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Reviewed, UniProtKB/Swiss-Prot Q6IQ22 (RAB12_HUMAN)

Last modified December 16, 2008. Version 48. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Putative Ras-related protein Rab-12
Gene names
Name: RAB12
OrganismHomo sapiens (Human)
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length244 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceUncertain.

General annotation (Comments)

Subcellular location

Golgi apparatus membrane; Lipid-anchorBy similarity.

Sequence similarities

Belongs to the small GTPase superfamily. Rab family.

Caution

Could be the product of a pseudogene.

Sequence caution

The sequence AAH71600.2 differs from that shown. Reason: Miscellaneous discrepancy. Intron retention.

The sequence AAH98407.1 differs from that shown. Reason: Miscellaneous discrepancy. Intron retention.

The sequence BC050338 differs from that shown. Reason: Frameshift at position 195.

Ontologies

Keywords

   Biological processProtein transport
Transport
   Cellular componentGolgi apparatus
Membrane
   LigandGTP-binding
Nucleotide-binding
   PTMLipoprotein
Phosphoprotein
Prenylation
   Technical term3D-structure

Gene Ontology (GO)

   Biological processprotein transport

Inferred from electronic annotation. Source: InterPro

small GTPase mediated signal transduction

Inferred from electronic annotation. Source: InterPro

   Cellular componentGolgi membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionGTP binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 244244Putative Ras-related protein Rab-12
PRO_0000271377

Regions

Nucleotide binding49 – 568GTP By similarity
Nucleotide binding97 – 1015GTP By similarity
Nucleotide binding155 – 1584GTP By similarity
Motif71 – 799Effector region By similarity

Amino acid modifications

Modified residue211Phosphoserine Ref.4
Modified residue251Phosphoserine Ref.4
Modified residue1061Phosphoserine By similarity
Lipidation2431S-geranylgeranyl cysteine By similarity
Lipidation2441S-geranylgeranyl cysteine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q6IQ22-1 [UniParc].

Last modified January 9, 2007. Version 3.
Checksum: B4DC65DD0DCB45C4

FASTA24427,248
        10         20         30         40         50         60 
MDPGAALQRR AGGGGGLGAG SPALSGGQGR RRKQPPRPAD FKLQVIIIGS RGVGKTSLME 

        70         80         90        100        110        120 
RFTDDTFCEA CKSTVGVDFK IKTVELRGKK IRLQIWDTAG QERFNSITSA YYRSAKGIIL 

       130        140        150        160        170        180 
VYDITKKETF DDLPKWMKMI DKYASEDAEL LLVGNKLDCE TDREITRQQG EKFAQQITGM 

       190        200        210        220        230        240 
RFCEASAKDN FNVDEIFLKL VDDILKKMPL DILRNELSNS ILSLQPEPEI PPELPPPRPH 


VRCC 

« Hide

References

[1]"DNA sequence and analysis of human chromosome 18."
Nusbaum C., Zody M.C., Borowsky M.L., Kamal M., Kodira C.D., Taylor T.D., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Abouelleil A., Allen N.R., Anderson S., Bloom T., Bugalter B., Butler J. expand/collapse author list , Cook A., DeCaprio D., Engels R., Garber M., Gnirke A., Hafez N., Hall J.L., Norman C.H., Itoh T., Jaffe D.B., Kuroki Y., Lehoczky J., Lui A., Macdonald P., Mauceli E., Mikkelsen T.S., Naylor J.W., Nicol R., Nguyen C., Noguchi H., O'Leary S.B., Piqani B., Smith C.L., Talamas J.A., Topham K., Totoki Y., Toyoda A., Wain H.M., Young S.K., Zeng Q., Zimmer A.R., Fujiyama A., Hattori M., Birren B.W., Sakaki Y., Lander E.S.
Nature 437:551-555(2005) [PubMed: 16177791] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Placenta.
[4]"A quantitative atlas of mitotic phosphorylation."
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-21 AND SER-25, MASS SPECTROMETRY.

Cross-references

Sequence databases

AP001793 Genomic DNA. No translation available.
CH471113 Genomic DNA. Translation: EAX01616.1.
BC050338 mRNA. No translation available.
BC071600 mRNA. Translation: AAH71600.2. Sequence problems.
BC098407 mRNA. Translation: AAH98407.1. Sequence problems.
RefSeqNP_001020471.2.
UniGeneHs.270074

3D structure databases

EntryMethodResolution (Å)ChainPositionsPDBsum
2IL1X-ray2.10A36-208[»]
SMRQ6IQ22. Positions 38-208.
ModBaseSearch...

PTM databases

PhosphoSiteQ6IQ22.

Proteomic databases

PRIDEQ6IQ22.

Genome annotation databases

EnsemblENSG00000206418. Homo sapiens. [Contig view]
GeneID201475.
KEGGhsa:201475.
NMPDRfig|9606.3.peg.14764.

Organism-specific databases

GeneCardsGC18P008600.
HGNCHGNC:31332. RAB12.
PharmGKBPA142671102.
GenAtlasSearch...

Phylogenomic databases

HOVERGENQ6IQ22.

Gene expression databases

ArrayExpressQ6IQ22.
CleanExHS_RAB12.

Family and domain databases

InterProIPR003579. GTPase_Rab.
IPR013753. Ras.
IPR001806. Ras_trnsfrmng.
IPR005225. Small_GTP_bd.
[Graphical view]
PfamPF00071. Ras. 1 hit.
[Graphical view]
PRINTSPR00449. RASTRNSFRMNG.
SMARTSM00175. RAB. 1 hit.
[Graphical view]
TIGRFAMsTIGR00231. small_GTP. 1 hit.
ProtoNetSearch...

Other Resources

NextBio90147.

Entry information

Entry nameRAB12_HUMAN
AccessionPrimary (citable) accession number: Q6IQ22
Secondary accession number(s): A6NEF5, Q4KMQ3
Entry history
Integrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: January 9, 2007
Last modified: December 16, 2008
This is version 48 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

Relevant documents

Human chromosome 18

Human chromosome 18: entries, gene names and cross-references to MIM

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents