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Q6IRC8 (GPX8A_XENLA) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 69. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable glutathione peroxidase 8-A

Short name=GPx-8-A
Short name=GSHPx-8-A
EC=1.11.1.9
Gene names
Name:gpx8-a
OrganismXenopus laevis (African clawed frog)
Taxonomic identifier8355 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Protein attributes

Sequence length209 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

2 glutathione + H2O2 = glutathione disulfide + 2 H2O.

Subcellular location

Membrane; Single-pass membrane protein Potential.

Sequence similarities

Belongs to the glutathione peroxidase family.

Ontologies

Keywords
   Cellular componentMembrane
   DomainTransmembrane
Transmembrane helix
   Molecular functionOxidoreductase
Peroxidase
Gene Ontology (GO)
   Biological_processresponse to oxidative stress

Inferred from electronic annotation. Source: InterPro

   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionglutathione peroxidase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 209209Probable glutathione peroxidase 8-A
PRO_0000317759

Regions

Transmembrane18 – 4023Helical; Potential

Sites

Active site791 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q6IRC8 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: 567A581F575EF44D

FASTA20923,517
        10         20         30         40         50         60 
MEPLNPYPVK FSSPKAKVSV VFLSMLLCTG ILCVLQLGFL RAKGGDFYSY EVTDAKGRAV 

        70         80         90        100        110        120 
ALSKYRGKAS LVVNVASGCP HAEANYRSLQ ELHREFGPSH FTVLAFPCNQ FGESEPGTNQ 

       130        140        150        160        170        180 
EIGALAKRNY GVTFPMFSKI KILGSEAEPA YRFLVDSTKK EPRWNFWKYL VDPQGQVVKY 

       190        200 
WRPDETAESI RPEVASLVRQ IIMKKKEEL 

« Hide

References

[1]NIH - Xenopus Gene Collection (XGC) project
Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Embryo.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC070970 mRNA. Translation: AAH70970.1.
RefSeqNP_001085022.1. NM_001091553.1.
UniGeneXl.47141.

3D structure databases

ProteinModelPortalQ6IRC8.
SMRQ6IRC8. Positions 47-209.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID432086.
KEGGxla:432086.

Organism-specific databases

CTD432086.
XenbaseXB-GENE-6256273. gpx8.

Phylogenomic databases

HOVERGENHBG004333.
KOK00432.

Family and domain databases

Gene3D3.40.30.10. 1 hit.
InterProIPR013376. Glut_perox_Gpx7.
IPR000889. Glutathione_peroxidase.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PANTHERPTHR11592. PTHR11592. 1 hit.
PfamPF00255. GSHPx. 1 hit.
[Graphical view]
PIRSFPIRSF000303. Glutathion_perox. 1 hit.
PRINTSPR01011. GLUTPROXDASE.
SUPFAMSSF52833. SSF52833. 1 hit.
TIGRFAMsTIGR02540. gpx7. 1 hit.
PROSITEPS00014. ER_TARGET. 1 hit.
PS00763. GLUTATHIONE_PEROXID_2. 1 hit.
PS51355. GLUTATHIONE_PEROXID_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGPX8A_XENLA
AccessionPrimary (citable) accession number: Q6IRC8
Entry history
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: July 5, 2004
Last modified: February 19, 2014
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families