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Protein

Eukaryotic translation initiation factor 5A-1-like

Gene

EIF5AL1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

mRNA-binding protein involved in translation elongation. Has an important function at the level of mRNA turnover, probably acting downstream of decapping. Involved in actin dynamics and cell cycle progression, mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity. Functions as a regulator of apoptosis. Mediates effects of polyamines on neuronal process extension and survival. May play an important role in brain development and function, and in skeletal muscle stem cell differentiation (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionElongation factor, RNA-binding
Biological processmRNA transport, Protein biosynthesis, Protein transport, Translocation, Transport

Protein family/group databases

TCDBi1.I.1.1.3 the eukaryotic nuclear pore complex (e-npc) family

Names & Taxonomyi

Protein namesi
Recommended name:
Eukaryotic translation initiation factor 5A-1-like
Short name:
eIF-5A-1-like
Short name:
eIF-5A1-like
Alternative name(s):
Eukaryotic initiation factor 5A isoform 1-like
Gene namesi
Name:EIF5AL1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000253626.3
HGNCiHGNC:17419 EIF5AL1
neXtProtiNX_Q6IS14

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Endoplasmic reticulum, Membrane, Nuclear pore complex, Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000253626
PharmGKBiPA134920977

Polymorphism and mutation databases

BioMutaiEIF5AL1
DMDMi190359775

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003402631 – 154Eukaryotic translation initiation factor 5A-1-likeAdd BLAST154

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei50HypusineBy similarity1

Post-translational modificationi

eIF-5A seems to be the only eukaryotic protein to have a hypusine residue which is a post-translational modification of a lysine by the addition of a butylamino group (from spermidine).By similarity

Keywords - PTMi

Hypusine

Proteomic databases

EPDiQ6IS14
MaxQBiQ6IS14
PaxDbiQ6IS14
PeptideAtlasiQ6IS14
PRIDEiQ6IS14
TopDownProteomicsiQ6IS14

PTM databases

iPTMnetiQ6IS14
PhosphoSitePlusiQ6IS14
SwissPalmiQ6IS14

Expressioni

Gene expression databases

BgeeiENSG00000253626
CleanExiHS_EIF5AL1
GenevisibleiQ6IS14 HS

Interactioni

Protein-protein interaction databases

BioGridi126793, 7 interactors
IntActiQ6IS14, 1 interactor
STRINGi9606.ENSP00000430706

Structurei

3D structure databases

ProteinModelPortaliQ6IS14
SMRiQ6IS14
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the eIF-5A family.Curated

Phylogenomic databases

eggNOGiKOG3271 Eukaryota
COG0231 LUCA
GeneTreeiENSGT00390000003738
HOVERGENiHBG001104
InParanoidiQ6IS14
OMAiEYNEDYQ
OrthoDBiEOG091G0P2P
PhylomeDBiQ6IS14
TreeFamiTF101534

Family and domain databases

Gene3Di2.30.30.30, 1 hit
InterProiView protein in InterPro
IPR001884 IF5A-like
IPR012340 NA-bd_OB-fold
IPR014722 Rib_L2_dom2
IPR019769 Trans_elong_IF5A_hypusine_site
IPR020189 Transl_elong_IF5A_C
IPR008991 Translation_prot_SH3-like_sf
PANTHERiPTHR11673 PTHR11673, 1 hit
PfamiView protein in Pfam
PF01287 eIF-5a, 1 hit
PIRSFiPIRSF003025 eIF5A, 1 hit
SMARTiView protein in SMART
SM01376 eIF-5a, 1 hit
SUPFAMiSSF50104 SSF50104, 1 hit
SSF50249 SSF50249, 1 hit
TIGRFAMsiTIGR00037 eIF_5A, 1 hit
PROSITEiView protein in PROSITE
PS00302 IF5A_HYPUSINE, 1 hit

Sequencei

Sequence statusi: Complete.

Q6IS14-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADDLDFETG DAGASATFPM QCSALRKNGF VVLKGWPCKI VEMSASKTGK
60 70 80 90 100
HGHAKVHLVG IDIFTGKKYE DICPSTHNMD VPNIKRNDFQ LIGIQDGYLS
110 120 130 140 150
LLQDSGEVPE DLRLPEGDLG KEIEQKYDCG EEILITVLSA MTEEAAVAIK

AMAK
Length:154
Mass (Da):16,773
Last modified:June 10, 2008 - v2
Checksum:i6A0F0426D24980C0
GO

Sequence cautioni

The sequence AAH70048 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC070048 mRNA Translation: AAH70048.1 Different initiation.
CCDSiCCDS53546.1
RefSeqiNP_001093162.1, NM_001099692.1
UniGeneiHs.104825

Genome annotation databases

EnsembliENST00000520547; ENSP00000430706; ENSG00000253626
GeneIDi143244
KEGGihsa:143244
UCSCiuc009xrx.4 human

Similar proteinsi

Entry informationi

Entry nameiIF5AL_HUMAN
AccessioniPrimary (citable) accession number: Q6IS14
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: June 10, 2008
Last modified: March 28, 2018
This is version 119 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Translation initiation factors
    List of translation initiation factor entries
  3. SIMILARITY comments
    Index of protein domains and families

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