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Protein

Transcription elongation factor A protein-like 6

Gene

TCEAL6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription elongation factor A protein-like 6
Short name:
TCEA-like protein 6
Alternative name(s):
Transcription elongation factor S-II protein-like 6
Gene namesi
Name:TCEAL6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:24553. TCEAL6.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142670828.

Polymorphism and mutation databases

BioMutaiTCEAL6.
DMDMi74736570.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 200200Transcription elongation factor A protein-like 6PRO_0000239213Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei30 – 301PhosphoserineBy similarity
Modified residuei65 – 651PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ6IPX3.
PaxDbiQ6IPX3.
PeptideAtlasiQ6IPX3.
PRIDEiQ6IPX3.

PTM databases

iPTMnetiQ6IPX3.
PhosphoSiteiQ6IPX3.

Expressioni

Gene expression databases

BgeeiQ6IPX3.
CleanExiHS_TCEAL6.
ExpressionAtlasiQ6IPX3. baseline and differential.

Organism-specific databases

HPAiHPA045564.
HPA058982.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ6IPX3. 1 interaction.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi9 – 7567Glu-richAdd
BLAST

Sequence similaritiesi

Belongs to the TFS-II family. TFA subfamily.Curated

Phylogenomic databases

GeneTreeiENSGT00510000046867.
HOVERGENiHBG055896.
InParanoidiQ6IPX3.
OrthoDBiEOG7QNVNM.
PhylomeDBiQ6IPX3.
TreeFamiTF336871.

Family and domain databases

InterProiIPR021156. TF_A-like/BEX-like.
[Graphical view]
PfamiPF04538. BEX. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6IPX3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEKPYNKNEG NLENEGKPED EVEPDDEGKS DEEEKPDAEG KTECEGKRKA
60 70 80 90 100
EGEPGDEGQL EDKGSQEKQG KSEGEGKPQG EGKPASQAKP EGQPRAAEKR
110 120 130 140 150
PAGDYVPRKA KRKTDRGTDD SPKDSQEDLQ ERHLSSEEMM RECGDVSRAQ
160 170 180 190 200
EELRKKQKMG GFHWMQRDVQ DPFAPRGQRG VRGVRGGGRG QRGLHDIPYL
Length:200
Mass (Da):22,298
Last modified:July 5, 2004 - v1
Checksum:i05D8DA7EDE49DB86
GO
Isoform 2 (identifier: Q6IPX3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     175-200: PRGQRGVRGVRGGGRGQRGLHDIPYL → QGDNGVSGE

Note: No experimental confirmation available.
Show »
Length:183
Mass (Da):20,345
Checksum:i55AFD0FF2AB99618
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei175 – 20026PRGQR…DIPYL → QGDNGVSGE in isoform 2. CuratedVSP_019110Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z70719 Genomic DNA. Translation: CAI42012.1.
BC071675 mRNA. Translation: AAH71675.1.
CCDSiCCDS43978.1. [Q6IPX3-2]
UniGeneiHs.447815.

Genome annotation databases

EnsembliENST00000372773; ENSP00000361859; ENSG00000204071. [Q6IPX3-2]
ENST00000372774; ENSP00000361860; ENSG00000204071. [Q6IPX3-2]
UCSCiuc004eiq.4. human. [Q6IPX3-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z70719 Genomic DNA. Translation: CAI42012.1.
BC071675 mRNA. Translation: AAH71675.1.
CCDSiCCDS43978.1. [Q6IPX3-2]
UniGeneiHs.447815.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ6IPX3. 1 interaction.

PTM databases

iPTMnetiQ6IPX3.
PhosphoSiteiQ6IPX3.

Polymorphism and mutation databases

BioMutaiTCEAL6.
DMDMi74736570.

Proteomic databases

EPDiQ6IPX3.
PaxDbiQ6IPX3.
PeptideAtlasiQ6IPX3.
PRIDEiQ6IPX3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000372773; ENSP00000361859; ENSG00000204071. [Q6IPX3-2]
ENST00000372774; ENSP00000361860; ENSG00000204071. [Q6IPX3-2]
UCSCiuc004eiq.4. human. [Q6IPX3-1]

Organism-specific databases

GeneCardsiTCEAL6.
H-InvDBHIX0056251.
HGNCiHGNC:24553. TCEAL6.
HPAiHPA045564.
HPA058982.
neXtProtiNX_Q6IPX3.
PharmGKBiPA142670828.
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00510000046867.
HOVERGENiHBG055896.
InParanoidiQ6IPX3.
OrthoDBiEOG7QNVNM.
PhylomeDBiQ6IPX3.
TreeFamiTF336871.

Miscellaneous databases

PROiQ6IPX3.

Gene expression databases

BgeeiQ6IPX3.
CleanExiHS_TCEAL6.
ExpressionAtlasiQ6IPX3. baseline and differential.

Family and domain databases

InterProiIPR021156. TF_A-like/BEX-like.
[Graphical view]
PfamiPF04538. BEX. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The DNA sequence of the human X chromosome."
    Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
    , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
    Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.

Entry informationi

Entry nameiTCAL6_HUMAN
AccessioniPrimary (citable) accession number: Q6IPX3
Secondary accession number(s): Q5H9J8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: July 5, 2004
Last modified: July 6, 2016
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.