SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q6IN85

- P4R3A_HUMAN

UniProt

Q6IN85 - P4R3A_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Serine/threonine-protein phosphatase 4 regulatory subunit 3A

Gene
SMEK1, KIAA2010, PP4R3A, PPP4R3A, MSTP033
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Regulatory subunit of serine/threonine-protein phosphatase 4. May regulate the activity of PPP4C at centrosomal microtubule organizing centers. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AFX phosphorylated on 'Ser-140' (gamma-H2AFX) generated during DNA replication and required for DNA DSB repair.1 Publication

GO - Biological processi

  1. positive regulation of gluconeogenesis Source: Ensembl
  2. protein dephosphorylation Source: Ensembl
Complete GO annotation...

Enzyme and pathway databases

SignaLinkiQ6IN85.

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein phosphatase 4 regulatory subunit 3A
Alternative name(s):
SMEK homolog 1
Gene namesi
Name:SMEK1
Synonyms:KIAA2010, PP4R3A, PPP4R3A
ORF Names:MSTP033
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 14

Organism-specific databases

HGNCiHGNC:20219. SMEK1.

Subcellular locationi

Cytoplasm. Cytoplasmcytoskeletonmicrotubule organizing centercentrosome. Nucleus
Note: In interphase localized in the cytoplasm and in the nucleus (with higher levels). During metaphase located in pericentriolar regions.1 Publication

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. microtubule organizing center Source: UniProtKB-SubCell
  3. nucleus Source: UniProtKB-SubCell
  4. protein phosphatase 4 complex Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162403940.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 833833Serine/threonine-protein phosphatase 4 regulatory subunit 3APRO_0000254598Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei117 – 1171Phosphoserine1 Publication
Modified residuei655 – 6551N6-acetyllysine1 Publication
Modified residuei741 – 7411Phosphoserine1 Publication
Modified residuei771 – 7711Phosphoserine2 Publications
Modified residuei774 – 7741Phosphoserine1 Publication
Modified residuei777 – 7771Phosphoserine1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ6IN85.
PaxDbiQ6IN85.
PRIDEiQ6IN85.

PTM databases

PhosphoSiteiQ6IN85.

Expressioni

Gene expression databases

ArrayExpressiQ6IN85.
BgeeiQ6IN85.
GenevestigatoriQ6IN85.

Organism-specific databases

HPAiHPA002568.

Interactioni

Subunit structurei

Serine/threonine-protein phosphatase 4 (PP4) occurs in different assemblies of the catalytic and one or more regulatory subunits. Component of the PP4 complex PPP4C-PPP4R2-PPP4R3A. Interacts with PPP4C; the interaction requires PPP4R2.2 Publications

Protein-protein interaction databases

BioGridi120803. 20 interactions.
IntActiQ6IN85. 5 interactions.
MINTiMINT-4827313.

Structurei

3D structure databases

ProteinModelPortaliQ6IN85.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 100100WH1Add
BLAST

Sequence similaritiesi

Belongs to the SMEK family.
Contains 1 WH1 domain.

Phylogenomic databases

eggNOGiNOG314899.
HOVERGENiHBG056624.
InParanoidiQ6IN85.
KOiK17491.
OMAiIEMFEYV.
OrthoDBiEOG7ZSHS7.
PhylomeDBiQ6IN85.
TreeFamiTF315190.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR016024. ARM-type_fold.
IPR006887. DUF625.
IPR011993. PH_like_dom.
[Graphical view]
PfamiPF04802. SMK-1. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q6IN85-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MTDTRRRVKV YTLNEDRQWD DRGTGHVSSG YVERLKGMSL LVRAESDGSL    50
LLESKINPNT AYQKQQDTLI VWSEAENYDL ALSFQEKAGC DEIWEKICQV 100
QGKDPSVDIT QDLVDESEEE RFDDMSSPGL ELPSCELSRL EEIAELVASS 150
LPSPLRREKL ALALENEGYI KKLLELFHVC EDLENIEGLH HLYEIIKGIF 200
LLNRTALFEV MFSEECIMDV IGCLEYDPAL SQPRKHREFL TKTAKFKEVI 250
PISDPELKQK IHQTYRVQYI QDMVLPTPSV FEENMLSTLH SFIFFNKVEI 300
VGMLQEDEKF LTDLFAQLTD EATDEEKRQE LVNFLKEFCA FSQTLQPQNR 350
DAFFKTLSNM GILPALEVIL GMDDTQVRSA ATDIFSYLVE YNPSMVREFV 400
MQEAQQNDDV SKKLTEQKIT SKDILLINLI IEHMICDTDP ELGGAVQLMG 450
LLRTLVDPEN MLATANKTEK TEFLGFFYKH CMHVLTAPLL ANTTEDKPSK 500
DDFQTAQLLA LVLELLTFCV EHHTYHIKNY IINKDILRRV LVLMASKHAF 550
LALCALRFKR KIIGLKDEFY NRYIMKSFLF EPVVKAFLNN GSRYNLMNSA 600
IIEMFEFIRV EDIKSLTAHV IENYWKALED VDYVQTFKGL KLRFEQQRER 650
QDNPKLDSMR SILRNHRYRR DARTLEDEEE MWFNTDEDDM EDGEAVVSPS 700
DKTKNDDDIM DPISKFMERK KLKESEEKEV LLKTNLSGRQ SPSFKLSLSS 750
GTKTNLTSQS STTNLPGSPG SPGSPGSPGS PGSVPKNTSQ TAAITTKGGL 800
VGLVDYPDDD EDDDEDEDKE DTLPLSKKAK FDS 833

Note: No experimental confirmation available.

Length:833
Mass (Da):95,368
Last modified:July 5, 2004 - v1
Checksum:iEDDB4E1F47197A94
GO
Isoform 2 (identifier: Q6IN85-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     410-422: Missing.

Note: No experimental confirmation available.

Show »
Length:820
Mass (Da):93,897
Checksum:iB87BA2CA6C7121C4
GO
Isoform 4 (identifier: Q6IN85-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     67-305: Missing.

Note: No experimental confirmation available.

Show »
Length:594
Mass (Da):67,812
Checksum:i571E51214496F24F
GO
Isoform 5 (identifier: Q6IN85-5) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     410-422: Missing.
     554-833: Missing.

Note: No experimental confirmation available.

Show »
Length:540
Mass (Da):62,020
Checksum:i0C55DF4DB36B8908
GO

Sequence cautioni

The sequence BAA91960.1 differs from that shown. Reason: Probable intron retention.
The sequence BAA91960.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
The sequence BAB14877.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
The sequence BAC23106.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei67 – 305239Missing in isoform 4. VSP_021252Add
BLAST
Alternative sequencei410 – 42213Missing in isoform 2 and isoform 5. VSP_021253Add
BLAST
Alternative sequencei554 – 833280Missing in isoform 5. VSP_021256Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB095930 mRNA. Translation: BAC23106.1. Different initiation.
AK000714 mRNA. Translation: BAA91338.1.
AK001885 mRNA. Translation: BAA91960.1. Sequence problems.
AK024297 mRNA. Translation: BAB14877.1. Different initiation.
AL133153 Genomic DNA. No translation available.
BC038932 mRNA. Translation: AAH38932.1.
BC072409 mRNA. Translation: AAH72409.1.
BX248247 mRNA. Translation: CAD62575.1.
AL832921 mRNA. Translation: CAH10634.1.
AF113213 mRNA. Translation: AAG39284.1. Sequence problems.
CCDSiCCDS61532.1. [Q6IN85-4]
CCDS9895.1. [Q6IN85-2]
RefSeqiNP_001271209.1. NM_001284280.1. [Q6IN85-2]
NP_001271210.1. NM_001284281.1. [Q6IN85-4]
XP_005267899.1. XM_005267842.1. [Q6IN85-1]
XP_006720257.1. XM_006720194.1. [Q6IN85-1]
UniGeneiHs.533887.

Genome annotation databases

EnsembliENST00000337238; ENSP00000337125; ENSG00000100796. [Q6IN85-2]
ENST00000428424; ENSP00000392704; ENSG00000100796. [Q6IN85-4]
ENST00000554684; ENSP00000450864; ENSG00000100796. [Q6IN85-2]
ENST00000554943; ENSP00000450883; ENSG00000100796. [Q6IN85-1]
ENST00000555462; ENSP00000450891; ENSG00000100796. [Q6IN85-4]
GeneIDi55671.
KEGGihsa:55671.
UCSCiuc001xzm.3. human. [Q6IN85-2]
uc001xzn.3. human. [Q6IN85-1]
uc001xzq.1. human. [Q6IN85-5]
uc010atz.3. human. [Q6IN85-4]

Polymorphism databases

DMDMi74736507.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB095930 mRNA. Translation: BAC23106.1 . Different initiation.
AK000714 mRNA. Translation: BAA91338.1 .
AK001885 mRNA. Translation: BAA91960.1 . Sequence problems.
AK024297 mRNA. Translation: BAB14877.1 . Different initiation.
AL133153 Genomic DNA. No translation available.
BC038932 mRNA. Translation: AAH38932.1 .
BC072409 mRNA. Translation: AAH72409.1 .
BX248247 mRNA. Translation: CAD62575.1 .
AL832921 mRNA. Translation: CAH10634.1 .
AF113213 mRNA. Translation: AAG39284.1 . Sequence problems.
CCDSi CCDS61532.1. [Q6IN85-4 ]
CCDS9895.1. [Q6IN85-2 ]
RefSeqi NP_001271209.1. NM_001284280.1. [Q6IN85-2 ]
NP_001271210.1. NM_001284281.1. [Q6IN85-4 ]
XP_005267899.1. XM_005267842.1. [Q6IN85-1 ]
XP_006720257.1. XM_006720194.1. [Q6IN85-1 ]
UniGenei Hs.533887.

3D structure databases

ProteinModelPortali Q6IN85.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 120803. 20 interactions.
IntActi Q6IN85. 5 interactions.
MINTi MINT-4827313.

PTM databases

PhosphoSitei Q6IN85.

Polymorphism databases

DMDMi 74736507.

Proteomic databases

MaxQBi Q6IN85.
PaxDbi Q6IN85.
PRIDEi Q6IN85.

Protocols and materials databases

DNASUi 55671.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000337238 ; ENSP00000337125 ; ENSG00000100796 . [Q6IN85-2 ]
ENST00000428424 ; ENSP00000392704 ; ENSG00000100796 . [Q6IN85-4 ]
ENST00000554684 ; ENSP00000450864 ; ENSG00000100796 . [Q6IN85-2 ]
ENST00000554943 ; ENSP00000450883 ; ENSG00000100796 . [Q6IN85-1 ]
ENST00000555462 ; ENSP00000450891 ; ENSG00000100796 . [Q6IN85-4 ]
GeneIDi 55671.
KEGGi hsa:55671.
UCSCi uc001xzm.3. human. [Q6IN85-2 ]
uc001xzn.3. human. [Q6IN85-1 ]
uc001xzq.1. human. [Q6IN85-5 ]
uc010atz.3. human. [Q6IN85-4 ]

Organism-specific databases

CTDi 55671.
GeneCardsi GC14M091923.
H-InvDB HIX0202046.
HGNCi HGNC:20219. SMEK1.
HPAi HPA002568.
MIMi 610351. gene.
neXtProti NX_Q6IN85.
PharmGKBi PA162403940.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG314899.
HOVERGENi HBG056624.
InParanoidi Q6IN85.
KOi K17491.
OMAi IEMFEYV.
OrthoDBi EOG7ZSHS7.
PhylomeDBi Q6IN85.
TreeFami TF315190.

Enzyme and pathway databases

SignaLinki Q6IN85.

Miscellaneous databases

ChiTaRSi SMEK1. human.
GenomeRNAii 55671.
NextBioi 60444.
PROi Q6IN85.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q6IN85.
Bgeei Q6IN85.
Genevestigatori Q6IN85.

Family and domain databases

Gene3Di 2.30.29.30. 1 hit.
InterProi IPR016024. ARM-type_fold.
IPR006887. DUF625.
IPR011993. PH_like_dom.
[Graphical view ]
Pfami PF04802. SMK-1. 1 hit.
[Graphical view ]
SUPFAMi SSF48371. SSF48371. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The nucleotide sequence of a long cDNA clone isolated from human."
    Nagase T., Kikuno R., Ohara O.
    Submitted (NOV-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Brain.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 98-833 (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 165-422 (ISOFORM 1).
    Tissue: Ileal mucosa and Placenta.
  3. "The DNA sequence and analysis of human chromosome 14."
    Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H.
    , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J.
    Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 4).
    Tissue: Eye.
  5. "Full-length cDNA libraries and normalization."
    Li W.B., Gruber C., Jessee J., Polayes D.
    Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 238-833.
    Tissue: Neuroblastoma.
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 667-833.
    Tissue: Melanoma.
  7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 808-833.
    Tissue: Aorta.
  8. "A novel, evolutionarily conserved protein phosphatase complex involved in cisplatin sensitivity."
    Gingras A.-C., Caballero M., Zarske M., Sanchez A., Hazbun T.R., Fields S., Sonenberg N., Hafen E., Raught B., Aebersold R.
    Mol. Cell. Proteomics 4:1725-1740(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN THE PPP4C-PPP4R2-PPP4R3A COMPLEX, INTERACTION WITH PPP4C, IDENTIFICATION BY MASS SPECTROMETRY.
  9. "Depletion of protein phosphatase 4 in human cells reveals essential roles in centrosome maturation, cell migration and the regulation of Rho GTPases."
    Martin-Granados C., Philp A., Oxenham S.K., Prescott A.R., Cohen P.T.W.
    Int. J. Biochem. Cell Biol. 40:2315-2332(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.
  10. "A PP4-phosphatase complex dephosphorylates gamma-H2AX generated during DNA replication."
    Chowdhury D., Xu X., Zhong X., Ahmed F., Zhong J., Liao J., Dykxhoorn D.M., Weinstock D.M., Pfeifer G.P., Lieberman J.
    Mol. Cell 31:33-46(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN THE PPP4C-PPP4R2-PPP4R3A COMPLEX, FUNCTION OF THE PPP4C-PPP4R2-PPP4R3A COMPLEX.
  11. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-117 AND SER-771, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  12. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  13. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-771; SER-774 AND SER-777, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  14. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
    Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
    Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-655, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  15. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  16. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-741, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiP4R3A_HUMAN
AccessioniPrimary (citable) accession number: Q6IN85
Secondary accession number(s): Q69YK6
, Q86U23, Q86YI7, Q8IVG1, Q9H3F1, Q9H7U8, Q9NV01, Q9NWP1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: July 5, 2004
Last modified: July 9, 2014
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi