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Q6INW9

- IGF2B_XENLA

UniProt

Q6INW9 - IGF2B_XENLA

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Protein
Insulin-like growth factor II-B
Gene
igf2-b
Organism
Xenopus laevis (African clawed frog)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. Promotes anterior neural development By similarity.By similarity

GO - Molecular functioni

  1. growth factor activity Source: UniProtKB
Complete GO annotation...

GO - Biological processi

  1. cell differentiation Source: UniProtKB-KW
  2. head morphogenesis Source: UniProtKB
  3. nervous system development Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Growth factor

Keywords - Biological processi

Differentiation, Neurogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Insulin-like growth factor II-B
Short name:
IGF-II-B
Alternative name(s):
Insulin-like growth factor 2-B
Gene namesi
Name:igf2-b
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-864886. igf2.

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. extracellular space Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 5656 Reviewed prediction
Add
BLAST
Chaini57 – 12367Insulin-like growth factor II-B
PRO_0000224641Add
BLAST
Propeptidei124 – 21794E peptide
PRO_0000224642Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi64 ↔ 103 By similarityBy similarity
Disulfide bondi76 ↔ 116 By similarityBy similarity
Disulfide bondi102 ↔ 107 By similarityBy similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PRIDEiQ6INW9.

Structurei

3D structure databases

ProteinModelPortaliQ6INW9.
SMRiQ6INW9. Positions 56-123.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni57 – 8327B
Add
BLAST
Regioni84 – 9613C
Add
BLAST
Regioni97 – 11721A
Add
BLAST
Regioni118 – 1236D

Sequence similaritiesi

Belongs to the insulin family.

Keywords - Domaini

Signal

Phylogenomic databases

HOVERGENiHBG006137.
KOiK13769.

Family and domain databases

Gene3Di1.10.100.10. 1 hit.
InterProiIPR022334. IGF2.
IPR013576. IGF2_C.
IPR016179. Insulin-like.
IPR022350. Insulin-like_growth_factor.
IPR022353. Insulin_CS.
IPR022352. Insulin_family.
[Graphical view]
PfamiPF08365. IGF2_C. 1 hit.
PF00049. Insulin. 2 hits.
[Graphical view]
PRINTSiPR02002. INSLNLIKEGF.
PR02006. INSLNLIKEGF2.
PR00276. INSULINFAMLY.
ProDomiPD005188. IGF2_C. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00078. IlGF. 1 hit.
[Graphical view]
SUPFAMiSSF56994. SSF56994. 1 hit.
PROSITEiPS00262. INSULIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6INW9-1 [UniParc]FASTAAdd to Basket

« Hide

MEQLSCKHRS SSMEAEAQLC RQTESRSTQL PRMSVMRHLF LLSITFLVYT    50
LDSAKAYRPT ETLCGGELVD TLQFVCGDRG FYFSTNNGRS NRRSNRGIVE 100
ECCFRSCDLE LLETYCAKPS KNERDVSTAP ATAIPPMNKQ DLYHKHHHTK 150
SSKYDIWQRK SIHRLRRGVP AIVRARQYRL LMQKAEESEQ ALLHRPLTTL 200
PITRPLHLQQ TSEPSHN 217
Length:217
Mass (Da):25,078
Last modified:March 7, 2006 - v2
Checksum:iEF7E476198C7B6F8
GO

Sequence cautioni

The sequence AAH72153.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC072153 mRNA. Translation: AAH72153.1. Different initiation.
RefSeqiNP_001085129.2. NM_001091660.1.
UniGeneiXl.47110.

Genome annotation databases

GeneIDi432206.
KEGGixla:432206.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC072153 mRNA. Translation: AAH72153.1 . Different initiation.
RefSeqi NP_001085129.2. NM_001091660.1.
UniGenei Xl.47110.

3D structure databases

ProteinModelPortali Q6INW9.
SMRi Q6INW9. Positions 56-123.
ModBasei Search...

Proteomic databases

PRIDEi Q6INW9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 432206.
KEGGi xla:432206.

Organism-specific databases

CTDi 432206.
Xenbasei XB-GENE-864886. igf2.

Phylogenomic databases

HOVERGENi HBG006137.
KOi K13769.

Family and domain databases

Gene3Di 1.10.100.10. 1 hit.
InterProi IPR022334. IGF2.
IPR013576. IGF2_C.
IPR016179. Insulin-like.
IPR022350. Insulin-like_growth_factor.
IPR022353. Insulin_CS.
IPR022352. Insulin_family.
[Graphical view ]
Pfami PF08365. IGF2_C. 1 hit.
PF00049. Insulin. 2 hits.
[Graphical view ]
PRINTSi PR02002. INSLNLIKEGF.
PR02006. INSLNLIKEGF2.
PR00276. INSULINFAMLY.
ProDomi PD005188. IGF2_C. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
SMARTi SM00078. IlGF. 1 hit.
[Graphical view ]
SUPFAMi SSF56994. SSF56994. 1 hit.
PROSITEi PS00262. INSULIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. NIH - Xenopus Gene Collection (XGC) project
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Spleen.

Entry informationi

Entry nameiIGF2B_XENLA
AccessioniPrimary (citable) accession number: Q6INW9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: March 7, 2006
Last modified: October 16, 2013
This is version 54 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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