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Q6IRC8

- GPX8A_XENLA

UniProt

Q6IRC8 - GPX8A_XENLA

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Protein

Probable glutathione peroxidase 8-A

Gene

gpx8-a

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Functioni

Catalytic activityi

2 glutathione + H2O2 = glutathione disulfide + 2 H2O.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei79 – 791By similarity

GO - Molecular functioni

  1. glutathione peroxidase activity Source: UniProtKB-EC

GO - Biological processi

  1. response to oxidative stress Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase, Peroxidase

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glutathione peroxidase 8-A (EC:1.11.1.9)
Short name:
GPx-8-A
Short name:
GSHPx-8-A
Gene namesi
Name:gpx8-a
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-6256273. gpx8.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 209209Probable glutathione peroxidase 8-APRO_0000317759Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ6IRC8.
SMRiQ6IRC8. Positions 47-209.
ModBaseiSearch...
MobiDBiSearch...

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei18 – 4023HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the glutathione peroxidase family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG004333.
KOiK00432.

Family and domain databases

Gene3Di3.40.30.10. 1 hit.
InterProiIPR013376. Glut_perox_Gpx7.
IPR000889. Glutathione_peroxidase.
IPR029760. GPX_CS.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PANTHERiPTHR11592. PTHR11592. 1 hit.
PfamiPF00255. GSHPx. 1 hit.
[Graphical view]
PIRSFiPIRSF000303. Glutathion_perox. 1 hit.
PRINTSiPR01011. GLUTPROXDASE.
SUPFAMiSSF52833. SSF52833. 1 hit.
TIGRFAMsiTIGR02540. gpx7. 1 hit.
PROSITEiPS00014. ER_TARGET. 1 hit.
PS00763. GLUTATHIONE_PEROXID_2. 1 hit.
PS51355. GLUTATHIONE_PEROXID_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6IRC8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEPLNPYPVK FSSPKAKVSV VFLSMLLCTG ILCVLQLGFL RAKGGDFYSY
60 70 80 90 100
EVTDAKGRAV ALSKYRGKAS LVVNVASGCP HAEANYRSLQ ELHREFGPSH
110 120 130 140 150
FTVLAFPCNQ FGESEPGTNQ EIGALAKRNY GVTFPMFSKI KILGSEAEPA
160 170 180 190 200
YRFLVDSTKK EPRWNFWKYL VDPQGQVVKY WRPDETAESI RPEVASLVRQ

IIMKKKEEL
Length:209
Mass (Da):23,517
Last modified:July 5, 2004 - v1
Checksum:i567A581F575EF44D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC070970 mRNA. Translation: AAH70970.1.
RefSeqiNP_001085022.1. NM_001091553.1.
UniGeneiXl.47141.

Genome annotation databases

GeneIDi432086.
KEGGixla:432086.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC070970 mRNA. Translation: AAH70970.1 .
RefSeqi NP_001085022.1. NM_001091553.1.
UniGenei Xl.47141.

3D structure databases

ProteinModelPortali Q6IRC8.
SMRi Q6IRC8. Positions 47-209.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 432086.
KEGGi xla:432086.

Organism-specific databases

CTDi 432086.
Xenbasei XB-GENE-6256273. gpx8.

Phylogenomic databases

HOVERGENi HBG004333.
KOi K00432.

Family and domain databases

Gene3Di 3.40.30.10. 1 hit.
InterProi IPR013376. Glut_perox_Gpx7.
IPR000889. Glutathione_peroxidase.
IPR029760. GPX_CS.
IPR012336. Thioredoxin-like_fold.
[Graphical view ]
PANTHERi PTHR11592. PTHR11592. 1 hit.
Pfami PF00255. GSHPx. 1 hit.
[Graphical view ]
PIRSFi PIRSF000303. Glutathion_perox. 1 hit.
PRINTSi PR01011. GLUTPROXDASE.
SUPFAMi SSF52833. SSF52833. 1 hit.
TIGRFAMsi TIGR02540. gpx7. 1 hit.
PROSITEi PS00014. ER_TARGET. 1 hit.
PS00763. GLUTATHIONE_PEROXID_2. 1 hit.
PS51355. GLUTATHIONE_PEROXID_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. NIH - Xenopus Gene Collection (XGC) project
    Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Embryo.

Entry informationi

Entry nameiGPX8A_XENLA
AccessioniPrimary (citable) accession number: Q6IRC8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: July 5, 2004
Last modified: October 29, 2014
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3