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Q6ING9

- PPM1K_XENLA

UniProt

Q6ING9 - PPM1K_XENLA

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Protein

Protein phosphatase 1K, mitochondrial

Gene

ppm1k

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Mg2+By similarity, Mn2+By similarityNote: Binds 1 Mg(2+) or Mn(2+) ion per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi128 – 1281MagnesiumBy similarity
Metal bindingi129 – 1291Magnesium; via carbonyl oxygenBy similarity
Metal bindingi338 – 3381MagnesiumBy similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. protein serine/threonine phosphatase activity Source: InterPro

GO - Biological processi

  1. protein dephosphorylation Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Keywords - Ligandi

Magnesium, Manganese, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Protein phosphatase 1K, mitochondrial (EC:3.1.3.16)
Alternative name(s):
Protein phosphatase 2C isoform kappa
Short name:
PP2C-kappa
Gene namesi
Name:ppm1k
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-956548. ppm1k.

Subcellular locationi

Mitochondrion matrix By similarity

GO - Cellular componenti

  1. mitochondrion Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini? – 373Protein phosphatase 1K, mitochondrialPRO_0000278211
Transit peptidei1 – ?MitochondrionBy similarity

Structurei

3D structure databases

ProteinModelPortaliQ6ING9.
SMRiQ6ING9. Positions 91-350.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini94 – 347254PP2C-likeAdd
BLAST

Sequence similaritiesi

Belongs to the PP2C family.Curated
Contains 1 PP2C-like domain.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

HOVERGENiHBG096199.
KOiK17505.

Family and domain databases

Gene3Di3.60.40.10. 1 hit.
InterProiIPR001932. PP2C-like_dom.
IPR000222. PP2C_Mn2_Asp60_BS.
IPR015655. Protein_Pase_2C.
[Graphical view]
PANTHERiPTHR13832. PTHR13832. 1 hit.
PfamiPF00481. PP2C. 1 hit.
[Graphical view]
SMARTiSM00331. PP2C_SIG. 1 hit.
SM00332. PP2Cc. 1 hit.
[Graphical view]
SUPFAMiSSF81606. SSF81606. 1 hit.
PROSITEiPS01032. PP2C. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6ING9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSTAILVSLL RNGRCQVNRG ALTLCFQKEH SCTTSTRHCF SANRRCFSSR
60 70 80 90 100
FDLDGSGRPA TWDSFGIWDN RIDEPIQLPP SIKYGKLIPH INLSKVGCST
110 120 130 140 150
QLGKRKENED RFKLARLTPD ILYFAVYDGH GGASAAEFCD RFMEDYIKEF
160 170 180 190 200
LVEEHDMEKV LVKAFLEINK AFARHAHLSV DASLLTCGTT ATVALLRDGI
210 220 230 240 250
ELVVASVGDS RALLCRRGKP FKLTIDHTPE RKEEKLRIKK SGGFVTWNSL
260 270 280 290 300
GQPNVNGRLA MTRSIGDLDL KSMGVIAEPE TKRVKLQHTD DGFLVLTTDG
310 320 330 340 350
INFIVNSQEI CDIINQCHDP KEAAQVLTEQ AIQYGTEDNS TAIVVPFGAW
360 370
GKHKSSEVSF SFSRGFASSG RWD
Length:373
Mass (Da):41,536
Last modified:July 5, 2004 - v1
Checksum:i58713D1A52099BB7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC072312 mRNA. Translation: AAH72312.1.
RefSeqiNP_001085111.1. NM_001091642.1.
UniGeneiXl.17302.

Genome annotation databases

GeneIDi432182.
KEGGixla:432182.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC072312 mRNA. Translation: AAH72312.1 .
RefSeqi NP_001085111.1. NM_001091642.1.
UniGenei Xl.17302.

3D structure databases

ProteinModelPortali Q6ING9.
SMRi Q6ING9. Positions 91-350.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 432182.
KEGGi xla:432182.

Organism-specific databases

CTDi 152926.
Xenbasei XB-GENE-956548. ppm1k.

Phylogenomic databases

HOVERGENi HBG096199.
KOi K17505.

Family and domain databases

Gene3Di 3.60.40.10. 1 hit.
InterProi IPR001932. PP2C-like_dom.
IPR000222. PP2C_Mn2_Asp60_BS.
IPR015655. Protein_Pase_2C.
[Graphical view ]
PANTHERi PTHR13832. PTHR13832. 1 hit.
Pfami PF00481. PP2C. 1 hit.
[Graphical view ]
SMARTi SM00331. PP2C_SIG. 1 hit.
SM00332. PP2Cc. 1 hit.
[Graphical view ]
SUPFAMi SSF81606. SSF81606. 1 hit.
PROSITEi PS01032. PP2C. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. NIH - Xenopus Gene Collection (XGC) project
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Ovary.

Entry informationi

Entry nameiPPM1K_XENLA
AccessioniPrimary (citable) accession number: Q6ING9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 20, 2007
Last sequence update: July 5, 2004
Last modified: November 26, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3