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Protein
Submitted name:

MGC80376 protein

Gene

ikbkb

Organism
Xenopus laevis (African clawed frog)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. ATP binding Source: InterPro
  2. IkappaB kinase activity Source: InterPro
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
MGC80376 proteinImported
Gene namesi
Name:ikbkbImported
Synonyms:MGC80376Imported
OrganismiXenopus laevis (African clawed frog)Imported
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-949882. ikbkb.

Interactioni

Protein-protein interaction databases

DIPiDIP-59194N.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3QA8X-ray3.60A/B/C/D/E/F/G/H1-659[»]
3RZFX-ray4.00A1-659[»]
ProteinModelPortaliQ6INT1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

HOVERGENiHBG018241.
KOiK07209.

Family and domain databases

InterProiIPR022007. IKKbetaNEMObind.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
IPR000626. Ubiquitin-like.
IPR029071. Ubiquitin-rel_dom.
[Graphical view]
PfamiPF12179. IKKbetaNEMObind. 1 hit.
PF00069. Pkinase. 1 hit.
[Graphical view]
SUPFAMiSSF54236. SSF54236. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
PS50053. UBIQUITIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6INT1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKERLGTGGF GYVLRWIHQD TGEQVAIKQC RQELSPKNRE RWCLEIQIMK
60 70 80 90 100
KLNHPNVVSA REVPDGLQKL APNDLPLLAM EYCEGGDLRK YLNQFENCCG
110 120 130 140 150
LKEGPIRTLL SDISSALRYL HENRIIHRDL KPENIVLQPG PQRLIHKIID
160 170 180 190 200
LGYAKELDQG SLCTSFVGTL QYLAPELLEQ KKYTVTVDYW SFGTLAFECI
210 220 230 240 250
TGFRPFLPNW QPVQWHGKVR EKSNEHIVVY DDLTGAVKFS SVLPTPNHLS
260 270 280 290 300
GILAGKLERW LQCMLMWHQR QRGTDPQNPN VGCFQALDSI LSLKLLSVMN
310 320 330 340 350
MVSGRVHTYP VTENENLQNL KSWLQQDTGI PEEEQELLQA SGLALNSAQP
360 370 380 390 400
LTQYVIDCTV IDGRQGEGDL IFLFDNRKTV YEPQISLPAH PESVSIVLQD
410 420 430 440 450
PKRPLTYTHL RRVWGQIWQT IRALKEDCAR LLQGQRTSMV NLLRYNTELS
460 470 480 490 500
KKKNSMTSEC EQLKAKLDFF RSSIQIDLEK YSEQMEFGIT SEKLLSAWRE
510 520 530 540 550
MEQAVELCGR EREVQALVDK MMALQTDSVD LQRNPLGRKH RGTLDDLEEQ
560 570 580 590 600
ARDLYRRLRE RPRDQRTPGD SNDMVRLLIL AIQSFEKRVI LIYDQLSKTV
610 620 630 640 650
VCKRKALELS PKVKEVMNLM REDEKIVVRR QEKRQQELWN LLKIACSKVR
660 670 680 690 700
GPVSGSPDSL GTSRMPGPSQ LLSQPPVLSV SLAQEYVKKS EDLRSESLNL
710 720 730 740
CSQLESSMRS FMKEQDGSLM SLDWSWLLQQ EEESGASPIT TS
Length:742
Mass (Da):85,135
Last modified:July 4, 2004 - v1
Checksum:i49CBF36951AAFB0A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC072192 mRNA. Translation: AAH72192.1.
RefSeqiNP_001085125.1. NM_001091656.1.
UniGeneiXl.24009.

Genome annotation databases

GeneIDi432200.
KEGGixla:432200.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC072192 mRNA. Translation: AAH72192.1.
RefSeqiNP_001085125.1. NM_001091656.1.
UniGeneiXl.24009.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3QA8X-ray3.60A/B/C/D/E/F/G/H1-659[»]
3RZFX-ray4.00A1-659[»]
ProteinModelPortaliQ6INT1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-59194N.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi432200.
KEGGixla:432200.

Organism-specific databases

CTDi3551.
XenbaseiXB-GENE-949882. ikbkb.

Phylogenomic databases

HOVERGENiHBG018241.
KOiK07209.

Family and domain databases

InterProiIPR022007. IKKbetaNEMObind.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
IPR000626. Ubiquitin-like.
IPR029071. Ubiquitin-rel_dom.
[Graphical view]
PfamiPF12179. IKKbetaNEMObind. 1 hit.
PF00069. Pkinase. 1 hit.
[Graphical view]
SUPFAMiSSF54236. SSF54236. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
PS50053. UBIQUITIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. NIH - Xenopus Gene Collection (XGC) project
    Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: OvaryImported.
  2. "Crystal structure of inhibitor of kappaB kinase beta."
    Xu G., Lo Y.C., Li Q., Napolitano G., Wu X., Jiang X., Dreano M., Karin M., Wu H.
    Nature 472:325-330(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.60 ANGSTROMS) OF 1-659.

Entry informationi

Entry nameiQ6INT1_XENLA
AccessioniPrimary (citable) accession number: Q6INT1
Entry historyi
Integrated into UniProtKB/TrEMBL: July 4, 2004
Last sequence update: July 4, 2004
Last modified: March 31, 2015
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.