Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

S-(hydroxymethyl)glutathione dehydrogenase

Gene

ADH5

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalytic activityi

S-(hydroxymethyl)glutathione + NAD(P)+ = S-formylglutathione + NAD(P)H.UniRule annotation

Cofactori

Zn2+UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotation
LigandMetal-bindingUniRule annotation, NADUniRule annotation, ZincUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
S-(hydroxymethyl)glutathione dehydrogenaseUniRule annotation (EC:1.1.1.284UniRule annotation)
Gene namesi
Name:ADH5Imported
Synonyms:HEL-S-60pImported
ORF Names:hCG_41483Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Organism-specific databases

EuPathDBiHostDB:ENSG00000197894.10

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA24574

Expressioni

Gene expression databases

BgeeiENSG00000197894

Interactioni

GO - Molecular functioni

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini33 – 154ADH_NInterPro annotationAdd BLAST122
Domaini202 – 327ADH_zinc_NInterPro annotationAdd BLAST126

Sequence similaritiesi

Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily.UniRule annotation

Phylogenomic databases

eggNOGiKOG0022 Eukaryota
COG1062 LUCA
HOVERGENiHBG000195
KOiK00121
OMAiCIGNVNT
OrthoDBiEOG091G08N3

Family and domain databases

CDDicd08300 alcohol_DH_class_III, 1 hit
InterProiView protein in InterPro
IPR014183 ADH_3
IPR013149 ADH_C
IPR013154 ADH_N
IPR002328 ADH_Zn_CS
IPR011032 GroES-like_sf
IPR036291 NAD(P)-bd_dom_sf
PfamiView protein in Pfam
PF08240 ADH_N, 1 hit
PF00107 ADH_zinc_N, 1 hit
SUPFAMiSSF50129 SSF50129, 2 hits
SSF51735 SSF51735, 1 hit
TIGRFAMsiTIGR02818 adh_III_F_hyde, 1 hit
PROSITEiView protein in PROSITE
PS00059 ADH_ZINC, 1 hit

Sequencei

Sequence statusi: Complete.

Q6IRT1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MANEVIKCKA AVAWEAGKPL SIEEIEVAPP KAHEVRIKII ATAVCHTDAY
60 70 80 90 100
TLSGADPEGC FPVILGHEGA GIVESVGEGV TKLKAGDTVI PLYIPQCGEC
110 120 130 140 150
KFCLNPKTNL CQKIRVTQGK GLMPDGTSRF TCKGKTILHY MGTSTFSEYT
160 170 180 190 200
VVADISVAKI DPLAPLDKVC LLGCGISTGY GAAVNTAKLE PGSVCAVFGL
210 220 230 240 250
GGVGLAVIMG CKVAGASRII GVDINKDKFA RAKEFGATEC INPQDFSKPI
260 270 280 290 300
QEVLIEMTDG GVDYSFECIG NVKVMRAALE ACHKGWGVSV VVGVAASGEE
310 320 330 340 350
IATRPFQLVT GRTWKGTAFG GWKSVESVPK LVSEYMSKKI KVDEFVTHNL
360 370
SFDEINKAFE LMHSGKSIRT VVKI
Length:374
Mass (Da):39,724
Last modified:April 17, 2007 - v2
Checksum:iF4F823B4A609C952
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC070491 mRNA Translation: AAH70491.2
GQ472236 mRNA Translation: ACV87211.1
AK312367 mRNA Translation: BAG35285.1
CH471057 Genomic DNA Translation: EAX06084.1
CH471057 Genomic DNA Translation: EAX06086.1
RefSeqiNP_000662.3, NM_000671.4
UniGeneiHs.78989

Genome annotation databases

GeneIDi128
KEGGihsa:128
UCSCiuc003hui.5 human

Similar proteinsi

Entry informationi

Entry nameiQ6IRT1_HUMAN
AccessioniPrimary (citable) accession number: Q6IRT1
Entry historyiIntegrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: April 17, 2007
Last modified: March 28, 2018
This is version 135 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health