ID GAR5A_HUMAN Reviewed; 247 AA. AC Q6IPT2; Q96EJ5; Q9BSM9; DT 20-MAY-2008, integrated into UniProtKB/Swiss-Prot. DT 20-MAY-2008, sequence version 2. DT 27-MAR-2024, entry version 126. DE RecName: Full=Golgi-associated RAB2 interactor protein 5A {ECO:0000305}; GN Name=GARIN5A {ECO:0000312|HGNC:HGNC:25107}; Synonyms=FAM71E1; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., RA Hunkapiller M.W., Myers E.W., Venter J.C.; RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases. RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), AND NUCLEOTIDE SEQUENCE RP [LARGE SCALE MRNA] OF 31-247 (ISOFORM 1). RC TISSUE=Brain, Ovary, and Pancreas; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA project: RT the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). CC -!- FUNCTION: RAB2B effector protein which promotes cytosolic DNA-induced CC innate immune responses. Regulates IFN responses against DNA viruses by CC regulating the CGAS-STING signaling axis. CC {ECO:0000250|UniProtKB:A1L3C1}. CC -!- SUBUNIT: Interacts (via N-terminus) with RAB2B (in GTP-bound form). CC {ECO:0000250|UniProtKB:A1L3C1}. CC -!- SUBCELLULAR LOCATION: Golgi apparatus {ECO:0000250|UniProtKB:A1L3C1}. CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=2; CC Name=1; CC IsoId=Q6IPT2-1; Sequence=Displayed; CC Name=2; CC IsoId=Q6IPT2-2; Sequence=VSP_033760; CC -!- SIMILARITY: Belongs to the GARIN family. {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; CH471135; EAW71869.1; -; Genomic_DNA. DR EMBL; BC004941; AAH04941.1; -; mRNA. DR EMBL; BC012203; AAH12203.1; -; mRNA. DR EMBL; BC071737; AAH71737.1; -; mRNA. DR CCDS; CCDS33081.1; -. [Q6IPT2-2] DR CCDS; CCDS77337.1; -. [Q6IPT2-1] DR RefSeq; NP_001295358.1; NM_001308429.1. [Q6IPT2-1] DR RefSeq; NP_612420.1; NM_138411.2. [Q6IPT2-2] DR AlphaFoldDB; Q6IPT2; -. DR BioGRID; 125198; 2. DR IntAct; Q6IPT2; 1. DR STRING; 9606.ENSP00000472421; -. DR PhosphoSitePlus; Q6IPT2; -. DR BioMuta; FAM71E1; -. DR DMDM; 189037931; -. DR MassIVE; Q6IPT2; -. DR PaxDb; 9606-ENSP00000471272; -. DR PeptideAtlas; Q6IPT2; -. DR ProteomicsDB; 66457; -. [Q6IPT2-1] DR ProteomicsDB; 66458; -. [Q6IPT2-2] DR Antibodypedia; 68558; 1 antibodies from 1 providers. DR DNASU; 112703; -. DR Ensembl; ENST00000595790.5; ENSP00000471272.2; ENSG00000142530.11. [Q6IPT2-2] DR Ensembl; ENST00000600100.6; ENSP00000472421.2; ENSG00000142530.11. [Q6IPT2-1] DR GeneID; 112703; -. DR KEGG; hsa:112703; -. DR MANE-Select; ENST00000600100.6; ENSP00000472421.2; NM_001308429.2; NP_001295358.1. DR UCSC; uc002psg.3; human. [Q6IPT2-1] DR AGR; HGNC:25107; -. DR CTD; 112703; -. DR GeneCards; GARIN5A; -. DR HGNC; HGNC:25107; GARIN5A. DR HPA; ENSG00000142530; Tissue enriched (testis). DR MalaCards; GARIN5A; -. DR MIM; 619890; gene. DR neXtProt; NX_Q6IPT2; -. DR OpenTargets; ENSG00000142530; -. DR VEuPathDB; HostDB:ENSG00000142530; -. DR eggNOG; ENOG502S585; Eukaryota. DR GeneTree; ENSGT00940000162319; -. DR InParanoid; Q6IPT2; -. DR OMA; VQFCPHI; -. DR OrthoDB; 4589933at2759; -. DR PhylomeDB; Q6IPT2; -. DR TreeFam; TF336050; -. DR PathwayCommons; Q6IPT2; -. DR BioGRID-ORCS; 112703; 35 hits in 1153 CRISPR screens. DR GenomeRNAi; 112703; -. DR Pharos; Q6IPT2; Tdark. DR PRO; PR:Q6IPT2; -. DR Proteomes; UP000005640; Chromosome 19. DR RNAct; Q6IPT2; Protein. DR Bgee; ENSG00000142530; Expressed in left testis and 114 other cell types or tissues. DR ExpressionAtlas; Q6IPT2; baseline and differential. DR GO; GO:0005794; C:Golgi apparatus; ISS:UniProtKB. DR GO; GO:0051607; P:defense response to virus; ISS:UniProtKB. DR GO; GO:0045087; P:innate immune response; ISS:UniProtKB. DR GO; GO:0032481; P:positive regulation of type I interferon production; ISS:UniProtKB. DR InterPro; IPR022168; GARIL-like_Rab2B-bd. DR PANTHER; PTHR22574:SF5; GOLGI ASSOCIATED RAB2 INTERACTOR PROTEIN 5A; 1. DR PANTHER; PTHR22574; UNCHARACTERIZED; 1. DR Pfam; PF12480; GARIL_Rab2_bd; 1. DR Genevisible; Q6IPT2; HS. PE 2: Evidence at transcript level; KW Alternative splicing; Golgi apparatus; Reference proteome. FT CHAIN 1..247 FT /note="Golgi-associated RAB2 interactor protein 5A" FT /id="PRO_0000334697" FT REGION 1..22 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 60..92 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 1..19 FT /note="Pro residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT VAR_SEQ 121..136 FT /note="Missing (in isoform 2)" FT /evidence="ECO:0000303|PubMed:15489334" FT /id="VSP_033760" FT VARIANT 206 FT /note="S -> I (in dbSNP:rs736769)" FT /id="VAR_043465" SQ SEQUENCE 247 AA; 27609 MW; ADACD74E710CB6C3 CRC64; MGPPLWPDLQ EPPPPGTSSQ IRSPLLCDVI KPAPHHDVTV RVVPPPRFLP LLLRPLPSDG DIAMRRDRGP KPALGGAGEV EPGGMAASPT GRPRRLQRYL QSGEFDQFRD FPIFESNFVQ FCPDIYPAPT SDLWPQVTRL GEVANEVTMG VAASSPALEL PDLLLLAGPA KENGHLQLFG LFPLKFVQLF VHDKSRCQLE VKLNTSRTFY LQLRAPLKTR DREFGQWVRL LYRLRFLSAS AVPFTQE //