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Q6IRU2 (TPM4_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 79. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Tropomyosin alpha-4 chain
Alternative name(s):
Tropomyosin-4
Gene names
Name:Tpm4
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length248 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments. Binds calcium By similarity.

Subunit structure

Heterodimer of an alpha and a beta chain By similarity.

Subcellular location

Cytoplasmcytoskeleton By similarity.

Domain

The molecule is in a coiled coil structure that is formed by 2 polypeptide chains. The sequence exhibits a prominent seven-residues periodicity.

Sequence similarities

Belongs to the tropomyosin family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 248247Tropomyosin alpha-4 chain
PRO_0000205636

Regions

Coiled coil2 – 248247 By similarity

Amino acid modifications

Modified residue21N-acetylalanine By similarity
Modified residue1771N6-acetyllysine By similarity
Modified residue2151N6-acetyllysine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q6IRU2 [UniParc].

Last modified January 23, 2007. Version 3.
Checksum: 2B6C388008A6AF1B

FASTA24828,468
        10         20         30         40         50         60 
MAGLNSLEAV KRKIQALQQQ ADDAEDRAQG LQRELDGERE RREKAEGDAA ALNRRIQLLE 

        70         80         90        100        110        120 
EELDRAQEQL ATALQNLEEA EKAADESERG MKVIENRAMK DEEKMEILEM QLKEAKHITD 

       130        140        150        160        170        180 
EADRKYEEVA RKLVILEGEL KRAEERAEVS ELKCGDLEEE LKNVTNNLKS LEAASEKYSE 

       190        200        210        220        230        240 
KEDKYEEEIK LLSDKLKEAE TRAEFAERTV SKLEKTIDDL EEKLAQAKEE NVGLHQTLDQ 


TLNELNCI 

« Hide

References

[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6 and FVB/N.
Tissue: Brain and Mammary tumor.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC023701 mRNA. Translation: AAH23701.1.
BC023827 mRNA. Translation: AAH23827.1.
BC070421 mRNA. Translation: AAH70421.1.
CCDSCCDS22408.1.
RefSeqNP_001001491.1. NM_001001491.1.
UniGeneMm.295124.

3D structure databases

ProteinModelPortalQ6IRU2.
SMRQ6IRU2. Positions 5-248.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid236471. 2 interactions.
IntActQ6IRU2. 1 interaction.
STRING10090.ENSMUSP00000003575.

PTM databases

PhosphoSiteQ6IRU2.

Proteomic databases

MaxQBQ6IRU2.
PaxDbQ6IRU2.
PRIDEQ6IRU2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000003575; ENSMUSP00000003575; ENSMUSG00000031799.
GeneID326618.
KEGGmmu:326618.
UCSCuc009mfi.1. mouse.

Organism-specific databases

CTD7171.
MGIMGI:2449202. Tpm4.

Phylogenomic databases

eggNOGNOG304012.
GeneTreeENSGT00550000074494.
HOGENOMHOG000231522.
HOVERGENHBG107404.
InParanoidQ6IRU2.
KOK10375.
OMAEKCKQVE.
OrthoDBEOG7673C8.
PhylomeDBQ6IRU2.
TreeFamTF351519.

Gene expression databases

BgeeQ6IRU2.
CleanExMM_TPM4.
GenevestigatorQ6IRU2.

Family and domain databases

InterProIPR000533. Tropomyosin.
[Graphical view]
PfamPF00261. Tropomyosin. 1 hit.
[Graphical view]
PRINTSPR00194. TROPOMYOSIN.
PROSITEPS00326. TROPOMYOSIN. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio397902.
PROQ6IRU2.
SOURCESearch...

Entry information

Entry nameTPM4_MOUSE
AccessionPrimary (citable) accession number: Q6IRU2
Entry history
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: January 23, 2007
Last modified: July 9, 2014
This is version 79 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot