Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Insulin-like growth factor II-B

Gene

igf2-b

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. Promotes anterior neural development. Acts as a ligand for integrin which is required for IGF2 signaling.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei79Important for interaction with integrinBy similarity1
Sitei89Important for interaction with integrinBy similarity1
Sitei92Important for interaction with integrinBy similarity1
Sitei93Important for interaction with integrinBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, Growth factor
Biological processDifferentiation, Neurogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Insulin-like growth factor II-B
Short name:
IGF-II-B
Alternative name(s):
Insulin-like growth factor 2-B
Gene namesi
Name:igf2-b
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-864886 igf2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 56Sequence analysisAdd BLAST56
ChainiPRO_000022464157 – 123Insulin-like growth factor II-BSequence analysisAdd BLAST67
PropeptideiPRO_0000224642124 – 217E peptideSequence analysisAdd BLAST94

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi64 ↔ 103By similarity
Disulfide bondi76 ↔ 116By similarity
Disulfide bondi102 ↔ 107By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PRIDEiQ6INW9

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliQ6INW9
SMRiQ6INW9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni57 – 83BSequence analysisAdd BLAST27
Regioni84 – 96CSequence analysisAdd BLAST13
Regioni97 – 117ASequence analysisAdd BLAST21
Regioni118 – 123DSequence analysis6

Sequence similaritiesi

Belongs to the insulin family.Sequence analysis

Keywords - Domaini

Signal

Phylogenomic databases

HOVERGENiHBG006137
KOiK13769

Family and domain databases

InterProiView protein in InterPro
IPR022334 IGF2
IPR013576 IGF2_C
IPR016179 Insulin-like
IPR022350 Insulin-like_growth_factor
IPR036438 Insulin-like_sf
IPR022353 Insulin_CS
IPR022352 Insulin_family
PfamiView protein in Pfam
PF08365 IGF2_C, 1 hit
PF00049 Insulin, 2 hits
PRINTSiPR02002 INSLNLIKEGF
PR02006 INSLNLIKEGF2
PR00276 INSULINFAMLY
ProDomiView protein in ProDom or Entries sharing at least one domain
PD005188 IGF2_C, 1 hit
SMARTiView protein in SMART
SM00078 IlGF, 1 hit
SUPFAMiSSF56994 SSF56994, 1 hit
PROSITEiView protein in PROSITE
PS00262 INSULIN, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6INW9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEQLSCKHRS SSMEAEAQLC RQTESRSTQL PRMSVMRHLF LLSITFLVYT
60 70 80 90 100
LDSAKAYRPT ETLCGGELVD TLQFVCGDRG FYFSTNNGRS NRRSNRGIVE
110 120 130 140 150
ECCFRSCDLE LLETYCAKPS KNERDVSTAP ATAIPPMNKQ DLYHKHHHTK
160 170 180 190 200
SSKYDIWQRK SIHRLRRGVP AIVRARQYRL LMQKAEESEQ ALLHRPLTTL
210
PITRPLHLQQ TSEPSHN
Length:217
Mass (Da):25,078
Last modified:March 7, 2006 - v2
Checksum:iEF7E476198C7B6F8
GO

Sequence cautioni

The sequence AAH72153 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC072153 mRNA Translation: AAH72153.1 Different initiation.
RefSeqiNP_001085129.2, NM_001091660.1
UniGeneiXl.47110

Genome annotation databases

GeneIDi432206
KEGGixla:432206

Similar proteinsi

Entry informationi

Entry nameiIGF2B_XENLA
AccessioniPrimary (citable) accession number: Q6INW9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: March 7, 2006
Last modified: May 23, 2018
This is version 64 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health