Q6IRU2 (TPM4_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Tropomyosin alpha-4 chain

Alternative name(s):
Tropomyosin-4

Gene names

Name:

Tpm4

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	248 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments. Binds calcium By similarity.
Subunit structure	Heterodimer of an alpha and a beta chain By similarity.
Subcellular location	Cytoplasm › cytoskeleton By similarity.
Domain	The molecule is in a coiled coil structure that is formed by 2 polypeptide chains. The sequence exhibits a prominent seven-residues periodicity.
Sequence similarities	Belongs to the tropomyosin family.

Ontologies

Keywords
Cellular component	Cytoplasm Cytoskeleton
Domain	Coiled coil
Ligand	Actin-binding Calcium Metal-binding
Molecular function	Muscle protein
PTM	Acetylation
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	response to oxidative stress Inferred from electronic annotation. Source: Compara
Cellular_component	cortical cytoskeleton Inferred from direct assay PubMed 16765662. Source: MGI podosome Inferred from direct assay PubMed 16765662. Source: MGI stress fiber Inferred from sequence orthology PubMed 16236705. Source: MGI
Molecular_function	metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed By similarity
	Chain	2 – 248	247	Tropomyosin alpha-4 chain		PRO_0000205636
Regions
	Coiled coil	2 – 248	247	By similarity
Amino acid modifications
	Modified residue	2	1	N-acetylalanine By similarity
	Modified residue	177	1	N6-acetyllysine By similarity
	Modified residue	215	1	N6-acetyllysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q6IRU2 [UniParc]. Last modified January 23, 2007. Version 3. Checksum: 2B6C388008A6AF1B	FASTA	248	28,468
	10 20 30 40 50 60 MAGLNSLEAV KRKIQALQQQ ADDAEDRAQG LQRELDGERE RREKAEGDAA ALNRRIQLLE 70 80 90 100 110 120 EELDRAQEQL ATALQNLEEA EKAADESERG MKVIENRAMK DEEKMEILEM QLKEAKHITD 130 140 150 160 170 180 EADRKYEEVA RKLVILEGEL KRAEERAEVS ELKCGDLEEE LKNVTNNLKS LEAASEKYSE 190 200 210 220 230 240 KEDKYEEEIK LLSDKLKEAE TRAEFAERTV SKLEKTIDDL EEKLAQAKEE NVGLHQTLDQ TLNELNCI

References

[1]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6 and FVB/N. Tissue: Brain and Mammary tumor.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC023701 mRNA. Translation: AAH23701.1. BC023827 mRNA. Translation: AAH23827.1. BC070421 mRNA. Translation: AAH70421.1.
IPI	IPI00421223.
RefSeq	NP_001001491.1. NM_001001491.1.
UniGene	Mm.295124.
3D structure databases
ProteinModelPortal	Q6IRU2.
SMR	Q6IRU2. Positions 5-248.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q6IRU2. 1 interaction.
STRING	10090.ENSMUSP00000003575.
PTM databases
PhosphoSite	Q6IRU2.
Proteomic databases
PaxDb	Q6IRU2.
PRIDE	Q6IRU2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000003575; ENSMUSP00000003575; ENSMUSG00000031799.
GeneID	326618.
KEGG	mmu:326618.
UCSC	uc009mfi.1. mouse.
Organism-specific databases
CTD	7171.
MGI	MGI:2449202. Tpm4.
Phylogenomic databases
eggNOG	NOG304012.
GeneTree	ENSGT00550000074494.
HOGENOM	HOG000231522.
HOVERGEN	HBG107404.
InParanoid	Q6IRU2.
KO	K10375.
OMA	EKCKQVE.
OrthoDB	EOG4TXBSM.
Gene expression databases
Bgee	Q6IRU2.
CleanEx	MM_TPM4.
Genevestigator	Q6IRU2.
GermOnline	ENSMUSG00000031799. Mus musculus.
Family and domain databases
InterPro	IPR000533. Tropomyosin. [Graphical view]
Pfam	PF00261. Tropomyosin. 1 hit. [Graphical view]
PRINTS	PR00194. TROPOMYOSIN.
PROSITE	PS00326. TROPOMYOSIN. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	397902.
SOURCE	Search...

Entry information

Entry name

TPM4_MOUSE

Accession

Primary (citable) accession number: Q6IRU2

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 11, 2004
Last sequence update:	January 23, 2007
Last modified:	April 3, 2013
This is version 70 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program