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Q6IQ23

- PKHA7_HUMAN

UniProt

Q6IQ23 - PKHA7_HUMAN

Protein

Pleckstrin homology domain-containing family A member 7

Gene

PLEKHA7

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 95 (01 Oct 2014)
      Sequence version 2 (25 Nov 2008)
      Previous versions | rss
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    Functioni

    Required for zonula adherens biogenesis and maintenance. Acts via its interaction with KIAA1543/Nezha, which anchors microtubules at their minus-ends to zonula adherens, leading to the recruitment of KIFC3 kinesin to the junctional site.1 Publication

    GO - Molecular functioni

    1. delta-catenin binding Source: UniProtKB

    GO - Biological processi

    1. epithelial cell-cell adhesion Source: UniProtKB
    2. zonula adherens maintenance Source: UniProtKB

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Pleckstrin homology domain-containing family A member 7
    Short name:
    PH domain-containing family A member 7
    Gene namesi
    Name:PLEKHA7
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:27049. PLEKHA7.

    Subcellular locationi

    Cell junctionadherens junction 1 Publication. Cytoplasm 1 Publication. Cytoplasmcytoskeletonmicrotubule organizing centercentrosome 1 Publication
    Note: Localizes to zonula adherens, recruited via its interaction with CTNND1.

    GO - Cellular componenti

    1. centrosome Source: UniProtKB
    2. cytoplasm Source: UniProtKB-SubCell
    3. extracellular vesicular exosome Source: UniProt
    4. zonula adherens Source: UniProtKB

    Keywords - Cellular componenti

    Cell junction, Cytoplasm, Cytoskeleton

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134894945.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 11211121Pleckstrin homology domain-containing family A member 7PRO_0000287692Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei536 – 5361PhosphoserineBy similarity
    Modified residuei545 – 5451PhosphoserineBy similarity
    Modified residuei604 – 6041Phosphoserine1 Publication
    Modified residuei612 – 6121Phosphoserine1 Publication
    Modified residuei903 – 9031Phosphoserine3 Publications
    Modified residuei907 – 9071Phosphoserine3 Publications
    Modified residuei986 – 9861Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ6IQ23.
    PaxDbiQ6IQ23.
    PRIDEiQ6IQ23.

    PTM databases

    PhosphoSiteiQ6IQ23.

    Expressioni

    Gene expression databases

    ArrayExpressiQ6IQ23.
    BgeeiQ6IQ23.
    CleanExiHS_PLEKHA7.
    GenevestigatoriQ6IQ23.

    Organism-specific databases

    HPAiHPA038610.

    Interactioni

    Subunit structurei

    Interacts with KIAA1543/Nezha and CTNND1.1 Publication

    Protein-protein interaction databases

    BioGridi126828. 5 interactions.
    IntActiQ6IQ23. 3 interactions.
    STRINGi9606.ENSP00000347883.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6IQ23.
    SMRiQ6IQ23. Positions 11-85, 157-282.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini9 – 4234WW 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini54 – 8734WW 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini164 – 282119PHPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni538 – 696159Interaction with CTNND1Add
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili700 – 801102Sequence AnalysisAdd
    BLAST
    Coiled coili1067 – 109428Sequence AnalysisAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi567 – 59933Pro-richAdd
    BLAST
    Compositional biasi845 – 94298Pro-richAdd
    BLAST

    Sequence similaritiesi

    Contains 1 PH domain.PROSITE-ProRule annotation
    Contains 2 WW domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Coiled coil, Repeat

    Phylogenomic databases

    eggNOGiNOG309520.
    HOGENOMiHOG000077378.
    HOVERGENiHBG103572.
    InParanoidiQ6IQ23.
    PhylomeDBiQ6IQ23.
    TreeFamiTF329090.

    Family and domain databases

    Gene3Di2.30.29.30. 1 hit.
    InterProiIPR001849. PH_domain.
    IPR011993. PH_like_dom.
    IPR001202. WW_dom.
    [Graphical view]
    PfamiPF00169. PH. 1 hit.
    [Graphical view]
    SMARTiSM00233. PH. 1 hit.
    SM00456. WW. 2 hits.
    [Graphical view]
    SUPFAMiSSF51045. SSF51045. 2 hits.
    PROSITEiPS50003. PH_DOMAIN. 1 hit.
    PS01159. WW_DOMAIN_1. 1 hit.
    PS50020. WW_DOMAIN_2. 2 hits.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q6IQ23-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAAATVGRDT LPEHWSYGVC RDGRVFFIND QLRCTTWLHP RTGEPVNSGH     50
    MIRSDLPRGW EEGFTEEGAS YFIDHNQQTT AFRHPVTGQF SPENSEFILQ 100
    EEPNPHMSKQ DRNQRPSSMV SETSTAGTAS TLEAKPGPKI IKSSSKVHSF 150
    GKRDQAIRRN PNVPVVVRGW LHKQDSSGMR LWKRRWFVLA DYCLFYYKDS 200
    REEAVLGSIP LPSYVISPVA PEDRISRKYS FKAVHTGMRA LIYNSSTAGS 250
    QAEQSGMRTY YFSADTQEDM NAWVRAMNQA AQVLSRSSLK RDMEKVERQA 300
    VPQANHTESC HECGRVGPGH TRDCPHRGHD DIVNFERQEQ EGEQYRSQRD 350
    PLEGKRDRSK ARSPYSPAEE DALFMDLPTG PRGQQAQPQR AEKNGMLPAS 400
    YGPGEQNGTG GYQRAFPPRT NPEKHSQRKS NLAQVEHWAR AQKGDSRSLP 450
    LDQTLPRQGP GQSLSFPENY QTLPKSTRHP SGGSSPPPRN LPSDYKYAQD 500
    RASHLKMSSE ERRAHRDGTV WQLYEWQQRQ QFRHGSPTAP ICLGSPEFTD 550
    QGRSRSMLEV PRSISVPPSP SDIPPPGPPR VFPPRRPHTP AERVTVKPPD 600
    QRRSVDISLG DSPRRARGHA VKNSSHVDRR SMPSMGYMTH TVSAPSLHGK 650
    SADDTYLQLK KDLEYLDLKM TGRDLLKDRS LKPVKIAESD TDVKLSIFCE 700
    QDRVLQDLED KIRALKENKD QLESVLEVLH RQMEQYRDQP QHLEKIAYQQ 750
    KLLQEDLVHI RAELSRESTE MENAWNEYLK LENDVEQLKQ TLQEQHRRAF 800
    FFQEKSQIQK DLWRIEDVTA GLSANKENFR ILVESVKNPE RKTVPLFPHP 850
    PVPSLSTSES KPPPQPSPPT SPVRTPLEVR LFPQLQTYVP YRPHPPQLRK 900
    VTSPLQSPTK AKPKVEDEAP PRPPLPELYS PEDQPPAVPP LPREATIIRH 950
    TSVRGLKRQS DERKRDRELG QCVNGDSRVE LRSYVSEPEL ATLSGDMAQP 1000
    SLGLVGPESR YQTLPGRGLS GSTSRLQQSS TIAPYVTLRR GLNAESSKAT 1050
    FPRPKSALER LYSGDHQRGK MSAEEQLERM KRHQKALVRE RKRTLGQGER 1100
    TGLPSSRYLS RPLPGDLGSV C 1121
    Length:1,121
    Mass (Da):127,135
    Last modified:November 25, 2008 - v2
    Checksum:i93F616CF3EF9E5C2
    GO
    Isoform 2 (identifier: Q6IQ23-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         915-915: V → VQ

    Show »
    Length:1,122
    Mass (Da):127,263
    Checksum:i9E8C9F36A22A030B
    GO
    Isoform 3 (identifier: Q6IQ23-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-447: MAAATVGRDT...WARAQKGDSR → MFPKACRTLAWLPDPFLPFLL
         915-915: V → VQ

    Note: No experimental confirmation available.

    Show »
    Length:696
    Mass (Da):79,104
    Checksum:i2E0584D8332267A3
    GO

    Sequence cautioni

    The sequence AAH33239.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
    The sequence BAG62985.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti494 – 4941D → N in BAG62985. (PubMed:14702039)Curated
    Sequence conflicti981 – 9811L → P in AAH71599. (PubMed:15489334)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti241 – 2411L → I.
    Corresponds to variant rs35908144 [ dbSNP | Ensembl ].
    VAR_032346
    Natural varianti248 – 2481A → V.
    Corresponds to variant rs16933529 [ dbSNP | Ensembl ].
    VAR_032347
    Natural varianti279 – 2791Q → R.
    Corresponds to variant rs369819 [ dbSNP | Ensembl ].
    VAR_032348
    Natural varianti689 – 6891S → R.
    Corresponds to variant rs61133161 [ dbSNP | Ensembl ].
    VAR_061517
    Natural varianti693 – 6931V → I.
    Corresponds to variant rs34556458 [ dbSNP | Ensembl ].
    VAR_032349

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 447447MAAAT…KGDSR → MFPKACRTLAWLPDPFLPFL L in isoform 3. 1 PublicationVSP_039543Add
    BLAST
    Alternative sequencei915 – 9151V → VQ in isoform 2 and isoform 3. 2 PublicationsVSP_025592

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK296371 mRNA. Translation: BAG59045.1.
    AK301465 mRNA. Translation: BAG62985.1. Different initiation.
    AC026639 Genomic DNA. No translation available.
    AC116533 Genomic DNA. No translation available.
    AC127033 Genomic DNA. No translation available.
    BC033239 mRNA. Translation: AAH33239.1. Different initiation.
    BC071599 mRNA. Translation: AAH71599.1.
    CCDSiCCDS31434.1. [Q6IQ23-1]
    RefSeqiNP_778228.3. NM_175058.4. [Q6IQ23-1]
    UniGeneiHs.12332.
    Hs.733020.

    Genome annotation databases

    EnsembliENST00000355661; ENSP00000347883; ENSG00000166689. [Q6IQ23-1]
    GeneIDi144100.
    KEGGihsa:144100.
    UCSCiuc001mmn.3. human. [Q6IQ23-2]
    uc001mmo.3. human. [Q6IQ23-1]
    uc010rcv.2. human. [Q6IQ23-3]

    Polymorphism databases

    DMDMi215273867.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK296371 mRNA. Translation: BAG59045.1 .
    AK301465 mRNA. Translation: BAG62985.1 . Different initiation.
    AC026639 Genomic DNA. No translation available.
    AC116533 Genomic DNA. No translation available.
    AC127033 Genomic DNA. No translation available.
    BC033239 mRNA. Translation: AAH33239.1 . Different initiation.
    BC071599 mRNA. Translation: AAH71599.1 .
    CCDSi CCDS31434.1. [Q6IQ23-1 ]
    RefSeqi NP_778228.3. NM_175058.4. [Q6IQ23-1 ]
    UniGenei Hs.12332.
    Hs.733020.

    3D structure databases

    ProteinModelPortali Q6IQ23.
    SMRi Q6IQ23. Positions 11-85, 157-282.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 126828. 5 interactions.
    IntActi Q6IQ23. 3 interactions.
    STRINGi 9606.ENSP00000347883.

    PTM databases

    PhosphoSitei Q6IQ23.

    Polymorphism databases

    DMDMi 215273867.

    Proteomic databases

    MaxQBi Q6IQ23.
    PaxDbi Q6IQ23.
    PRIDEi Q6IQ23.

    Protocols and materials databases

    DNASUi 144100.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000355661 ; ENSP00000347883 ; ENSG00000166689 . [Q6IQ23-1 ]
    GeneIDi 144100.
    KEGGi hsa:144100.
    UCSCi uc001mmn.3. human. [Q6IQ23-2 ]
    uc001mmo.3. human. [Q6IQ23-1 ]
    uc010rcv.2. human. [Q6IQ23-3 ]

    Organism-specific databases

    CTDi 144100.
    GeneCardsi GC11M016809.
    HGNCi HGNC:27049. PLEKHA7.
    HPAi HPA038610.
    MIMi 612686. gene.
    neXtProti NX_Q6IQ23.
    PharmGKBi PA134894945.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG309520.
    HOGENOMi HOG000077378.
    HOVERGENi HBG103572.
    InParanoidi Q6IQ23.
    PhylomeDBi Q6IQ23.
    TreeFami TF329090.

    Miscellaneous databases

    ChiTaRSi PLEKHA7. human.
    GenomeRNAii 144100.
    NextBioi 84824.
    PROi Q6IQ23.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q6IQ23.
    Bgeei Q6IQ23.
    CleanExi HS_PLEKHA7.
    Genevestigatori Q6IQ23.

    Family and domain databases

    Gene3Di 2.30.29.30. 1 hit.
    InterProi IPR001849. PH_domain.
    IPR011993. PH_like_dom.
    IPR001202. WW_dom.
    [Graphical view ]
    Pfami PF00169. PH. 1 hit.
    [Graphical view ]
    SMARTi SM00233. PH. 1 hit.
    SM00456. WW. 2 hits.
    [Graphical view ]
    SUPFAMi SSF51045. SSF51045. 2 hits.
    PROSITEi PS50003. PH_DOMAIN. 1 hit.
    PS01159. WW_DOMAIN_1. 1 hit.
    PS50020. WW_DOMAIN_2. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
      Tissue: Synovium and Thalamus.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Brain and Placenta.
    4. "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry."
      Brill L.M., Salomon A.R., Ficarro S.B., Mukherji M., Stettler-Gill M., Peters E.C.
      Anal. Chem. 76:2763-2772(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    5. "Anchorage of microtubule minus ends to adherens junctions regulates epithelial cell-cell contacts."
      Meng W., Mushika Y., Ichii T., Takeichi M.
      Cell 135:948-959(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH KIAA1543 AND CTNND1.
    6. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-903 AND SER-907, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    7. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    8. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-604; SER-612; SER-903; SER-907 AND SER-986, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    9. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-903 AND SER-907, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiPKHA7_HUMAN
    AccessioniPrimary (citable) accession number: Q6IQ23
    Secondary accession number(s): B4DK33, B4DWC3, Q86VZ7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 15, 2007
    Last sequence update: November 25, 2008
    Last modified: October 1, 2014
    This is version 95 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3