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Q6IQ16

- SPOPL_HUMAN

UniProt

Q6IQ16 - SPOPL_HUMAN

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Protein
Speckle-type POZ protein-like
Gene
SPOPL
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins, but with relatively low efficiency. Cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes containing homodimeric SPOPL or the heterodimer formed by SPOP and SPOPL are less efficient than ubiquitin ligase complexes containing only SPOP. May function to down-regulate the activity of cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that contain SPOP.1 Publication

Pathwayi

GO - Biological processi

  1. negative regulation of protein ubiquitination Source: UniProtKB
  2. proteasome-mediated ubiquitin-dependent protein catabolic process Source: UniProtKB
  3. protein ubiquitination Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Biological processi

Ubl conjugation pathway

Enzyme and pathway databases

SignaLinkiQ6IQ16.
UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
Speckle-type POZ protein-like
Alternative name(s):
HIB homolog 2
Roadkill homolog 2
Gene namesi
Name:SPOPL
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 2

Organism-specific databases

HGNCiHGNC:27934. SPOPL.

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. Cul3-RING ubiquitin ligase complex Source: UniProtKB
  2. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162404650.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 392392Speckle-type POZ protein-like
PRO_0000274588Add
BLAST

Proteomic databases

PaxDbiQ6IQ16.
PRIDEiQ6IQ16.

PTM databases

PhosphoSiteiQ6IQ16.

Expressioni

Gene expression databases

ArrayExpressiQ6IQ16.
BgeeiQ6IQ16.
CleanExiHS_SPOPL.
GenevestigatoriQ6IQ16.

Organism-specific databases

HPAiHPA034687.

Interactioni

Subunit structurei

Homodimer. Heterodimer with SPOP. Component of cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes containing homodimeric SPOPL or the heterodimer formed by SPOP and SPOPL. Interacts with CUL3 and H2AFY.1 Publication

Protein-protein interaction databases

IntActiQ6IQ16. 1 interaction.
STRINGi9606.ENSP00000280098.

Structurei

3D structure databases

ProteinModelPortaliQ6IQ16.
SMRiQ6IQ16. Positions 28-374.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini31 – 161131MATH
Add
BLAST
Domaini200 – 26768BTB
Add
BLAST

Sequence similaritiesi

Belongs to the Tdpoz family.
Contains 1 BTB (POZ) domain.
Contains 1 MATH domain.

Phylogenomic databases

eggNOGiNOG273048.
HOGENOMiHOG000231621.
HOVERGENiHBG001393.
InParanoidiQ6IQ16.
KOiK10523.
OMAiMEESKKX.
OrthoDBiEOG73NG3G.
PhylomeDBiQ6IQ16.
TreeFamiTF313419.

Family and domain databases

Gene3Di3.30.710.10. 1 hit.
InterProiIPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR013069. BTB_POZ.
IPR002083. MATH.
IPR008974. TRAF-like.
[Graphical view]
PfamiPF00651. BTB. 1 hit.
PF00917. MATH. 1 hit.
[Graphical view]
SMARTiSM00225. BTB. 1 hit.
SM00061. MATH. 1 hit.
[Graphical view]
SUPFAMiSSF49599. SSF49599. 1 hit.
SSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
PS50144. MATH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6IQ16-1 [UniParc]FASTAAdd to Basket

« Hide

MSREPTPPLP GDMSTGPIAE SWCYTQVKVV KFSYMWTINN FSFCREEMGE    50
VLKSSTFSSG PSDKMKWCLR VNPKGLDDES KDYLSLYLLL VSCPKSEVRA 100
KFKFSLLNAK REETKAMESQ RAYRFVQGKD WGFKKFIRRD FLLDEANGLL 150
PDDKLTLFCE VSVVQDSVNI SGHTNTNTLK VPECRLAEDL GNLWENTRFT 200
DCSFFVRGQE FKAHKSVLAA RSPVFNAMFE HEMEESKKNR VEINDLDPEV 250
FKEMMRFIYT GRAPNLDKMA DNLLAAADKY ALERLKVMCE EALCSNLSVE 300
NVADTLVLAD LHSAEQLKAQ AIDFINRCSV LRQLGCKDGK NWNSNQATDI 350
METSGWKSMI QSHPHLVAEA FRALASAQCP QFGIPRKRLK QS 392
Length:392
Mass (Da):44,647
Last modified:July 5, 2004 - v1
Checksum:iCEB4243BD732DFEF
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti45 – 451R → Q.
Corresponds to variant rs36099753 [ dbSNP | Ensembl ].
VAR_053719

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC071613 mRNA. Translation: AAH71613.1.
CCDSiCCDS33298.1.
RefSeqiNP_001001664.1. NM_001001664.2.
UniGeneiHs.333297.

Genome annotation databases

EnsembliENST00000280098; ENSP00000280098; ENSG00000144228.
GeneIDi339745.
KEGGihsa:339745.
UCSCiuc002tvh.3. human.

Polymorphism databases

DMDMi74736582.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC071613 mRNA. Translation: AAH71613.1 .
CCDSi CCDS33298.1.
RefSeqi NP_001001664.1. NM_001001664.2.
UniGenei Hs.333297.

3D structure databases

ProteinModelPortali Q6IQ16.
SMRi Q6IQ16. Positions 28-374.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q6IQ16. 1 interaction.
STRINGi 9606.ENSP00000280098.

PTM databases

PhosphoSitei Q6IQ16.

Polymorphism databases

DMDMi 74736582.

Proteomic databases

PaxDbi Q6IQ16.
PRIDEi Q6IQ16.

Protocols and materials databases

DNASUi 339745.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000280098 ; ENSP00000280098 ; ENSG00000144228 .
GeneIDi 339745.
KEGGi hsa:339745.
UCSCi uc002tvh.3. human.

Organism-specific databases

CTDi 339745.
GeneCardsi GC02P139259.
HGNCi HGNC:27934. SPOPL.
HPAi HPA034687.
neXtProti NX_Q6IQ16.
PharmGKBi PA162404650.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG273048.
HOGENOMi HOG000231621.
HOVERGENi HBG001393.
InParanoidi Q6IQ16.
KOi K10523.
OMAi MEESKKX.
OrthoDBi EOG73NG3G.
PhylomeDBi Q6IQ16.
TreeFami TF313419.

Enzyme and pathway databases

UniPathwayi UPA00143 .
SignaLinki Q6IQ16.

Miscellaneous databases

GenomeRNAii 339745.
NextBioi 97504.
PROi Q6IQ16.

Gene expression databases

ArrayExpressi Q6IQ16.
Bgeei Q6IQ16.
CleanExi HS_SPOPL.
Genevestigatori Q6IQ16.

Family and domain databases

Gene3Di 3.30.710.10. 1 hit.
InterProi IPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR013069. BTB_POZ.
IPR002083. MATH.
IPR008974. TRAF-like.
[Graphical view ]
Pfami PF00651. BTB. 1 hit.
PF00917. MATH. 1 hit.
[Graphical view ]
SMARTi SM00225. BTB. 1 hit.
SM00061. MATH. 1 hit.
[Graphical view ]
SUPFAMi SSF49599. SSF49599. 1 hit.
SSF54695. SSF54695. 1 hit.
PROSITEi PS50097. BTB. 1 hit.
PS50144. MATH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  2. "Roadkill attenuates Hedgehog responses through degradation of Cubitus interruptus."
    Kent D., Bush E.W., Hooper J.E.
    Development 133:2001-2010(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.
  3. "A hedgehog-induced BTB protein modulates hedgehog signaling by degrading Ci/Gli transcription factor."
    Zhang Q., Zhang L., Wang B., Ou C.-Y., Chien C.-T., Jiang J.
    Dev. Cell 10:719-729(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.
  4. "Adaptor protein self-assembly drives the control of a cullin-RING ubiquitin ligase."
    Errington W.J., Khan M.Q., Bueler S.A., Rubinstein J.L., Chakrabartty A., Prive G.G.
    Structure 20:1141-1153(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBUNIT, INTERACTION WITH CUL3 AND H2AFY.

Entry informationi

Entry nameiSPOPL_HUMAN
AccessioniPrimary (citable) accession number: Q6IQ16
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: July 5, 2004
Last modified: July 9, 2014
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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