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Protein

Isocitrate dehydrogenase [NAD] subunit, mitochondrial

Gene

idh3b

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Isocitrate + NAD+ = 2-oxoglutarate + CO2 + NADH.UniRule annotation

Cofactori

Mg2+UniRule annotation, Mn2+UniRule annotationNote: Binds 1 Mg2+ or Mn2+ ion per subunit.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Keywords - Biological processi

Tricarboxylic acid cycleUniRule annotation

Keywords - Ligandi

MagnesiumUniRule annotation, ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NAD] subunit, mitochondrialUniRule annotation (EC:1.1.1.41UniRule annotation)
Gene namesi
Name:idh3bImported
Synonyms:zgc:86647Imported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio

Organism-specific databases

ZFINiZDB-GENE-040625-174. idh3b.

Subcellular locationi

  • Mitochondrion UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

MitochondrionUniRule annotation

PTM / Processingi

Proteomic databases

PaxDbiQ6IQR5.
PRIDEiQ6IQR5.

Expressioni

Gene expression databases

BgeeiENSDARG00000044753.

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000124593.

Structurei

3D structure databases

ProteinModelPortaliQ6IQR5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini50 – 376327Iso_dhInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the isocitrate and isopropylmalate dehydrogenases family.UniRule annotation

Keywords - Domaini

Transit peptideUniRule annotation

Phylogenomic databases

eggNOGiKOG0784. Eukaryota.
COG0473. LUCA.
HOGENOMiHOG000021113.
HOVERGENiHBG052080.
KOiK00030.
OMAiHTEGELQ.
PhylomeDBiQ6IQR5.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR004434. Isocitrate_DH_NAD.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11835. PTHR11835. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
SMARTiSM01329. Iso_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00175. mito_nad_idh. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6IQR5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAALRGSVL TLAKGLTGVR LQPLCARSLS LTSSQNVPES PPARADSTFK
60 70 80 90 100
VTMVPGDGVG PELMTAVKEV FKAADVPVEF EEFHLSEVQN MASEEKLNEV
110 120 130 140 150
LSSMKNNRVA IKGKIHTPME YKGELASYEM RLRRKLDLFA NVVHVKSLPG
160 170 180 190 200
YSTRHNNLDL VIIREQTEGE YSSLEHESVA GVVECLKIIT REKSRRIAKF
210 220 230 240 250
AFDYATKKGR SKVTAVHKAN IMKLGDGLFL QSCAEVAELY PKIKYENVII
260 270 280 290 300
DNCCMQLVQN PYQFDVLVMP NLYGNIIDNL AAGLVGGAGV VPGESYSAEY
310 320 330 340 350
AVFETGARHP FAQAVGRNIA NPTAMLLSAS NMLKHLNLEY HSNMVSEAVK
360 370 380
KVIKQGKVRT SDLGGYASND EFTRAVITNL AV
Length:382
Mass (Da):41,856
Last modified:July 5, 2004 - v1
Checksum:iAE716077C6A6858A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC071339 mRNA. Translation: AAH71339.1.
RefSeqiNP_001002157.1. NM_001002157.1.
UniGeneiDr.119750.

Genome annotation databases

GeneIDi415247.
KEGGidre:415247.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC071339 mRNA. Translation: AAH71339.1.
RefSeqiNP_001002157.1. NM_001002157.1.
UniGeneiDr.119750.

3D structure databases

ProteinModelPortaliQ6IQR5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000124593.

Proteomic databases

PaxDbiQ6IQR5.
PRIDEiQ6IQR5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi415247.
KEGGidre:415247.

Organism-specific databases

CTDi3420.
ZFINiZDB-GENE-040625-174. idh3b.

Phylogenomic databases

eggNOGiKOG0784. Eukaryota.
COG0473. LUCA.
HOGENOMiHOG000021113.
HOVERGENiHBG052080.
KOiK00030.
OMAiHTEGELQ.
PhylomeDBiQ6IQR5.

Gene expression databases

BgeeiENSDARG00000044753.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR004434. Isocitrate_DH_NAD.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11835. PTHR11835. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
SMARTiSM01329. Iso_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00175. mito_nad_idh. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ6IQR5_DANRE
AccessioniPrimary (citable) accession number: Q6IQR5
Entry historyi
Integrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: September 7, 2016
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.