ID   GPX8A_XENLA             Reviewed;         209 AA.
AC   Q6IRC8;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   16-JUN-2009, entry version 42.
DE   RecName: Full=Probable glutathione peroxidase 8-A;
DE            EC=1.11.1.9;
GN   Name=gpx8-A;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Amphibia; Batrachia; Anura; Mesobatrachia; Pipoidea; Pipidae;
OC   Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY: 2 glutathione + H(2)O(2) = glutathione
CC       disulfide + 2 H(2)O.
CC   -!- SUBCELLULAR LOCATION: Membrane; Single-pass membrane protein
CC       (Potential).
CC   -!- SIMILARITY: Belongs to the glutathione peroxidase family.
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DR   EMBL; BC070970; AAH70970.1; -; mRNA.
DR   RefSeq; NP_001085022.1; -.
DR   UniGene; Xl.47141; -.
DR   GeneID; 432086; -.
DR   KEGG; xla:432086; -.
DR   HOVERGEN; Q6IRC8; -.
DR   BRENDA; 1.11.1.9; 648.
DR   GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR   GO; GO:0004602; F:glutathione peroxidase activity; IEA:EC.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   GO; GO:0006979; P:response to oxidative stress; IEA:InterPro.
DR   InterPro; IPR000886; ER_targeting_sequence.
DR   InterPro; IPR013376; Glut_perox_Gpx7.
DR   InterPro; IPR000889; Glutathione_peroxidase.
DR   InterPro; IPR012335; Thioredoxin_fold.
DR   Gene3D; G3DSA:3.40.30.10; Thioredoxin_fold; 1.
DR   PANTHER; PTHR11592; Glut_peroxidase; 1.
DR   Pfam; PF00255; GSHPx; 1.
DR   PIRSF; PIRSF000303; Glutathion_perox; 1.
DR   PRINTS; PR01011; GLUTPROXDASE.
DR   TIGRFAMs; TIGR02540; gpx7; 1.
DR   PROSITE; PS00014; ER_TARGET; UNKNOWN_1.
DR   PROSITE; PS00460; GLUTATHIONE_PEROXID_1; FALSE_NEG.
DR   PROSITE; PS00763; GLUTATHIONE_PEROXID_2; 1.
DR   PROSITE; PS51355; GLUTATHIONE_PEROXID_3; 1.
PE   2: Evidence at transcript level;
KW   Membrane; Oxidoreductase; Peroxidase; Transmembrane.
FT   CHAIN         1    209       Probable glutathione peroxidase 8-A.
FT                                /FTId=PRO_0000317759.
FT   TRANSMEM     18     40       Potential.
FT   ACT_SITE     79     79       By similarity.
SQ   SEQUENCE   209 AA;  23517 MW;  567A581F575EF44D CRC64;
     MEPLNPYPVK FSSPKAKVSV VFLSMLLCTG ILCVLQLGFL RAKGGDFYSY EVTDAKGRAV
     ALSKYRGKAS LVVNVASGCP HAEANYRSLQ ELHREFGPSH FTVLAFPCNQ FGESEPGTNQ
     EIGALAKRNY GVTFPMFSKI KILGSEAEPA YRFLVDSTKK EPRWNFWKYL VDPQGQVVKY
     WRPDETAESI RPEVASLVRQ IIMKKKEEL
//