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Protein

Centromere protein P

Gene

CENPP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex.1 Publication

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-HSA-2467813. Separation of Sister Chromatids.
R-HSA-2500257. Resolution of Sister Chromatid Cohesion.
R-HSA-5663220. RHO GTPases Activate Formins.
R-HSA-606279. Deposition of new CENPA-containing nucleosomes at the centromere.
R-HSA-68877. Mitotic Prometaphase.

Names & Taxonomyi

Protein namesi
Recommended name:
Centromere protein P
Short name:
CENP-P
Gene namesi
Name:CENPP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:32933. CENPP.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Centromere, Chromosome, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA145149143.

Polymorphism and mutation databases

DMDMi74748817.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 288288Centromere protein PPRO_0000249506Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei38 – 381PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ6IPU0.
MaxQBiQ6IPU0.
PaxDbiQ6IPU0.
PeptideAtlasiQ6IPU0.
PRIDEiQ6IPU0.

PTM databases

iPTMnetiQ6IPU0.
PhosphoSiteiQ6IPU0.

Expressioni

Gene expression databases

BgeeiENSG00000188312.
CleanExiHS_CENPP.
ExpressionAtlasiQ6IPU0. baseline and differential.
GenevisibleiQ6IPU0. HS.

Organism-specific databases

HPAiHPA021787.
HPA058945.

Interactioni

Subunit structurei

Component of the CENPA-CAD complex, composed of CENPI, CENPK, CENPL, CENPO, CENPP, CENPQ, CENPR and CENPS. The CENPA-CAD complex interacts with the CENPA-NAC complex, at least composed of CENPA, CENPC, CENPH, CENPM, CENPN, CENPT and CENPU.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
CENPOQ9BU644EBI-10250303,EBI-745954
GOLGA2Q083793EBI-10250303,EBI-618309
KLC3Q6P5973EBI-10250303,EBI-1643885
NHLH1Q5T2033EBI-10250303,EBI-10197511
RPIAP492473EBI-10250303,EBI-744831
TEX11Q8IYF33EBI-10250303,EBI-742397
USHBP1Q8N6Y03EBI-10250303,EBI-739895
ZNF341Q9BYN73EBI-10250303,EBI-9089622

Protein-protein interaction databases

BioGridi135138. 20 interactions.
IntActiQ6IPU0. 13 interactions.
STRINGi9606.ENSP00000364737.

Structurei

3D structure databases

ProteinModelPortaliQ6IPU0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili1 – 7171Sequence analysisAdd
BLAST

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IJM3. Eukaryota.
ENOG410YMCC. LUCA.
GeneTreeiENSGT00390000011897.
HOGENOMiHOG000060252.
HOVERGENiHBG081087.
InParanoidiQ6IPU0.
KOiK11508.
OMAiQILEIQX.
OrthoDBiEOG091G0P30.
PhylomeDBiQ6IPU0.
TreeFamiTF333784.

Family and domain databases

InterProiIPR027801. CENP-P.
[Graphical view]
PfamiPF13096. CENP-P. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6IPU0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDAELAEVRA LQAEIAALRR ACEDPPAPWE EKSRVQKSFQ AIHQFNLEGW
60 70 80 90 100
KSSKDLKNQL GHLESELSFL STLTGINIRN HSKQTEDLTS TEMTEKSIRK
110 120 130 140 150
VLQRHRLSGN CHMVTFQLEF QILEIQNKER LSSAVTDLNI IMEPTECSEL
160 170 180 190 200
SEFVSRAEER KDLFMFFRSL HFFVEWFEYR KRTFKHLKEK YPDAVYLSEG
210 220 230 240 250
PSSCSMGIRS ASRPGFELVI VWRIQIDEDG KVFPKLDLLT KVPQRALELD
260 270 280
KNRAIETAPL SFRTLVGLLG IEAALESLIK SLCAEENN
Length:288
Mass (Da):33,165
Last modified:July 5, 2004 - v1
Checksum:i19D32EF404E9EA7D
GO
Isoform 2 (identifier: Q6IPU0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-15: MDAELAEVRALQAEI → MEAPSWSVLQRSGDE
     16-188: Missing.

Note: No experimental confirmation available.
Show »
Length:115
Mass (Da):12,707
Checksum:iD9A41D07618853DF
GO

Sequence cautioni

The sequence CAI12591 differs from that shown. Reason: Erroneous gene model prediction. Curated
The sequence CAI12592 differs from that shown. Reason: Erroneous gene model prediction. Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 1515MDAEL…LQAEI → MEAPSWSVLQRSGDE in isoform 2. 1 PublicationVSP_055368Add
BLAST
Alternative sequencei16 – 188173Missing in isoform 2. 1 PublicationVSP_055369Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK091247 mRNA. Translation: BAG52317.1.
AK092603 mRNA. Translation: BAG52579.1.
AL157827 Genomic DNA. Translation: CAI12591.1. Sequence problems.
AL157827 Genomic DNA. Translation: CAI12592.1. Sequence problems.
AL157827, AL136097, AL137848 Genomic DNA. Translation: CAI12594.1.
AL137848, AL136097, AL157827 Genomic DNA. Translation: CAI16699.1.
AL136097, AL137848, AL157827 Genomic DNA. Translation: CAI16210.1.
BC071726 mRNA. Translation: AAH71726.1.
CCDSiCCDS35063.1. [Q6IPU0-1]
CCDS69618.1. [Q6IPU0-2]
RefSeqiNP_001012267.1. NM_001012267.2. [Q6IPU0-1]
NP_001273900.1. NM_001286971.1. [Q6IPU0-2]
UniGeneiHs.713775.

Genome annotation databases

EnsembliENST00000375579; ENSP00000364729; ENSG00000188312. [Q6IPU0-2]
ENST00000375587; ENSP00000364737; ENSG00000188312. [Q6IPU0-1]
GeneIDi401541.
KEGGihsa:401541.
UCSCiuc004arz.5. human. [Q6IPU0-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK091247 mRNA. Translation: BAG52317.1.
AK092603 mRNA. Translation: BAG52579.1.
AL157827 Genomic DNA. Translation: CAI12591.1. Sequence problems.
AL157827 Genomic DNA. Translation: CAI12592.1. Sequence problems.
AL157827, AL136097, AL137848 Genomic DNA. Translation: CAI12594.1.
AL137848, AL136097, AL157827 Genomic DNA. Translation: CAI16699.1.
AL136097, AL137848, AL157827 Genomic DNA. Translation: CAI16210.1.
BC071726 mRNA. Translation: AAH71726.1.
CCDSiCCDS35063.1. [Q6IPU0-1]
CCDS69618.1. [Q6IPU0-2]
RefSeqiNP_001012267.1. NM_001012267.2. [Q6IPU0-1]
NP_001273900.1. NM_001286971.1. [Q6IPU0-2]
UniGeneiHs.713775.

3D structure databases

ProteinModelPortaliQ6IPU0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi135138. 20 interactions.
IntActiQ6IPU0. 13 interactions.
STRINGi9606.ENSP00000364737.

PTM databases

iPTMnetiQ6IPU0.
PhosphoSiteiQ6IPU0.

Polymorphism and mutation databases

DMDMi74748817.

Proteomic databases

EPDiQ6IPU0.
MaxQBiQ6IPU0.
PaxDbiQ6IPU0.
PeptideAtlasiQ6IPU0.
PRIDEiQ6IPU0.

Protocols and materials databases

DNASUi401541.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000375579; ENSP00000364729; ENSG00000188312. [Q6IPU0-2]
ENST00000375587; ENSP00000364737; ENSG00000188312. [Q6IPU0-1]
GeneIDi401541.
KEGGihsa:401541.
UCSCiuc004arz.5. human. [Q6IPU0-1]

Organism-specific databases

CTDi401541.
GeneCardsiCENPP.
HGNCiHGNC:32933. CENPP.
HPAiHPA021787.
HPA058945.
MIMi611505. gene.
neXtProtiNX_Q6IPU0.
PharmGKBiPA145149143.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IJM3. Eukaryota.
ENOG410YMCC. LUCA.
GeneTreeiENSGT00390000011897.
HOGENOMiHOG000060252.
HOVERGENiHBG081087.
InParanoidiQ6IPU0.
KOiK11508.
OMAiQILEIQX.
OrthoDBiEOG091G0P30.
PhylomeDBiQ6IPU0.
TreeFamiTF333784.

Enzyme and pathway databases

ReactomeiR-HSA-2467813. Separation of Sister Chromatids.
R-HSA-2500257. Resolution of Sister Chromatid Cohesion.
R-HSA-5663220. RHO GTPases Activate Formins.
R-HSA-606279. Deposition of new CENPA-containing nucleosomes at the centromere.
R-HSA-68877. Mitotic Prometaphase.

Miscellaneous databases

ChiTaRSiCENPP. human.
GenomeRNAii401541.
PROiQ6IPU0.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000188312.
CleanExiHS_CENPP.
ExpressionAtlasiQ6IPU0. baseline and differential.
GenevisibleiQ6IPU0. HS.

Family and domain databases

InterProiIPR027801. CENP-P.
[Graphical view]
PfamiPF13096. CENP-P. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCENPP_HUMAN
AccessioniPrimary (citable) accession number: Q6IPU0
Secondary accession number(s): B3KRA5
, B3KS17, Q5T9F8, Q5T9F9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2006
Last sequence update: July 5, 2004
Last modified: September 7, 2016
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.