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Protein

Protein SDE2 homolog

Gene

SDE2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Protein SDE2 homolog
Gene namesi
Name:SDE2
Synonyms:C1orf55
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:26643. SDE2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142672506.

Polymorphism and mutation databases

BioMutaiSDE2.
DMDMi74748828.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 451451Protein SDE2 homologPRO_0000286084Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei266 – 2661PhosphoserineBy similarity
Modified residuei278 – 2781PhosphoserineCombined sources
Modified residuei319 – 3191PhosphothreonineCombined sources
Modified residuei326 – 3261PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ6IQ49.
MaxQBiQ6IQ49.
PaxDbiQ6IQ49.
PRIDEiQ6IQ49.

PTM databases

iPTMnetiQ6IQ49.
PhosphoSiteiQ6IQ49.
SwissPalmiQ6IQ49.

Expressioni

Gene expression databases

BgeeiQ6IQ49.
CleanExiHS_C1orf55.
GenevisibleiQ6IQ49. HS.

Organism-specific databases

HPAiHPA028467.
HPA031255.
HPA031256.

Interactioni

Protein-protein interaction databases

BioGridi127881. 9 interactions.
IntActiQ6IQ49. 4 interactions.
MINTiMINT-4654866.
STRINGi9606.ENSP00000272091.

Structurei

3D structure databases

ProteinModelPortaliQ6IQ49.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili109 – 14941Sequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the SDE2 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG2827. Eukaryota.
ENOG4111WBQ. LUCA.
GeneTreeiENSGT00530000063402.
HOGENOMiHOG000013081.
HOVERGENiHBG107551.
InParanoidiQ6IQ49.
OMAiTRGLKCG.
OrthoDBiEOG7VHSXR.
PhylomeDBiQ6IQ49.
TreeFamiTF314323.

Family and domain databases

InterProiIPR024974. Sde2_N.
[Graphical view]
PfamiPF13019. Telomere_Sde2. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6IQ49-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAEAAALVWI RGPGFGCKAV RCASGRCTVR DFIHRHCQDQ NVPVENFFVK
60 70 80 90 100
CNGALINTSD TVQHGAVYSL EPRLCGGKGG FGSMLRALGA QIEKTTNREA
110 120 130 140 150
CRDLSGRRLR DVNHEKAMAE WVKQQAEREA EKEQKRLERL QRKLVEPKHC
160 170 180 190 200
FTSPDYQQQC HEMAERLEDS VLKGMQAASS KMVSAEISEN RKRQWPTKSQ
210 220 230 240 250
TDRGASAGKR RCFWLGMEGL ETAEGSNSES SDDDSEEAPS TSGMGFHAPK
260 270 280 290 300
IGSNGVEMAA KFPSGSQRAR VVNTDHGSPE QLQIPVTDSG RHILEDSCAE
310 320 330 340 350
LGESKEHMES RMVTETEETQ EKKAESKEPI EEEPTGAGLN KDKETEERTD
360 370 380 390 400
GERVAEVAPE ERENVAVAKL QESQPGNAVI DKETIDLLAF TSVAELELLG
410 420 430 440 450
LEKLKCELMA LGLKCGGTLQ ERAARLFSVR GLAKEQIDPA LFAKPLKGKK

K
Length:451
Mass (Da):49,742
Last modified:July 5, 2004 - v1
Checksum:iD7C19152E0051A21
GO
Isoform 2 (identifier: Q6IQ49-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     53-64: Missing.

Note: No experimental confirmation available.
Show »
Length:439
Mass (Da):48,505
Checksum:i413D6C606BC71AA5
GO
Isoform 3 (identifier: Q6IQ49-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-142: MAEAAALVWI...EQKRLERLQR → MEHSLTPVTQ...VLRLRRQPIE

Note: No experimental confirmation available.
Show »
Length:356
Mass (Da):39,367
Checksum:iF581B893396191BB
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti162 – 1621E → G in BAC87130 (PubMed:14702039).Curated
Sequence conflicti229 – 2291E → D in BAC03952 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti312 – 3121M → I.
Corresponds to variant rs34348128 [ dbSNP | Ensembl ].
VAR_032068

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 142142MAEAA…ERLQR → MEHSLTPVTQCSMELFIVWN PDFAVEKEVLDLCSEHLVLR LRRQPIE in isoform 3. 1 PublicationVSP_024981Add
BLAST
Alternative sequencei53 – 6412Missing in isoform 2. 1 PublicationVSP_024982Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK092701 mRNA. Translation: BAC03952.1.
AK127780 mRNA. Translation: BAC87130.1.
AK291008 mRNA. Translation: BAF83697.1.
AL133288 Genomic DNA. Translation: CAI22305.1.
AL133288 Genomic DNA. Translation: CAI22306.1.
CH471098 Genomic DNA. Translation: EAW69769.1.
BC071563 mRNA. Translation: AAH71563.1.
CCDSiCCDS41473.1. [Q6IQ49-1]
RefSeqiNP_689821.3. NM_152608.3. [Q6IQ49-1]
UniGeneiHs.520192.

Genome annotation databases

EnsembliENST00000272091; ENSP00000272091; ENSG00000143751. [Q6IQ49-1]
GeneIDi163859.
KEGGihsa:163859.
UCSCiuc001hpu.5. human. [Q6IQ49-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK092701 mRNA. Translation: BAC03952.1.
AK127780 mRNA. Translation: BAC87130.1.
AK291008 mRNA. Translation: BAF83697.1.
AL133288 Genomic DNA. Translation: CAI22305.1.
AL133288 Genomic DNA. Translation: CAI22306.1.
CH471098 Genomic DNA. Translation: EAW69769.1.
BC071563 mRNA. Translation: AAH71563.1.
CCDSiCCDS41473.1. [Q6IQ49-1]
RefSeqiNP_689821.3. NM_152608.3. [Q6IQ49-1]
UniGeneiHs.520192.

3D structure databases

ProteinModelPortaliQ6IQ49.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127881. 9 interactions.
IntActiQ6IQ49. 4 interactions.
MINTiMINT-4654866.
STRINGi9606.ENSP00000272091.

PTM databases

iPTMnetiQ6IQ49.
PhosphoSiteiQ6IQ49.
SwissPalmiQ6IQ49.

Polymorphism and mutation databases

BioMutaiSDE2.
DMDMi74748828.

Proteomic databases

EPDiQ6IQ49.
MaxQBiQ6IQ49.
PaxDbiQ6IQ49.
PRIDEiQ6IQ49.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000272091; ENSP00000272091; ENSG00000143751. [Q6IQ49-1]
GeneIDi163859.
KEGGihsa:163859.
UCSCiuc001hpu.5. human. [Q6IQ49-1]

Organism-specific databases

CTDi163859.
GeneCardsiSDE2.
H-InvDBHIX0001641.
HGNCiHGNC:26643. SDE2.
HPAiHPA028467.
HPA031255.
HPA031256.
neXtProtiNX_Q6IQ49.
PharmGKBiPA142672506.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2827. Eukaryota.
ENOG4111WBQ. LUCA.
GeneTreeiENSGT00530000063402.
HOGENOMiHOG000013081.
HOVERGENiHBG107551.
InParanoidiQ6IQ49.
OMAiTRGLKCG.
OrthoDBiEOG7VHSXR.
PhylomeDBiQ6IQ49.
TreeFamiTF314323.

Miscellaneous databases

GenomeRNAii163859.
NextBioi88413.
PROiQ6IQ49.

Gene expression databases

BgeeiQ6IQ49.
CleanExiHS_C1orf55.
GenevisibleiQ6IQ49. HS.

Family and domain databases

InterProiIPR024974. Sde2_N.
[Graphical view]
PfamiPF13019. Telomere_Sde2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3).
    Tissue: Brain and Skeletal muscle.
  2. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-319, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic kidney.
  6. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."
    Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III
    J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-278, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  7. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-278, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  8. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  9. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-278, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  10. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  11. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiSDE2_HUMAN
AccessioniPrimary (citable) accession number: Q6IQ49
Secondary accession number(s): A8K4P3
, Q5TD36, Q6ZS26, Q8NAG7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: July 5, 2004
Last modified: April 13, 2016
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.