ID Q6IRB5_XENLA Unreviewed; 772 AA. AC Q6IRB5; DT 05-JUL-2004, integrated into UniProtKB/TrEMBL. DT 05-JUL-2004, sequence version 1. DT 27-MAR-2024, entry version 95. DE SubName: Full=MGC78846 protein {ECO:0000313|EMBL:AAH70985.1}; GN Name=dgcr8.L {ECO:0000313|RefSeq:NP_001085043.1, GN ECO:0000313|RefSeq:XP_041435614.1, ECO:0000313|RefSeq:XP_041435618.1, GN ECO:0000313|Xenbase:XB-GENE-976038}; GN Synonyms=dgcr8 {ECO:0000313|RefSeq:NP_001085043.1, GN ECO:0000313|RefSeq:XP_041435614.1, ECO:0000313|RefSeq:XP_041435618.1, GN ECO:0000313|Xenbase:XB-GENE-976038}, MGC78846 GN {ECO:0000313|EMBL:AAH70985.1}; OS Xenopus laevis (African clawed frog). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus. OX NCBI_TaxID=8355 {ECO:0000313|EMBL:AAH70985.1, ECO:0000313|Proteomes:UP000186698}; RN [1] {ECO:0000313|RefSeq:NP_001085043.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=12454917; DOI=10.1002/dvdy.10174; RA Klein S.L., Strausberg R.L., Wagner L., Pontius J., Clifton S.W., RA Richardson P.; RT "Genetic and genomic tools for Xenopus research: The NIH Xenopus RT initiative."; RL Dev. Dyn. 225:384-391(2002). RN [2] {ECO:0000313|EMBL:AAH70985.1} RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Embryo {ECO:0000313|EMBL:AAH70985.1}; RG NIH - Xenopus Gene Collection (XGC) project; RL Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases. RN [3] {ECO:0007829|PDB:4E5R} RP X-RAY CRYSTALLOGRAPHY (1.90 ANGSTROMS) OF 300-355. RX PubMed=22768307; DOI=10.1371/journal.pone.0039688; RA Senturia R., Laganowsky A., Barr I., Scheidemantle B.D., Guo F.; RT "Dimerization and heme binding are conserved in amphibian and starfish RT homologues of the microRNA processing protein DGCR8."; RL PLoS ONE 7:e39688-e39688(2012). RN [4] {ECO:0000313|RefSeq:NP_001085043.1, ECO:0000313|RefSeq:XP_041435614.1} RP IDENTIFICATION. RC STRAIN=J_2021 {ECO:0000313|RefSeq:XP_041435614.1, RC ECO:0000313|RefSeq:XP_041435618.1}; RC TISSUE=Erythrocytes {ECO:0000313|RefSeq:XP_041435614.1, RC ECO:0000313|RefSeq:XP_041435618.1}; RG RefSeq; RL Submitted (NOV-2023) to UniProtKB. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; BC070985; AAH70985.1; -; mRNA. DR RefSeq; NP_001085043.1; NM_001091574.1. DR RefSeq; XP_041435614.1; XM_041579680.1. DR RefSeq; XP_041435618.1; XM_041579684.1. DR PDB; 4E5R; X-ray; 1.90 A; A=300-355. DR PDBsum; 4E5R; -. DR DNASU; 432110; -. DR GeneID; 432110; -. DR KEGG; xla:432110; -. DR AGR; Xenbase:XB-GENE-976038; -. DR CTD; 432110; -. DR Xenbase; XB-GENE-976038; dgcr8.L. DR OrthoDB; 5404886at2759; -. DR Proteomes; UP000186698; Chromosome 1L. DR Bgee; 432110; Expressed in spleen and 19 other cell types or tissues. DR GO; GO:0070877; C:microprocessor complex; IEA:InterPro. DR GO; GO:0020037; F:heme binding; IEA:InterPro. DR GO; GO:0042802; F:identical protein binding; IEA:InterPro. DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule. DR GO; GO:0031053; P:primary miRNA processing; IEA:InterPro. DR CDD; cd19867; DSRM_DGCR8_rpt1; 1. DR CDD; cd19868; DSRM_DGCR8_rpt2; 1. DR CDD; cd00201; WW; 1. DR Gene3D; 2.20.70.10; -; 1. DR Gene3D; 3.30.160.20; -; 2. DR Gene3D; 3.30.160.590; -; 1. DR InterPro; IPR040375; DGCR8. DR InterPro; IPR014720; dsRBD_dom. DR InterPro; IPR001202; WW_dom. DR InterPro; IPR036020; WW_dom_sf. DR PANTHER; PTHR13482:SF3; MICROPROCESSOR COMPLEX SUBUNIT DGCR8; 1. DR PANTHER; PTHR13482; MICRORNA PROCESSOR COMPLEX SUBUNIT DGCR8; 1. DR Pfam; PF00035; dsrm; 2. DR SMART; SM00358; DSRM; 2. DR SMART; SM00456; WW; 1. DR SUPFAM; SSF54768; dsRNA-binding domain-like; 2. DR SUPFAM; SSF51045; WW domain; 1. DR PROSITE; PS50137; DS_RBD; 1. DR PROSITE; PS50020; WW_DOMAIN_2; 1. PE 1: Evidence at protein level; KW 3D-structure {ECO:0007829|PDB:4E5R}; KW Reference proteome {ECO:0000313|Proteomes:UP000186698}; KW RNA-binding {ECO:0000256|PROSITE-ProRule:PRU00266}. FT DOMAIN 303..336 FT /note="WW" FT /evidence="ECO:0000259|PROSITE:PS50020" FT DOMAIN 510..577 FT /note="DRBM" FT /evidence="ECO:0000259|PROSITE:PS50137" FT REGION 1..69 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 87..109 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 368..407 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 23..42 FT /note="Pro residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 54..69 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 87..104 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 369..399 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 772 AA; 87193 MW; 4E80583B7E05BA29 CRC64; MEECEEVAPF PEVNGHDVTE MNPASPPPLP PEEEPPPPPL QTSSDAEVMD VGSGGDGQSQ TPAGDLQQNN GLQLFTKGST SYKSHRTVLD PFHSDQSPRT ARHAPSNKRF TPDLKLLKDV KVSVSFTESC RSKDRHVLYT GLECEGSLHG GSNMNSVNGD MYVCPFAGSS NGNVTDSIEI TLKKNYEPEI EQEKKVEYAV LDELEDFTEN VMDVDEDGAE FVSESILQRE KIDEEALIYS YEDEFDNDVD ALLEESLHTP KKRRIDEKYD IDSDHQSDGE SSVQPMVTKI KTVLKSRGRP PTEPLPDGWI MTFHNSGLPV YLHRETRVVT WSRPYFLGTG SIRKHDPPIS SIPCLHYKKM KDNDIKEQSN DVTSALVSVS SSTKSSDTSH NSEEPDTTAA DSFVSDERES VSEVAQGALG QVKAKVEVCK DESINLEDFR SYLEKRFDFE QVTVKKFRTW AERRQFNREM KRKQAECERP ILPANQKLIT LSVQDAPTKK EFVINPNGKS EVCILHEYMQ RVLKVRPVYN FFECENPSEP FGASVIINGV TYGTGTASSK KLAKNKAARA TLEILIPDFV KQTCIEKPKD TDELEYFNHI SIEDSRVYEL TNKAGLLSPY QILHECLKRN HGMGDTSIKF EVIPGKNQKS EYVMTCGKHT VRGWCKNKRV GKQLASQKIL QLLHPHVKNW GSLLRMYGRE NSKIVKQETA DKSVIELQQF AKKNKPNLHI LNKLQEEMRR LAQEREETRK KPKMTIVESA QPGSEPLCTV DV //