Q6ING9 (PPM1K_XENLA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein phosphatase 1K, mitochondrial
EC=3.1.3.16

Alternative name(s):
Protein phosphatase 2C isoform kappa
Short name=PP2C-kappa

Gene names

Name:

ppm1k

Organism

Xenopus laevis (African clawed frog)

Taxonomic identifier

8355 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amphibia › Batrachia › Anura › Pipoidea › Pipidae › Xenopodinae › Xenopus › Xenopus

Protein attributes

Sequence length	373 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Catalytic activity	A phosphoprotein + H2O = a protein + phosphate.
Cofactor	Binds 1 magnesium or manganese ion per subunit By similarity.
Subcellular location	Mitochondrion matrix By similarity.
Sequence similarities	Belongs to the PP2C family. Contains 1 PP2C-like domain.

Ontologies

Keywords
Cellular component	Mitochondrion
Domain	Transit peptide
Ligand	Magnesium Manganese Metal-binding
Molecular function	Hydrolase Protein phosphatase
Gene Ontology (GO)
Biological_process	protein dephosphorylation Inferred from electronic annotation. Source: InterPro
Cellular_component	mitochondrial matrix Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW protein serine/threonine phosphatase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Transit peptide	1 – ?		Mitochondrion By similarity
	Chain	? – 373		Protein phosphatase 1K, mitochondrial		PRO_0000278211
Regions
	Domain	94 – 347	254	PP2C-like
Sites
	Metal binding	128	1	Magnesium By similarity
	Metal binding	129	1	Magnesium; via carbonyl oxygen By similarity
	Metal binding	338	1	Magnesium By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q6ING9 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: 58713D1A52099BB7	FASTA	373	41,536
	10 20 30 40 50 60 MSTAILVSLL RNGRCQVNRG ALTLCFQKEH SCTTSTRHCF SANRRCFSSR FDLDGSGRPA 70 80 90 100 110 120 TWDSFGIWDN RIDEPIQLPP SIKYGKLIPH INLSKVGCST QLGKRKENED RFKLARLTPD 130 140 150 160 170 180 ILYFAVYDGH GGASAAEFCD RFMEDYIKEF LVEEHDMEKV LVKAFLEINK AFARHAHLSV 190 200 210 220 230 240 DASLLTCGTT ATVALLRDGI ELVVASVGDS RALLCRRGKP FKLTIDHTPE RKEEKLRIKK 250 260 270 280 290 300 SGGFVTWNSL GQPNVNGRLA MTRSIGDLDL KSMGVIAEPE TKRVKLQHTD DGFLVLTTDG 310 320 330 340 350 360 INFIVNSQEI CDIINQCHDP KEAAQVLTEQ AIQYGTEDNS TAIVVPFGAW GKHKSSEVSF 370 SFSRGFASSG RWD

References

[1]	NIH - Xenopus Gene Collection (XGC) project Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Ovary.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC072312 mRNA. Translation: AAH72312.1.
RefSeq	NP_001085111.1. NM_001091642.1.
UniGene	Xl.17302.
3D structure databases
ProteinModelPortal	Q6ING9.
SMR	Q6ING9. Positions 91-350.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	432182.
KEGG	xla:432182.
Organism-specific databases
CTD	152926.
Xenbase	XB-GENE-956548. ppm1k.
Phylogenomic databases
HOVERGEN	HBG096199.
Family and domain databases
Gene3D	3.60.40.10. 1 hit.
InterPro	IPR001932. PP2C-like. IPR000222. PP2C_Mn2_Asp60_BS. IPR015655. Protein_Pase_2C. [Graphical view]
PANTHER	PTHR13832. PTHR13832. 1 hit.
Pfam	PF00481. PP2C. 1 hit. [Graphical view]
SMART	SM00331. PP2C_SIG. 1 hit. SM00332. PP2Cc. 1 hit. [Graphical view]
SUPFAM	SSF81606. PP2C-related. 1 hit.
PROSITE	PS01032. PP2C. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PPM1K_XENLA

Accession

Primary (citable) accession number: Q6ING9

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 20, 2007
Last sequence update:	July 5, 2004
Last modified:	May 29, 2013
This is version 54 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program