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Q6IPT2 (F71E1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 70. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein FAM71E1
Gene names
Name:FAM71E1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length247 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Sequence similarities

Belongs to the FAM71 family.

Ontologies

Keywords
   Coding sequence diversityAlternative splicing
Polymorphism
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q6IPT2-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q6IPT2-2)

The sequence of this isoform differs from the canonical sequence as follows:
     121-136: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 247247Protein FAM71E1
PRO_0000334697

Natural variations

Alternative sequence121 – 13616Missing in isoform 2.
VSP_033760
Natural variant2061S → I.
Corresponds to variant rs736769 [ dbSNP | Ensembl ].
VAR_043465

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified May 20, 2008. Version 2.
Checksum: ADACD74E710CB6C3

FASTA24727,609
        10         20         30         40         50         60 
MGPPLWPDLQ EPPPPGTSSQ IRSPLLCDVI KPAPHHDVTV RVVPPPRFLP LLLRPLPSDG 

        70         80         90        100        110        120 
DIAMRRDRGP KPALGGAGEV EPGGMAASPT GRPRRLQRYL QSGEFDQFRD FPIFESNFVQ 

       130        140        150        160        170        180 
FCPDIYPAPT SDLWPQVTRL GEVANEVTMG VAASSPALEL PDLLLLAGPA KENGHLQLFG 

       190        200        210        220        230        240 
LFPLKFVQLF VHDKSRCQLE VKLNTSRTFY LQLRAPLKTR DREFGQWVRL LYRLRFLSAS 


AVPFTQE 

« Hide

Isoform 2 [UniParc].

Checksum: 480EC8F78AA7A2AB
Show »

FASTA23125,777

References

[1]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 31-247 (ISOFORM 1).
Tissue: Brain, Ovary and Pancreas.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CH471135 Genomic DNA. Translation: EAW71869.1.
BC004941 mRNA. Translation: AAH04941.1.
BC012203 mRNA. Translation: AAH12203.1.
BC071737 mRNA. Translation: AAH71737.1.
RefSeqNP_612420.1. NM_138411.1.
XP_005258529.1. XM_005258472.2.
UniGeneHs.448941.

3D structure databases

ProteinModelPortalQ6IPT2.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid125198. 1 interaction.

Polymorphism databases

DMDM189037931.

Proteomic databases

PaxDbQ6IPT2.
PRIDEQ6IPT2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000595790; ENSP00000471272; ENSG00000142530. [Q6IPT2-2]
ENST00000600100; ENSP00000472421; ENSG00000142530. [Q6IPT2-1]
GeneID112703.
KEGGhsa:112703.
UCSCuc002psg.3. human. [Q6IPT2-2]
uc002psh.3. human. [Q6IPT2-1]

Organism-specific databases

CTD112703.
GeneCardsGC19M050970.
HGNCHGNC:25107. FAM71E1.
HPAHPA043262.
HPA048111.
neXtProtNX_Q6IPT2.
PharmGKBPA162387782.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG113014.
HOGENOMHOG000112465.
HOVERGENHBG107890.
InParanoidQ6IPT2.
OMAFPLKFVQ.
OrthoDBEOG71ZP2J.
PhylomeDBQ6IPT2.
TreeFamTF336050.

Gene expression databases

ArrayExpressQ6IPT2.
BgeeQ6IPT2.
CleanExHS_FAM71E1.
GenevestigatorQ6IPT2.

Family and domain databases

InterProIPR022168. DUF3699.
[Graphical view]
PfamPF12480. DUF3699. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi112703.
NextBio78636.
PROQ6IPT2.

Entry information

Entry nameF71E1_HUMAN
AccessionPrimary (citable) accession number: Q6IPT2
Secondary accession number(s): Q96EJ5, Q9BSM9
Entry history
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: May 20, 2008
Last modified: April 16, 2014
This is version 70 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 19

Human chromosome 19: entries, gene names and cross-references to MIM