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Protein

Speckle-type POZ protein-like

Gene

SPOPL

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins, but with relatively low efficiency. Cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes containing homodimeric SPOPL or the heterodimer formed by SPOP and SPOPL are less efficient than ubiquitin ligase complexes containing only SPOP. May function to down-regulate the activity of cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that contain SPOP.1 Publication

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Molecular functioni

GO - Biological processi

  • negative regulation of protein ubiquitination Source: UniProtKB
  • proteasome-mediated ubiquitin-dependent protein catabolic process Source: UniProtKB
  • protein ubiquitination Source: UniProtKB-UniPathway
  • regulation of proteolysis Source: GO_Central

Keywordsi

Biological processUbl conjugation pathway

Enzyme and pathway databases

ReactomeiR-HSA-5632684 Hedgehog 'on' state
SignaLinkiQ6IQ16
UniPathwayiUPA00143

Names & Taxonomyi

Protein namesi
Recommended name:
Speckle-type POZ protein-like
Alternative name(s):
HIB homolog 2
Roadkill homolog 2
Gene namesi
Name:SPOPL
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000144228.8
HGNCiHGNC:27934 SPOPL
neXtProtiNX_Q6IQ16

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000144228
PharmGKBiPA162404650

Polymorphism and mutation databases

BioMutaiSPOPL
DMDMi74736582

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002745881 – 392Speckle-type POZ protein-likeAdd BLAST392

Proteomic databases

MaxQBiQ6IQ16
PaxDbiQ6IQ16
PeptideAtlasiQ6IQ16
PRIDEiQ6IQ16

PTM databases

iPTMnetiQ6IQ16
PhosphoSitePlusiQ6IQ16

Expressioni

Gene expression databases

BgeeiENSG00000144228
CleanExiHS_SPOPL
ExpressionAtlasiQ6IQ16 baseline and differential
GenevisibleiQ6IQ16 HS

Organism-specific databases

HPAiHPA034687

Interactioni

Subunit structurei

Homodimer. Heterodimer with SPOP. Component of cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes containing homodimeric SPOPL or the heterodimer formed by SPOP and SPOPL. Interacts with CUL3 and H2AFY.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
KPNA5O151313EBI-2822161,EBI-540602

GO - Molecular functioni

Protein-protein interaction databases

BioGridi130923, 2 interactors
IntActiQ6IQ16, 6 interactors
STRINGi9606.ENSP00000280098

Structurei

3D structure databases

ProteinModelPortaliQ6IQ16
SMRiQ6IQ16
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini31 – 161MATHPROSITE-ProRule annotationAdd BLAST131
Domaini200 – 267BTBPROSITE-ProRule annotationAdd BLAST68

Sequence similaritiesi

Belongs to the Tdpoz family.Curated

Phylogenomic databases

eggNOGiKOG1987 Eukaryota
ENOG410XQV8 LUCA
GeneTreeiENSGT00390000000361
HOGENOMiHOG000231621
HOVERGENiHBG001393
InParanoidiQ6IQ16
KOiK10523
OMAiMEESKKX
OrthoDBiEOG091G07ZM
PhylomeDBiQ6IQ16
TreeFamiTF313419

Family and domain databases

CDDicd14734 SPOP_C, 1 hit
Gene3Di2.60.210.10, 1 hit
InterProiView protein in InterPro
IPR000210 BTB/POZ_dom
IPR002083 MATH/TRAF_dom
IPR011333 SKP1/BTB/POZ_sf
IPR034089 SPOP_C
IPR008974 TRAF-like
PfamiView protein in Pfam
PF00651 BTB, 1 hit
PF00917 MATH, 1 hit
SMARTiView protein in SMART
SM00225 BTB, 1 hit
SM00061 MATH, 1 hit
SUPFAMiSSF49599 SSF49599, 1 hit
SSF54695 SSF54695, 1 hit
PROSITEiView protein in PROSITE
PS50097 BTB, 1 hit
PS50144 MATH, 1 hit

Sequencei

Sequence statusi: Complete.

Q6IQ16-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSREPTPPLP GDMSTGPIAE SWCYTQVKVV KFSYMWTINN FSFCREEMGE
60 70 80 90 100
VLKSSTFSSG PSDKMKWCLR VNPKGLDDES KDYLSLYLLL VSCPKSEVRA
110 120 130 140 150
KFKFSLLNAK REETKAMESQ RAYRFVQGKD WGFKKFIRRD FLLDEANGLL
160 170 180 190 200
PDDKLTLFCE VSVVQDSVNI SGHTNTNTLK VPECRLAEDL GNLWENTRFT
210 220 230 240 250
DCSFFVRGQE FKAHKSVLAA RSPVFNAMFE HEMEESKKNR VEINDLDPEV
260 270 280 290 300
FKEMMRFIYT GRAPNLDKMA DNLLAAADKY ALERLKVMCE EALCSNLSVE
310 320 330 340 350
NVADTLVLAD LHSAEQLKAQ AIDFINRCSV LRQLGCKDGK NWNSNQATDI
360 370 380 390
METSGWKSMI QSHPHLVAEA FRALASAQCP QFGIPRKRLK QS
Length:392
Mass (Da):44,647
Last modified:July 5, 2004 - v1
Checksum:iCEB4243BD732DFEF
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05371945R → Q. Corresponds to variant dbSNP:rs36099753Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC071613 mRNA Translation: AAH71613.1
CCDSiCCDS33298.1
RefSeqiNP_001001664.1, NM_001001664.2
UniGeneiHs.333297

Genome annotation databases

EnsembliENST00000280098; ENSP00000280098; ENSG00000144228
GeneIDi339745
KEGGihsa:339745
UCSCiuc002tvh.5 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiSPOPL_HUMAN
AccessioniPrimary (citable) accession number: Q6IQ16
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: July 5, 2004
Last modified: April 25, 2018
This is version 116 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health