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Protein

ADNP homeobox protein 2

Gene

ADNP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri73 – 9624C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri106 – 12823C2H2-type 2; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri155 – 17824C2H2-type 3; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri215 – 24026C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri694 – 71623C2H2-type 5; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri747 – 76822C2H2-type 6; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri770 – 79324C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri875 – 89824C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri913 – 93725C2H2-type 9; degeneratePROSITE-ProRule annotationAdd
BLAST
DNA bindingi1043 – 110260HomeoboxAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
ADNP homeobox protein 2
Alternative name(s):
Zinc finger protein 508
Gene namesi
Name:ADNP2
Synonyms:KIAA0863, ZNF508
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 18

Organism-specific databases

HGNCiHGNC:23803. ADNP2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162375700.

Polymorphism and mutation databases

BioMutaiADNP2.
DMDMi74757998.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11311131ADNP homeobox protein 2PRO_0000280416Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1024 – 10241PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ6IQ32.
MaxQBiQ6IQ32.
PaxDbiQ6IQ32.
PRIDEiQ6IQ32.

PTM databases

iPTMnetiQ6IQ32.
PhosphoSiteiQ6IQ32.

Expressioni

Gene expression databases

BgeeiQ6IQ32.
CleanExiHS_ADNP2.
ExpressionAtlasiQ6IQ32. baseline and differential.
GenevisibleiQ6IQ32. HS.

Organism-specific databases

HPAiHPA007126.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
CBX1P839162EBI-2838654,EBI-78129

Protein-protein interaction databases

BioGridi116522. 15 interactions.
IntActiQ6IQ32. 12 interactions.
STRINGi9606.ENSP00000262198.

Structurei

3D structure databases

ProteinModelPortaliQ6IQ32.
SMRiQ6IQ32. Positions 1052-1102.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi268 – 427160Pro-richAdd
BLAST

Sequence similaritiesi

Contains 9 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 homeobox DNA-binding domain.Curated

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri73 – 9624C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri106 – 12823C2H2-type 2; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri155 – 17824C2H2-type 3; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri215 – 24026C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri694 – 71623C2H2-type 5; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri747 – 76822C2H2-type 6; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri770 – 79324C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri875 – 89824C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri913 – 93725C2H2-type 9; degeneratePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Homeobox, Repeat, Zinc-finger

Phylogenomic databases

eggNOGiENOG410IHQQ. Eukaryota.
ENOG410ZPT3. LUCA.
GeneTreeiENSGT00530000063631.
HOGENOMiHOG000247070.
HOVERGENiHBG059494.
InParanoidiQ6IQ32.
OMAiHEDEIDQ.
OrthoDBiEOG7KSX7W.
PhylomeDBiQ6IQ32.
TreeFamiTF328818.

Family and domain databases

InterProiIPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
[Graphical view]
SMARTiSM00389. HOX. 1 hit.
SM00355. ZnF_C2H2. 8 hits.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 2 hits.
PS50157. ZINC_FINGER_C2H2_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6IQ32-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFQIPVENLD NIRKVRKKVK GILVDIGLDS CKELLKDLKG FDPGEKYFHN
60 70 80 90 100
TSWGDVSLWE PSGKKVRYRT KPYCCGLCKY STKVLTSFKN HLHRYHEDEI
110 120 130 140 150
DQELVIPCPN CVFASQPKVV GRHFRMFHAP VRKVQNYTVN ILGETKSSRS
160 170 180 190 200
DVISFTCLKC NFSNTLYYSM KKHVLVAHFH YLINSYFGLR TEEMGEQPKT
210 220 230 240 250
NDTVSIEKIP PPDKYYCKKC NANASSQDAL MYHILTSDIH RDLENKLRSV
260 270 280 290 300
ISEHIKRTGL LKQTHIAPKP AAHLAAPANG SAPSAPAQPP CFHLALPQNS
310 320 330 340 350
PSPAAGQPVT VAQGAPGSLT HSPPAAGQSH MTLVSSPLPV GQNSLTLQPP
360 370 380 390 400
APQPVFLSHG VPLHQSVNPP VLPLSQPVGP VNKSVGTSVL PINQTVRPGV
410 420 430 440 450
LPLTQPVGPI NRPVGPGVLP VSPSVTPGVL QAVSPGVLSV SRAVPSGVLP
460 470 480 490 500
AGQMTPAGQM TPAGVIPGQT ATSGVLPTGQ MVQSGVLPVG QTAPSRVLPP
510 520 530 540 550
GQTAPLRVIS AGQVVPSGLL SPNQTVSSSA VVPVNQGVNS GVLQLSQPVV
560 570 580 590 600
SGVLPVGQPV RPGVLQLNQT VGTNILPVNQ PVRPGASQNT TFLTSGSILR
610 620 630 640 650
QLIPTGKQVN GIPTYTLAPV SVTLPVPPGG LATVAPPQMP IQLLPSGAAA
660 670 680 690 700
PMAGSMPGMP SPPVLVNAAQ SVFVQASSSA ADTNQVLKQA KQWKTCPVCN
710 720 730 740 750
ELFPSNVYQV HMEVAHKHSE SKSGEKLEPE KLAACAPFLK WMREKTVRCL
760 770 780 790 800
SCKCLVSEEE LIHHLLMHGL GCLFCPCTFH DIKGLSEHSR NRHLGKKKLP
810 820 830 840 850
MDYSNRGFQL DVDANGNLLF PHLDFITILP KEKLGEREVY LAILAGIHSK
860 870 880 890 900
SLVPVYVKVR PQAEGTPGST GKRVSTCPFC FGPFVTTEAY ELHLKERHHI
910 920 930 940 950
MPTVHTVLKS PAFKCIHCCG VYTGNMTLAA IAVHLVRCRS APKDSSSDLQ
960 970 980 990 1000
AQPGFIHNSE LLLVSGEVMH DSSFSVKRKL PDGHLGAEDQ RHGEEQPPIL
1010 1020 1030 1040 1050
NADAAPGPEK VTSVVPFKRQ RNESRTEGPI VKDEALQILA LDPKKYEGRS
1060 1070 1080 1090 1100
YEEKKQFLKD YFHKKPYPSK KEIELLSSLF WVWKIDVASF FGKRRYICMK
1110 1120 1130
AIKNHKPSVL LGFDMSELKN VKHRLNFEYE P
Length:1,131
Mass (Da):122,833
Last modified:July 5, 2004 - v1
Checksum:i73BCB3F755E6906D
GO

Sequence cautioni

The sequence BAA74886.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAB14180.1 differs from that shown. Reason: Frameshift at position 466. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti757 – 7571S → P in BAB14180 (PubMed:14702039).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB020670 mRNA. Translation: BAA74886.2. Different initiation.
AK022688 mRNA. Translation: BAB14180.1. Frameshift.
AK292566 mRNA. Translation: BAF85255.1.
CH471117 Genomic DNA. Translation: EAW66646.1.
BC071589 mRNA. Translation: AAH71589.1.
CCDSiCCDS32853.1.
RefSeqiNP_055728.1. NM_014913.3.
XP_005266713.1. XM_005266656.3.
UniGeneiHs.131915.

Genome annotation databases

EnsembliENST00000262198; ENSP00000262198; ENSG00000101544.
GeneIDi22850.
KEGGihsa:22850.
UCSCiuc032hie.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB020670 mRNA. Translation: BAA74886.2. Different initiation.
AK022688 mRNA. Translation: BAB14180.1. Frameshift.
AK292566 mRNA. Translation: BAF85255.1.
CH471117 Genomic DNA. Translation: EAW66646.1.
BC071589 mRNA. Translation: AAH71589.1.
CCDSiCCDS32853.1.
RefSeqiNP_055728.1. NM_014913.3.
XP_005266713.1. XM_005266656.3.
UniGeneiHs.131915.

3D structure databases

ProteinModelPortaliQ6IQ32.
SMRiQ6IQ32. Positions 1052-1102.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116522. 15 interactions.
IntActiQ6IQ32. 12 interactions.
STRINGi9606.ENSP00000262198.

PTM databases

iPTMnetiQ6IQ32.
PhosphoSiteiQ6IQ32.

Polymorphism and mutation databases

BioMutaiADNP2.
DMDMi74757998.

Proteomic databases

EPDiQ6IQ32.
MaxQBiQ6IQ32.
PaxDbiQ6IQ32.
PRIDEiQ6IQ32.

Protocols and materials databases

DNASUi22850.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000262198; ENSP00000262198; ENSG00000101544.
GeneIDi22850.
KEGGihsa:22850.
UCSCiuc032hie.2. human.

Organism-specific databases

CTDi22850.
GeneCardsiADNP2.
HGNCiHGNC:23803. ADNP2.
HPAiHPA007126.
neXtProtiNX_Q6IQ32.
PharmGKBiPA162375700.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IHQQ. Eukaryota.
ENOG410ZPT3. LUCA.
GeneTreeiENSGT00530000063631.
HOGENOMiHOG000247070.
HOVERGENiHBG059494.
InParanoidiQ6IQ32.
OMAiHEDEIDQ.
OrthoDBiEOG7KSX7W.
PhylomeDBiQ6IQ32.
TreeFamiTF328818.

Miscellaneous databases

ChiTaRSiADNP2. human.
GenomeRNAii22850.
PROiQ6IQ32.

Gene expression databases

BgeeiQ6IQ32.
CleanExiHS_ADNP2.
ExpressionAtlasiQ6IQ32. baseline and differential.
GenevisibleiQ6IQ32. HS.

Family and domain databases

InterProiIPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
[Graphical view]
SMARTiSM00389. HOX. 1 hit.
SM00355. ZnF_C2H2. 8 hits.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 2 hits.
PS50157. ZINC_FINGER_C2H2_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Ishikawa K., Suyama M., Kikuno R., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
    DNA Res. 5:355-364(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  2. Ohara O., Suyama M., Kikuno R., Nagase T., Ishikawa K.
    Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Teratocarcinoma and Testis.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Placenta.
  6. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1024, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiADNP2_HUMAN
AccessioniPrimary (citable) accession number: Q6IQ32
Secondary accession number(s): A8K951, O94943, Q9H9P3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: July 5, 2004
Last modified: June 8, 2016
This is version 125 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 18
    Human chromosome 18: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.