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Protein

Centromere protein P

Gene

CENPP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex.1 Publication

Caution

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-HSA-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
R-HSA-2467813 Separation of Sister Chromatids
R-HSA-2500257 Resolution of Sister Chromatid Cohesion
R-HSA-5663220 RHO GTPases Activate Formins
R-HSA-606279 Deposition of new CENPA-containing nucleosomes at the centromere
R-HSA-68877 Mitotic Prometaphase

Names & Taxonomyi

Protein namesi
Recommended name:
Centromere protein P
Short name:
CENP-P
Gene namesi
Name:CENPP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000188312.13
HGNCiHGNC:32933 CENPP
MIMi611505 gene
neXtProtiNX_Q6IPU0

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Centromere, Chromosome, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi401541
OpenTargetsiENSG00000188312
PharmGKBiPA145149143

Polymorphism and mutation databases

DMDMi74748817

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002495061 – 288Centromere protein PAdd BLAST288

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei38PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ6IPU0
MaxQBiQ6IPU0
PaxDbiQ6IPU0
PeptideAtlasiQ6IPU0
PRIDEiQ6IPU0

PTM databases

iPTMnetiQ6IPU0
PhosphoSitePlusiQ6IPU0

Expressioni

Gene expression databases

BgeeiENSG00000188312
CleanExiHS_CENPP
ExpressionAtlasiQ6IPU0 baseline and differential
GenevisibleiQ6IPU0 HS

Organism-specific databases

HPAiHPA021787
HPA058945

Interactioni

Subunit structurei

Component of the CENPA-CAD complex, composed of CENPI, CENPK, CENPL, CENPO, CENPP, CENPQ, CENPR and CENPS. The CENPA-CAD complex interacts with the CENPA-NAC complex, at least composed of CENPA, CENPC, CENPH, CENPM, CENPN, CENPT and CENPU.2 Publications

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi13513821 interactors.
CORUMiQ6IPU0
IntActiQ6IPU0 29 interactors.
STRINGi9606.ENSP00000364737

Structurei

3D structure databases

ProteinModelPortaliQ6IPU0
SMRiQ6IPU0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili1 – 71Sequence analysisAdd BLAST71

Sequence similaritiesi

Belongs to the CENP-P/CTF19 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IJM3 Eukaryota
ENOG410YMCC LUCA
GeneTreeiENSGT00390000011897
HOGENOMiHOG000060252
HOVERGENiHBG081087
InParanoidiQ6IPU0
KOiK11508
OMAiTFLHFKA
OrthoDBiEOG091G0P30
PhylomeDBiQ6IPU0
TreeFamiTF333784

Family and domain databases

InterProiView protein in InterPro
IPR027801 CENP-P
PANTHERiPTHR28577 PTHR28577, 1 hit
PfamiView protein in Pfam
PF13096 CENP-P, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6IPU0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDAELAEVRA LQAEIAALRR ACEDPPAPWE EKSRVQKSFQ AIHQFNLEGW
60 70 80 90 100
KSSKDLKNQL GHLESELSFL STLTGINIRN HSKQTEDLTS TEMTEKSIRK
110 120 130 140 150
VLQRHRLSGN CHMVTFQLEF QILEIQNKER LSSAVTDLNI IMEPTECSEL
160 170 180 190 200
SEFVSRAEER KDLFMFFRSL HFFVEWFEYR KRTFKHLKEK YPDAVYLSEG
210 220 230 240 250
PSSCSMGIRS ASRPGFELVI VWRIQIDEDG KVFPKLDLLT KVPQRALELD
260 270 280
KNRAIETAPL SFRTLVGLLG IEAALESLIK SLCAEENN
Length:288
Mass (Da):33,165
Last modified:July 5, 2004 - v1
Checksum:i19D32EF404E9EA7D
GO
Isoform 2 (identifier: Q6IPU0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-15: MDAELAEVRALQAEI → MEAPSWSVLQRSGDE
     16-188: Missing.

Note: No experimental confirmation available.
Show »
Length:115
Mass (Da):12,707
Checksum:iD9A41D07618853DF
GO

Sequence cautioni

The sequence CAI12591 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAI12592 differs from that shown. Reason: Erroneous gene model prediction.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0553681 – 15MDAEL…LQAEI → MEAPSWSVLQRSGDE in isoform 2. 1 PublicationAdd BLAST15
Alternative sequenceiVSP_05536916 – 188Missing in isoform 2. 1 PublicationAdd BLAST173

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK091247 mRNA Translation: BAG52317.1
AK092603 mRNA Translation: BAG52579.1
AL157827 Genomic DNA Translation: CAI12591.1 Sequence problems.
AL157827 Genomic DNA Translation: CAI12592.1 Sequence problems.
AL157827, AL136097, AL137848 Genomic DNA Translation: CAI12594.1
AL137848, AL136097, AL157827 Genomic DNA Translation: CAI16699.1
AL136097, AL137848, AL157827 Genomic DNA Translation: CAI16210.1
BC071726 mRNA Translation: AAH71726.1
CCDSiCCDS35063.1 [Q6IPU0-1]
CCDS69618.1 [Q6IPU0-2]
RefSeqiNP_001012267.1, NM_001012267.2 [Q6IPU0-1]
NP_001273900.1, NM_001286971.1 [Q6IPU0-2]
UniGeneiHs.713775

Genome annotation databases

EnsembliENST00000375579; ENSP00000364729; ENSG00000188312 [Q6IPU0-2]
ENST00000375587; ENSP00000364737; ENSG00000188312 [Q6IPU0-1]
GeneIDi401541
KEGGihsa:401541
UCSCiuc004arz.5 human [Q6IPU0-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiCENPP_HUMAN
AccessioniPrimary (citable) accession number: Q6IPU0
Secondary accession number(s): B3KRA5
, B3KS17, Q5T9F8, Q5T9F9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 19, 2006
Last sequence update: July 5, 2004
Last modified: April 25, 2018
This is version 121 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome