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Protein

Centrosomal protein of 78 kDa

Gene

Cep78

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Enzyme and pathway databases

ReactomeiR-MMU-2565942. Regulation of PLK1 Activity at G2/M Transition.
R-MMU-380259. Loss of Nlp from mitotic centrosomes.
R-MMU-380270. Recruitment of mitotic centrosome proteins and complexes.
R-MMU-5620912. Anchoring of the basal body to the plasma membrane.
R-MMU-8854518. AURKA Activation by TPX2.

Names & Taxonomyi

Protein namesi
Recommended name:
Centrosomal protein of 78 kDa
Short name:
Cep78
Gene namesi
Name:Cep78
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:1924386. Cep78.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 790790Centrosomal protein of 78 kDaPRO_0000291953Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei330 – 3301PhosphoserineBy similarity
Modified residuei332 – 3321PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ6IRU7.
MaxQBiQ6IRU7.
PaxDbiQ6IRU7.
PeptideAtlasiQ6IRU7.
PRIDEiQ6IRU7.

PTM databases

iPTMnetiQ6IRU7.
PhosphoSiteiQ6IRU7.

Expressioni

Gene expression databases

BgeeiQ6IRU7.
CleanExiMM_CEP78.
GenevisibleiQ6IRU7. MM.

Interactioni

Protein-protein interaction databases

BioGridi228987. 35 interactions.
IntActiQ6IRU7. 35 interactions.
STRINGi10090.ENSMUSP00000037596.

Structurei

3D structure databases

ProteinModelPortaliQ6IRU7.
SMRiQ6IRU7. Positions 49-308.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili455 – 51056Sequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the CEP78 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG4308. Eukaryota.
ENOG410ZBX3. LUCA.
GeneTreeiENSGT00390000013287.
HOGENOMiHOG000015235.
HOVERGENiHBG056294.
InParanoidiQ6IRU7.
KOiK16765.
OMAiMMKAVIK.
OrthoDBiEOG7R831R.
PhylomeDBiQ6IRU7.
TreeFamiTF328928.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiIPR026212. Cep78.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
[Graphical view]
PfamiPF13516. LRR_6. 3 hits.
[Graphical view]
PRINTSiPR02062. CENTROSOME78.

Sequencei

Sequence statusi: Complete.

Q6IRU7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIDSVKLRRD CAADFFSHYE YLCALQDSVP LPAVRACLRD GVLDFNADRL
60 70 80 90 100
RAVDWAPLLS TLRVNRDLPL VAIKSSFQPW LGETVLRSGG ADTHRICRNR
110 120 130 140 150
VPAVRSKDIS FQLCKALRGC LSVSGVLRNL ELNGLILRER DLTSLTKGLS
160 170 180 190 200
KSTSLVHLSL ANCPIGDGGL EIICQGIKNS VTLKTVNFTG CNLTWQGACH
210 220 230 240 250
MAKILKYQTM RRHEETWAES LRYRRPDLDC MAGLRRITLN CNTLIGDQGA
260 270 280 290 300
SAFADSLSED LWLRALDLQQ CGLTSEGAKA LLEALETNRT LVVLDIRKNP
310 320 330 340 350
LIDHSMMKAV IKKVLQNGRS ADSEYQWVTS PSSKEPSKTA KQRKKTIVLG
360 370 380 390 400
SSRKGKATIR IGLATKKPSS NGRKQGLGKD CYAPNPLPPG ASGFLPWRTA
410 420 430 440 450
ERAKRSRSSS LIKTRDLSNH LKKSDFPVTV TVESPSSSET DETEDSSESV
460 470 480 490 500
QEAPQKTSIK EETLQEKLEE CLRQLKEERV IRLKADKRVS ELEHENAQLR
510 520 530 540 550
NINFSLSEAL HAQSLTNMIL DDEGVLGSIE NSFQKFHAFL DLLKDAGLGQ
560 570 580 590 600
LATMAGIDQS DFHLLGRPQM NSTVNTPIQE QKALEDETLH PKQTATGQMQ
610 620 630 640 650
DIRFQKITSD ALIPLPLNTV QDPASAQEAV GASRDHLGVV GLEQQEGSAA
660 670 680 690 700
GFIAKTGSPL AGGIPGGRSQ REEEVLSKHS RSSSEKGSTA SEPSRRPSAE
710 720 730 740 750
RHPRKDLLSD ADPPGNSESK GPGDRRSLLN EPIKSESLKK CISIKKENRI
760 770 780 790
VTVSSKTIKS KPNLLEHSES DTLGSDFELQ ERVHSSAHLT
Length:790
Mass (Da):86,890
Last modified:July 5, 2004 - v1
Checksum:i3A6A098B010B6869
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC070400 mRNA. Translation: AAH70400.1.
CCDSiCCDS29682.1.
RefSeqiNP_932136.2. NM_198019.2.
UniGeneiMm.105652.

Genome annotation databases

EnsembliENSMUST00000047704; ENSMUSP00000037596; ENSMUSG00000041491.
GeneIDi208518.
KEGGimmu:208518.
UCSCiuc008gwq.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC070400 mRNA. Translation: AAH70400.1.
CCDSiCCDS29682.1.
RefSeqiNP_932136.2. NM_198019.2.
UniGeneiMm.105652.

3D structure databases

ProteinModelPortaliQ6IRU7.
SMRiQ6IRU7. Positions 49-308.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi228987. 35 interactions.
IntActiQ6IRU7. 35 interactions.
STRINGi10090.ENSMUSP00000037596.

PTM databases

iPTMnetiQ6IRU7.
PhosphoSiteiQ6IRU7.

Proteomic databases

EPDiQ6IRU7.
MaxQBiQ6IRU7.
PaxDbiQ6IRU7.
PeptideAtlasiQ6IRU7.
PRIDEiQ6IRU7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000047704; ENSMUSP00000037596; ENSMUSG00000041491.
GeneIDi208518.
KEGGimmu:208518.
UCSCiuc008gwq.1. mouse.

Organism-specific databases

CTDi84131.
MGIiMGI:1924386. Cep78.

Phylogenomic databases

eggNOGiKOG4308. Eukaryota.
ENOG410ZBX3. LUCA.
GeneTreeiENSGT00390000013287.
HOGENOMiHOG000015235.
HOVERGENiHBG056294.
InParanoidiQ6IRU7.
KOiK16765.
OMAiMMKAVIK.
OrthoDBiEOG7R831R.
PhylomeDBiQ6IRU7.
TreeFamiTF328928.

Enzyme and pathway databases

ReactomeiR-MMU-2565942. Regulation of PLK1 Activity at G2/M Transition.
R-MMU-380259. Loss of Nlp from mitotic centrosomes.
R-MMU-380270. Recruitment of mitotic centrosome proteins and complexes.
R-MMU-5620912. Anchoring of the basal body to the plasma membrane.
R-MMU-8854518. AURKA Activation by TPX2.

Miscellaneous databases

PROiQ6IRU7.
SOURCEiSearch...

Gene expression databases

BgeeiQ6IRU7.
CleanExiMM_CEP78.
GenevisibleiQ6IRU7. MM.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiIPR026212. Cep78.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
[Graphical view]
PfamiPF13516. LRR_6. 3 hits.
[Graphical view]
PRINTSiPR02062. CENTROSOME78.
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Brain.

Entry informationi

Entry nameiCEP78_MOUSE
AccessioniPrimary (citable) accession number: Q6IRU7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: July 5, 2004
Last modified: July 6, 2016
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.