Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q6IRU2

- TPM4_MOUSE

UniProt

Q6IRU2 - TPM4_MOUSE

Protein

Tropomyosin alpha-4 chain

Gene

Tpm4

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 80 (01 Oct 2014)
      Sequence version 3 (23 Jan 2007)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments. Binds calcium By similarity.By similarity

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW

    Keywords - Molecular functioni

    Muscle protein

    Keywords - Ligandi

    Actin-binding, Calcium, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tropomyosin alpha-4 chain
    Alternative name(s):
    Tropomyosin-4
    Gene namesi
    Name:Tpm4
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 8

    Organism-specific databases

    MGIiMGI:2449202. Tpm4.

    Subcellular locationi

    Cytoplasmcytoskeleton By similarity

    GO - Cellular componenti

    1. cortical cytoskeleton Source: MGI
    2. cytoplasm Source: MGI
    3. podosome Source: MGI
    4. stress fiber Source: MGI

    Keywords - Cellular componenti

    Cytoplasm, Cytoskeleton

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 248247Tropomyosin alpha-4 chainPRO_0000205636Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanineBy similarity
    Modified residuei177 – 1771N6-acetyllysineBy similarity
    Modified residuei215 – 2151N6-acetyllysineBy similarity

    Keywords - PTMi

    Acetylation

    Proteomic databases

    MaxQBiQ6IRU2.
    PaxDbiQ6IRU2.
    PRIDEiQ6IRU2.

    PTM databases

    PhosphoSiteiQ6IRU2.

    Expressioni

    Gene expression databases

    BgeeiQ6IRU2.
    CleanExiMM_TPM4.
    GenevestigatoriQ6IRU2.

    Interactioni

    Subunit structurei

    Heterodimer of an alpha and a beta chain.By similarity

    Protein-protein interaction databases

    BioGridi236471. 2 interactions.
    IntActiQ6IRU2. 1 interaction.
    STRINGi10090.ENSMUSP00000003575.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6IRU2.
    SMRiQ6IRU2. Positions 5-248.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili2 – 248247By similarityAdd
    BLAST

    Domaini

    The molecule is in a coiled coil structure that is formed by 2 polypeptide chains. The sequence exhibits a prominent seven-residues periodicity.

    Sequence similaritiesi

    Belongs to the tropomyosin family.Curated

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiNOG304012.
    GeneTreeiENSGT00550000074494.
    HOGENOMiHOG000231522.
    HOVERGENiHBG107404.
    InParanoidiQ6IRU2.
    KOiK10375.
    OMAiEKCKQVE.
    OrthoDBiEOG7673C8.
    PhylomeDBiQ6IRU2.
    TreeFamiTF351519.

    Family and domain databases

    InterProiIPR000533. Tropomyosin.
    [Graphical view]
    PfamiPF00261. Tropomyosin. 1 hit.
    [Graphical view]
    PRINTSiPR00194. TROPOMYOSIN.
    PROSITEiPS00326. TROPOMYOSIN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q6IRU2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAGLNSLEAV KRKIQALQQQ ADDAEDRAQG LQRELDGERE RREKAEGDAA    50
    ALNRRIQLLE EELDRAQEQL ATALQNLEEA EKAADESERG MKVIENRAMK 100
    DEEKMEILEM QLKEAKHITD EADRKYEEVA RKLVILEGEL KRAEERAEVS 150
    ELKCGDLEEE LKNVTNNLKS LEAASEKYSE KEDKYEEEIK LLSDKLKEAE 200
    TRAEFAERTV SKLEKTIDDL EEKLAQAKEE NVGLHQTLDQ TLNELNCI 248
    Length:248
    Mass (Da):28,468
    Last modified:January 23, 2007 - v3
    Checksum:i2B6C388008A6AF1B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC023701 mRNA. Translation: AAH23701.1.
    BC023827 mRNA. Translation: AAH23827.1.
    BC070421 mRNA. Translation: AAH70421.1.
    CCDSiCCDS22408.1.
    RefSeqiNP_001001491.1. NM_001001491.1.
    UniGeneiMm.295124.

    Genome annotation databases

    EnsembliENSMUST00000003575; ENSMUSP00000003575; ENSMUSG00000031799.
    GeneIDi326618.
    KEGGimmu:326618.
    UCSCiuc009mfi.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC023701 mRNA. Translation: AAH23701.1 .
    BC023827 mRNA. Translation: AAH23827.1 .
    BC070421 mRNA. Translation: AAH70421.1 .
    CCDSi CCDS22408.1.
    RefSeqi NP_001001491.1. NM_001001491.1.
    UniGenei Mm.295124.

    3D structure databases

    ProteinModelPortali Q6IRU2.
    SMRi Q6IRU2. Positions 5-248.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 236471. 2 interactions.
    IntActi Q6IRU2. 1 interaction.
    STRINGi 10090.ENSMUSP00000003575.

    PTM databases

    PhosphoSitei Q6IRU2.

    Proteomic databases

    MaxQBi Q6IRU2.
    PaxDbi Q6IRU2.
    PRIDEi Q6IRU2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000003575 ; ENSMUSP00000003575 ; ENSMUSG00000031799 .
    GeneIDi 326618.
    KEGGi mmu:326618.
    UCSCi uc009mfi.1. mouse.

    Organism-specific databases

    CTDi 7171.
    MGIi MGI:2449202. Tpm4.

    Phylogenomic databases

    eggNOGi NOG304012.
    GeneTreei ENSGT00550000074494.
    HOGENOMi HOG000231522.
    HOVERGENi HBG107404.
    InParanoidi Q6IRU2.
    KOi K10375.
    OMAi EKCKQVE.
    OrthoDBi EOG7673C8.
    PhylomeDBi Q6IRU2.
    TreeFami TF351519.

    Miscellaneous databases

    NextBioi 397902.
    PROi Q6IRU2.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q6IRU2.
    CleanExi MM_TPM4.
    Genevestigatori Q6IRU2.

    Family and domain databases

    InterProi IPR000533. Tropomyosin.
    [Graphical view ]
    Pfami PF00261. Tropomyosin. 1 hit.
    [Graphical view ]
    PRINTSi PR00194. TROPOMYOSIN.
    PROSITEi PS00326. TROPOMYOSIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6 and FVB/N.
      Tissue: Brain and Mammary tumor.

    Entry informationi

    Entry nameiTPM4_MOUSE
    AccessioniPrimary (citable) accession number: Q6IRU2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 11, 2004
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 80 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3