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Q6IQ21

- ZN770_HUMAN

UniProt

Q6IQ21 - ZN770_HUMAN

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Protein

Zinc finger protein 770

Gene

ZNF770

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri27 – 4923C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri55 – 7723C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri81 – 10323C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri160 – 18223C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri188 – 21023C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri216 – 23823C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri294 – 31825C2H2-type 7; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri475 – 49723C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri503 – 52523C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri625 – 64723C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri653 – 67523C2H2-type 11PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW
  3. sequence-specific DNA binding RNA polymerase II transcription factor activity Source: RefGenome

GO - Biological processi

  1. regulation of transcription from RNA polymerase II promoter Source: GOC
  2. transcription from RNA polymerase II promoter Source: GOC
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_12627. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 770
Gene namesi
Name:ZNF770
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 15

Organism-specific databases

HGNCiHGNC:26061. ZNF770.

Subcellular locationi

Nucleus Curated

GO - Cellular componenti

  1. nucleus Source: RefGenome
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162410336.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 691691Zinc finger protein 770PRO_0000280436Add
BLAST

Proteomic databases

MaxQBiQ6IQ21.
PaxDbiQ6IQ21.
PRIDEiQ6IQ21.

PTM databases

PhosphoSiteiQ6IQ21.

Expressioni

Gene expression databases

BgeeiQ6IQ21.
CleanExiHS_ZNF770.
ExpressionAtlasiQ6IQ21. baseline and differential.
GenevestigatoriQ6IQ21.

Organism-specific databases

HPAiHPA024518.

Interactioni

Protein-protein interaction databases

BioGridi120324. 7 interactions.
IntActiQ6IQ21. 2 interactions.
STRINGi9606.ENSP00000348673.

Structurei

3D structure databases

ProteinModelPortaliQ6IQ21.
SMRiQ6IQ21. Positions 25-312, 458-675.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 11 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri27 – 4923C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri55 – 7723C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri81 – 10323C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri160 – 18223C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri188 – 21023C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri216 – 23823C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri294 – 31825C2H2-type 7; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri475 – 49723C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri503 – 52523C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri625 – 64723C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri653 – 67523C2H2-type 11PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiNOG290562.
GeneTreeiENSGT00750000117721.
HOGENOMiHOG000155809.
HOVERGENiHBG094197.
InParanoidiQ6IQ21.
OMAiRHQLTHN.
OrthoDBiEOG789C9N.
PhylomeDBiQ6IQ21.
TreeFamiTF335560.

Family and domain databases

Gene3Di3.30.160.60. 9 hits.
InterProiIPR027775. C2H2_Znf_fam.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PANTHERiPTHR10032. PTHR10032. 1 hit.
PfamiPF00096. zf-C2H2. 2 hits.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 11 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 10 hits.
PS50157. ZINC_FINGER_C2H2_2. 11 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6IQ21-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MMAENNLKML KIQQCVVANK LPRNRPYVCN ICFKHFETPS KLARHYLIHT
60 70 80 90 100
GQKPFECDVC HKTFRQLVHL ERHQLTHSLP FKCSICQRHF KNLKTFVKHQ
110 120 130 140 150
QLHNETYQNN VKQVRRLLEA KQEKSMYGVY NTFTTEERWA LHPCSKSDPM
160 170 180 190 200
YSMKRRKNIH ACTICGKMFP SQSKLDRHVL IHTGQRPFKC VLCTKSFRQS
210 220 230 240 250
THLKIHQLTH SEERPFQCCF CQKGFKIQSK LLKHKQIHTR NKAFRALLLK
260 270 280 290 300
KRRTESRPLP NKLNANQGGF ENGEIGESEE NNPLDVHSIY IVPFQCPKCE
310 320 330 340 350
KCFESEQILN EHSCFAARSG KIPSRFKRSY NYKTIVKKIL AKLKRARSKK
360 370 380 390 400
LDNFQSEKKV FKKSFLRNCD LISGEQSSEQ TQRTFVGSLG KHGTYKTIGN
410 420 430 440 450
RKKKTLTLPF SWQNMGKNLK GILTTENILS IDNSVNKKDL SICGSSGEEF
460 470 480 490 500
FNNCEVLQCG FSVPRENIRT RHKICPCDKC EKVFPSISKL KRHYLIHTGQ
510 520 530 540 550
RPFGCNICGK SFRQSAHLKR HEQTHNEKSP YASLCQVEFG NFNNLSNHSG
560 570 580 590 600
NNVNYNASQQ CQAPGVQKYE VSESDQMSGV KAESQDFIPG STGQPCLPNV
610 620 630 640 650
LLESEQSNPF CSYSEHQEKN DVFLYRCSVC AKSFRSPSKL ERHYLIHAGQ
660 670 680 690
KPFECSVCGK TFRQAPHWKR HQLTHFKERP QGKVVALDSV M
Length:691
Mass (Da):80,007
Last modified:July 5, 2004 - v1
Checksum:i1DA3E337BAC06A67
GO

Sequence cautioni

The sequence BAD18579.1 differs from that shown. Reason: Erroneous initiation.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti22 – 221P → L in BAA91274. (PubMed:14702039)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC071603 mRNA. Translation: AAH71603.1.
AK000589 mRNA. Translation: BAA91274.1. Different termination.
AK131433 mRNA. Translation: BAD18579.1. Different initiation.
CCDSiCCDS10042.1.
RefSeqiNP_054825.2. NM_014106.3.
UniGeneiHs.744990.

Genome annotation databases

EnsembliENST00000356321; ENSP00000348673; ENSG00000198146.
GeneIDi54989.
KEGGihsa:54989.
UCSCiuc001ziw.3. human.

Polymorphism databases

DMDMi74757996.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC071603 mRNA. Translation: AAH71603.1 .
AK000589 mRNA. Translation: BAA91274.1 . Different termination.
AK131433 mRNA. Translation: BAD18579.1 . Different initiation.
CCDSi CCDS10042.1.
RefSeqi NP_054825.2. NM_014106.3.
UniGenei Hs.744990.

3D structure databases

ProteinModelPortali Q6IQ21.
SMRi Q6IQ21. Positions 25-312, 458-675.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 120324. 7 interactions.
IntActi Q6IQ21. 2 interactions.
STRINGi 9606.ENSP00000348673.

PTM databases

PhosphoSitei Q6IQ21.

Polymorphism databases

DMDMi 74757996.

Proteomic databases

MaxQBi Q6IQ21.
PaxDbi Q6IQ21.
PRIDEi Q6IQ21.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000356321 ; ENSP00000348673 ; ENSG00000198146 .
GeneIDi 54989.
KEGGi hsa:54989.
UCSCi uc001ziw.3. human.

Organism-specific databases

CTDi 54989.
GeneCardsi GC15M035270.
HGNCi HGNC:26061. ZNF770.
HPAi HPA024518.
neXtProti NX_Q6IQ21.
PharmGKBi PA162410336.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG290562.
GeneTreei ENSGT00750000117721.
HOGENOMi HOG000155809.
HOVERGENi HBG094197.
InParanoidi Q6IQ21.
OMAi RHQLTHN.
OrthoDBi EOG789C9N.
PhylomeDBi Q6IQ21.
TreeFami TF335560.

Enzyme and pathway databases

Reactomei REACT_12627. Generic Transcription Pathway.

Miscellaneous databases

GenomeRNAii 54989.
NextBioi 58286.
PROi Q6IQ21.

Gene expression databases

Bgeei Q6IQ21.
CleanExi HS_ZNF770.
ExpressionAtlasi Q6IQ21. baseline and differential.
Genevestigatori Q6IQ21.

Family and domain databases

Gene3Di 3.30.160.60. 9 hits.
InterProi IPR027775. C2H2_Znf_fam.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view ]
PANTHERi PTHR10032. PTHR10032. 1 hit.
Pfami PF00096. zf-C2H2. 2 hits.
[Graphical view ]
SMARTi SM00355. ZnF_C2H2. 11 hits.
[Graphical view ]
PROSITEi PS00028. ZINC_FINGER_C2H2_1. 10 hits.
PS50157. ZINC_FINGER_C2H2_2. 11 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Placenta.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-181 AND 259-691.
    Tissue: Carcinoma and Synovium.

Entry informationi

Entry nameiZN770_HUMAN
AccessioniPrimary (citable) accession number: Q6IQ21
Secondary accession number(s): Q6ZMZ6, Q9NWV2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: July 5, 2004
Last modified: October 29, 2014
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3