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Protein
Submitted name:

Gas6 protein

Gene

Gas6

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

Keywordsi

LigandCalciumSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Gas6 proteinImported
Gene namesi
Name:Gas6Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus

Organism-specific databases

RGDi61913. Gas6.

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 27Sequence analysisAdd BLAST27
ChainiPRO_500427592528 – 674Sequence analysisAdd BLAST647

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi122 ↔ 139PROSITE-ProRule annotation
Disulfide bondi141 ↔ 150PROSITE-ProRule annotation
Disulfide bondi639 ↔ 666PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bondPROSITE-ProRule annotationSAAS annotation

Proteomic databases

PaxDbiQ6IRL1.
PRIDEiQ6IRL1.

Expressioni

Gene expression databases

GenevisibleiQ6IRL1. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000024677.

Structurei

3D structure databases

ProteinModelPortaliQ6IRL1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini45 – 91Gla (gamma-carboxy-glutamate)InterPro annotationAdd BLAST47
Domaini113 – 151EGF-likeInterPro annotationAdd BLAST39
Domaini153 – 193EGF-likeInterPro annotationAdd BLAST41
Domaini194 – 234EGF-likeInterPro annotationAdd BLAST41
Domaini235 – 275EGF-likeInterPro annotationAdd BLAST41
Domaini295 – 467LAM_G_DOMAINInterPro annotationAdd BLAST173
Domaini481 – 666LAM_G_DOMAINInterPro annotationAdd BLAST186

Keywords - Domaini

EGF-like domainPROSITE-ProRule annotationSAAS annotation, RepeatSAAS annotation, SignalSequence analysis

Phylogenomic databases

eggNOGiENOG410IGK1. Eukaryota.
ENOG410ZPM2. LUCA.
HOVERGENiHBG051702.
KOiK05464.

Family and domain databases

Gene3Di4.10.740.10. 1 hit.
InterProiView protein in InterPro
IPR017857. Coagulation_fac_subgr_Gla_dom.
IPR013320. ConA-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR000294. GLA_domain.
IPR009030. Growth_fac_rcpt_.
IPR001791. Laminin_G.
PfamiView protein in Pfam
PF07645. EGF_CA. 2 hits.
PF00594. Gla. 1 hit.
PF00054. Laminin_G_1. 1 hit.
PF02210. Laminin_G_2. 1 hit.
PRINTSiPR00001. GLABLOOD.
SMARTiView protein in SMART
SM00181. EGF. 4 hits.
SM00179. EGF_CA. 4 hits.
SM00069. GLA. 1 hit.
SM00282. LamG. 2 hits.
SUPFAMiSSF49899. SSF49899. 2 hits.
SSF57184. SSF57184. 1 hit.
SSF57630. SSF57630. 1 hit.
PROSITEiView protein in PROSITE
PS00010. ASX_HYDROXYL. 4 hits.
PS00022. EGF_1. 1 hit.
PS01186. EGF_2. 3 hits.
PS50026. EGF_3. 4 hits.
PS01187. EGF_CA. 2 hits.
PS00011. GLA_1. 1 hit.
PS50998. GLA_2. 1 hit.
PS50025. LAM_G_DOMAIN. 2 hits.

Sequencei

Sequence statusi: Complete.

Q6IRL1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPPPPGPTAA LGTALLLLLL ASESSHTVLL RAREAAQFLR PRQRRAYQVF
60 70 80 90 100
EEAKQGHLER ECVEEVCSKE EAREVFENDP ETDYFYPRYQ ECMRKYGRPE
110 120 130 140 150
DKNPNFATCV KNLPDQCTPN PCDKKGTQLC QDLMGNFFCL CKDGWGGRLC
160 170 180 190 200
DKDVNECSQK NGGCSQVCHN KPGSFQCACH SGFSLQSDNK SCQDIDECTD
210 220 230 240 250
SDTCGDARCK NLPGSYSCLC DKGYTYSSKE KTCQDVDECQ QDRCEQTCVN
260 270 280 290 300
SPGSYTCHCN GRGGLKLSPD MDTCEDILPC VPFSMAKSVK SLYLGRMFSG
310 320 330 340 350
TPVIRLRFKR LQPTRLLAEF DFRTFDPEGV LFFAGGRSDS TWIVLGFRAG
360 370 380 390 400
RLELQLRYNG VGRITSSGPT INHGMWQTIS VEELDRNLVI KVNKDAVMKI
410 420 430 440 450
AVAGGLFQLE RGLYHLNLTV GGIPFKESDL VQPINPRLDG CMRSWNWLNG
460 470 480 490 500
EDSAIQETVK ANTKMQCFSV TERGSFFPGN GFAFYSLNYT RTSLDVGTET
510 520 530 540 550
TWEVEVVARI RPATDTGVLM ALVGDKDVVL LSVALVDYHS TKKLKKQLVV
560 570 580 590 600
LAVENVALAL MEIKVCDSQE HTVTVSLRDG EATLEVDGTK GQSEVSTAQL
610 620 630 640 650
QERLDLLKTR LQGSVLTFVG GLPDVQVTST PVTAFYRGCM TLEVNGKTLD
660 670
LDTASYKHSD ITSHSCPPVE HVTA
Length:674
Mass (Da):74,672
Last modified:July 5, 2004 - v1
Checksum:iCC9A5EBD04480AE7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC070881 mRNA. Translation: AAH70881.1.
RefSeqiNP_476441.2. NM_057100.2.
UniGeneiRn.52228.

Genome annotation databases

GeneIDi58935.
KEGGirno:58935.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC070881 mRNA. Translation: AAH70881.1.
RefSeqiNP_476441.2. NM_057100.2.
UniGeneiRn.52228.

3D structure databases

ProteinModelPortaliQ6IRL1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000024677.

Proteomic databases

PaxDbiQ6IRL1.
PRIDEiQ6IRL1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi58935.
KEGGirno:58935.

Organism-specific databases

CTDi2621.
RGDi61913. Gas6.

Phylogenomic databases

eggNOGiENOG410IGK1. Eukaryota.
ENOG410ZPM2. LUCA.
HOVERGENiHBG051702.
KOiK05464.

Gene expression databases

GenevisibleiQ6IRL1. RN.

Family and domain databases

Gene3Di4.10.740.10. 1 hit.
InterProiView protein in InterPro
IPR017857. Coagulation_fac_subgr_Gla_dom.
IPR013320. ConA-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR000294. GLA_domain.
IPR009030. Growth_fac_rcpt_.
IPR001791. Laminin_G.
PfamiView protein in Pfam
PF07645. EGF_CA. 2 hits.
PF00594. Gla. 1 hit.
PF00054. Laminin_G_1. 1 hit.
PF02210. Laminin_G_2. 1 hit.
PRINTSiPR00001. GLABLOOD.
SMARTiView protein in SMART
SM00181. EGF. 4 hits.
SM00179. EGF_CA. 4 hits.
SM00069. GLA. 1 hit.
SM00282. LamG. 2 hits.
SUPFAMiSSF49899. SSF49899. 2 hits.
SSF57184. SSF57184. 1 hit.
SSF57630. SSF57630. 1 hit.
PROSITEiView protein in PROSITE
PS00010. ASX_HYDROXYL. 4 hits.
PS00022. EGF_1. 1 hit.
PS01186. EGF_2. 3 hits.
PS50026. EGF_3. 4 hits.
PS01187. EGF_CA. 2 hits.
PS00011. GLA_1. 1 hit.
PS50998. GLA_2. 1 hit.
PS50025. LAM_G_DOMAIN. 2 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiQ6IRL1_RAT
AccessioniPrimary (citable) accession number: Q6IRL1
Entry historyiIntegrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: May 10, 2017
This is version 108 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.