST154

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei50HypusineBy similarity1

Post-translational modificationi

eIF-5A seems to be the only eukaryotic protein to have a hypusine residue which is a post-translational modification of a lysine by the addition of a butylamino group (from spermidine).By similarity

Keywords - PTMi

Hypusine

Proteomic databases

MaxQBiQ6IS14.
PaxDbiQ6IS14.
PeptideAtlasiQ6IS14.
PRIDEiQ6IS14.
TopDownProteomicsiQ6IS14.

PTM databases

iPTMnetiQ6IS14.
PhosphoSitePlusiQ6IS14.
SwissPalmiQ6IS14.

Expressioni

Gene expression databases

BgeeiENSG00000253626.
CleanExiHS_EIF5AL1.
GenevisibleiQ6IS14. HS.

Interactioni

Protein-protein interaction databases

BioGridi126793. 7 interactors.
IntActiQ6IS14. 1 interactor.
STRINGi9606.ENSP00000430706.

Structurei

3D structure databases

ProteinModelPortaliQ6IS14.
SMRiQ6IS14.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the eIF-5A family.Curated

Phylogenomic databases

eggNOGiKOG3271. Eukaryota.
COG0231. LUCA.
GeneTreeiENSGT00900000141354.
HOVERGENiHBG001104.
InParanoidiQ6IS14.
OMAiMARPIST.
OrthoDBiEOG091G0P2P.
PhylomeDBiQ6IS14.
TreeFamiTF101534.

Family and domain databases

Gene3Di2.30.30.30. 1 hit.
InterProiView protein in InterPro
IPR012340. NA-bd_OB-fold.
IPR014722. Rib_L2_dom2.
IPR019769. Trans_elong_IF5A_hypusine_site.
IPR001884. Transl_elong_IF5A.
IPR020189. Transl_elong_IF5A_C.
IPR008991. Translation_prot_SH3-like_sf.
PANTHERiPTHR11673. PTHR11673. 1 hit.
PfamiView protein in Pfam
PF01287. eIF-5a. 1 hit.
PIRSFiPIRSF003025. eIF5A. 1 hit.
SMARTiView protein in SMART
SM01376. eIF-5a. 1 hit.
SUPFAMiSSF50104. SSF50104. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00037. eIF_5A. 1 hit.
PROSITEiView protein in PROSITE
PS00302. IF5A_HYPUSINE. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6IS14-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADDLDFETG DAGASATFPM QCSALRKNGF VVLKGWPCKI VEMSASKTGK
60 70 80 90 100
HGHAKVHLVG IDIFTGKKYE DICPSTHNMD VPNIKRNDFQ LIGIQDGYLS
110 120 130 140 150
LLQDSGEVPE DLRLPEGDLG KEIEQKYDCG EEILITVLSA MTEEAAVAIK

AMAK
Length:154
Mass (Da):16,773
Last modified:June 10, 2008 - v2
Checksum:i6A0F0426D24980C0
GO

Sequence cautioni

The sequence AAH70048 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC070048 mRNA. Translation: AAH70048.1. Different initiation.
CCDSiCCDS53546.1.
RefSeqiNP_001093162.1. NM_001099692.1.
UniGeneiHs.104825.

Genome annotation databases

EnsembliENST00000520547; ENSP00000430706; ENSG00000253626.
GeneIDi143244.
KEGGihsa:143244.
UCSCiuc009xrx.4. human.

Similar proteinsi

Entry informationi

Entry nameiIF5AL_HUMAN
AccessioniPrimary (citable) accession number: Q6IS14
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: June 10, 2008
Last modified: November 22, 2017
This is version 115 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Translation initiation factors
    List of translation initiation factor entries
  3. SIMILARITY comments
    Index of protein domains and families