Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

G-protein-signaling modulator 1

Gene

Gpsm1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Guanine nucleotide dissociation inhibitor (GDI) which functions as a receptor-independent activator of heterotrimeric G-protein signaling. Keeps G(i/o) alpha subunit in its GDP-bound form thus uncoupling heterotrimeric G-proteins signaling from G protein-coupled receptors. Controls spindle orientation and asymmetric cell fate of cerebral cortical progenitors. May also be involved in macroautophagy in intestinal cells. May play a role in drug addiction.1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, Neurogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
G-protein-signaling modulator 1
Alternative name(s):
Activator of G-protein signaling 3
Gene namesi
Name:Gpsm1
Synonyms:Ags3
ORF Names:C10a
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1915089. Gpsm1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Endoplasmic reticulum, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 673673G-protein-signaling modulator 1PRO_0000252403Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei410 – 4101PhosphoserineCombined sources
Modified residuei469 – 4691PhosphoserineBy similarity
Modified residuei490 – 4901PhosphoserineCombined sources
Modified residuei491 – 4911PhosphoserineCombined sources
Modified residuei543 – 5431PhosphoserineBy similarity
Modified residuei567 – 5671PhosphoserineBy similarity
Modified residuei653 – 6531PhosphoserineCombined sources

Post-translational modificationi

Phosphorylation regulates interaction with G(i/o) alpha.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ6IR34.
MaxQBiQ6IR34.
PaxDbiQ6IR34.
PRIDEiQ6IR34.

PTM databases

iPTMnetiQ6IR34.
PhosphoSiteiQ6IR34.

Expressioni

Tissue specificityi

Expressed in neural progenitor cells (at protein level).1 Publication

Developmental stagei

Expressed in brain at E14.1 Publication

Gene expression databases

BgeeiQ6IR34.
ExpressionAtlasiQ6IR34. baseline and differential.
GenevisibleiQ6IR34. MM.

Interactioni

Subunit structurei

Interacts with GNAI1 and GNAI2 preferentially in their GDP-bound state. May also interact with GNAO1. Interacts with INSC/inscuteable and FRMPD1 (By similarity). Interacts with GNAI3. Interacts with STK11/LKB1 and MACF1.By similarity2 Publications

Protein-protein interaction databases

BioGridi212469. 11 interactions.
IntActiQ6IR34. 12 interactions.
MINTiMINT-8305267.
STRINGi10090.ENSMUSP00000067964.

Structurei

3D structure databases

ProteinModelPortaliQ6IR34.
SMRiQ6IR34. Positions 24-565, 593-648.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati28 – 6134TPR 1Add
BLAST
Repeati66 – 9934TPR 2Add
BLAST
Repeati106 – 13934TPR 3Add
BLAST
Repeati146 – 17833TPR 4Add
BLAST
Repeati180 – 19920TPR 5Add
BLAST
Repeati206 – 23934TPR 6Add
BLAST
Repeati246 – 27934TPR 7Add
BLAST
Repeati286 – 31934TPR 8Add
BLAST
Repeati326 – 35934TPR 9Add
BLAST
Domaini493 – 51523GoLoco 1PROSITE-ProRule annotationAdd
BLAST
Domaini546 – 56823GoLoco 2PROSITE-ProRule annotationAdd
BLAST
Domaini594 – 61623GoLoco 3PROSITE-ProRule annotationAdd
BLAST
Domaini628 – 65023GoLoco 4PROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 507507Mediates association with membranesBy similarityAdd
BLAST
Regioni361 – 485125Interaction with STK11/LKB1By similarityAdd
BLAST

Domaini

The GoLoco domains are essential for the GDI activity toward G(i/o) alpha. The GoLoco domains mediate interaction with G(i/o) alpha (By similarity).By similarity

Sequence similaritiesi

Belongs to the GPSM family.Curated
Contains 4 GoLoco domains.PROSITE-ProRule annotation
Contains 9 TPR repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

eggNOGiKOG1130. Eukaryota.
ENOG410XP6N. LUCA.
GeneTreeiENSGT00530000063126.
HOVERGENiHBG051823.
InParanoidiQ6IR34.
KOiK15839.
OMAiQEPGDDF.
OrthoDBiEOG7WHH8W.
PhylomeDBiQ6IR34.
TreeFamiTF328344.

Family and domain databases

Gene3Di1.25.40.10. 2 hits.
InterProiIPR024804. G_prot_signal_mod_1.
IPR003109. GoLoco_motif.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR019734. TPR_repeat.
[Graphical view]
PANTHERiPTHR10098:SF36. PTHR10098:SF36. 1 hit.
PfamiPF02188. GoLoco. 4 hits.
[Graphical view]
SMARTiSM00390. GoLoco. 4 hits.
SM00028. TPR. 6 hits.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 2 hits.
PROSITEiPS50877. GOLOCO. 4 hits.
PS50005. TPR. 6 hits.
PS50293. TPR_REGION. 2 hits.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6IR34-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MASPAPPVAE ELPGPASRRL YSRMEASCLE LALEGERLCK AGDFKAGVAF
60 70 80 90 100
FEAAVQVGTE DLKTLSAIYS QLGNAYFYLK EYARALQFHK HDLLLARTIG
110 120 130 140 150
DRMGEAKASG NLGNTLKVLG RFDEAIVCCQ RHLDIAQEQG DKVGEARALY
160 170 180 190 200
NIGNVYHAKG KQLSWNAAQD PGHLPPDVRE TLHRASEFYE RNLSLVKELG
210 220 230 240 250
DRAAQGRAYG NLGNTHYLLG NFTEATTFHK ERLAIAKEFG DKAAERRAYS
260 270 280 290 300
NLGNAHIFLG RFDVAAEHYK KTLQLSRQLR DQAVEAQACY SLGNTYTLLQ
310 320 330 340 350
DYERAAEYHL RHLVIAQELA DRVGEGRACW SLGNAYVSMG SPAQALTFAK
360 370 380 390 400
KHLQISQEIG DRNGELTARM NIAHLQLALG RLTSPAAAEK PDLAGYEAQG
410 420 430 440 450
ARPKRTQRLS AETWDLLRLP LDREQNGETH HTGDWRGPGR DSLPLPMRSR
460 470 480 490 500
KYQEGPDAIE RRPREGSHSP LDSADVRVQV PRTGIPRAPS SDEECFFDLL
510 520 530 540 550
SKFQSSRMDD QRCPLEEGQA GAAEATAAPS VEDRAAQSSV TASPQTEEFF
560 570 580 590 600
DLIASSQSRR LDDQRASVGS LPGLRITLNN VGHLRGDGDA QEPGDEFFNM
610 620 630 640 650
LIKYQSSRID DQRCPPPDVL PRGPTMPDED FFSLIQRVQA KRMDEQRVDL
660 670
AGSPEQEASG LPDPQQQCPP GAS
Length:673
Mass (Da):74,362
Last modified:April 20, 2010 - v3
Checksum:i60D284A5340604E7
GO
Isoform 2 (identifier: Q6IR34-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     424-483: Missing.

Show »
Length:613
Mass (Da):67,564
Checksum:iFC2FBD68094DB658
GO
Isoform 3 (identifier: Q6IR34-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-23: Missing.

Show »
Length:650
Mass (Da):71,927
Checksum:iC6F8183601175AD7
GO
Isoform 4 (identifier: Q6IR34-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-22: MASPAPPVAEELPGPASRRLYS → MLASAMEGQP...VQKMRNLQRK
     251-271: NLGNAHIFLGRFDVAAEHYKK → QPYPTLDSVGSRLSTVAMIPQ
     272-673: Missing.

Note: No experimental confirmation available.
Show »
Length:303
Mass (Da):33,585
Checksum:iF989E9131BC88A20
GO
Isoform 5 (identifier: Q6IR34-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-22: MASPAPPVAEELPGPASRRLYS → MLASAMEGQP...VQKMRNLQRK

Show »
Length:705
Mass (Da):78,114
Checksum:iBCE1187E2231D151
GO

Sequence cautioni

The sequence AAH26486.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAH71197.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti668 – 6681C → Y in AAB00119 (Ref. 6) Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 2323Missing in isoform 3. CuratedVSP_039029Add
BLAST
Alternative sequencei1 – 2222MASPA…RRLYS → MLASAMEGQPLALSLAEKAV CKVVYGAPRPRPLLLPVGLE LWLYVQKMRNLQRK in isoform 4 and isoform 5. 1 PublicationVSP_039030Add
BLAST
Alternative sequencei251 – 27121NLGNA…EHYKK → QPYPTLDSVGSRLSTVAMIP Q in isoform 4. 1 PublicationVSP_039031Add
BLAST
Alternative sequencei272 – 673402Missing in isoform 4. 1 PublicationVSP_039032Add
BLAST
Alternative sequencei424 – 48360Missing in isoform 2. 1 PublicationVSP_039033Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK048691 mRNA. Translation: BAC33422.1.
AK084631 mRNA. Translation: BAC39236.1.
AL732541 Genomic DNA. Translation: CAM20327.1.
AL732541 Genomic DNA. Translation: CAM20328.1.
AL732541 Genomic DNA. Translation: CAM20329.1.
CH466542 Genomic DNA. Translation: EDL08301.1.
CH466542 Genomic DNA. Translation: EDL08300.1.
BC026486 mRNA. Translation: AAH26486.1. Different initiation.
BC071197 mRNA. Translation: AAH71197.1. Different initiation.
L23316 mRNA. Translation: AAB00119.1.
CCDSiCCDS15800.1. [Q6IR34-1]
CCDS57158.1. [Q6IR34-2]
CCDS57159.1. [Q6IR34-5]
RefSeqiNP_001186075.1. NM_001199146.1. [Q6IR34-2]
NP_001186076.1. NM_001199147.1. [Q6IR34-5]
NP_700459.2. NM_153410.5. [Q6IR34-1]
XP_006498316.1. XM_006498253.2. [Q6IR34-3]
UniGeneiMm.266611.

Genome annotation databases

EnsembliENSMUST00000066889; ENSMUSP00000067964; ENSMUSG00000026930. [Q6IR34-5]
ENSMUST00000066936; ENSMUSP00000065000; ENSMUSG00000026930. [Q6IR34-1]
ENSMUST00000078616; ENSMUSP00000077686; ENSMUSG00000026930. [Q6IR34-2]
GeneIDi67839.
KEGGimmu:67839.
UCSCiuc008iun.2. mouse. [Q6IR34-1]
uc008iuo.2. mouse. [Q6IR34-2]
uc008iup.2. mouse. [Q6IR34-5]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK048691 mRNA. Translation: BAC33422.1.
AK084631 mRNA. Translation: BAC39236.1.
AL732541 Genomic DNA. Translation: CAM20327.1.
AL732541 Genomic DNA. Translation: CAM20328.1.
AL732541 Genomic DNA. Translation: CAM20329.1.
CH466542 Genomic DNA. Translation: EDL08301.1.
CH466542 Genomic DNA. Translation: EDL08300.1.
BC026486 mRNA. Translation: AAH26486.1. Different initiation.
BC071197 mRNA. Translation: AAH71197.1. Different initiation.
L23316 mRNA. Translation: AAB00119.1.
CCDSiCCDS15800.1. [Q6IR34-1]
CCDS57158.1. [Q6IR34-2]
CCDS57159.1. [Q6IR34-5]
RefSeqiNP_001186075.1. NM_001199146.1. [Q6IR34-2]
NP_001186076.1. NM_001199147.1. [Q6IR34-5]
NP_700459.2. NM_153410.5. [Q6IR34-1]
XP_006498316.1. XM_006498253.2. [Q6IR34-3]
UniGeneiMm.266611.

3D structure databases

ProteinModelPortaliQ6IR34.
SMRiQ6IR34. Positions 24-565, 593-648.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi212469. 11 interactions.
IntActiQ6IR34. 12 interactions.
MINTiMINT-8305267.
STRINGi10090.ENSMUSP00000067964.

PTM databases

iPTMnetiQ6IR34.
PhosphoSiteiQ6IR34.

Proteomic databases

EPDiQ6IR34.
MaxQBiQ6IR34.
PaxDbiQ6IR34.
PRIDEiQ6IR34.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000066889; ENSMUSP00000067964; ENSMUSG00000026930. [Q6IR34-5]
ENSMUST00000066936; ENSMUSP00000065000; ENSMUSG00000026930. [Q6IR34-1]
ENSMUST00000078616; ENSMUSP00000077686; ENSMUSG00000026930. [Q6IR34-2]
GeneIDi67839.
KEGGimmu:67839.
UCSCiuc008iun.2. mouse. [Q6IR34-1]
uc008iuo.2. mouse. [Q6IR34-2]
uc008iup.2. mouse. [Q6IR34-5]

Organism-specific databases

CTDi26086.
MGIiMGI:1915089. Gpsm1.

Phylogenomic databases

eggNOGiKOG1130. Eukaryota.
ENOG410XP6N. LUCA.
GeneTreeiENSGT00530000063126.
HOVERGENiHBG051823.
InParanoidiQ6IR34.
KOiK15839.
OMAiQEPGDDF.
OrthoDBiEOG7WHH8W.
PhylomeDBiQ6IR34.
TreeFamiTF328344.

Miscellaneous databases

ChiTaRSiGpsm1. mouse.
PROiQ6IR34.
SOURCEiSearch...

Gene expression databases

BgeeiQ6IR34.
ExpressionAtlasiQ6IR34. baseline and differential.
GenevisibleiQ6IR34. MM.

Family and domain databases

Gene3Di1.25.40.10. 2 hits.
InterProiIPR024804. G_prot_signal_mod_1.
IPR003109. GoLoco_motif.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR019734. TPR_repeat.
[Graphical view]
PANTHERiPTHR10098:SF36. PTHR10098:SF36. 1 hit.
PfamiPF02188. GoLoco. 4 hits.
[Graphical view]
SMARTiSM00390. GoLoco. 4 hits.
SM00028. TPR. 6 hits.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 2 hits.
PROSITEiPS50877. GOLOCO. 4 hits.
PS50005. TPR. 6 hits.
PS50293. TPR_REGION. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Strain: C57BL/6J.
    Tissue: Cerebellum and Embryonic heart.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 4 AND 5).
    Strain: C57BL/6J.
    Tissue: Retina.
  5. Lubec G., Sunyer B., Chen W.-Q.
    Submitted (JAN-2009) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 46-63, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: OF1.
    Tissue: Hippocampus.
  6. "Subtractive cloning of murine erythroleukemia mRNAs."
    Miller I.J., Bieker J.J.
    Submitted (SEP-1993) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 419-673.
    Tissue: Erythroleukemia.
  7. "Interaction of activator of G-protein signaling 3 (AGS3) with LKB1, a serine/threonine kinase involved in cell polarity and cell cycle progression: phosphorylation of the G-protein regulatory (GPR) motif as a regulatory mechanism for the interaction of GPR motifs with Gi alpha."
    Blumer J.B., Bernard M.L., Peterson Y.K., Nezu J., Chung P., Dunican D.J., Knoblich J.A., Lanier S.M.
    J. Biol. Chem. 278:23217-23220(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH STK11/LKB1 AND MACF1, PHOSPHORYLATION.
  8. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-653, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic brain.
  9. "G protein betagamma subunits and AGS3 control spindle orientation and asymmetric cell fate of cerebral cortical progenitors."
    Sanada K., Tsai L.-H.
    Cell 122:119-131(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, INTERACTION WITH GNAI3.
  10. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-410; SER-490 AND SER-491, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Heart, Kidney, Lung, Pancreas, Spleen and Testis.

Entry informationi

Entry nameiGPSM1_MOUSE
AccessioniPrimary (citable) accession number: Q6IR34
Secondary accession number(s): A2AIX7
, A2AIX8, A2AIX9, Q61366, Q8BUK4, Q8BX78, Q8R0R9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: April 20, 2010
Last modified: June 8, 2016
This is version 113 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.