ID   Q6IRV4_HUMAN            Unreviewed;       278 AA.
AC   Q6IRV4;
DT   05-JUL-2004, integrated into UniProtKB/TrEMBL.
DT   05-JUL-2004, sequence version 1.
DT   27-MAR-2024, entry version 85.
DE   SubName: Full=TRA@ protein {ECO:0000313|EMBL:AAH70337.1};
GN   Name=TRA@ {ECO:0000313|EMBL:AAH70337.1};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|EMBL:AAH70337.1};
RN   [1] {ECO:0000313|EMBL:AAH70337.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RA   Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H.,
RA   Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M.,
RA   Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.,
RA   Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F.,
RA   Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T.,
RA   Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F.,
RA   Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E.,
RA   Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y.,
RA   Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E.,
RA   Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y.,
RA   Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W.,
RA   Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J.,
RA   Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S.,
RA   Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J.,
RA   Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W.,
RA   Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J.,
RA   Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I.,
RA   Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U.,
RA   Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A.,
RA   Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [2] {ECO:0007829|PDB:6BJ2, ECO:0007829|PDB:6BJ3}
RP   X-RAY CRYSTALLOGRAPHY (1.75 ANGSTROMS) OF 22-228, AND DISULFIDE BONDS.
RX   PubMed=30053426; DOI=10.1016/j.cell.2018.06.017;
RA   Sibener L.V., Fernandes R.A., Kolawole E.M., Carbone C.B., Liu F.,
RA   McAffee D., Birnbaum M.E., Yang X., Su L.F., Yu W., Dong S., Gee M.H.,
RA   Jude K.M., Davis M.M., Groves J.T., Goddard W.A., Heath J.R., Evavold B.D.,
RA   Vale R.D., Garcia K.C.;
RT   "Isolation of a Structural Mechanism for Uncoupling T Cell Receptor
RT   Signaling from Peptide-MHC Binding.";
RL   Cell 174:672-687.e27(2018).
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DR   EMBL; BC070337; AAH70337.1; -; mRNA.
DR   PDB; 6BJ2; X-ray; 3.35 A; D=22-227.
DR   PDB; 6BJ3; X-ray; 1.90 A; D=22-228.
DR   PDB; 6BJ8; X-ray; 1.75 A; D=22-228.
DR   AlphaFoldDB; Q6IRV4; -.
DR   SMR; Q6IRV4; -.
DR   MaxQB; Q6IRV4; -.
DR   PeptideAtlas; Q6IRV4; -.
DR   ChiTaRS; TRA; human.
DR   CDD; cd07688; IgC_TCR_alpha; 1.
DR   Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR003599; Ig_sub.
DR   InterPro; IPR013106; Ig_V-set.
DR   InterPro; IPR015370; TCR_alpha_C.
DR   PANTHER; PTHR19433:SF72; T CELL RECEPTOR ALPHA CHAIN MC.7.G5-RELATED; 1.
DR   PANTHER; PTHR19433; T-CELL RECEPTOR ALPHA CHAIN V REGION-RELATED; 1.
DR   Pfam; PF09291; DUF1968; 1.
DR   Pfam; PF07686; V-set; 1.
DR   SMART; SM00409; IG; 1.
DR   SMART; SM00406; IGv; 1.
DR   SUPFAM; SSF48726; Immunoglobulin; 2.
DR   PROSITE; PS50835; IG_LIKE; 1.
PE   1: Evidence at protein level;
KW   3D-structure {ECO:0007829|PDB:6BJ2, ECO:0007829|PDB:6BJ3};
KW   Metal-binding {ECO:0007829|PDB:6BJ2}; Signal {ECO:0000256|SAM:SignalP};
KW   Zinc {ECO:0007829|PDB:6BJ2}.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           22..278
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5004274825"
FT   DOMAIN          22..112
FT                   /note="Ig-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50835"
FT   BINDING         143
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0007829|PDB:6BJ2"
FT   DISULFID        43..112
FT                   /evidence="ECO:0007829|PDB:6BJ2, ECO:0007829|PDB:6BJ3"
FT   DISULFID        160..210
FT                   /evidence="ECO:0007829|PDB:6BJ2, ECO:0007829|PDB:6BJ3"
SQ   SEQUENCE   278 AA;  31358 MW;  E33D4FC4EF8C2703 CRC64;
     MACPGFLWAL VISTCLEFSM AQTVTQSQPE MSVQEAETVT LSCTYDTSES DYYLFWYKQP
     PSRQMILVIR QEAYKQQNAT ENRFSVNFQK AAKSFSLKIS DSQLGDAAMY FCAYRSYLQG
     GSEKLVFGKG TKLTVNPYIQ NPDPAVYQLR DSKSSDKSVC LFTDFDSQTN VSQSKDSDVY
     ITDKTVLDMR SMDFKSNSAV AWSNKSDFAC ANAFNNSIIP EDTFFPSPES SCDVKLVEKS
     FETDTNLNFQ NLSVIGFRIL LLKVAGFNLL MTLRLWSS
//