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Protein

Protein FAM71E1

Gene

FAM71E1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Protein FAM71E1
Gene namesi
Name:FAM71E1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:25107. FAM71E1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000142530.
PharmGKBiPA162387782.

Polymorphism and mutation databases

BioMutaiFAM71E1.
DMDMi189037931.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003346971 – 247Protein FAM71E1Add BLAST247

Proteomic databases

PRIDEiQ6IPT2.

PTM databases

PhosphoSitePlusiQ6IPT2.

Expressioni

Gene expression databases

BgeeiENSG00000142530.
CleanExiHS_FAM71E1.
ExpressionAtlasiQ6IPT2. baseline and differential.
GenevisibleiQ6IPT2. HS.

Organism-specific databases

HPAiHPA043262.
HPA048111.

Structurei

3D structure databases

ProteinModelPortaliQ6IPT2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the FAM71 family.Curated

Phylogenomic databases

GeneTreeiENSGT00530000063078.
HOGENOMiHOG000112465.
HOVERGENiHBG107890.
InParanoidiQ6IPT2.
OMAiFPLKFVQ.
OrthoDBiEOG091G0EE4.
PhylomeDBiQ6IPT2.
TreeFamiTF336050.

Family and domain databases

InterProiIPR022168. DUF3699.
[Graphical view]
PfamiPF12480. DUF3699. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6IPT2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGPPLWPDLQ EPPPPGTSSQ IRSPLLCDVI KPAPHHDVTV RVVPPPRFLP
60 70 80 90 100
LLLRPLPSDG DIAMRRDRGP KPALGGAGEV EPGGMAASPT GRPRRLQRYL
110 120 130 140 150
QSGEFDQFRD FPIFESNFVQ FCPDIYPAPT SDLWPQVTRL GEVANEVTMG
160 170 180 190 200
VAASSPALEL PDLLLLAGPA KENGHLQLFG LFPLKFVQLF VHDKSRCQLE
210 220 230 240
VKLNTSRTFY LQLRAPLKTR DREFGQWVRL LYRLRFLSAS AVPFTQE
Length:247
Mass (Da):27,609
Last modified:May 20, 2008 - v2
Checksum:iADACD74E710CB6C3
GO
Isoform 2 (identifier: Q6IPT2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     121-136: Missing.

Show »
Length:231
Mass (Da):25,777
Checksum:i480EC8F78AA7A2AB
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_043465206S → I.Corresponds to variant rs736769dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_033760121 – 136Missing in isoform 2. 1 PublicationAdd BLAST16

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH471135 Genomic DNA. Translation: EAW71869.1.
BC004941 mRNA. Translation: AAH04941.1.
BC012203 mRNA. Translation: AAH12203.1.
BC071737 mRNA. Translation: AAH71737.1.
CCDSiCCDS33081.1. [Q6IPT2-2]
CCDS77337.1. [Q6IPT2-1]
RefSeqiNP_001295358.1. NM_001308429.1. [Q6IPT2-1]
NP_612420.1. NM_138411.2. [Q6IPT2-2]
UniGeneiHs.448941.

Genome annotation databases

EnsembliENST00000595790; ENSP00000471272; ENSG00000142530. [Q6IPT2-2]
ENST00000600100; ENSP00000472421; ENSG00000142530. [Q6IPT2-1]
GeneIDi112703.
KEGGihsa:112703.
UCSCiuc002psg.3. human. [Q6IPT2-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH471135 Genomic DNA. Translation: EAW71869.1.
BC004941 mRNA. Translation: AAH04941.1.
BC012203 mRNA. Translation: AAH12203.1.
BC071737 mRNA. Translation: AAH71737.1.
CCDSiCCDS33081.1. [Q6IPT2-2]
CCDS77337.1. [Q6IPT2-1]
RefSeqiNP_001295358.1. NM_001308429.1. [Q6IPT2-1]
NP_612420.1. NM_138411.2. [Q6IPT2-2]
UniGeneiHs.448941.

3D structure databases

ProteinModelPortaliQ6IPT2.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

PhosphoSitePlusiQ6IPT2.

Polymorphism and mutation databases

BioMutaiFAM71E1.
DMDMi189037931.

Proteomic databases

PRIDEiQ6IPT2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000595790; ENSP00000471272; ENSG00000142530. [Q6IPT2-2]
ENST00000600100; ENSP00000472421; ENSG00000142530. [Q6IPT2-1]
GeneIDi112703.
KEGGihsa:112703.
UCSCiuc002psg.3. human. [Q6IPT2-1]

Organism-specific databases

CTDi112703.
GeneCardsiFAM71E1.
HGNCiHGNC:25107. FAM71E1.
HPAiHPA043262.
HPA048111.
neXtProtiNX_Q6IPT2.
OpenTargetsiENSG00000142530.
PharmGKBiPA162387782.
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00530000063078.
HOGENOMiHOG000112465.
HOVERGENiHBG107890.
InParanoidiQ6IPT2.
OMAiFPLKFVQ.
OrthoDBiEOG091G0EE4.
PhylomeDBiQ6IPT2.
TreeFamiTF336050.

Miscellaneous databases

GenomeRNAii112703.
PROiQ6IPT2.

Gene expression databases

BgeeiENSG00000142530.
CleanExiHS_FAM71E1.
ExpressionAtlasiQ6IPT2. baseline and differential.
GenevisibleiQ6IPT2. HS.

Family and domain databases

InterProiIPR022168. DUF3699.
[Graphical view]
PfamiPF12480. DUF3699. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiF71E1_HUMAN
AccessioniPrimary (citable) accession number: Q6IPT2
Secondary accession number(s): Q96EJ5, Q9BSM9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: May 20, 2008
Last modified: November 2, 2016
This is version 89 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.