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Protein

Protein phosphatase 1K, mitochondrial

Gene

ppm1k

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Mg2+By similarity, Mn2+By similarityNote: Binds 1 Mg(2+) or Mn2+ ion per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi128 – 1281MagnesiumBy similarity
Metal bindingi129 – 1291Magnesium; via carbonyl oxygenBy similarity
Metal bindingi338 – 3381MagnesiumBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Keywords - Ligandi

Magnesium, Manganese, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Protein phosphatase 1K, mitochondrial (EC:3.1.3.16)
Alternative name(s):
Protein phosphatase 2C isoform kappa
Short name:
PP2C-kappa
Gene namesi
Name:ppm1k
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-956548. ppm1k.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini? – 373Protein phosphatase 1K, mitochondrialPRO_0000278211
Transit peptidei1 – ?MitochondrionBy similarity

Structurei

3D structure databases

ProteinModelPortaliQ6ING9.
SMRiQ6ING9. Positions 91-350.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini95 – 347253PPM-type phosphatasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the PP2C family.Curated
Contains 1 PPM-type phosphatase domain.PROSITE-ProRule annotation

Keywords - Domaini

Transit peptide

Phylogenomic databases

HOVERGENiHBG096199.
KOiK17505.

Family and domain databases

Gene3Di3.60.40.10. 1 hit.
InterProiIPR015655. PP2C.
IPR000222. PP2C_BS.
IPR001932. PPM-type_phosphatase_dom.
[Graphical view]
PANTHERiPTHR13832. PTHR13832. 1 hit.
PfamiPF00481. PP2C. 1 hit.
[Graphical view]
SMARTiSM00331. PP2C_SIG. 1 hit.
SM00332. PP2Cc. 1 hit.
[Graphical view]
SUPFAMiSSF81606. SSF81606. 1 hit.
PROSITEiPS01032. PPM_1. 1 hit.
PS51746. PPM_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6ING9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTAILVSLL RNGRCQVNRG ALTLCFQKEH SCTTSTRHCF SANRRCFSSR
60 70 80 90 100
FDLDGSGRPA TWDSFGIWDN RIDEPIQLPP SIKYGKLIPH INLSKVGCST
110 120 130 140 150
QLGKRKENED RFKLARLTPD ILYFAVYDGH GGASAAEFCD RFMEDYIKEF
160 170 180 190 200
LVEEHDMEKV LVKAFLEINK AFARHAHLSV DASLLTCGTT ATVALLRDGI
210 220 230 240 250
ELVVASVGDS RALLCRRGKP FKLTIDHTPE RKEEKLRIKK SGGFVTWNSL
260 270 280 290 300
GQPNVNGRLA MTRSIGDLDL KSMGVIAEPE TKRVKLQHTD DGFLVLTTDG
310 320 330 340 350
INFIVNSQEI CDIINQCHDP KEAAQVLTEQ AIQYGTEDNS TAIVVPFGAW
360 370
GKHKSSEVSF SFSRGFASSG RWD
Length:373
Mass (Da):41,536
Last modified:July 5, 2004 - v1
Checksum:i58713D1A52099BB7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC072312 mRNA. Translation: AAH72312.1.
RefSeqiNP_001085111.1. NM_001091642.1.
UniGeneiXl.17302.

Genome annotation databases

GeneIDi432182.
KEGGixla:432182.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC072312 mRNA. Translation: AAH72312.1.
RefSeqiNP_001085111.1. NM_001091642.1.
UniGeneiXl.17302.

3D structure databases

ProteinModelPortaliQ6ING9.
SMRiQ6ING9. Positions 91-350.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi432182.
KEGGixla:432182.

Organism-specific databases

CTDi152926.
XenbaseiXB-GENE-956548. ppm1k.

Phylogenomic databases

HOVERGENiHBG096199.
KOiK17505.

Family and domain databases

Gene3Di3.60.40.10. 1 hit.
InterProiIPR015655. PP2C.
IPR000222. PP2C_BS.
IPR001932. PPM-type_phosphatase_dom.
[Graphical view]
PANTHERiPTHR13832. PTHR13832. 1 hit.
PfamiPF00481. PP2C. 1 hit.
[Graphical view]
SMARTiSM00331. PP2C_SIG. 1 hit.
SM00332. PP2Cc. 1 hit.
[Graphical view]
SUPFAMiSSF81606. SSF81606. 1 hit.
PROSITEiPS01032. PPM_1. 1 hit.
PS51746. PPM_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. NIH - Xenopus Gene Collection (XGC) project
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Ovary.

Entry informationi

Entry nameiPPM1K_XENLA
AccessioniPrimary (citable) accession number: Q6ING9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 20, 2007
Last sequence update: July 5, 2004
Last modified: June 24, 2015
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.