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Reviewed, UniProtKB/Swiss-Prot Q6IP76 (AKT2B_XENLA)

Last modified June 16, 2009. Version 43. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    RAC-beta serine/threonine-protein kinase B
    EC=2.7.11.1
Alternative name(s):
    RAC-PK-beta-B
    Protein kinase Akt-2-B
    Protein kinase B, beta-B
      Short name=PKB beta-B
Gene names
Name: akt2-B
OrganismXenopus laevis (African clawed frog)
Taxonomic identifier8355 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Mesobatrachia › Pipoidea › Pipidae › Xenopodinae › Xenopus › Xenopus

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Protein attributes

Sequence length485 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at transcript level.

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General annotation (Comments)

Function

General protein kinase capable of phosphorylating several known proteins By similarity.

Catalytic activity

ATP + a protein = ADP + a phosphoprotein. UniProtKB Q60823

Enzyme regulation

Two specific sites, one in the kinase domain (Thr-313) and the other in the C-terminal regulatory region (Ser-478), need to be phosphorylated for its full activation By similarity.

Sequence similarities

Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. RAC subfamily.

Contains 1 AGC-kinase C-terminal domain.

Contains 1 PH domain.

Contains 1 protein kinase domain.

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 485485RAC-beta serine/threonine-protein kinase B
PRO_0000223509

Regions

Domain5 – 109105PH
Domain156 – 413258Protein kinase
Domain414 – 48572AGC-kinase C-terminal
Nucleotide binding162 – 1709ATP By similarity

Sites

Active site2791Proton acceptor By similarity
Binding site1851ATP By similarity

Amino acid modifications

Modified residue3131Phosphothreonine By similarity
Modified residue4781Phosphoserine By similarity

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Sequences

Sequence LengthMass (Da)Tools
Q6IP76-1 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: 27D584109098CC56

FASTA48556,024
        10         20         30         40         50         60 
MNEVMVIKEG WLQKRGEYIK TWRPRYFLLK SDGSFIGYKE KPDSTEHSLL PPLNNFSVAE 

        70         80         90        100        110        120 
CQLMKTERPR PNTFVIRCLQ WTTVIERTFH VDTPEEREEW IIAIQTVANG LKNQVPEDEE 

       130        140        150        160        170        180 
EEAMEVKYGS PSDVSSAEQM DVAMSKGRPK VTMNDFDYLK LLGKGTFGKV ILVREKATGL 

       190        200        210        220        230        240 
YYAMKILRKE VIIAKDEVAH TLTESRVLQN TKHPFLTGLK YAFQTSDRLC FVMEYANGGE 

       250        260        270        280        290        300 
LFFHLSRERV FTEDRARFYG AEIVSALEYL HSRNVVYRDI KLENLMLDKD GHVKITDFGL 

       310        320        330        340        350        360 
CKEGITDGAT MRTFCGTPEY LAPEVLEDND YGRAVDWWGL GVVMYEMMCG RLPFYNQDHE 

       370        380        390        400        410        420 
RLFELILMEE TRFPRTLSPE AKSLLAGLLK KDPKQRLGGG PDDAQEVMSH GFFASINWQD 

       430        440        450        460        470        480 
VTERKLSPPF KPQVTSEIDT RYFDDEFTAQ SITLTPPDRY DNLDALESEQ RPHFPQFSYS 


SSIRE

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References

[1]NIH - Xenopus Gene Collection (XGC) project
Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Spleen.

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Cross-references

Sequence databases

BC072041 mRNA. Translation: AAH72041.1.
RefSeqNP_001085101.1.
UniGeneXl.62681

3D structure databases

HSSPHSSP built from PDB template 1ATP based on UniProtKB P05132.
SMRQ6IP76. Positions 1-112.
ModBaseSearch...

Genome annotation databases

GeneID432172.
KEGGxla:432172.

Phylogenomic databases

HOVERGENQ6IP76.

Enzyme and pathway databases

BRENDA2.7.11.1. 648.

Family and domain databases

InterProIPR000961. AGC-kinase_C.
IPR011993. PH_type.
IPR017892. Pkinase_C.
IPR001849. Pleckstrin_homology.
IPR000719. Prot_kinase_core.
IPR017441. Protein_kinase_ATP_BS.
IPR017442. Se/Thr_pkinase-rel.
IPR008271. Ser_thr_pkin_AS.
IPR002290. Ser_thr_pkinase.
IPR015744. Serine/threonine_Kinase_Rac.
[Graphical view]
Gene3DG3DSA:2.30.29.30. PH_type. 1 hit.
PANTHERPTHR22985:SF69. Akt. 1 hit.
PfamPF00169. PH. 1 hit.
PF00069. Pkinase. 1 hit.
PF00433. Pkinase_C. 1 hit.
[Graphical view]
ProDomPD000001. Prot_kinase. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTSM00233. PH. 1 hit.
SM00133. S_TK_X. 1 hit.
SM00220. S_TKc. 1 hit.
[Graphical view]
PROSITEPS51285. AGC_KINASE_CTER. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry nameAKT2B_XENLA
AccessionPrimary (citable) accession number: Q6IP76
Entry history
Integrated into UniProtKB/Swiss-Prot: February 21, 2006
Last sequence update: July 5, 2004
Last modified: June 16, 2009
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectXenopus annotation project

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Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents