Q6IQ26 (DEN5A_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
DENN domain-containing protein 5A

Alternative name(s):
Rab6-interacting protein 1
Short name=Rab6IP1

Gene names

Name:	DENND5A
Synonyms:	KIAA1091, RAB6IP1

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	1287 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May be involved in Rab6-mediated GTPase signaling.
Subunit structure	Probably interacts with RAB6A bound to GTP By similarity.
Sequence similarities	Belongs to the RAB6IP1 family. Contains 1 dDENN domain. Contains 1 DENN domain. Contains 1 PLAT domain. Contains 2 RUN domains. Contains 1 uDENN domain.
Sequence caution	The sequence BAA83043.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened. The sequence BAB15155.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Ontologies

Keywords
Coding sequence diversity	Polymorphism
Domain	Repeat
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1287	1287	DENN domain-containing protein 5A		PRO_0000097142
Regions
	Domain	68 – 138	71	UDENN
	Domain	202 – 390	189	DENN
	Domain	512 – 588	77	dDENN
	Domain	787 – 950	164	RUN 1
	Domain	954 – 1062	109	PLAT
	Domain	1134 – 1282	149	RUN 2
	Compositional bias	3 – 9	7	Poly-Gly
	Compositional bias	593 – 598	6	Poly-Asp
Amino acid modifications
	Modified residue	193	1	Phosphoserine Ref.6
Natural variations
	Natural variant	224	1	E → Q. Ref.1 Ref.4 Corresponds to variant rs952374 [ dbSNP | Ensembl ].		VAR_028409
Experimental info
	Sequence conflict	597	1	K → E in BAB15155. Ref.5
	Sequence conflict	1100	1	K → E in BAB15155. Ref.5

Sequences

	Sequence		Length	Mass (Da)
	Q6IQ26 [UniParc]. Last modified January 11, 2011. Version 2. Checksum: 7633D36BE076C576	FASTA	1,287	147,096
	10 20 30 40 50 60 MSGGGGGGGS APSRFADYFV ICGLDTETGL EPDELSALCQ YIQASKARDG ASPFISSTTE 70 80 90 100 110 120 GENFEQTPLR RTFKSKVLAR YPENVEWNPF DQDAVGMLCM PKGLAFKTQA DPREPQFHAF 130 140 150 160 170 180 IITREDGSRT FGFALTFYEE VTSKQICSAM QTLYHMHNAE YDVLHAPPAD DRDQSSMEDG 190 200 210 220 230 240 EDTPVTKLQR FNSYDISRDT LYVSKCICLI TPMSFMKACR SVLEQLHQAV TSPQPPPLPL 250 260 270 280 290 300 ESYIYNVLYE VPLPPPGRSL KFSGVYGPII CQRPSTNELP LFDFPVKEVF ELLGVENVFQ 310 320 330 340 350 360 LFTCALLEFQ ILLYSQHYQR LMTVAETITA LMFPFQWQHV YVPILPASLL HFLDAPVPYL 370 380 390 400 410 420 MGLHSNGLDD RSKLELPQEA NLCFVDIDNH FIELPEDLPQ FPNKLEFVQE VSEILMAFGI 430 440 450 460 470 480 PPEGNLHCSE SASKLKRLRA SELVSDKRNG NIAGSPLHSY ELLKENETIA RLQALVKRTG 490 500 510 520 530 540 VSLEKLEVRE DPSSNKDLKV QCDEEELRIY QLNIQIREVF ANRFTQMFAD YEVFVIQPSQ 550 560 570 580 590 600 DKESWFTNRE QMQNFDKASF LSDQPEPYLP FLSRFLETQM FASFIDNKIM CHDDDDKDPV 610 620 630 640 650 660 LRVFDSRVDK IRLLNVRTPT LRTSMYQKCT TVDEAEKAIE LRLAKIDHTA IHPHLLDMKI 670 680 690 700 710 720 GQGKYEPGFF PKLQSDVLST GPASNKWTKR NAPAQWRRKD RQKQHTEHLR LDNDQREKYI 730 740 750 760 770 780 QEARTMGSTI RQPKLSNLSP SVIAQTNWKF VEGLLKECRN KTKRMLVEKM GREAVELGHG 790 800 810 820 830 840 EVNITGVEEN TLIASLCDLL ERIWSHGLQV KQGKSALWSH LLHYQDNRQR KLTSGSLSTS 850 860 870 880 890 900 GILLDSERRK SDASSLMPPL RISLIQDMRH IQNIGEIKTD VGKARAWVRL SMEKKLLSRH 910 920 930 940 950 960 LKQLLSDHEL TKKLYKRYAF LRCDDEKEQF LYHLLSFNAV DYFCFTNVFT TILIPYHILI 970 980 990 1000 1010 1020 VPSKKLGGSM FTANPWICIS GELGETQIMQ IPRNVLEMTF ECQNLGKLTT VQIGHDNSGL 1030 1040 1050 1060 1070 1080 YAKWLVEYVM VRNEITGHTY KFPCGRWLGK GMDDGSLERI LVGELLTSQP EVDERPCRTP 1090 1100 1110 1120 1130 1140 PLQQSPSVIR RLVTISPNNK PKLNTGQIQE SIGEAVNGIV KHFHKPEKER GSLTLLLCGE 1150 1160 1170 1180 1190 1200 CGLVSALEQA FQHGFKSPRL FKNVFIWDFL EKAQTYYETL EKNEVVPEEN WHTRARNFCR 1210 1220 1230 1240 1250 1260 FVTAINNTPR NIGKDGKFQM LVCLGARDHL LHHWIALLAD CPITAHMYED VALIKDHTLV 1270 1280 NSLIRVLQTL QEFNITLETS LVKGIDI

References

[1]	"Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro." Kikuno R., Nagase T., Ishikawa K., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O. DNA Res. 6:197-205(1999) [PubMed: 10470851] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT GLN-224. Tissue: Brain.
[2]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed: 17974005] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Uterus.
[3]	"Human chromosome 11 DNA sequence and analysis including novel gene identification." Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K., Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T., Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G. , Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C., Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A., Hattori M., Rogers J., Lander E.S., Sakaki Y. Nature 440:497-500(2006) [PubMed: 16554811] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT GLN-224. Tissue: Placenta and Skin.
[5]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 379-1287.
[6]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-193, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB029014 mRNA. Translation: BAA83043.1. Different initiation. AL117448 mRNA. Translation: CAB55932.2. AC055845 Genomic DNA. No translation available. AC079296 Genomic DNA. No translation available. AP006259 Genomic DNA. No translation available. BC009354 mRNA. Translation: AAH09354.2. BC071596 mRNA. Translation: AAH71596.1. AK025499 mRNA. Translation: BAB15155.1. Different initiation.
IPI	IPI00456737.
PIR	T17242.
RefSeq	NP_001230183.1. NM_001243254.1. NP_056028.2. NM_015213.3.
UniGene	Hs.501857.
3D structure databases
ProteinModelPortal	Q6IQ26.
SMR	Q6IQ26. Positions 737-1072.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q6IQ26. 1 interaction.
STRING	Q6IQ26.
PTM databases
PhosphoSite	Q6IQ26.
Polymorphism databases
DMDM	52000795.
Proteomic databases
PRIDE	Q6IQ26.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000328194; ENSP00000328524; ENSG00000184014.
GeneID	23258.
KEGG	hsa:23258.
UCSC	uc001mhl.1. human.
Organism-specific databases
CTD	23258.
GeneCards	GC11M009117.
H-InvDB	HIX0009434.
HGNC	HGNC:19344. DENND5A.
neXtProt	NX_Q6IQ26.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG07411.
GeneTree	ENSGT00550000074509.
HOGENOM	HBG381256.
HOVERGEN	HBG059906.
InParanoid	Q6IQ26.
OMA	IQEARTM.
OrthoDB	EOG4M397P.
PhylomeDB	Q6IQ26.
Gene expression databases
ArrayExpress	Q6IQ26.
Bgee	Q6IQ26.
CleanEx	HS_DENND5A.
Genevestigator	Q6IQ26.
GermOnline	ENSG00000184014. Homo sapiens.
Family and domain databases
InterPro	IPR005112. dDENN. IPR001194. DENN. IPR008976. Lipase_LipOase. IPR001024. LipOase_LH2. IPR004012. Run. IPR005113. uDENN. [Graphical view]
Gene3D	G3DSA:2.60.60.20. Lipase_LipOase. 1 hit.
Pfam	PF03455. dDENN. 1 hit. PF02141. DENN. 1 hit. PF01477. PLAT. 1 hit. PF02759. RUN. 2 hits. PF03456. uDENN. 1 hit. [Graphical view]
SMART	SM00801. dDENN. 1 hit. SM00799. DENN. 1 hit. SM00593. RUN. 2 hits. SM00800. uDENN. 1 hit. [Graphical view]
SUPFAM	SSF49723. Lipase_LipOase. 1 hit.
PROSITE	PS50947. DDENN. 1 hit. PS50211. DENN. 1 hit. PS50095. PLAT. 1 hit. PS50826. RUN. 2 hits. PS50946. UDENN. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	44988.

Entry information

Entry name

DEN5A_HUMAN

Accession

Primary (citable) accession number: Q6IQ26
Secondary accession number(s): Q96GN3 , Q9H6U7, Q9UFV0, Q9UPR1

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 13, 2004
Last sequence update:	January 11, 2011
Last modified:	January 25, 2012
This is version 75 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.