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Q6IRC8

- GPX8A_XENLA

UniProt

Q6IRC8 - GPX8A_XENLA

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Protein
Probable glutathione peroxidase 8-A
Gene
gpx8-a
Organism
Xenopus laevis (African clawed frog)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalytic activityi

2 glutathione + H2O2 = glutathione disulfide + 2 H2O.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei79 – 791 By similarity

GO - Molecular functioni

  1. glutathione peroxidase activity Source: UniProtKB-EC

GO - Biological processi

  1. response to oxidative stress Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase, Peroxidase

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glutathione peroxidase 8-A (EC:1.11.1.9)
Short name:
GPx-8-A
Short name:
GSHPx-8-A
Gene namesi
Name:gpx8-a
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-6256273. gpx8.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei18 – 4023Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 209209Probable glutathione peroxidase 8-A
PRO_0000317759Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ6IRC8.
SMRiQ6IRC8. Positions 47-209.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG004333.
KOiK00432.

Family and domain databases

Gene3Di3.40.30.10. 1 hit.
InterProiIPR013376. Glut_perox_Gpx7.
IPR000889. Glutathione_peroxidase.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PANTHERiPTHR11592. PTHR11592. 1 hit.
PfamiPF00255. GSHPx. 1 hit.
[Graphical view]
PIRSFiPIRSF000303. Glutathion_perox. 1 hit.
PRINTSiPR01011. GLUTPROXDASE.
SUPFAMiSSF52833. SSF52833. 1 hit.
TIGRFAMsiTIGR02540. gpx7. 1 hit.
PROSITEiPS00014. ER_TARGET. 1 hit.
PS00763. GLUTATHIONE_PEROXID_2. 1 hit.
PS51355. GLUTATHIONE_PEROXID_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6IRC8-1 [UniParc]FASTAAdd to Basket

« Hide

MEPLNPYPVK FSSPKAKVSV VFLSMLLCTG ILCVLQLGFL RAKGGDFYSY    50
EVTDAKGRAV ALSKYRGKAS LVVNVASGCP HAEANYRSLQ ELHREFGPSH 100
FTVLAFPCNQ FGESEPGTNQ EIGALAKRNY GVTFPMFSKI KILGSEAEPA 150
YRFLVDSTKK EPRWNFWKYL VDPQGQVVKY WRPDETAESI RPEVASLVRQ 200
IIMKKKEEL 209
Length:209
Mass (Da):23,517
Last modified:July 5, 2004 - v1
Checksum:i567A581F575EF44D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC070970 mRNA. Translation: AAH70970.1.
RefSeqiNP_001085022.1. NM_001091553.1.
UniGeneiXl.47141.

Genome annotation databases

GeneIDi432086.
KEGGixla:432086.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC070970 mRNA. Translation: AAH70970.1 .
RefSeqi NP_001085022.1. NM_001091553.1.
UniGenei Xl.47141.

3D structure databases

ProteinModelPortali Q6IRC8.
SMRi Q6IRC8. Positions 47-209.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 432086.
KEGGi xla:432086.

Organism-specific databases

CTDi 432086.
Xenbasei XB-GENE-6256273. gpx8.

Phylogenomic databases

HOVERGENi HBG004333.
KOi K00432.

Family and domain databases

Gene3Di 3.40.30.10. 1 hit.
InterProi IPR013376. Glut_perox_Gpx7.
IPR000889. Glutathione_peroxidase.
IPR012336. Thioredoxin-like_fold.
[Graphical view ]
PANTHERi PTHR11592. PTHR11592. 1 hit.
Pfami PF00255. GSHPx. 1 hit.
[Graphical view ]
PIRSFi PIRSF000303. Glutathion_perox. 1 hit.
PRINTSi PR01011. GLUTPROXDASE.
SUPFAMi SSF52833. SSF52833. 1 hit.
TIGRFAMsi TIGR02540. gpx7. 1 hit.
PROSITEi PS00014. ER_TARGET. 1 hit.
PS00763. GLUTATHIONE_PEROXID_2. 1 hit.
PS51355. GLUTATHIONE_PEROXID_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. NIH - Xenopus Gene Collection (XGC) project
    Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Embryo.

Entry informationi

Entry nameiGPX8A_XENLA
AccessioniPrimary (citable) accession number: Q6IRC8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: July 5, 2004
Last modified: February 19, 2014
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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