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Q6IRC8

- GPX8A_XENLA

UniProt

Q6IRC8 - GPX8A_XENLA

Protein

Probable glutathione peroxidase 8-A

Gene

gpx8-a

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 70 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    2 glutathione + H2O2 = glutathione disulfide + 2 H2O.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei79 – 791By similarity

    GO - Molecular functioni

    1. glutathione peroxidase activity Source: UniProtKB-EC

    GO - Biological processi

    1. response to oxidative stress Source: InterPro

    Keywords - Molecular functioni

    Oxidoreductase, Peroxidase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable glutathione peroxidase 8-A (EC:1.11.1.9)
    Short name:
    GPx-8-A
    Short name:
    GSHPx-8-A
    Gene namesi
    Name:gpx8-a
    OrganismiXenopus laevis (African clawed frog)
    Taxonomic identifieri8355 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

    Organism-specific databases

    XenbaseiXB-GENE-6256273. gpx8.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 209209Probable glutathione peroxidase 8-APRO_0000317759Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliQ6IRC8.
    SMRiQ6IRC8. Positions 47-209.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei18 – 4023HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glutathione peroxidase family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    HOVERGENiHBG004333.
    KOiK00432.

    Family and domain databases

    Gene3Di3.40.30.10. 1 hit.
    InterProiIPR013376. Glut_perox_Gpx7.
    IPR000889. Glutathione_peroxidase.
    IPR012336. Thioredoxin-like_fold.
    [Graphical view]
    PANTHERiPTHR11592. PTHR11592. 1 hit.
    PfamiPF00255. GSHPx. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000303. Glutathion_perox. 1 hit.
    PRINTSiPR01011. GLUTPROXDASE.
    SUPFAMiSSF52833. SSF52833. 1 hit.
    TIGRFAMsiTIGR02540. gpx7. 1 hit.
    PROSITEiPS00014. ER_TARGET. 1 hit.
    PS00763. GLUTATHIONE_PEROXID_2. 1 hit.
    PS51355. GLUTATHIONE_PEROXID_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q6IRC8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEPLNPYPVK FSSPKAKVSV VFLSMLLCTG ILCVLQLGFL RAKGGDFYSY    50
    EVTDAKGRAV ALSKYRGKAS LVVNVASGCP HAEANYRSLQ ELHREFGPSH 100
    FTVLAFPCNQ FGESEPGTNQ EIGALAKRNY GVTFPMFSKI KILGSEAEPA 150
    YRFLVDSTKK EPRWNFWKYL VDPQGQVVKY WRPDETAESI RPEVASLVRQ 200
    IIMKKKEEL 209
    Length:209
    Mass (Da):23,517
    Last modified:July 5, 2004 - v1
    Checksum:i567A581F575EF44D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC070970 mRNA. Translation: AAH70970.1.
    RefSeqiNP_001085022.1. NM_001091553.1.
    UniGeneiXl.47141.

    Genome annotation databases

    GeneIDi432086.
    KEGGixla:432086.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC070970 mRNA. Translation: AAH70970.1 .
    RefSeqi NP_001085022.1. NM_001091553.1.
    UniGenei Xl.47141.

    3D structure databases

    ProteinModelPortali Q6IRC8.
    SMRi Q6IRC8. Positions 47-209.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 432086.
    KEGGi xla:432086.

    Organism-specific databases

    CTDi 432086.
    Xenbasei XB-GENE-6256273. gpx8.

    Phylogenomic databases

    HOVERGENi HBG004333.
    KOi K00432.

    Family and domain databases

    Gene3Di 3.40.30.10. 1 hit.
    InterProi IPR013376. Glut_perox_Gpx7.
    IPR000889. Glutathione_peroxidase.
    IPR012336. Thioredoxin-like_fold.
    [Graphical view ]
    PANTHERi PTHR11592. PTHR11592. 1 hit.
    Pfami PF00255. GSHPx. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000303. Glutathion_perox. 1 hit.
    PRINTSi PR01011. GLUTPROXDASE.
    SUPFAMi SSF52833. SSF52833. 1 hit.
    TIGRFAMsi TIGR02540. gpx7. 1 hit.
    PROSITEi PS00014. ER_TARGET. 1 hit.
    PS00763. GLUTATHIONE_PEROXID_2. 1 hit.
    PS51355. GLUTATHIONE_PEROXID_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. NIH - Xenopus Gene Collection (XGC) project
      Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Embryo.

    Entry informationi

    Entry nameiGPX8A_XENLA
    AccessioniPrimary (citable) accession number: Q6IRC8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 5, 2008
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 70 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3