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Protein
Submitted name:

PTPN9 protein

Gene

PTPN9

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.SAAS annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphataseSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
PTPN9 proteinImported
Gene namesi
Name:PTPN9Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

PTM / Processingi

Proteomic databases

PaxDbiQ6IQ43.
PeptideAtlasiQ6IQ43.

Interactioni

Protein-protein interaction databases

IntActiQ6IQ43. 5 interactors.
STRINGi9606.ENSP00000303554.

Structurei

3D structure databases

ProteinModelPortaliQ6IQ43.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini74 – 233CRAL-TRIOInterPro annotationAdd BLAST160
Domaini293 – 564Tyrosine-protein phosphataseInterPro annotationAdd BLAST272
Domaini471 – 555TYR_PHOSPHATASE_2InterPro annotationAdd BLAST85

Phylogenomic databases

eggNOGiENOG410IF2N. Eukaryota.
COG5599. LUCA.
HOVERGENiHBG006880.
KOiK18038.

Family and domain databases

Gene3Di3.40.525.10. 1 hit.
3.90.190.10. 1 hit.
InterProiIPR001251. CRAL-TRIO_dom.
IPR011074. CRAL/TRIO_N_dom.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000242. PTPase_domain.
IPR016130. Tyr_Pase_AS.
IPR003595. Tyr_Pase_cat.
IPR000387. TYR_PHOSPHATASE_dom.
[Graphical view]
PfamiPF00650. CRAL_TRIO. 1 hit.
PF00102. Y_phosphatase. 1 hit.
[Graphical view]
PRINTSiPR00700. PRTYPHPHTASE.
SMARTiSM01100. CRAL_TRIO_N. 1 hit.
SM00194. PTPc. 1 hit.
SM00404. PTPc_motif. 1 hit.
SM00516. SEC14. 1 hit.
[Graphical view]
SUPFAMiSSF46938. SSF46938. 1 hit.
SSF52087. SSF52087. 1 hit.
SSF52799. SSF52799. 1 hit.
PROSITEiPS50191. CRAL_TRIO. 1 hit.
PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6IQ43-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPELTPEEE QATKQFLEEI NKWTVQYNVS PLSWNVAVKF LMARKFDVLR
60 70 80 90 100
AIELFHSYRE TRRKEGIVKL KPHEEPLRSE ILSGKFTILN VRDPTGASIA
110 120 130 140 150
LFTARLHHPH KSVQHVVLQA LFYLLDRAVD SFETQRNGLV FIYDMCGSNY
160 170 180 190 200
ADFELDLGKK VLNLLKGAFP ARLKKVLIVG APIWFRVPYS IISLLLKDKV
210 220 230 240 250
RERIQILKTS EVTQHLPREC LPENLGGYVK IDLATWNFQF LPQVNGHPDR
260 270 280 290 300
FDEIILFSLP PALDWDSVHV PGPHAMTIQE LVDYVNARQK QGIYEEYEDI
310 320 330 340 350
RRENPVGTFH CSMSPGNLEK NRYGDVPCLD QTRVKLTKRS GHTQTDYINA
360 370 380 390 400
SFMDGYKQKN AYIGTQGPLE NTYRDFWLMV WEQKVLVIVM TTRFEEGGRR
410 420 430 440 450
KCGQYWPLEK DSRIRFGFLT VTNLGVENMN HYKKTTLEIH NTEERQKRQV
460 470 480 490 500
THFQFLSWPD YGVPSSAASL IDFLRVVRNQ QSLAVSNMGA RSKGQCPEPP
510 520 530 540 550
IVVHCSAGIG RTGTFCSLDI CLAQLEELGT LNVFQTVSRM RTQRAFSIQT
560 570 580
PEQYYFCYKA ILEFAEKEGM VSSGQNLLAV ESQ
Length:583
Mass (Da):67,014
Last modified:July 5, 2004 - v1
Checksum:i81F9923FFF2852A8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC071574 mRNA. Translation: AAH71574.1.
RefSeqiNP_002824.1. NM_002833.3.
UniGeneiHs.445775.

Genome annotation databases

GeneIDi5780.
KEGGihsa:5780.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC071574 mRNA. Translation: AAH71574.1.
RefSeqiNP_002824.1. NM_002833.3.
UniGeneiHs.445775.

3D structure databases

ProteinModelPortaliQ6IQ43.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ6IQ43. 5 interactors.
STRINGi9606.ENSP00000303554.

Proteomic databases

PaxDbiQ6IQ43.
PeptideAtlasiQ6IQ43.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi5780.
KEGGihsa:5780.

Organism-specific databases

CTDi5780.

Phylogenomic databases

eggNOGiENOG410IF2N. Eukaryota.
COG5599. LUCA.
HOVERGENiHBG006880.
KOiK18038.

Miscellaneous databases

ChiTaRSiPTPN9. human.
GenomeRNAii5780.

Family and domain databases

Gene3Di3.40.525.10. 1 hit.
3.90.190.10. 1 hit.
InterProiIPR001251. CRAL-TRIO_dom.
IPR011074. CRAL/TRIO_N_dom.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000242. PTPase_domain.
IPR016130. Tyr_Pase_AS.
IPR003595. Tyr_Pase_cat.
IPR000387. TYR_PHOSPHATASE_dom.
[Graphical view]
PfamiPF00650. CRAL_TRIO. 1 hit.
PF00102. Y_phosphatase. 1 hit.
[Graphical view]
PRINTSiPR00700. PRTYPHPHTASE.
SMARTiSM01100. CRAL_TRIO_N. 1 hit.
SM00194. PTPc. 1 hit.
SM00404. PTPc_motif. 1 hit.
SM00516. SEC14. 1 hit.
[Graphical view]
SUPFAMiSSF46938. SSF46938. 1 hit.
SSF52087. SSF52087. 1 hit.
SSF52799. SSF52799. 1 hit.
PROSITEiPS50191. CRAL_TRIO. 1 hit.
PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ6IQ43_HUMAN
AccessioniPrimary (citable) accession number: Q6IQ43
Entry historyi
Integrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: November 30, 2016
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.