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Protein

Tropomyosin alpha-4 chain

Gene

Tpm4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments. Binds calcium.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActin-binding, Muscle protein
LigandCalcium, Metal-binding

Enzyme and pathway databases

ReactomeiR-MMU-390522 Striated Muscle Contraction
R-MMU-445355 Smooth Muscle Contraction

Names & Taxonomyi

Protein namesi
Recommended name:
Tropomyosin alpha-4 chain
Alternative name(s):
Tropomyosin-4
Gene namesi
Name:Tpm4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:2449202 Tpm4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002056362 – 248Tropomyosin alpha-4 chainAdd BLAST247

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei6PhosphoserineBy similarity1
Modified residuei177N6-acetyllysineBy similarity1
Modified residuei215N6-acetyllysineBy similarity1
Modified residuei216PhosphothreonineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ6IRU2
MaxQBiQ6IRU2
PaxDbiQ6IRU2
PeptideAtlasiQ6IRU2
PRIDEiQ6IRU2

PTM databases

iPTMnetiQ6IRU2
PhosphoSitePlusiQ6IRU2
SwissPalmiQ6IRU2

Expressioni

Gene expression databases

BgeeiENSMUSG00000031799
CleanExiMM_TPM4
GenevisibleiQ6IRU2 MM

Interactioni

Subunit structurei

Homodimer. Heterodimer of an alpha (TPM1, TPM3 or TPM4) and a beta (TPM2) chain.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi23647114 interactors.
IntActiQ6IRU2 13 interactors.
STRINGi10090.ENSMUSP00000003575

Structurei

3D structure databases

ProteinModelPortaliQ6IRU2
SMRiQ6IRU2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili2 – 248By similarityAdd BLAST247

Domaini

The molecule is in a coiled coil structure that is formed by 2 polypeptide chains. The sequence exhibits a prominent seven-residues periodicity.

Sequence similaritiesi

Belongs to the tropomyosin family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG1003 Eukaryota
ENOG410XR5K LUCA
GeneTreeiENSGT00550000074494
HOGENOMiHOG000231522
HOVERGENiHBG107404
InParanoidiQ6IRU2
KOiK10375
OMAiEDKCKQM
OrthoDBiEOG091G0UO7
PhylomeDBiQ6IRU2
TreeFamiTF351519

Family and domain databases

InterProiView protein in InterPro
IPR000533 Tropomyosin
PfamiView protein in Pfam
PF00261 Tropomyosin, 1 hit
PRINTSiPR00194 TROPOMYOSIN
PROSITEiView protein in PROSITE
PS00326 TROPOMYOSIN, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6IRU2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGLNSLEAV KRKIQALQQQ ADDAEDRAQG LQRELDGERE RREKAEGDAA
60 70 80 90 100
ALNRRIQLLE EELDRAQEQL ATALQNLEEA EKAADESERG MKVIENRAMK
110 120 130 140 150
DEEKMEILEM QLKEAKHITD EADRKYEEVA RKLVILEGEL KRAEERAEVS
160 170 180 190 200
ELKCGDLEEE LKNVTNNLKS LEAASEKYSE KEDKYEEEIK LLSDKLKEAE
210 220 230 240
TRAEFAERTV SKLEKTIDDL EEKLAQAKEE NVGLHQTLDQ TLNELNCI
Length:248
Mass (Da):28,468
Last modified:January 23, 2007 - v3
Checksum:i2B6C388008A6AF1B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC023701 mRNA Translation: AAH23701.1
BC023827 mRNA Translation: AAH23827.1
BC070421 mRNA Translation: AAH70421.1
CCDSiCCDS22408.1
RefSeqiNP_001001491.1, NM_001001491.1
UniGeneiMm.295124

Genome annotation databases

EnsembliENSMUST00000003575; ENSMUSP00000003575; ENSMUSG00000031799
GeneIDi326618
KEGGimmu:326618
UCSCiuc009mfi.1 mouse

Similar proteinsi

Entry informationi

Entry nameiTPM4_MOUSE
AccessioniPrimary (citable) accession number: Q6IRU2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: January 23, 2007
Last modified: March 28, 2018
This is version 110 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome