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Q6ING7

- FLAD1_XENLA

UniProt

Q6ING7 - FLAD1_XENLA

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Protein

FAD synthase

Gene
flad1
Organism
Xenopus laevis (African clawed frog)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalyzes the adenylation of flavin mononucleotide (FMN) to form flavin adenine dinucleotide (FAD) coenzyme By similarity.

Catalytic activityi

ATP + FMN = diphosphate + FAD.

Cofactori

Magnesium By similarity.

Pathwayi

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. FMN adenylyltransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. FAD biosynthetic process Source: UniProtKB-UniPathway
  2. Mo-molybdopterin cofactor biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Ligandi

ATP-binding, FAD, Flavoprotein, FMN, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00277; UER00407.

Names & Taxonomyi

Protein namesi
Recommended name:
FAD synthase (EC:2.7.7.2)
Alternative name(s):
FAD pyrophosphorylase
FMN adenylyltransferase
Flavin adenine dinucleotide synthase
Including the following 2 domains:
Molybdenum cofactor biosynthesis protein-like region
FAD synthase region
Gene namesi
Name:flad1
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-5915969. flad1.

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 496496FAD synthasePRO_0000302741Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ6ING7.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni18 – 10992Molybdenum cofactor biosynthesis protein-likeAdd
BLAST
Regioni307 – 464158FAD synthaseAdd
BLAST

Domaini

The molybdenum cofactor biosynthesis protein-like region may not be functional.

Sequence similaritiesi

In the N-terminal section; belongs to the MoaB/Mog family.
In the C-terminal section; belongs to the PAPS reductase family. FAD1 subfamily.

Phylogenomic databases

HOVERGENiHBG058211.
KOiK00953.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
3.40.980.10. 1 hit.
InterProiIPR012183. FAD_synth_Mopterin-bd.
IPR001453. Mopterin-bd_dom.
IPR002500. PAPS_reduct.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PfamiPF00994. MoCF_biosynth. 1 hit.
PF01507. PAPS_reduct. 1 hit.
[Graphical view]
PIRSFiPIRSF036620. MPTbdFAD. 1 hit.
SMARTiSM00852. MoCF_biosynth. 1 hit.
[Graphical view]
SUPFAMiSSF53218. SSF53218. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6ING7-1 [UniParc]FASTAAdd to Basket

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MTSTSPCLAT NVPPVTAGII IIGDEILKGH TQDTNSFFMC KKLRSIGVQV    50
NKISVIPDDI DIIAGEIAGF SSRYTYVLTS GGIGPTHDDV TFEGVAKAFG 100
EKTFPHPELV SLVQTFFGKS ESWCPEMKLA QIPVSSRLNY GTDKRTGDCF 150
KYPLVSVGNV YVFPGIPSLL EKSLEGLDHL FRNDKTHFHY REICVSADEV 200
AIAGVLGEVN GRFRKHVSLG SYPDWSNNYF RVLLVLDSHS EAHLEEAHKF 250
LIEHLPPGVV VPFVKDPVTQ AAAQVYQLAH SGSPLGDKVA AALKTLEEAL 300
DTYSLEKICV AFNGGKDCTA LLHLFHATVQ RKFPDQKDKL QALYIRIVSP 350
FPEMEQFMQS TTKRYNLQIY TIQGYIKQAL VELKVEQPNL EAVLMGTRRS 400
DPYSRTLTPM CLTDPDWPKY MRVNPLLDWS YRDIWDFLRT LFIPYCILYD 450
KGYTSLGSME NTVKNPALRF TTPAGAESYH PAYKLQNEEE ERVSRK 496
Length:496
Mass (Da):55,709
Last modified:July 5, 2004 - v1
Checksum:iD4252F3B84B672E3
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC072314 mRNA. Translation: AAH72314.1.
RefSeqiNP_001085184.1. NM_001091715.1.
UniGeneiXl.3706.

Genome annotation databases

GeneIDi432268.
KEGGixla:432268.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC072314 mRNA. Translation: AAH72314.1 .
RefSeqi NP_001085184.1. NM_001091715.1.
UniGenei Xl.3706.

3D structure databases

ProteinModelPortali Q6ING7.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 432268.
KEGGi xla:432268.

Organism-specific databases

CTDi 80308.
Xenbasei XB-GENE-5915969. flad1.

Phylogenomic databases

HOVERGENi HBG058211.
KOi K00953.

Enzyme and pathway databases

UniPathwayi UPA00277 ; UER00407 .

Family and domain databases

Gene3Di 3.40.50.620. 1 hit.
3.40.980.10. 1 hit.
InterProi IPR012183. FAD_synth_Mopterin-bd.
IPR001453. Mopterin-bd_dom.
IPR002500. PAPS_reduct.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view ]
Pfami PF00994. MoCF_biosynth. 1 hit.
PF01507. PAPS_reduct. 1 hit.
[Graphical view ]
PIRSFi PIRSF036620. MPTbdFAD. 1 hit.
SMARTi SM00852. MoCF_biosynth. 1 hit.
[Graphical view ]
SUPFAMi SSF53218. SSF53218. 1 hit.
ProtoNeti Search...

Publicationsi

  1. NIH - Xenopus Gene Collection (XGC) project
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Ovary.

Entry informationi

Entry nameiFLAD1_XENLA
AccessioniPrimary (citable) accession number: Q6ING7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: July 5, 2004
Last modified: January 22, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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