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Protein

Probable glutathione peroxidase 8-A

Gene

gpx8-a

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

2 glutathione + H2O2 = glutathione disulfide + 2 H2O.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei79 – 791By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase, Peroxidase

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glutathione peroxidase 8-A (EC:1.11.1.9)
Short name:
GPx-8-A
Short name:
GSHPx-8-A
Gene namesi
Name:gpx8-a
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-6256273. gpx8.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei18 – 4023HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 209209Probable glutathione peroxidase 8-APRO_0000317759Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ6IRC8.
SMRiQ6IRC8. Positions 47-209.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glutathione peroxidase family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG004333.
KOiK00432.

Family and domain databases

Gene3Di3.40.30.10. 1 hit.
InterProiIPR013376. Glut_perox_Gpx7.
IPR000889. Glutathione_peroxidase.
IPR029760. GPX_CS.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PANTHERiPTHR11592. PTHR11592. 1 hit.
PfamiPF00255. GSHPx. 1 hit.
[Graphical view]
PRINTSiPR01011. GLUTPROXDASE.
SUPFAMiSSF52833. SSF52833. 1 hit.
TIGRFAMsiTIGR02540. gpx7. 1 hit.
PROSITEiPS00014. ER_TARGET. 1 hit.
PS00763. GLUTATHIONE_PEROXID_2. 1 hit.
PS51355. GLUTATHIONE_PEROXID_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6IRC8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEPLNPYPVK FSSPKAKVSV VFLSMLLCTG ILCVLQLGFL RAKGGDFYSY
60 70 80 90 100
EVTDAKGRAV ALSKYRGKAS LVVNVASGCP HAEANYRSLQ ELHREFGPSH
110 120 130 140 150
FTVLAFPCNQ FGESEPGTNQ EIGALAKRNY GVTFPMFSKI KILGSEAEPA
160 170 180 190 200
YRFLVDSTKK EPRWNFWKYL VDPQGQVVKY WRPDETAESI RPEVASLVRQ

IIMKKKEEL
Length:209
Mass (Da):23,517
Last modified:July 5, 2004 - v1
Checksum:i567A581F575EF44D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC070970 mRNA. Translation: AAH70970.1.
RefSeqiNP_001085022.1. NM_001091553.1.
UniGeneiXl.47141.

Genome annotation databases

GeneIDi432086.
KEGGixla:432086.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC070970 mRNA. Translation: AAH70970.1.
RefSeqiNP_001085022.1. NM_001091553.1.
UniGeneiXl.47141.

3D structure databases

ProteinModelPortaliQ6IRC8.
SMRiQ6IRC8. Positions 47-209.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi432086.
KEGGixla:432086.

Organism-specific databases

CTDi432086.
XenbaseiXB-GENE-6256273. gpx8.

Phylogenomic databases

HOVERGENiHBG004333.
KOiK00432.

Family and domain databases

Gene3Di3.40.30.10. 1 hit.
InterProiIPR013376. Glut_perox_Gpx7.
IPR000889. Glutathione_peroxidase.
IPR029760. GPX_CS.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PANTHERiPTHR11592. PTHR11592. 1 hit.
PfamiPF00255. GSHPx. 1 hit.
[Graphical view]
PRINTSiPR01011. GLUTPROXDASE.
SUPFAMiSSF52833. SSF52833. 1 hit.
TIGRFAMsiTIGR02540. gpx7. 1 hit.
PROSITEiPS00014. ER_TARGET. 1 hit.
PS00763. GLUTATHIONE_PEROXID_2. 1 hit.
PS51355. GLUTATHIONE_PEROXID_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. NIH - Xenopus Gene Collection (XGC) project
    Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Embryo.

Entry informationi

Entry nameiGPX8A_XENLA
AccessioniPrimary (citable) accession number: Q6IRC8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: July 5, 2004
Last modified: April 1, 2015
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.