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Q6INW9

- IGF2B_XENLA

UniProt

Q6INW9 - IGF2B_XENLA

Protein

Insulin-like growth factor II-B

Gene

igf2-b

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 55 (01 Oct 2014)
      Sequence version 2 (07 Mar 2006)
      Previous versions | rss
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    Functioni

    The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. Promotes anterior neural development By similarity.By similarityCurated

    GO - Molecular functioni

    1. growth factor activity Source: UniProtKB

    GO - Biological processi

    1. cell differentiation Source: UniProtKB-KW
    2. head morphogenesis Source: UniProtKB
    3. nervous system development Source: UniProtKB

    Keywords - Molecular functioni

    Developmental protein, Growth factor

    Keywords - Biological processi

    Differentiation, Neurogenesis

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Insulin-like growth factor II-B
    Short name:
    IGF-II-B
    Alternative name(s):
    Insulin-like growth factor 2-B
    Gene namesi
    Name:igf2-b
    OrganismiXenopus laevis (African clawed frog)
    Taxonomic identifieri8355 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

    Organism-specific databases

    XenbaseiXB-GENE-864886. igf2.

    Subcellular locationi

    Secreted By similarity

    GO - Cellular componenti

    1. extracellular space Source: InterPro

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 5656Sequence AnalysisAdd
    BLAST
    Chaini57 – 12367Insulin-like growth factor II-BSequence AnalysisPRO_0000224641Add
    BLAST
    Propeptidei124 – 21794E peptideSequence AnalysisPRO_0000224642Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi64 ↔ 103By similarity
    Disulfide bondi76 ↔ 116By similarity
    Disulfide bondi102 ↔ 107By similarity

    Keywords - PTMi

    Disulfide bond

    Proteomic databases

    PRIDEiQ6INW9.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6INW9.
    SMRiQ6INW9. Positions 56-123.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni57 – 8327BSequence AnalysisAdd
    BLAST
    Regioni84 – 9613CSequence AnalysisAdd
    BLAST
    Regioni97 – 11721ASequence AnalysisAdd
    BLAST
    Regioni118 – 1236DSequence Analysis

    Sequence similaritiesi

    Belongs to the insulin family.Sequence Analysis

    Keywords - Domaini

    Signal

    Phylogenomic databases

    HOVERGENiHBG006137.
    KOiK13769.

    Family and domain databases

    Gene3Di1.10.100.10. 1 hit.
    InterProiIPR022334. IGF2.
    IPR013576. IGF2_C.
    IPR016179. Insulin-like.
    IPR022350. Insulin-like_growth_factor.
    IPR022353. Insulin_CS.
    IPR022352. Insulin_family.
    [Graphical view]
    PfamiPF08365. IGF2_C. 1 hit.
    PF00049. Insulin. 2 hits.
    [Graphical view]
    PRINTSiPR02002. INSLNLIKEGF.
    PR02006. INSLNLIKEGF2.
    PR00276. INSULINFAMLY.
    ProDomiPD005188. IGF2_C. 1 hit.
    [Graphical view] [Entries sharing at least one domain]
    SMARTiSM00078. IlGF. 1 hit.
    [Graphical view]
    SUPFAMiSSF56994. SSF56994. 1 hit.
    PROSITEiPS00262. INSULIN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q6INW9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEQLSCKHRS SSMEAEAQLC RQTESRSTQL PRMSVMRHLF LLSITFLVYT    50
    LDSAKAYRPT ETLCGGELVD TLQFVCGDRG FYFSTNNGRS NRRSNRGIVE 100
    ECCFRSCDLE LLETYCAKPS KNERDVSTAP ATAIPPMNKQ DLYHKHHHTK 150
    SSKYDIWQRK SIHRLRRGVP AIVRARQYRL LMQKAEESEQ ALLHRPLTTL 200
    PITRPLHLQQ TSEPSHN 217
    Length:217
    Mass (Da):25,078
    Last modified:March 7, 2006 - v2
    Checksum:iEF7E476198C7B6F8
    GO

    Sequence cautioni

    The sequence AAH72153.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC072153 mRNA. Translation: AAH72153.1. Different initiation.
    RefSeqiNP_001085129.2. NM_001091660.1.
    UniGeneiXl.47110.

    Genome annotation databases

    GeneIDi432206.
    KEGGixla:432206.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC072153 mRNA. Translation: AAH72153.1 . Different initiation.
    RefSeqi NP_001085129.2. NM_001091660.1.
    UniGenei Xl.47110.

    3D structure databases

    ProteinModelPortali Q6INW9.
    SMRi Q6INW9. Positions 56-123.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi Q6INW9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 432206.
    KEGGi xla:432206.

    Organism-specific databases

    CTDi 432206.
    Xenbasei XB-GENE-864886. igf2.

    Phylogenomic databases

    HOVERGENi HBG006137.
    KOi K13769.

    Family and domain databases

    Gene3Di 1.10.100.10. 1 hit.
    InterProi IPR022334. IGF2.
    IPR013576. IGF2_C.
    IPR016179. Insulin-like.
    IPR022350. Insulin-like_growth_factor.
    IPR022353. Insulin_CS.
    IPR022352. Insulin_family.
    [Graphical view ]
    Pfami PF08365. IGF2_C. 1 hit.
    PF00049. Insulin. 2 hits.
    [Graphical view ]
    PRINTSi PR02002. INSLNLIKEGF.
    PR02006. INSLNLIKEGF2.
    PR00276. INSULINFAMLY.
    ProDomi PD005188. IGF2_C. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    SMARTi SM00078. IlGF. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56994. SSF56994. 1 hit.
    PROSITEi PS00262. INSULIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. NIH - Xenopus Gene Collection (XGC) project
      Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: SpleenImported.

    Entry informationi

    Entry nameiIGF2B_XENLA
    AccessioniPrimary (citable) accession number: Q6INW9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 7, 2006
    Last sequence update: March 7, 2006
    Last modified: October 1, 2014
    This is version 55 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3