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Q6IQ16 (SPOPL_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 88. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Speckle-type POZ protein-like
Alternative name(s):
HIB homolog 2
Roadkill homolog 2
Gene names
Name:SPOPL
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length392 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins, but with relatively low efficiency. Cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes containing homodimeric SPOPL or the heterodimer formed by SPOP and SPOPL are less efficient than ubiquitin ligase complexes containing only SPOP. May function to down-regulate the activity of cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that contain SPOP. Ref.4

Pathway

Protein modification; protein ubiquitination.

Subunit structure

Homodimer. Heterodimer with SPOP. Component of cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes containing homodimeric SPOPL or the heterodimer formed by SPOP and SPOPL. Interacts with CUL3 and H2AFY. Ref.4

Subcellular location

Nucleus By similarity.

Sequence similarities

Belongs to the Tdpoz family.

Contains 1 BTB (POZ) domain.

Contains 1 MATH domain.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 392392Speckle-type POZ protein-like
PRO_0000274588

Regions

Domain31 – 161131MATH
Domain200 – 26768BTB

Natural variations

Natural variant451R → Q.
Corresponds to variant rs36099753 [ dbSNP | Ensembl ].
VAR_053719

Sequences

Sequence LengthMass (Da)Tools
Q6IQ16 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: CEB4243BD732DFEF

FASTA39244,647
        10         20         30         40         50         60 
MSREPTPPLP GDMSTGPIAE SWCYTQVKVV KFSYMWTINN FSFCREEMGE VLKSSTFSSG 

        70         80         90        100        110        120 
PSDKMKWCLR VNPKGLDDES KDYLSLYLLL VSCPKSEVRA KFKFSLLNAK REETKAMESQ 

       130        140        150        160        170        180 
RAYRFVQGKD WGFKKFIRRD FLLDEANGLL PDDKLTLFCE VSVVQDSVNI SGHTNTNTLK 

       190        200        210        220        230        240 
VPECRLAEDL GNLWENTRFT DCSFFVRGQE FKAHKSVLAA RSPVFNAMFE HEMEESKKNR 

       250        260        270        280        290        300 
VEINDLDPEV FKEMMRFIYT GRAPNLDKMA DNLLAAADKY ALERLKVMCE EALCSNLSVE 

       310        320        330        340        350        360 
NVADTLVLAD LHSAEQLKAQ AIDFINRCSV LRQLGCKDGK NWNSNQATDI METSGWKSMI 

       370        380        390 
QSHPHLVAEA FRALASAQCP QFGIPRKRLK QS 

« Hide

References

« Hide 'large scale' references
[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
[2]"Roadkill attenuates Hedgehog responses through degradation of Cubitus interruptus."
Kent D., Bush E.W., Hooper J.E.
Development 133:2001-2010(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION.
[3]"A hedgehog-induced BTB protein modulates hedgehog signaling by degrading Ci/Gli transcription factor."
Zhang Q., Zhang L., Wang B., Ou C.-Y., Chien C.-T., Jiang J.
Dev. Cell 10:719-729(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION.
[4]"Adaptor protein self-assembly drives the control of a cullin-RING ubiquitin ligase."
Errington W.J., Khan M.Q., Bueler S.A., Rubinstein J.L., Chakrabartty A., Prive G.G.
Structure 20:1141-1153(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, SUBUNIT, INTERACTION WITH CUL3 AND H2AFY.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC071613 mRNA. Translation: AAH71613.1.
CCDSCCDS33298.1.
RefSeqNP_001001664.1. NM_001001664.2.
UniGeneHs.333297.

3D structure databases

ProteinModelPortalQ6IQ16.
SMRQ6IQ16. Positions 28-374.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ6IQ16. 1 interaction.
STRING9606.ENSP00000280098.

PTM databases

PhosphoSiteQ6IQ16.

Polymorphism databases

DMDM74736582.

Proteomic databases

PaxDbQ6IQ16.
PRIDEQ6IQ16.

Protocols and materials databases

DNASU339745.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000280098; ENSP00000280098; ENSG00000144228.
GeneID339745.
KEGGhsa:339745.
UCSCuc002tvh.3. human.

Organism-specific databases

CTD339745.
GeneCardsGC02P139259.
HGNCHGNC:27934. SPOPL.
HPAHPA034687.
neXtProtNX_Q6IQ16.
PharmGKBPA162404650.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG273048.
HOGENOMHOG000231621.
HOVERGENHBG001393.
InParanoidQ6IQ16.
KOK10523.
OMAMEESKKX.
OrthoDBEOG73NG3G.
PhylomeDBQ6IQ16.
TreeFamTF313419.

Enzyme and pathway databases

SignaLinkQ6IQ16.
UniPathwayUPA00143.

Gene expression databases

ArrayExpressQ6IQ16.
BgeeQ6IQ16.
CleanExHS_SPOPL.
GenevestigatorQ6IQ16.

Family and domain databases

Gene3D3.30.710.10. 1 hit.
InterProIPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR013069. BTB_POZ.
IPR002083. MATH.
IPR008974. TRAF-like.
[Graphical view]
PfamPF00651. BTB. 1 hit.
PF00917. MATH. 1 hit.
[Graphical view]
SMARTSM00225. BTB. 1 hit.
SM00061. MATH. 1 hit.
[Graphical view]
SUPFAMSSF49599. SSF49599. 1 hit.
SSF54695. SSF54695. 1 hit.
PROSITEPS50097. BTB. 1 hit.
PS50144. MATH. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi339745.
NextBio97504.
PROQ6IQ16.

Entry information

Entry nameSPOPL_HUMAN
AccessionPrimary (citable) accession number: Q6IQ16
Entry history
Integrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: July 5, 2004
Last modified: July 9, 2014
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 2

Human chromosome 2: entries, gene names and cross-references to MIM