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Q6IQ21 (ZN770_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 93. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Zinc finger protein 770
Gene names
Name:ZNF770
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length691 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May be involved in transcriptional regulation.

Subcellular location

Nucleus Probable.

Sequence similarities

Belongs to the krueppel C2H2-type zinc-finger protein family.

Contains 11 C2H2-type zinc fingers.

Sequence caution

The sequence BAD18579.1 differs from that shown. Reason: Erroneous initiation.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 691691Zinc finger protein 770
PRO_0000280436

Regions

Zinc finger27 – 4923C2H2-type 1
Zinc finger55 – 7723C2H2-type 2
Zinc finger81 – 10323C2H2-type 3
Zinc finger160 – 18223C2H2-type 4
Zinc finger188 – 21023C2H2-type 5
Zinc finger216 – 23823C2H2-type 6
Zinc finger294 – 31825C2H2-type 7; degenerate
Zinc finger475 – 49723C2H2-type 8
Zinc finger503 – 52523C2H2-type 9
Zinc finger625 – 64723C2H2-type 10
Zinc finger653 – 67523C2H2-type 11

Experimental info

Sequence conflict221P → L in BAA91274. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Q6IQ21 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: 1DA3E337BAC06A67

FASTA69180,007
        10         20         30         40         50         60 
MMAENNLKML KIQQCVVANK LPRNRPYVCN ICFKHFETPS KLARHYLIHT GQKPFECDVC 

        70         80         90        100        110        120 
HKTFRQLVHL ERHQLTHSLP FKCSICQRHF KNLKTFVKHQ QLHNETYQNN VKQVRRLLEA 

       130        140        150        160        170        180 
KQEKSMYGVY NTFTTEERWA LHPCSKSDPM YSMKRRKNIH ACTICGKMFP SQSKLDRHVL 

       190        200        210        220        230        240 
IHTGQRPFKC VLCTKSFRQS THLKIHQLTH SEERPFQCCF CQKGFKIQSK LLKHKQIHTR 

       250        260        270        280        290        300 
NKAFRALLLK KRRTESRPLP NKLNANQGGF ENGEIGESEE NNPLDVHSIY IVPFQCPKCE 

       310        320        330        340        350        360 
KCFESEQILN EHSCFAARSG KIPSRFKRSY NYKTIVKKIL AKLKRARSKK LDNFQSEKKV 

       370        380        390        400        410        420 
FKKSFLRNCD LISGEQSSEQ TQRTFVGSLG KHGTYKTIGN RKKKTLTLPF SWQNMGKNLK 

       430        440        450        460        470        480 
GILTTENILS IDNSVNKKDL SICGSSGEEF FNNCEVLQCG FSVPRENIRT RHKICPCDKC 

       490        500        510        520        530        540 
EKVFPSISKL KRHYLIHTGQ RPFGCNICGK SFRQSAHLKR HEQTHNEKSP YASLCQVEFG 

       550        560        570        580        590        600 
NFNNLSNHSG NNVNYNASQQ CQAPGVQKYE VSESDQMSGV KAESQDFIPG STGQPCLPNV 

       610        620        630        640        650        660 
LLESEQSNPF CSYSEHQEKN DVFLYRCSVC AKSFRSPSKL ERHYLIHAGQ KPFECSVCGK 

       670        680        690 
TFRQAPHWKR HQLTHFKERP QGKVVALDSV M 

« Hide

References

[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Placenta.
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-181 AND 259-691.
Tissue: Carcinoma and Synovium.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC071603 mRNA. Translation: AAH71603.1.
AK000589 mRNA. Translation: BAA91274.1. Different termination.
AK131433 mRNA. Translation: BAD18579.1. Different initiation.
RefSeqNP_054825.2. NM_014106.3.
UniGeneHs.744990.

3D structure databases

ProteinModelPortalQ6IQ21.
SMRQ6IQ21. Positions 25-312, 409-675.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid120324. 3 interactions.
IntActQ6IQ21. 2 interactions.
STRING9606.ENSP00000348673.

PTM databases

PhosphoSiteQ6IQ21.

Polymorphism databases

DMDM74757996.

Proteomic databases

PaxDbQ6IQ21.
PRIDEQ6IQ21.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000356321; ENSP00000348673; ENSG00000198146.
GeneID54989.
KEGGhsa:54989.
UCSCuc001ziw.3. human.

Organism-specific databases

CTD54989.
GeneCardsGC15M035270.
HGNCHGNC:26061. ZNF770.
HPAHPA024518.
neXtProtNX_Q6IQ21.
PharmGKBPA162410336.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG290562.
HOGENOMHOG000155809.
HOVERGENHBG094197.
InParanoidQ6IQ21.
OMARHQLTHN.
OrthoDBEOG789C9N.
PhylomeDBQ6IQ21.
TreeFamTF335560.

Enzyme and pathway databases

ReactomeREACT_71. Gene Expression.

Gene expression databases

ArrayExpressQ6IQ21.
BgeeQ6IQ21.
CleanExHS_ZNF770.
GenevestigatorQ6IQ21.

Family and domain databases

Gene3D3.30.160.60. 9 hits.
InterProIPR027775. C2H2_Znf_fam.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PANTHERPTHR10032. PTHR10032. 1 hit.
PfamPF00096. zf-C2H2. 2 hits.
[Graphical view]
SMARTSM00355. ZnF_C2H2. 11 hits.
[Graphical view]
PROSITEPS00028. ZINC_FINGER_C2H2_1. 10 hits.
PS50157. ZINC_FINGER_C2H2_2. 11 hits.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi54989.
NextBio58286.
PROQ6IQ21.

Entry information

Entry nameZN770_HUMAN
AccessionPrimary (citable) accession number: Q6IQ21
Secondary accession number(s): Q6ZMZ6, Q9NWV2
Entry history
Integrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: July 5, 2004
Last modified: April 16, 2014
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human chromosome 15

Human chromosome 15: entries, gene names and cross-references to MIM