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Q6IQ16

- SPOPL_HUMAN

UniProt

Q6IQ16 - SPOPL_HUMAN

Protein

Speckle-type POZ protein-like

Gene

SPOPL

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 89 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins, but with relatively low efficiency. Cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes containing homodimeric SPOPL or the heterodimer formed by SPOP and SPOPL are less efficient than ubiquitin ligase complexes containing only SPOP. May function to down-regulate the activity of cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that contain SPOP.1 Publication

    Pathwayi

    GO - Biological processi

    1. negative regulation of protein ubiquitination Source: UniProtKB
    2. proteasome-mediated ubiquitin-dependent protein catabolic process Source: UniProtKB
    3. protein ubiquitination Source: UniProtKB-UniPathway

    Keywords - Biological processi

    Ubl conjugation pathway

    Enzyme and pathway databases

    SignaLinkiQ6IQ16.
    UniPathwayiUPA00143.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Speckle-type POZ protein-like
    Alternative name(s):
    HIB homolog 2
    Roadkill homolog 2
    Gene namesi
    Name:SPOPL
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 2

    Organism-specific databases

    HGNCiHGNC:27934. SPOPL.

    Subcellular locationi

    Nucleus By similarity

    GO - Cellular componenti

    1. Cul3-RING ubiquitin ligase complex Source: UniProtKB
    2. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA162404650.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 392392Speckle-type POZ protein-likePRO_0000274588Add
    BLAST

    Proteomic databases

    PaxDbiQ6IQ16.
    PRIDEiQ6IQ16.

    PTM databases

    PhosphoSiteiQ6IQ16.

    Expressioni

    Gene expression databases

    ArrayExpressiQ6IQ16.
    BgeeiQ6IQ16.
    CleanExiHS_SPOPL.
    GenevestigatoriQ6IQ16.

    Organism-specific databases

    HPAiHPA034687.

    Interactioni

    Subunit structurei

    Homodimer. Heterodimer with SPOP. Component of cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes containing homodimeric SPOPL or the heterodimer formed by SPOP and SPOPL. Interacts with CUL3 and H2AFY.1 Publication

    Protein-protein interaction databases

    IntActiQ6IQ16. 1 interaction.
    STRINGi9606.ENSP00000280098.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6IQ16.
    SMRiQ6IQ16. Positions 28-374.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini31 – 161131MATHPROSITE-ProRule annotationAdd
    BLAST
    Domaini200 – 26768BTBPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the Tdpoz family.Curated
    Contains 1 BTB (POZ) domain.PROSITE-ProRule annotation
    Contains 1 MATH domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG273048.
    HOGENOMiHOG000231621.
    HOVERGENiHBG001393.
    InParanoidiQ6IQ16.
    KOiK10523.
    OMAiMEESKKX.
    OrthoDBiEOG73NG3G.
    PhylomeDBiQ6IQ16.
    TreeFamiTF313419.

    Family and domain databases

    Gene3Di3.30.710.10. 1 hit.
    InterProiIPR000210. BTB/POZ-like.
    IPR011333. BTB/POZ_fold.
    IPR013069. BTB_POZ.
    IPR002083. MATH.
    IPR008974. TRAF-like.
    [Graphical view]
    PfamiPF00651. BTB. 1 hit.
    PF00917. MATH. 1 hit.
    [Graphical view]
    SMARTiSM00225. BTB. 1 hit.
    SM00061. MATH. 1 hit.
    [Graphical view]
    SUPFAMiSSF49599. SSF49599. 1 hit.
    SSF54695. SSF54695. 1 hit.
    PROSITEiPS50097. BTB. 1 hit.
    PS50144. MATH. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q6IQ16-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSREPTPPLP GDMSTGPIAE SWCYTQVKVV KFSYMWTINN FSFCREEMGE    50
    VLKSSTFSSG PSDKMKWCLR VNPKGLDDES KDYLSLYLLL VSCPKSEVRA 100
    KFKFSLLNAK REETKAMESQ RAYRFVQGKD WGFKKFIRRD FLLDEANGLL 150
    PDDKLTLFCE VSVVQDSVNI SGHTNTNTLK VPECRLAEDL GNLWENTRFT 200
    DCSFFVRGQE FKAHKSVLAA RSPVFNAMFE HEMEESKKNR VEINDLDPEV 250
    FKEMMRFIYT GRAPNLDKMA DNLLAAADKY ALERLKVMCE EALCSNLSVE 300
    NVADTLVLAD LHSAEQLKAQ AIDFINRCSV LRQLGCKDGK NWNSNQATDI 350
    METSGWKSMI QSHPHLVAEA FRALASAQCP QFGIPRKRLK QS 392
    Length:392
    Mass (Da):44,647
    Last modified:July 5, 2004 - v1
    Checksum:iCEB4243BD732DFEF
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti45 – 451R → Q.
    Corresponds to variant rs36099753 [ dbSNP | Ensembl ].
    VAR_053719

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC071613 mRNA. Translation: AAH71613.1.
    CCDSiCCDS33298.1.
    RefSeqiNP_001001664.1. NM_001001664.2.
    UniGeneiHs.333297.

    Genome annotation databases

    EnsembliENST00000280098; ENSP00000280098; ENSG00000144228.
    GeneIDi339745.
    KEGGihsa:339745.
    UCSCiuc002tvh.3. human.

    Polymorphism databases

    DMDMi74736582.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC071613 mRNA. Translation: AAH71613.1 .
    CCDSi CCDS33298.1.
    RefSeqi NP_001001664.1. NM_001001664.2.
    UniGenei Hs.333297.

    3D structure databases

    ProteinModelPortali Q6IQ16.
    SMRi Q6IQ16. Positions 28-374.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q6IQ16. 1 interaction.
    STRINGi 9606.ENSP00000280098.

    PTM databases

    PhosphoSitei Q6IQ16.

    Polymorphism databases

    DMDMi 74736582.

    Proteomic databases

    PaxDbi Q6IQ16.
    PRIDEi Q6IQ16.

    Protocols and materials databases

    DNASUi 339745.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000280098 ; ENSP00000280098 ; ENSG00000144228 .
    GeneIDi 339745.
    KEGGi hsa:339745.
    UCSCi uc002tvh.3. human.

    Organism-specific databases

    CTDi 339745.
    GeneCardsi GC02P139259.
    HGNCi HGNC:27934. SPOPL.
    HPAi HPA034687.
    neXtProti NX_Q6IQ16.
    PharmGKBi PA162404650.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG273048.
    HOGENOMi HOG000231621.
    HOVERGENi HBG001393.
    InParanoidi Q6IQ16.
    KOi K10523.
    OMAi MEESKKX.
    OrthoDBi EOG73NG3G.
    PhylomeDBi Q6IQ16.
    TreeFami TF313419.

    Enzyme and pathway databases

    UniPathwayi UPA00143 .
    SignaLinki Q6IQ16.

    Miscellaneous databases

    GenomeRNAii 339745.
    NextBioi 97504.
    PROi Q6IQ16.

    Gene expression databases

    ArrayExpressi Q6IQ16.
    Bgeei Q6IQ16.
    CleanExi HS_SPOPL.
    Genevestigatori Q6IQ16.

    Family and domain databases

    Gene3Di 3.30.710.10. 1 hit.
    InterProi IPR000210. BTB/POZ-like.
    IPR011333. BTB/POZ_fold.
    IPR013069. BTB_POZ.
    IPR002083. MATH.
    IPR008974. TRAF-like.
    [Graphical view ]
    Pfami PF00651. BTB. 1 hit.
    PF00917. MATH. 1 hit.
    [Graphical view ]
    SMARTi SM00225. BTB. 1 hit.
    SM00061. MATH. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49599. SSF49599. 1 hit.
    SSF54695. SSF54695. 1 hit.
    PROSITEi PS50097. BTB. 1 hit.
    PS50144. MATH. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    2. "Roadkill attenuates Hedgehog responses through degradation of Cubitus interruptus."
      Kent D., Bush E.W., Hooper J.E.
      Development 133:2001-2010(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION.
    3. "A hedgehog-induced BTB protein modulates hedgehog signaling by degrading Ci/Gli transcription factor."
      Zhang Q., Zhang L., Wang B., Ou C.-Y., Chien C.-T., Jiang J.
      Dev. Cell 10:719-729(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION.
    4. "Adaptor protein self-assembly drives the control of a cullin-RING ubiquitin ligase."
      Errington W.J., Khan M.Q., Bueler S.A., Rubinstein J.L., Chakrabartty A., Prive G.G.
      Structure 20:1141-1153(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBUNIT, INTERACTION WITH CUL3 AND H2AFY.

    Entry informationi

    Entry nameiSPOPL_HUMAN
    AccessioniPrimary (citable) accession number: Q6IQ16
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 6, 2007
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 89 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 2
      Human chromosome 2: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3