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Protein

Probable palmitoyltransferase ZDHHC24

Gene

Zdhhc24

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Palmitoyl-CoA + [protein]-L-cysteine = [protein]-S-palmitoyl-L-cysteine + CoA.

GO - Molecular functioni

Keywordsi

Molecular functionAcyltransferase, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Probable palmitoyltransferase ZDHHC24 (EC:2.3.1.225)
Alternative name(s):
Zinc finger DHHC domain-containing protein 24
Short name:
DHHC-24
Gene namesi
Name:Zdhhc24
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:1917855. Zdhhc24.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei19 – 39HelicalSequence analysisAdd BLAST21
Transmembranei53 – 73HelicalSequence analysisAdd BLAST21
Transmembranei138 – 158HelicalSequence analysisAdd BLAST21
Transmembranei167 – 187HelicalSequence analysisAdd BLAST21
Transmembranei196 – 216HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002337111 – 284Probable palmitoyltransferase ZDHHC24Add BLAST284

Keywords - PTMi

Lipoprotein, Palmitate

Proteomic databases

PaxDbiQ6IR37.
PRIDEiQ6IR37.

PTM databases

PhosphoSitePlusiQ6IR37.

Expressioni

Gene expression databases

BgeeiENSMUSG00000006463.
CleanExiMM_ZDHHC24.
ExpressionAtlasiQ6IR37. baseline and differential.
GenevisibleiQ6IR37. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000006632.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini94 – 144DHHCPROSITE-ProRule annotationAdd BLAST51

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi140 – 222Leu-richAdd BLAST83

Domaini

The DHHC domain is required for palmitoyltransferase activity.By similarity

Sequence similaritiesi

Belongs to the DHHC palmitoyltransferase family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1311. Eukaryota.
COG5273. LUCA.
GeneTreeiENSGT00850000132405.
HOGENOMiHOG000155773.
HOVERGENiHBG061265.
InParanoidiQ6IR37.
KOiK18932.
OMAiRCVGFRN.
OrthoDBiEOG091G0RWR.
PhylomeDBiQ6IR37.
TreeFamiTF319523.

Family and domain databases

InterProiView protein in InterPro
IPR001594. Palmitoyltrfase_DHHC.
PfamiView protein in Pfam
PF01529. DHHC. 1 hit.
PROSITEiView protein in PROSITE
PS50216. DHHC. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6IR37-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGESWAARGA EGAPARMPLV LTALWAAVVV LELAYVMVLG PGPPPLGPLA
60 70 80 90 100
RALQLALAAY QLLNLLGNVV LFLRSDPSIR GVMLAGRGLG QGWAYCYQCQ
110 120 130 140 150
SQVPPRSGHC SACRVCILRR DHHCRLLGCC VGFHNYRPFL CLLLHSAGVL
160 170 180 190 200
LHISVLLGPA LSALLQAHSA LYTVALLLLP WLMLLTGKVS LAQFALAFVV
210 220 230 240 250
DTCVAGALLC GAGLLFHGML LLRGQTTWEW ARGHHCYDLG TCHNLQAALG
260 270 280
PRWALVWFWP FLASPLPGDG ISFQTPGDVG LVTS
Length:284
Mass (Da):30,430
Last modified:May 2, 2006 - v2
Checksum:i5DEE2138A442364C
GO

Sequence cautioni

The sequence BAB30905 differs from that shown. Reason: Frameshift at position 58.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti4S → P in BAE41089 (PubMed:16141072).Curated1
Sequence conflicti32E → G in BAE41651 (PubMed:16141072).Curated1
Sequence conflicti128G → D in BC071194 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK017737 mRNA. Translation: BAB30905.2. Frameshift.
AK169337 mRNA. Translation: BAE41089.1.
AK170233 mRNA. Translation: BAE41651.1.
AK170706 mRNA. Translation: BAE41967.1.
AK171568 mRNA. Translation: BAE42530.1.
BC071194 mRNA. No translation available.
CCDSiCCDS50353.1.
RefSeqiNP_081752.2. NM_027476.3.
UniGeneiMm.36885.
Mm.392101.

Genome annotation databases

EnsembliENSMUST00000006632; ENSMUSP00000006632; ENSMUSG00000006463.
GeneIDi70605.
KEGGimmu:70605.
UCSCiuc008gbh.2. mouse.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiZDH24_MOUSE
AccessioniPrimary (citable) accession number: Q6IR37
Secondary accession number(s): Q3TAY4
, Q3TDF1, Q3TF09, Q9CS66
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: May 2, 2006
Last modified: July 5, 2017
This is version 102 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families