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Protein

Pleckstrin homology domain-containing family A member 7

Gene

PLEKHA7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Required for zonula adherens biogenesis and maintenance. Acts via its interaction with KIAA1543/Nezha, which anchors microtubules at their minus-ends to zonula adherens, leading to the recruitment of KIFC3 kinesin to the junctional site.1 Publication

GO - Molecular functioni

  • delta-catenin binding Source: UniProtKB

GO - Biological processi

  • epithelial cell-cell adhesion Source: UniProtKB
  • zonula adherens maintenance Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Pleckstrin homology domain-containing family A member 7
Short name:
PH domain-containing family A member 7
Gene namesi
Name:PLEKHA7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:27049. PLEKHA7.

Subcellular locationi

GO - Cellular componenti

  • cell junction Source: HPA
  • centrosome Source: UniProtKB
  • cytoplasm Source: HPA
  • extracellular exosome Source: UniProtKB
  • nucleus Source: HPA
  • zonula adherens Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cytoplasm, Cytoskeleton

Pathology & Biotechi

Organism-specific databases

DisGeNETi144100.
OpenTargetsiENSG00000166689.
PharmGKBiPA134894945.

Polymorphism and mutation databases

BioMutaiPLEKHA7.
DMDMi215273867.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002876921 – 1121Pleckstrin homology domain-containing family A member 7Add BLAST1121

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei536PhosphoserineCombined sources1
Modified residuei545PhosphoserineBy similarity1
Modified residuei569PhosphoserineCombined sources1
Modified residuei604PhosphoserineCombined sources1
Modified residuei608PhosphoserineCombined sources1
Modified residuei612PhosphoserineCombined sources1
Modified residuei858PhosphoserineCombined sources1
Modified residuei860PhosphoserineCombined sources1
Modified residuei867PhosphoserineCombined sources1
Modified residuei870PhosphothreonineCombined sources1
Modified residuei871PhosphoserineCombined sources1
Modified residuei903PhosphoserineCombined sources1
Modified residuei907PhosphoserineCombined sources1
Modified residuei986PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ6IQ23.
PaxDbiQ6IQ23.
PeptideAtlasiQ6IQ23.
PRIDEiQ6IQ23.

PTM databases

iPTMnetiQ6IQ23.
PhosphoSitePlusiQ6IQ23.

Expressioni

Gene expression databases

BgeeiENSG00000166689.
CleanExiHS_PLEKHA7.
ExpressionAtlasiQ6IQ23. baseline and differential.
GenevisibleiQ6IQ23. HS.

Organism-specific databases

HPAiHPA038610.

Interactioni

Subunit structurei

Interacts with KIAA1543/Nezha and CTNND1.1 Publication

GO - Molecular functioni

  • delta-catenin binding Source: UniProtKB

Protein-protein interaction databases

BioGridi126828. 7 interactors.
IntActiQ6IQ23. 8 interactors.
STRINGi9606.ENSP00000347883.

Structurei

3D structure databases

ProteinModelPortaliQ6IQ23.
SMRiQ6IQ23.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini9 – 42WW 1PROSITE-ProRule annotationAdd BLAST34
Domaini54 – 87WW 2PROSITE-ProRule annotationAdd BLAST34
Domaini164 – 282PHPROSITE-ProRule annotationAdd BLAST119

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni538 – 696Interaction with CTNND11 PublicationAdd BLAST159

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili700 – 801Sequence analysisAdd BLAST102
Coiled coili1067 – 1094Sequence analysisAdd BLAST28

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi567 – 599Pro-richAdd BLAST33
Compositional biasi845 – 942Pro-richAdd BLAST98

Sequence similaritiesi

Contains 1 PH domain.PROSITE-ProRule annotation
Contains 2 WW domains.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

eggNOGiENOG410INUD. Eukaryota.
ENOG4111YSB. LUCA.
GeneTreeiENSGT00530000063012.
HOGENOMiHOG000077378.
HOVERGENiHBG103572.
InParanoidiQ6IQ23.
PhylomeDBiQ6IQ23.
TreeFamiTF329090.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR011993. PH_dom-like.
IPR001849. PH_domain.
IPR001202. WW_dom.
[Graphical view]
PfamiPF00169. PH. 1 hit.
[Graphical view]
SMARTiSM00233. PH. 1 hit.
SM00456. WW. 2 hits.
[Graphical view]
SUPFAMiSSF50729. SSF50729. 1 hit.
SSF51045. SSF51045. 2 hits.
PROSITEiPS50003. PH_DOMAIN. 1 hit.
PS01159. WW_DOMAIN_1. 1 hit.
PS50020. WW_DOMAIN_2. 2 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6IQ23-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAATVGRDT LPEHWSYGVC RDGRVFFIND QLRCTTWLHP RTGEPVNSGH
60 70 80 90 100
MIRSDLPRGW EEGFTEEGAS YFIDHNQQTT AFRHPVTGQF SPENSEFILQ
110 120 130 140 150
EEPNPHMSKQ DRNQRPSSMV SETSTAGTAS TLEAKPGPKI IKSSSKVHSF
160 170 180 190 200
GKRDQAIRRN PNVPVVVRGW LHKQDSSGMR LWKRRWFVLA DYCLFYYKDS
210 220 230 240 250
REEAVLGSIP LPSYVISPVA PEDRISRKYS FKAVHTGMRA LIYNSSTAGS
260 270 280 290 300
QAEQSGMRTY YFSADTQEDM NAWVRAMNQA AQVLSRSSLK RDMEKVERQA
310 320 330 340 350
VPQANHTESC HECGRVGPGH TRDCPHRGHD DIVNFERQEQ EGEQYRSQRD
360 370 380 390 400
PLEGKRDRSK ARSPYSPAEE DALFMDLPTG PRGQQAQPQR AEKNGMLPAS
410 420 430 440 450
YGPGEQNGTG GYQRAFPPRT NPEKHSQRKS NLAQVEHWAR AQKGDSRSLP
460 470 480 490 500
LDQTLPRQGP GQSLSFPENY QTLPKSTRHP SGGSSPPPRN LPSDYKYAQD
510 520 530 540 550
RASHLKMSSE ERRAHRDGTV WQLYEWQQRQ QFRHGSPTAP ICLGSPEFTD
560 570 580 590 600
QGRSRSMLEV PRSISVPPSP SDIPPPGPPR VFPPRRPHTP AERVTVKPPD
610 620 630 640 650
QRRSVDISLG DSPRRARGHA VKNSSHVDRR SMPSMGYMTH TVSAPSLHGK
660 670 680 690 700
SADDTYLQLK KDLEYLDLKM TGRDLLKDRS LKPVKIAESD TDVKLSIFCE
710 720 730 740 750
QDRVLQDLED KIRALKENKD QLESVLEVLH RQMEQYRDQP QHLEKIAYQQ
760 770 780 790 800
KLLQEDLVHI RAELSRESTE MENAWNEYLK LENDVEQLKQ TLQEQHRRAF
810 820 830 840 850
FFQEKSQIQK DLWRIEDVTA GLSANKENFR ILVESVKNPE RKTVPLFPHP
860 870 880 890 900
PVPSLSTSES KPPPQPSPPT SPVRTPLEVR LFPQLQTYVP YRPHPPQLRK
910 920 930 940 950
VTSPLQSPTK AKPKVEDEAP PRPPLPELYS PEDQPPAVPP LPREATIIRH
960 970 980 990 1000
TSVRGLKRQS DERKRDRELG QCVNGDSRVE LRSYVSEPEL ATLSGDMAQP
1010 1020 1030 1040 1050
SLGLVGPESR YQTLPGRGLS GSTSRLQQSS TIAPYVTLRR GLNAESSKAT
1060 1070 1080 1090 1100
FPRPKSALER LYSGDHQRGK MSAEEQLERM KRHQKALVRE RKRTLGQGER
1110 1120
TGLPSSRYLS RPLPGDLGSV C
Length:1,121
Mass (Da):127,135
Last modified:November 25, 2008 - v2
Checksum:i93F616CF3EF9E5C2
GO
Isoform 2 (identifier: Q6IQ23-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     915-915: V → VQ

Show »
Length:1,122
Mass (Da):127,263
Checksum:i9E8C9F36A22A030B
GO
Isoform 3 (identifier: Q6IQ23-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-447: MAAATVGRDT...WARAQKGDSR → MFPKACRTLAWLPDPFLPFLL
     915-915: V → VQ

Note: No experimental confirmation available.
Show »
Length:696
Mass (Da):79,104
Checksum:i2E0584D8332267A3
GO

Sequence cautioni

The sequence AAH33239 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAG62985 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti494D → N in BAG62985 (PubMed:14702039).Curated1
Sequence conflicti981L → P in AAH71599 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_032346241L → I.Corresponds to variant rs35908144dbSNPEnsembl.1
Natural variantiVAR_032347248A → V.Corresponds to variant rs16933529dbSNPEnsembl.1
Natural variantiVAR_032348279Q → R.Corresponds to variant rs369819dbSNPEnsembl.1
Natural variantiVAR_061517689S → R.Corresponds to variant rs61133161dbSNPEnsembl.1
Natural variantiVAR_032349693V → I.Corresponds to variant rs34556458dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0395431 – 447MAAAT…KGDSR → MFPKACRTLAWLPDPFLPFL L in isoform 3. 1 PublicationAdd BLAST447
Alternative sequenceiVSP_025592915V → VQ in isoform 2 and isoform 3. 2 Publications1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK296371 mRNA. Translation: BAG59045.1.
AK301465 mRNA. Translation: BAG62985.1. Different initiation.
AC026639 Genomic DNA. No translation available.
AC116533 Genomic DNA. No translation available.
AC127033 Genomic DNA. No translation available.
BC033239 mRNA. Translation: AAH33239.1. Different initiation.
BC071599 mRNA. Translation: AAH71599.1.
CCDSiCCDS31434.1. [Q6IQ23-1]
RefSeqiNP_001316559.1. NM_001329630.1.
NP_001316560.1. NM_001329631.1. [Q6IQ23-2]
NP_778228.3. NM_175058.4. [Q6IQ23-1]
UniGeneiHs.12332.
Hs.729280.
Hs.733020.

Genome annotation databases

EnsembliENST00000355661; ENSP00000347883; ENSG00000166689. [Q6IQ23-1]
GeneIDi144100.
KEGGihsa:144100.
UCSCiuc001mmo.4. human. [Q6IQ23-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK296371 mRNA. Translation: BAG59045.1.
AK301465 mRNA. Translation: BAG62985.1. Different initiation.
AC026639 Genomic DNA. No translation available.
AC116533 Genomic DNA. No translation available.
AC127033 Genomic DNA. No translation available.
BC033239 mRNA. Translation: AAH33239.1. Different initiation.
BC071599 mRNA. Translation: AAH71599.1.
CCDSiCCDS31434.1. [Q6IQ23-1]
RefSeqiNP_001316559.1. NM_001329630.1.
NP_001316560.1. NM_001329631.1. [Q6IQ23-2]
NP_778228.3. NM_175058.4. [Q6IQ23-1]
UniGeneiHs.12332.
Hs.729280.
Hs.733020.

3D structure databases

ProteinModelPortaliQ6IQ23.
SMRiQ6IQ23.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126828. 7 interactors.
IntActiQ6IQ23. 8 interactors.
STRINGi9606.ENSP00000347883.

PTM databases

iPTMnetiQ6IQ23.
PhosphoSitePlusiQ6IQ23.

Polymorphism and mutation databases

BioMutaiPLEKHA7.
DMDMi215273867.

Proteomic databases

MaxQBiQ6IQ23.
PaxDbiQ6IQ23.
PeptideAtlasiQ6IQ23.
PRIDEiQ6IQ23.

Protocols and materials databases

DNASUi144100.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000355661; ENSP00000347883; ENSG00000166689. [Q6IQ23-1]
GeneIDi144100.
KEGGihsa:144100.
UCSCiuc001mmo.4. human. [Q6IQ23-1]

Organism-specific databases

CTDi144100.
DisGeNETi144100.
GeneCardsiPLEKHA7.
HGNCiHGNC:27049. PLEKHA7.
HPAiHPA038610.
MIMi612686. gene.
neXtProtiNX_Q6IQ23.
OpenTargetsiENSG00000166689.
PharmGKBiPA134894945.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410INUD. Eukaryota.
ENOG4111YSB. LUCA.
GeneTreeiENSGT00530000063012.
HOGENOMiHOG000077378.
HOVERGENiHBG103572.
InParanoidiQ6IQ23.
PhylomeDBiQ6IQ23.
TreeFamiTF329090.

Miscellaneous databases

ChiTaRSiPLEKHA7. human.
GenomeRNAii144100.
PROiQ6IQ23.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000166689.
CleanExiHS_PLEKHA7.
ExpressionAtlasiQ6IQ23. baseline and differential.
GenevisibleiQ6IQ23. HS.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR011993. PH_dom-like.
IPR001849. PH_domain.
IPR001202. WW_dom.
[Graphical view]
PfamiPF00169. PH. 1 hit.
[Graphical view]
SMARTiSM00233. PH. 1 hit.
SM00456. WW. 2 hits.
[Graphical view]
SUPFAMiSSF50729. SSF50729. 1 hit.
SSF51045. SSF51045. 2 hits.
PROSITEiPS50003. PH_DOMAIN. 1 hit.
PS01159. WW_DOMAIN_1. 1 hit.
PS50020. WW_DOMAIN_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPKHA7_HUMAN
AccessioniPrimary (citable) accession number: Q6IQ23
Secondary accession number(s): B4DK33, B4DWC3, Q86VZ7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: November 25, 2008
Last modified: November 30, 2016
This is version 117 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.