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Q6INW9 (IGF2B_XENLA) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 54. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Insulin-like growth factor II-B

Short name=IGF-II-B
Alternative name(s):
Insulin-like growth factor 2-B
Gene names
Name:igf2-b
OrganismXenopus laevis (African clawed frog)
Taxonomic identifier8355 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Protein attributes

Sequence length217 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. Promotes anterior neural development By similarity. UniProtKB Q90WW4

Subcellular location

Secreted By similarity.

Sequence similarities

Belongs to the insulin family.

Sequence caution

The sequence AAH72153.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Biological processDifferentiation
Neurogenesis
   Cellular componentSecreted
   DomainSignal
   Molecular functionDevelopmental protein
Growth factor
   PTMDisulfide bond
Gene Ontology (GO)
   Biological_processcell differentiation

Inferred from electronic annotation. Source: UniProtKB-KW

head morphogenesis

Inferred from sequence or structural similarity. Source: UniProtKB

nervous system development

Inferred from sequence or structural similarity. Source: UniProtKB

   Cellular_componentextracellular space

Inferred from electronic annotation. Source: InterPro

   Molecular_functiongrowth factor activity

Inferred from sequence or structural similarity. Source: UniProtKB

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 5656 Potential
Chain57 – 12367Insulin-like growth factor II-B
PRO_0000224641
Propeptide124 – 21794E peptide
PRO_0000224642

Regions

Region57 – 8327B
Region84 – 9613C
Region97 – 11721A
Region118 – 1236D

Amino acid modifications

Disulfide bond64 ↔ 103 By similarity UniProtKB P01344
Disulfide bond76 ↔ 116 By similarity UniProtKB P01344
Disulfide bond102 ↔ 107 By similarity UniProtKB P01344

Sequences

Sequence LengthMass (Da)Tools
Q6INW9 [UniParc].

Last modified March 7, 2006. Version 2.
Checksum: EF7E476198C7B6F8

FASTA21725,078
        10         20         30         40         50         60 
MEQLSCKHRS SSMEAEAQLC RQTESRSTQL PRMSVMRHLF LLSITFLVYT LDSAKAYRPT 

        70         80         90        100        110        120 
ETLCGGELVD TLQFVCGDRG FYFSTNNGRS NRRSNRGIVE ECCFRSCDLE LLETYCAKPS 

       130        140        150        160        170        180 
KNERDVSTAP ATAIPPMNKQ DLYHKHHHTK SSKYDIWQRK SIHRLRRGVP AIVRARQYRL 

       190        200        210 
LMQKAEESEQ ALLHRPLTTL PITRPLHLQQ TSEPSHN 

« Hide

References

[1]NIH - Xenopus Gene Collection (XGC) project
Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Spleen.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC072153 mRNA. Translation: AAH72153.1. Different initiation.
RefSeqNP_001085129.2. NM_001091660.1.
UniGeneXl.47110.

3D structure databases

ProteinModelPortalQ6INW9.
SMRQ6INW9. Positions 56-123.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEQ6INW9.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID432206.
KEGGxla:432206.

Organism-specific databases

CTD432206.
XenbaseXB-GENE-864886. igf2.

Phylogenomic databases

HOVERGENHBG006137.
KOK13769.

Family and domain databases

Gene3D1.10.100.10. 1 hit.
InterProIPR022334. IGF2.
IPR013576. IGF2_C.
IPR016179. Insulin-like.
IPR022350. Insulin-like_growth_factor.
IPR022353. Insulin_CS.
IPR022352. Insulin_family.
[Graphical view]
PfamPF08365. IGF2_C. 1 hit.
PF00049. Insulin. 2 hits.
[Graphical view]
PRINTSPR02002. INSLNLIKEGF.
PR02006. INSLNLIKEGF2.
PR00276. INSULINFAMLY.
ProDomPD005188. IGF2_C. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTSM00078. IlGF. 1 hit.
[Graphical view]
SUPFAMSSF56994. SSF56994. 1 hit.
PROSITEPS00262. INSULIN. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameIGF2B_XENLA
AccessionPrimary (citable) accession number: Q6INW9
Entry history
Integrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: March 7, 2006
Last modified: October 16, 2013
This is version 54 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families