Q6IQ32 (ADNP2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
ADNP homeobox protein 2

Alternative name(s):
Zinc finger protein 508

Gene names

Name:	ADNP2
Synonyms:	KIAA0863, ZNF508

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	1131 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May be involved in transcriptional regulation.
Subcellular location	Nucleus Probable.
Sequence similarities	Belongs to the krueppel C2H2-type zinc-finger protein family. Contains 4 C2H2-type zinc fingers. Contains 1 homeobox DNA-binding domain.
Sequence caution	The sequence BAA74886.2 differs from that shown. Reason: Erroneous initiation. The sequence BAB14180.1 differs from that shown. Reason: Frameshift at position 466.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Domain	Homeobox Repeat Zinc-finger
Ligand	DNA-binding Metal-binding Zinc
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	cellular response to oxidative stress Inferred from sequence or structural similarity. Source: UniProtKB cellular response to retinoic acid Inferred from sequence or structural similarity. Source: UniProtKB negative regulation of cell death Inferred from sequence or structural similarity. Source: UniProtKB neuron differentiation Inferred from sequence or structural similarity. Source: UniProtKB positive regulation of cell growth Inferred from sequence or structural similarity. Source: UniProtKB transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	protein binding Inferred from physical interaction. Source: IntAct sequence-specific DNA binding Inferred from electronic annotation. Source: InterPro sequence-specific DNA binding transcription factor activity Inferred from electronic annotation. Source: InterPro zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
CBX1	P83916	2	EBI-2838654,EBI-78129

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1131	1131	ADNP homeobox protein 2		PRO_0000280416
Regions
	Zinc finger	73 – 96	24	C2H2-type 1
	Zinc finger	215 – 240	26	C2H2-type 2
	Zinc finger	770 – 793	24	C2H2-type 3
	Zinc finger	875 – 905	31	C2H2-type 4
	DNA binding	1043 – 1102	60	Homeobox
	Compositional bias	268 – 427	160	Pro-rich
Experimental info
	Sequence conflict	757	1	S → P in BAB14180. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Q6IQ32 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: 73BCB3F755E6906D	FASTA	1,131	122,833
	10 20 30 40 50 60 MFQIPVENLD NIRKVRKKVK GILVDIGLDS CKELLKDLKG FDPGEKYFHN TSWGDVSLWE 70 80 90 100 110 120 PSGKKVRYRT KPYCCGLCKY STKVLTSFKN HLHRYHEDEI DQELVIPCPN CVFASQPKVV 130 140 150 160 170 180 GRHFRMFHAP VRKVQNYTVN ILGETKSSRS DVISFTCLKC NFSNTLYYSM KKHVLVAHFH 190 200 210 220 230 240 YLINSYFGLR TEEMGEQPKT NDTVSIEKIP PPDKYYCKKC NANASSQDAL MYHILTSDIH 250 260 270 280 290 300 RDLENKLRSV ISEHIKRTGL LKQTHIAPKP AAHLAAPANG SAPSAPAQPP CFHLALPQNS 310 320 330 340 350 360 PSPAAGQPVT VAQGAPGSLT HSPPAAGQSH MTLVSSPLPV GQNSLTLQPP APQPVFLSHG 370 380 390 400 410 420 VPLHQSVNPP VLPLSQPVGP VNKSVGTSVL PINQTVRPGV LPLTQPVGPI NRPVGPGVLP 430 440 450 460 470 480 VSPSVTPGVL QAVSPGVLSV SRAVPSGVLP AGQMTPAGQM TPAGVIPGQT ATSGVLPTGQ 490 500 510 520 530 540 MVQSGVLPVG QTAPSRVLPP GQTAPLRVIS AGQVVPSGLL SPNQTVSSSA VVPVNQGVNS 550 560 570 580 590 600 GVLQLSQPVV SGVLPVGQPV RPGVLQLNQT VGTNILPVNQ PVRPGASQNT TFLTSGSILR 610 620 630 640 650 660 QLIPTGKQVN GIPTYTLAPV SVTLPVPPGG LATVAPPQMP IQLLPSGAAA PMAGSMPGMP 670 680 690 700 710 720 SPPVLVNAAQ SVFVQASSSA ADTNQVLKQA KQWKTCPVCN ELFPSNVYQV HMEVAHKHSE 730 740 750 760 770 780 SKSGEKLEPE KLAACAPFLK WMREKTVRCL SCKCLVSEEE LIHHLLMHGL GCLFCPCTFH 790 800 810 820 830 840 DIKGLSEHSR NRHLGKKKLP MDYSNRGFQL DVDANGNLLF PHLDFITILP KEKLGEREVY 850 860 870 880 890 900 LAILAGIHSK SLVPVYVKVR PQAEGTPGST GKRVSTCPFC FGPFVTTEAY ELHLKERHHI 910 920 930 940 950 960 MPTVHTVLKS PAFKCIHCCG VYTGNMTLAA IAVHLVRCRS APKDSSSDLQ AQPGFIHNSE 970 980 990 1000 1010 1020 LLLVSGEVMH DSSFSVKRKL PDGHLGAEDQ RHGEEQPPIL NADAAPGPEK VTSVVPFKRQ 1030 1040 1050 1060 1070 1080 RNESRTEGPI VKDEALQILA LDPKKYEGRS YEEKKQFLKD YFHKKPYPSK KEIELLSSLF 1090 1100 1110 1120 1130 WVWKIDVASF FGKRRYICMK AIKNHKPSVL LGFDMSELKN VKHRLNFEYE P

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro." Nagase T., Ishikawa K., Suyama M., Kikuno R., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O. DNA Res. 5:355-364(1998) [PubMed: 10048485] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
[2]	Ohara O., Suyama M., Kikuno R., Nagase T., Ishikawa K. Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases Cited for: SEQUENCE REVISION.
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Teratocarcinoma and Testis.
[4]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Placenta.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB020670 mRNA. Translation: BAA74886.2. Different initiation. AK022688 mRNA. Translation: BAB14180.1. Frameshift. AK292566 mRNA. Translation: BAF85255.1. CH471117 Genomic DNA. Translation: EAW66646.1. BC071589 mRNA. Translation: AAH71589.1.
IPI	IPI00402209.
RefSeq	NP_055728.1. NM_014913.3.
UniGene	Hs.131915.
3D structure databases
ProteinModelPortal	Q6IQ32.
SMR	Q6IQ32. Positions 69-131, 693-808, 1051-1100.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q6IQ32. 5 interactions.
Polymorphism databases
DMDM	74757998.
Proteomic databases
PRIDE	Q6IQ32.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000262198; ENSP00000262198; ENSG00000101544.
GeneID	22850.
KEGG	hsa:22850.
UCSC	uc002lnw.1. human.
Organism-specific databases
CTD	22850.
GeneCards	GC18P077866.
H-InvDB	HIX0014546.
HGNC	HGNC:23803. ADNP2.
HPA	HPA007126.
neXtProt	NX_Q6IQ32.
PharmGKB	PA162375700.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG19273.
GeneTree	ENSGT00530000063631.
HOGENOM	HBG403001.
HOVERGEN	HBG059494.
InParanoid	Q6IQ32.
OMA	ELIHHLL.
OrthoDB	EOG41JZBF.
Gene expression databases
ArrayExpress	Q6IQ32.
Bgee	Q6IQ32.
CleanEx	HS_ADNP2.
Genevestigator	Q6IQ32.
Family and domain databases
InterPro	IPR001356. Homeobox. IPR009057. Homeodomain-like. IPR012287. Homeodomain-rel. IPR007087. Znf_C2H2. IPR015880. Znf_C2H2-like. [Graphical view]
Gene3D	G3DSA:1.10.10.60. Homeodomain-rel. 1 hit.
SMART	SM00389. HOX. 1 hit. SM00355. ZnF_C2H2. 8 hits. [Graphical view]
SUPFAM	SSF46689. Homeodomain_like. 1 hit.
PROSITE	PS00027. HOMEOBOX_1. False negative. PS50071. HOMEOBOX_2. False negative. PS00028. ZINC_FINGER_C2H2_1. 2 hits. PS50157. ZINC_FINGER_C2H2_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	43325.

Entry information

Entry name

ADNP2_HUMAN

Accession

Primary (citable) accession number: Q6IQ32
Secondary accession number(s): A8K951, O94943, Q9H9P3

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 20, 2007
Last sequence update:	July 5, 2004
Last modified:	January 25, 2012
This is version 86 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.