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Protein

Tropomyosin alpha-4 chain

Gene

Tpm4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments. Binds calcium (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Muscle protein

Keywords - Ligandi

Actin-binding, Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Tropomyosin alpha-4 chain
Alternative name(s):
Tropomyosin-4
Gene namesi
Name:Tpm4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:2449202. Tpm4.

Subcellular locationi

GO - Cellular componenti

  • cortical cytoskeleton Source: MGI
  • cytoplasm Source: MGI
  • extracellular exosome Source: Ensembl
  • focal adhesion Source: Ensembl
  • membrane Source: Ensembl
  • podosome Source: MGI
  • stress fiber Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 248247Tropomyosin alpha-4 chainPRO_0000205636Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity
Modified residuei177 – 1771N6-acetyllysineBy similarity
Modified residuei215 – 2151N6-acetyllysineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ6IRU2.
PaxDbiQ6IRU2.
PRIDEiQ6IRU2.

PTM databases

PhosphoSiteiQ6IRU2.

Expressioni

Gene expression databases

BgeeiQ6IRU2.
CleanExiMM_TPM4.
GenevisibleiQ6IRU2. MM.

Interactioni

Subunit structurei

Heterodimer of an alpha and a beta chain.By similarity

Protein-protein interaction databases

BioGridi236471. 2 interactions.
IntActiQ6IRU2. 1 interaction.
STRINGi10090.ENSMUSP00000003575.

Structurei

3D structure databases

ProteinModelPortaliQ6IRU2.
SMRiQ6IRU2. Positions 5-248.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili2 – 248247By similarityAdd
BLAST

Domaini

The molecule is in a coiled coil structure that is formed by 2 polypeptide chains. The sequence exhibits a prominent seven-residues periodicity.

Sequence similaritiesi

Belongs to the tropomyosin family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG304012.
GeneTreeiENSGT00550000074494.
HOGENOMiHOG000231522.
HOVERGENiHBG107404.
InParanoidiQ6IRU2.
KOiK10375.
OMAiAELKCSD.
OrthoDBiEOG7673C8.
PhylomeDBiQ6IRU2.
TreeFamiTF351519.

Family and domain databases

InterProiIPR000533. Tropomyosin.
[Graphical view]
PfamiPF00261. Tropomyosin. 1 hit.
[Graphical view]
PRINTSiPR00194. TROPOMYOSIN.
PROSITEiPS00326. TROPOMYOSIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6IRU2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGLNSLEAV KRKIQALQQQ ADDAEDRAQG LQRELDGERE RREKAEGDAA
60 70 80 90 100
ALNRRIQLLE EELDRAQEQL ATALQNLEEA EKAADESERG MKVIENRAMK
110 120 130 140 150
DEEKMEILEM QLKEAKHITD EADRKYEEVA RKLVILEGEL KRAEERAEVS
160 170 180 190 200
ELKCGDLEEE LKNVTNNLKS LEAASEKYSE KEDKYEEEIK LLSDKLKEAE
210 220 230 240
TRAEFAERTV SKLEKTIDDL EEKLAQAKEE NVGLHQTLDQ TLNELNCI
Length:248
Mass (Da):28,468
Last modified:January 23, 2007 - v3
Checksum:i2B6C388008A6AF1B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC023701 mRNA. Translation: AAH23701.1.
BC023827 mRNA. Translation: AAH23827.1.
BC070421 mRNA. Translation: AAH70421.1.
CCDSiCCDS22408.1.
RefSeqiNP_001001491.1. NM_001001491.1.
UniGeneiMm.295124.

Genome annotation databases

EnsembliENSMUST00000003575; ENSMUSP00000003575; ENSMUSG00000031799.
GeneIDi326618.
KEGGimmu:326618.
UCSCiuc009mfi.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC023701 mRNA. Translation: AAH23701.1.
BC023827 mRNA. Translation: AAH23827.1.
BC070421 mRNA. Translation: AAH70421.1.
CCDSiCCDS22408.1.
RefSeqiNP_001001491.1. NM_001001491.1.
UniGeneiMm.295124.

3D structure databases

ProteinModelPortaliQ6IRU2.
SMRiQ6IRU2. Positions 5-248.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi236471. 2 interactions.
IntActiQ6IRU2. 1 interaction.
STRINGi10090.ENSMUSP00000003575.

PTM databases

PhosphoSiteiQ6IRU2.

Proteomic databases

MaxQBiQ6IRU2.
PaxDbiQ6IRU2.
PRIDEiQ6IRU2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000003575; ENSMUSP00000003575; ENSMUSG00000031799.
GeneIDi326618.
KEGGimmu:326618.
UCSCiuc009mfi.1. mouse.

Organism-specific databases

CTDi7171.
MGIiMGI:2449202. Tpm4.

Phylogenomic databases

eggNOGiNOG304012.
GeneTreeiENSGT00550000074494.
HOGENOMiHOG000231522.
HOVERGENiHBG107404.
InParanoidiQ6IRU2.
KOiK10375.
OMAiAELKCSD.
OrthoDBiEOG7673C8.
PhylomeDBiQ6IRU2.
TreeFamiTF351519.

Miscellaneous databases

NextBioi397902.
PROiQ6IRU2.
SOURCEiSearch...

Gene expression databases

BgeeiQ6IRU2.
CleanExiMM_TPM4.
GenevisibleiQ6IRU2. MM.

Family and domain databases

InterProiIPR000533. Tropomyosin.
[Graphical view]
PfamiPF00261. Tropomyosin. 1 hit.
[Graphical view]
PRINTSiPR00194. TROPOMYOSIN.
PROSITEiPS00326. TROPOMYOSIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6 and FVB/N.
    Tissue: Brain and Mammary tumor.

Entry informationi

Entry nameiTPM4_MOUSE
AccessioniPrimary (citable) accession number: Q6IRU2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: January 23, 2007
Last modified: June 24, 2015
This is version 87 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.