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Protein
Submitted name:

EF1a

Gene

EEF1A1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.UniRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Elongation factorUniRule annotationImported

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

GTP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Submitted name:
EF1aImported
Submitted name:
Eukaryotic translation elongation factor 1 alpha 1Imported
Submitted name:
MSTP056Imported
Submitted name:
cDNA FLJ30496 fis, clone BRAWH2000362, highly similar to ELONGATION FACTOR 1-ALPHA 1Imported
Submitted name:
cDNA FLJ45463 fis, clone BRSTN2012069, highly similar to Elongation factor 1-alpha 1Imported
Submitted name:
cDNA FLJ77689, highly similar to Homo sapiens eukaryotic translation elongation factor 1 alpha 1 (EEF1A1), mRNAImported
Submitted name:
cDNA FLJ77960, highly similar to Homo sapiens eukaryotic translation elongation factor 1 alpha 1 (EEF1A1), mRNAImported
Submitted name:
cDNA, FLJ79476, highly similar to Elongation factor 1-alpha 1Imported
Gene namesi
Name:EEF1A1Imported
ORF Names:hCG_2033271Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA27625.

PTM / Processingi

Proteomic databases

MaxQBiQ6IPS9.

Expressioni

Gene expression databases

BgeeiENSG00000156508.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000330054.

Structurei

3D structure databases

SMRiQ6IPS9. Positions 4-455.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini5 – 242238Tr-type G (guanine nucleotide-binding)InterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.UniRule annotation

Phylogenomic databases

eggNOGiKOG0052. Eukaryota.
COG5256. LUCA.
HOVERGENiHBG000179.
KOiK03231.
OMAiFEQISHE.
OrthoDBiEOG091G05LW.
PhylomeDBiQ6IPS9.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00118_A. EF_Tu_A. 1 hit.
InterProiIPR004161. EFTu-like_2.
IPR031157. G_TR_CS.
IPR027417. P-loop_NTPase.
IPR000795. TF_GTP-bd_dom.
IPR009000. Transl_B-barrel.
IPR009001. Transl_elong_EF1A/Init_IF2_C.
IPR004539. Transl_elong_EF1A_euk/arc.
IPR004160. Transl_elong_EFTu/EF1A_C.
[Graphical view]
PfamiPF03144. GTP_EFTU_D2. 1 hit.
PF03143. GTP_EFTU_D3. 1 hit.
[Graphical view]
PRINTSiPR00315. ELONGATNFCT.
SUPFAMiSSF50447. SSF50447. 1 hit.
SSF50465. SSF50465. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00483. EF-1_alpha. 1 hit.
PROSITEiPS00301. G_TR_1. 1 hit.
PS51722. G_TR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6IPS9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGKEKTHINI VVIGHVDSGK STTTGHLIYK CGGIDKRTIE KFEKEAAEMG
60 70 80 90 100
KGSFKYAWVL DKLKAERERG ITIDISLWKF ETSKYYVTII DAPGHRDFIK
110 120 130 140 150
NMITGTSQAD CAVLIVAAGV GEFEAGISKN GQTREHALLA YTLGVKQLIV
160 170 180 190 200
GVNKMDSTEP PYSQKRYEEI VKEVSTYIKK IGYNPDTVAF VPISGWNGDN
210 220 230 240 250
MLEPSANMPW FKGWKVTRKD GNASGTTLLE ALDCILPPTR PTDKPLRLPL
260 270 280 290 300
QDVYKIGGIG TVPVGRVETG VLKPGMVVTF APVNVTTEVK SVEMHHEALS
310 320 330 340 350
EALPGDNVGF NVKNVSVKDV RRGNVAGDSK NDPPMEAAGF TAQVIILNHP
360 370 380 390 400
GQISAGYAPV LDCHTAHIAC KFAELKEKID RRSGKKLEDG PKFLKSGDAA
410 420 430 440 450
IVDMVPGKPM CVESFSDYPP LGRFAVRDMR QTVAVGVIKA VDKKAAGAGK
460
VTKSAQKAQK AK
Length:462
Mass (Da):50,141
Last modified:May 10, 2005 - v1
Checksum:iD465615545AF686A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC071741 mRNA. Translation: AAH71741.1.
BC111051 mRNA. Translation: AAI11052.1.
AF116726 mRNA. Translation: AAO15302.1.
EF362804 mRNA. Translation: ABO30531.1.
AK289374 mRNA. Translation: BAF82063.1.
AK290691 mRNA. Translation: BAF83380.1.
AK315827 mRNA. Translation: BAF98718.1.
AK055058 mRNA. Translation: BAG51457.1.
AK127384 mRNA. Translation: BAG54498.1.
CH471051 Genomic DNA. Translation: EAW48759.1.
RefSeqiNP_001393.1. NM_001402.5.
XP_011533816.1. XM_011535514.2.
UniGeneiHs.535192.
Hs.586423.
Hs.745122.

Genome annotation databases

GeneIDi1915.
KEGGihsa:1915.
UCSCiuc003phi.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC071741 mRNA. Translation: AAH71741.1.
BC111051 mRNA. Translation: AAI11052.1.
AF116726 mRNA. Translation: AAO15302.1.
EF362804 mRNA. Translation: ABO30531.1.
AK289374 mRNA. Translation: BAF82063.1.
AK290691 mRNA. Translation: BAF83380.1.
AK315827 mRNA. Translation: BAF98718.1.
AK055058 mRNA. Translation: BAG51457.1.
AK127384 mRNA. Translation: BAG54498.1.
CH471051 Genomic DNA. Translation: EAW48759.1.
RefSeqiNP_001393.1. NM_001402.5.
XP_011533816.1. XM_011535514.2.
UniGeneiHs.535192.
Hs.586423.
Hs.745122.

3D structure databases

SMRiQ6IPS9. Positions 4-455.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000330054.

Proteomic databases

MaxQBiQ6IPS9.

Protocols and materials databases

DNASUi1915.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi1915.
KEGGihsa:1915.
UCSCiuc003phi.3. human.

Organism-specific databases

CTDi1915.
PharmGKBiPA27625.

Phylogenomic databases

eggNOGiKOG0052. Eukaryota.
COG5256. LUCA.
HOVERGENiHBG000179.
KOiK03231.
OMAiFEQISHE.
OrthoDBiEOG091G05LW.
PhylomeDBiQ6IPS9.

Miscellaneous databases

ChiTaRSiEEF1A1. human.
GenomeRNAii1915.

Gene expression databases

BgeeiENSG00000156508.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00118_A. EF_Tu_A. 1 hit.
InterProiIPR004161. EFTu-like_2.
IPR031157. G_TR_CS.
IPR027417. P-loop_NTPase.
IPR000795. TF_GTP-bd_dom.
IPR009000. Transl_B-barrel.
IPR009001. Transl_elong_EF1A/Init_IF2_C.
IPR004539. Transl_elong_EF1A_euk/arc.
IPR004160. Transl_elong_EFTu/EF1A_C.
[Graphical view]
PfamiPF03144. GTP_EFTU_D2. 1 hit.
PF03143. GTP_EFTU_D3. 1 hit.
[Graphical view]
PRINTSiPR00315. ELONGATNFCT.
SUPFAMiSSF50447. SSF50447. 1 hit.
SSF50465. SSF50465. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00483. EF-1_alpha. 1 hit.
PROSITEiPS00301. G_TR_1. 1 hit.
PS51722. G_TR_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ6IPS9_HUMAN
AccessioniPrimary (citable) accession number: Q6IPS9
Entry historyi
Integrated into UniProtKB/TrEMBL: May 10, 2005
Last sequence update: May 10, 2005
Last modified: September 7, 2016
This is version 125 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.