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Protein

Activity-dependent neuroprotector homeobox protein 2

Gene

ADNP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri73 – 96C2H2-type 1PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri106 – 128C2H2-type 2; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri155 – 178C2H2-type 3; degeneratePROSITE-ProRule annotationAdd BLAST24
Zinc fingeri215 – 240C2H2-type 4PROSITE-ProRule annotationAdd BLAST26
Zinc fingeri694 – 716C2H2-type 5; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri747 – 768C2H2-type 6; degeneratePROSITE-ProRule annotationAdd BLAST22
Zinc fingeri770 – 793C2H2-type 7PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri875 – 898C2H2-type 8PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri913 – 937C2H2-type 9; degeneratePROSITE-ProRule annotationAdd BLAST25
DNA bindingi1043 – 1102HomeoboxAdd BLAST60

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Activity-dependent neuroprotector homeobox protein 2
Short name:
ADNP homeobox protein 2
Alternative name(s):
Zinc finger protein 508
Gene namesi
Name:ADNP2
Synonyms:KIAA0863, ZNF508
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 18

Organism-specific databases

EuPathDBiHostDB:ENSG00000101544.8.
HGNCiHGNC:23803. ADNP2.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi22850.
OpenTargetsiENSG00000101544.
PharmGKBiPA162375700.

Polymorphism and mutation databases

BioMutaiADNP2.
DMDMi74757998.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002804161 – 1131Activity-dependent neuroprotector homeobox protein 2Add BLAST1131

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki118Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki146Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki979Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki1018Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei1024PhosphoserineCombined sources1
Cross-linki1032Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)Combined sources
Cross-linki1032Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ6IQ32.
MaxQBiQ6IQ32.
PaxDbiQ6IQ32.
PeptideAtlasiQ6IQ32.
PRIDEiQ6IQ32.

PTM databases

iPTMnetiQ6IQ32.
PhosphoSitePlusiQ6IQ32.

Expressioni

Gene expression databases

BgeeiENSG00000101544.
CleanExiHS_ADNP2.
ExpressionAtlasiQ6IQ32. baseline and differential.
GenevisibleiQ6IQ32. HS.

Organism-specific databases

HPAiHPA007126.

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi116522. 15 interactors.
IntActiQ6IQ32. 12 interactors.
STRINGi9606.ENSP00000262198.

Structurei

3D structure databases

ProteinModelPortaliQ6IQ32.
SMRiQ6IQ32.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi268 – 427Pro-richAdd BLAST160

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri73 – 96C2H2-type 1PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri106 – 128C2H2-type 2; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri155 – 178C2H2-type 3; degeneratePROSITE-ProRule annotationAdd BLAST24
Zinc fingeri215 – 240C2H2-type 4PROSITE-ProRule annotationAdd BLAST26
Zinc fingeri694 – 716C2H2-type 5; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri747 – 768C2H2-type 6; degeneratePROSITE-ProRule annotationAdd BLAST22
Zinc fingeri770 – 793C2H2-type 7PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri875 – 898C2H2-type 8PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri913 – 937C2H2-type 9; degeneratePROSITE-ProRule annotationAdd BLAST25

Keywords - Domaini

Homeobox, Repeat, Zinc-finger

Phylogenomic databases

eggNOGiENOG410IHQQ. Eukaryota.
ENOG410ZPT3. LUCA.
GeneTreeiENSGT00530000063631.
HOGENOMiHOG000247070.
HOVERGENiHBG059494.
InParanoidiQ6IQ32.
OMAiDVASFFG.
OrthoDBiEOG091G03Q0.
PhylomeDBiQ6IQ32.
TreeFamiTF328818.

Family and domain databases

CDDicd00086. homeodomain. 1 hit.
InterProiView protein in InterPro
IPR009057. Homeobox-like_sf.
IPR001356. Homeobox_dom.
IPR013087. Znf_C2H2_type.
SMARTiView protein in SMART
SM00389. HOX. 1 hit.
SM00355. ZnF_C2H2. 8 hits.
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiView protein in PROSITE
PS00028. ZINC_FINGER_C2H2_1. 2 hits.
PS50157. ZINC_FINGER_C2H2_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6IQ32-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFQIPVENLD NIRKVRKKVK GILVDIGLDS CKELLKDLKG FDPGEKYFHN
60 70 80 90 100
TSWGDVSLWE PSGKKVRYRT KPYCCGLCKY STKVLTSFKN HLHRYHEDEI
110 120 130 140 150
DQELVIPCPN CVFASQPKVV GRHFRMFHAP VRKVQNYTVN ILGETKSSRS
160 170 180 190 200
DVISFTCLKC NFSNTLYYSM KKHVLVAHFH YLINSYFGLR TEEMGEQPKT
210 220 230 240 250
NDTVSIEKIP PPDKYYCKKC NANASSQDAL MYHILTSDIH RDLENKLRSV
260 270 280 290 300
ISEHIKRTGL LKQTHIAPKP AAHLAAPANG SAPSAPAQPP CFHLALPQNS
310 320 330 340 350
PSPAAGQPVT VAQGAPGSLT HSPPAAGQSH MTLVSSPLPV GQNSLTLQPP
360 370 380 390 400
APQPVFLSHG VPLHQSVNPP VLPLSQPVGP VNKSVGTSVL PINQTVRPGV
410 420 430 440 450
LPLTQPVGPI NRPVGPGVLP VSPSVTPGVL QAVSPGVLSV SRAVPSGVLP
460 470 480 490 500
AGQMTPAGQM TPAGVIPGQT ATSGVLPTGQ MVQSGVLPVG QTAPSRVLPP
510 520 530 540 550
GQTAPLRVIS AGQVVPSGLL SPNQTVSSSA VVPVNQGVNS GVLQLSQPVV
560 570 580 590 600
SGVLPVGQPV RPGVLQLNQT VGTNILPVNQ PVRPGASQNT TFLTSGSILR
610 620 630 640 650
QLIPTGKQVN GIPTYTLAPV SVTLPVPPGG LATVAPPQMP IQLLPSGAAA
660 670 680 690 700
PMAGSMPGMP SPPVLVNAAQ SVFVQASSSA ADTNQVLKQA KQWKTCPVCN
710 720 730 740 750
ELFPSNVYQV HMEVAHKHSE SKSGEKLEPE KLAACAPFLK WMREKTVRCL
760 770 780 790 800
SCKCLVSEEE LIHHLLMHGL GCLFCPCTFH DIKGLSEHSR NRHLGKKKLP
810 820 830 840 850
MDYSNRGFQL DVDANGNLLF PHLDFITILP KEKLGEREVY LAILAGIHSK
860 870 880 890 900
SLVPVYVKVR PQAEGTPGST GKRVSTCPFC FGPFVTTEAY ELHLKERHHI
910 920 930 940 950
MPTVHTVLKS PAFKCIHCCG VYTGNMTLAA IAVHLVRCRS APKDSSSDLQ
960 970 980 990 1000
AQPGFIHNSE LLLVSGEVMH DSSFSVKRKL PDGHLGAEDQ RHGEEQPPIL
1010 1020 1030 1040 1050
NADAAPGPEK VTSVVPFKRQ RNESRTEGPI VKDEALQILA LDPKKYEGRS
1060 1070 1080 1090 1100
YEEKKQFLKD YFHKKPYPSK KEIELLSSLF WVWKIDVASF FGKRRYICMK
1110 1120 1130
AIKNHKPSVL LGFDMSELKN VKHRLNFEYE P
Length:1,131
Mass (Da):122,833
Last modified:July 5, 2004 - v1
Checksum:i73BCB3F755E6906D
GO

Sequence cautioni

The sequence BAA74886 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAB14180 differs from that shown. Reason: Frameshift at position 466.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti757S → P in BAB14180 (PubMed:14702039).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB020670 mRNA. Translation: BAA74886.2. Different initiation.
AK022688 mRNA. Translation: BAB14180.1. Frameshift.
AK292566 mRNA. Translation: BAF85255.1.
CH471117 Genomic DNA. Translation: EAW66646.1.
BC071589 mRNA. Translation: AAH71589.1.
CCDSiCCDS32853.1.
RefSeqiNP_055728.1. NM_014913.3.
XP_005266713.1. XM_005266656.4.
UniGeneiHs.131915.

Genome annotation databases

EnsembliENST00000262198; ENSP00000262198; ENSG00000101544.
GeneIDi22850.
KEGGihsa:22850.
UCSCiuc032hie.2. human.

Similar proteinsi

Entry informationi

Entry nameiADNP2_HUMAN
AccessioniPrimary (citable) accession number: Q6IQ32
Secondary accession number(s): A8K951, O94943, Q9H9P3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: July 5, 2004
Last modified: November 22, 2017
This is version 138 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 18
    Human chromosome 18: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families