Q6IRC8 (GPX8A_XENLA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable glutathione peroxidase 8-A
Short name=GPx-8-A
Short name=GSHPx-8-A
EC=1.11.1.9

Gene names

Name:

gpx8-a

Organism

Xenopus laevis (African clawed frog)

Taxonomic identifier

8355 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amphibia › Batrachia › Anura › Pipoidea › Pipidae › Xenopodinae › Xenopus › Xenopus

Protein attributes

Sequence length	209 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Catalytic activity	2 glutathione + H2O2 = glutathione disulfide + 2 H2O.
Subcellular location	Membrane; Single-pass membrane protein Potential.
Sequence similarities	Belongs to the glutathione peroxidase family.

Ontologies

Keywords
Cellular component	Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	Oxidoreductase Peroxidase
Gene Ontology (GO)
Biological_process	response to oxidative stress Inferred from electronic annotation. Source: InterPro
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	glutathione peroxidase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 209	209	Probable glutathione peroxidase 8-A		PRO_0000317759
Regions
	Transmembrane	18 – 40	23	Helical; Potential
Sites
	Active site	79	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q6IRC8 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: 567A581F575EF44D	FASTA	209	23,517
	10 20 30 40 50 60 MEPLNPYPVK FSSPKAKVSV VFLSMLLCTG ILCVLQLGFL RAKGGDFYSY EVTDAKGRAV 70 80 90 100 110 120 ALSKYRGKAS LVVNVASGCP HAEANYRSLQ ELHREFGPSH FTVLAFPCNQ FGESEPGTNQ 130 140 150 160 170 180 EIGALAKRNY GVTFPMFSKI KILGSEAEPA YRFLVDSTKK EPRWNFWKYL VDPQGQVVKY 190 200 WRPDETAESI RPEVASLVRQ IIMKKKEEL

References

[1]	NIH - Xenopus Gene Collection (XGC) project Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Embryo.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC070970 mRNA. Translation: AAH70970.1.
RefSeq	NP_001085022.1. NM_001091553.1.
UniGene	Xl.47141.
3D structure databases
HSSP	HSSP built from PDB template 2F8A based on UniProtKB P07203.
ProteinModelPortal	Q6IRC8.
SMR	Q6IRC8. Positions 47-209.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	432086.
KEGG	xla:432086.
Organism-specific databases
CTD	432086.
Xenbase	XB-GENE-6256273. gpx8.
Phylogenomic databases
HOVERGEN	HBG004333.
KO	K00432.
Family and domain databases
Gene3D	3.40.30.10. 1 hit.
InterPro	IPR013376. Glut_perox_Gpx7. IPR000889. Glutathione_peroxidase. IPR012336. Thioredoxin-like_fold. [Graphical view]
PANTHER	PTHR11592. PTHR11592. 1 hit.
Pfam	PF00255. GSHPx. 1 hit. [Graphical view]
PIRSF	PIRSF000303. Glutathion_perox. 1 hit.
PRINTS	PR01011. GLUTPROXDASE.
SUPFAM	SSF52833. Thiordxn-like_fd. 1 hit.
TIGRFAMs	TIGR02540. gpx7. 1 hit.
PROSITE	PS00014. ER_TARGET. 1 hit. Uncertain. PS00460. GLUTATHIONE_PEROXID_1. False negative. PS00763. GLUTATHIONE_PEROXID_2. 1 hit. PS51355. GLUTATHIONE_PEROXID_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GPX8A_XENLA

Accession

Primary (citable) accession number: Q6IRC8

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	July 5, 2004
Last modified:	March 6, 2013
This is version 66 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program