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Q6IQ21

- ZN770_HUMAN

UniProt

Q6IQ21 - ZN770_HUMAN

Protein

Zinc finger protein 770

Gene

ZNF770

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 98 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    May be involved in transcriptional regulation.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri27 – 4923C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri55 – 7723C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri81 – 10323C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri160 – 18223C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri188 – 21023C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri216 – 23823C2H2-type 6PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri294 – 31825C2H2-type 7; degeneratePROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri475 – 49723C2H2-type 8PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri503 – 52523C2H2-type 9PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri625 – 64723C2H2-type 10PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri653 – 67523C2H2-type 11PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-KW
    3. sequence-specific DNA binding RNA polymerase II transcription factor activity Source: RefGenome

    GO - Biological processi

    1. regulation of transcription from RNA polymerase II promoter Source: GOC
    2. transcription from RNA polymerase II promoter Source: GOC

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Enzyme and pathway databases

    ReactomeiREACT_12627. Generic Transcription Pathway.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Zinc finger protein 770
    Gene namesi
    Name:ZNF770
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 15

    Organism-specific databases

    HGNCiHGNC:26061. ZNF770.

    Subcellular locationi

    Nucleus Curated

    GO - Cellular componenti

    1. nucleus Source: RefGenome

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA162410336.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 691691Zinc finger protein 770PRO_0000280436Add
    BLAST

    Proteomic databases

    MaxQBiQ6IQ21.
    PaxDbiQ6IQ21.
    PRIDEiQ6IQ21.

    PTM databases

    PhosphoSiteiQ6IQ21.

    Expressioni

    Gene expression databases

    ArrayExpressiQ6IQ21.
    BgeeiQ6IQ21.
    CleanExiHS_ZNF770.
    GenevestigatoriQ6IQ21.

    Organism-specific databases

    HPAiHPA024518.

    Interactioni

    Protein-protein interaction databases

    BioGridi120324. 3 interactions.
    IntActiQ6IQ21. 2 interactions.
    STRINGi9606.ENSP00000348673.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6IQ21.
    SMRiQ6IQ21. Positions 25-312, 458-675.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Contains 11 C2H2-type zinc fingers.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri27 – 4923C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri55 – 7723C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri81 – 10323C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri160 – 18223C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri188 – 21023C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri216 – 23823C2H2-type 6PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri294 – 31825C2H2-type 7; degeneratePROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri475 – 49723C2H2-type 8PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri503 – 52523C2H2-type 9PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri625 – 64723C2H2-type 10PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri653 – 67523C2H2-type 11PROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiNOG290562.
    HOGENOMiHOG000155809.
    HOVERGENiHBG094197.
    InParanoidiQ6IQ21.
    OMAiRHQLTHN.
    OrthoDBiEOG789C9N.
    PhylomeDBiQ6IQ21.
    TreeFamiTF335560.

    Family and domain databases

    Gene3Di3.30.160.60. 9 hits.
    InterProiIPR027775. C2H2_Znf_fam.
    IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view]
    PANTHERiPTHR10032. PTHR10032. 1 hit.
    PfamiPF00096. zf-C2H2. 2 hits.
    [Graphical view]
    SMARTiSM00355. ZnF_C2H2. 11 hits.
    [Graphical view]
    PROSITEiPS00028. ZINC_FINGER_C2H2_1. 10 hits.
    PS50157. ZINC_FINGER_C2H2_2. 11 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q6IQ21-1 [UniParc]FASTAAdd to Basket

    « Hide

    MMAENNLKML KIQQCVVANK LPRNRPYVCN ICFKHFETPS KLARHYLIHT    50
    GQKPFECDVC HKTFRQLVHL ERHQLTHSLP FKCSICQRHF KNLKTFVKHQ 100
    QLHNETYQNN VKQVRRLLEA KQEKSMYGVY NTFTTEERWA LHPCSKSDPM 150
    YSMKRRKNIH ACTICGKMFP SQSKLDRHVL IHTGQRPFKC VLCTKSFRQS 200
    THLKIHQLTH SEERPFQCCF CQKGFKIQSK LLKHKQIHTR NKAFRALLLK 250
    KRRTESRPLP NKLNANQGGF ENGEIGESEE NNPLDVHSIY IVPFQCPKCE 300
    KCFESEQILN EHSCFAARSG KIPSRFKRSY NYKTIVKKIL AKLKRARSKK 350
    LDNFQSEKKV FKKSFLRNCD LISGEQSSEQ TQRTFVGSLG KHGTYKTIGN 400
    RKKKTLTLPF SWQNMGKNLK GILTTENILS IDNSVNKKDL SICGSSGEEF 450
    FNNCEVLQCG FSVPRENIRT RHKICPCDKC EKVFPSISKL KRHYLIHTGQ 500
    RPFGCNICGK SFRQSAHLKR HEQTHNEKSP YASLCQVEFG NFNNLSNHSG 550
    NNVNYNASQQ CQAPGVQKYE VSESDQMSGV KAESQDFIPG STGQPCLPNV 600
    LLESEQSNPF CSYSEHQEKN DVFLYRCSVC AKSFRSPSKL ERHYLIHAGQ 650
    KPFECSVCGK TFRQAPHWKR HQLTHFKERP QGKVVALDSV M 691
    Length:691
    Mass (Da):80,007
    Last modified:July 5, 2004 - v1
    Checksum:i1DA3E337BAC06A67
    GO

    Sequence cautioni

    The sequence BAD18579.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti22 – 221P → L in BAA91274. (PubMed:14702039)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC071603 mRNA. Translation: AAH71603.1.
    AK000589 mRNA. Translation: BAA91274.1. Different termination.
    AK131433 mRNA. Translation: BAD18579.1. Different initiation.
    CCDSiCCDS10042.1.
    RefSeqiNP_054825.2. NM_014106.3.
    UniGeneiHs.744990.

    Genome annotation databases

    EnsembliENST00000356321; ENSP00000348673; ENSG00000198146.
    GeneIDi54989.
    KEGGihsa:54989.
    UCSCiuc001ziw.3. human.

    Polymorphism databases

    DMDMi74757996.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC071603 mRNA. Translation: AAH71603.1 .
    AK000589 mRNA. Translation: BAA91274.1 . Different termination.
    AK131433 mRNA. Translation: BAD18579.1 . Different initiation.
    CCDSi CCDS10042.1.
    RefSeqi NP_054825.2. NM_014106.3.
    UniGenei Hs.744990.

    3D structure databases

    ProteinModelPortali Q6IQ21.
    SMRi Q6IQ21. Positions 25-312, 458-675.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 120324. 3 interactions.
    IntActi Q6IQ21. 2 interactions.
    STRINGi 9606.ENSP00000348673.

    PTM databases

    PhosphoSitei Q6IQ21.

    Polymorphism databases

    DMDMi 74757996.

    Proteomic databases

    MaxQBi Q6IQ21.
    PaxDbi Q6IQ21.
    PRIDEi Q6IQ21.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000356321 ; ENSP00000348673 ; ENSG00000198146 .
    GeneIDi 54989.
    KEGGi hsa:54989.
    UCSCi uc001ziw.3. human.

    Organism-specific databases

    CTDi 54989.
    GeneCardsi GC15M035270.
    HGNCi HGNC:26061. ZNF770.
    HPAi HPA024518.
    neXtProti NX_Q6IQ21.
    PharmGKBi PA162410336.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG290562.
    HOGENOMi HOG000155809.
    HOVERGENi HBG094197.
    InParanoidi Q6IQ21.
    OMAi RHQLTHN.
    OrthoDBi EOG789C9N.
    PhylomeDBi Q6IQ21.
    TreeFami TF335560.

    Enzyme and pathway databases

    Reactomei REACT_12627. Generic Transcription Pathway.

    Miscellaneous databases

    GenomeRNAii 54989.
    NextBioi 58286.
    PROi Q6IQ21.

    Gene expression databases

    ArrayExpressi Q6IQ21.
    Bgeei Q6IQ21.
    CleanExi HS_ZNF770.
    Genevestigatori Q6IQ21.

    Family and domain databases

    Gene3Di 3.30.160.60. 9 hits.
    InterProi IPR027775. C2H2_Znf_fam.
    IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view ]
    PANTHERi PTHR10032. PTHR10032. 1 hit.
    Pfami PF00096. zf-C2H2. 2 hits.
    [Graphical view ]
    SMARTi SM00355. ZnF_C2H2. 11 hits.
    [Graphical view ]
    PROSITEi PS00028. ZINC_FINGER_C2H2_1. 10 hits.
    PS50157. ZINC_FINGER_C2H2_2. 11 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Placenta.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-181 AND 259-691.
      Tissue: Carcinoma and Synovium.

    Entry informationi

    Entry nameiZN770_HUMAN
    AccessioniPrimary (citable) accession number: Q6IQ21
    Secondary accession number(s): Q6ZMZ6, Q9NWV2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 20, 2007
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 98 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 15
      Human chromosome 15: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3