Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q6ING7

- FLAD1_XENLA

UniProt

Q6ING7 - FLAD1_XENLA

Protein

FAD synthase

Gene

flad1

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 58 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Catalyzes the adenylation of flavin mononucleotide (FMN) to form flavin adenine dinucleotide (FAD) coenzyme.By similarity

    Catalytic activityi

    ATP + FMN = diphosphate + FAD.

    Cofactori

    Magnesium.By similarity

    Pathwayi

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. FMN adenylyltransferase activity Source: UniProtKB-EC

    GO - Biological processi

    1. FAD biosynthetic process Source: UniProtKB-UniPathway
    2. Mo-molybdopterin cofactor biosynthetic process Source: InterPro

    Keywords - Molecular functioni

    Nucleotidyltransferase, Transferase

    Keywords - Ligandi

    ATP-binding, FAD, Flavoprotein, FMN, Nucleotide-binding

    Enzyme and pathway databases

    UniPathwayiUPA00277; UER00407.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    FAD synthase (EC:2.7.7.2)
    Alternative name(s):
    FAD pyrophosphorylase
    FMN adenylyltransferase
    Flavin adenine dinucleotide synthase
    Including the following 2 domains:
    Molybdenum cofactor biosynthesis protein-like region
    FAD synthase region
    Gene namesi
    Name:flad1
    OrganismiXenopus laevis (African clawed frog)
    Taxonomic identifieri8355 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

    Organism-specific databases

    XenbaseiXB-GENE-5915969. flad1.

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 496496FAD synthasePRO_0000302741Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliQ6ING7.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni18 – 10992Molybdenum cofactor biosynthesis protein-likeAdd
    BLAST
    Regioni307 – 464158FAD synthaseAdd
    BLAST

    Domaini

    The molybdenum cofactor biosynthesis protein-like region may not be functional.

    Sequence similaritiesi

    In the N-terminal section; belongs to the MoaB/Mog family.Curated
    In the C-terminal section; belongs to the PAPS reductase family. FAD1 subfamily.Curated

    Phylogenomic databases

    HOVERGENiHBG058211.
    KOiK00953.

    Family and domain databases

    Gene3Di3.40.50.620. 1 hit.
    3.40.980.10. 1 hit.
    InterProiIPR012183. FAD_synth_Mopterin-bd.
    IPR001453. Mopterin-bd_dom.
    IPR002500. PAPS_reduct.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view]
    PfamiPF00994. MoCF_biosynth. 1 hit.
    PF01507. PAPS_reduct. 1 hit.
    [Graphical view]
    PIRSFiPIRSF036620. MPTbdFAD. 1 hit.
    SMARTiSM00852. MoCF_biosynth. 1 hit.
    [Graphical view]
    SUPFAMiSSF53218. SSF53218. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q6ING7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTSTSPCLAT NVPPVTAGII IIGDEILKGH TQDTNSFFMC KKLRSIGVQV    50
    NKISVIPDDI DIIAGEIAGF SSRYTYVLTS GGIGPTHDDV TFEGVAKAFG 100
    EKTFPHPELV SLVQTFFGKS ESWCPEMKLA QIPVSSRLNY GTDKRTGDCF 150
    KYPLVSVGNV YVFPGIPSLL EKSLEGLDHL FRNDKTHFHY REICVSADEV 200
    AIAGVLGEVN GRFRKHVSLG SYPDWSNNYF RVLLVLDSHS EAHLEEAHKF 250
    LIEHLPPGVV VPFVKDPVTQ AAAQVYQLAH SGSPLGDKVA AALKTLEEAL 300
    DTYSLEKICV AFNGGKDCTA LLHLFHATVQ RKFPDQKDKL QALYIRIVSP 350
    FPEMEQFMQS TTKRYNLQIY TIQGYIKQAL VELKVEQPNL EAVLMGTRRS 400
    DPYSRTLTPM CLTDPDWPKY MRVNPLLDWS YRDIWDFLRT LFIPYCILYD 450
    KGYTSLGSME NTVKNPALRF TTPAGAESYH PAYKLQNEEE ERVSRK 496
    Length:496
    Mass (Da):55,709
    Last modified:July 5, 2004 - v1
    Checksum:iD4252F3B84B672E3
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC072314 mRNA. Translation: AAH72314.1.
    RefSeqiNP_001085184.1. NM_001091715.1.
    UniGeneiXl.3706.

    Genome annotation databases

    GeneIDi432268.
    KEGGixla:432268.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC072314 mRNA. Translation: AAH72314.1 .
    RefSeqi NP_001085184.1. NM_001091715.1.
    UniGenei Xl.3706.

    3D structure databases

    ProteinModelPortali Q6ING7.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 432268.
    KEGGi xla:432268.

    Organism-specific databases

    CTDi 80308.
    Xenbasei XB-GENE-5915969. flad1.

    Phylogenomic databases

    HOVERGENi HBG058211.
    KOi K00953.

    Enzyme and pathway databases

    UniPathwayi UPA00277 ; UER00407 .

    Family and domain databases

    Gene3Di 3.40.50.620. 1 hit.
    3.40.980.10. 1 hit.
    InterProi IPR012183. FAD_synth_Mopterin-bd.
    IPR001453. Mopterin-bd_dom.
    IPR002500. PAPS_reduct.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view ]
    Pfami PF00994. MoCF_biosynth. 1 hit.
    PF01507. PAPS_reduct. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF036620. MPTbdFAD. 1 hit.
    SMARTi SM00852. MoCF_biosynth. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53218. SSF53218. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. NIH - Xenopus Gene Collection (XGC) project
      Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Ovary.

    Entry informationi

    Entry nameiFLAD1_XENLA
    AccessioniPrimary (citable) accession number: Q6ING7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 11, 2007
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 58 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3