Q6IN85 (P4R3A_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Serine/threonine-protein phosphatase 4 regulatory subunit 3A

Alternative name(s):
SMEK homolog 1

Gene names

Name:	SMEK1
Synonyms:	KIAA2010, PP4R3A, PPP4R3A
ORF Names:	MSTP033

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	833 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Regulatory subunit of serine/threonine-protein phosphatase 4. May regulate the activity of PPP4C at centrosomal microtubule organizing centers. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AFX phosphorylated on 'Ser-140' (gamma-H2AFX) generated during DNA replication and required for DNA DSB repair. Ref.10
Subunit structure	Serine/threonine-protein phosphatase 4 (PP4) occurs in different assemblies of the catalytic and one or more regulatory subunits. Component of the PP4 complex PPP4C-PPP4R2-PPP4R3A. Interacts with PPP4C; the interaction requires PPP4R2. Ref.8 Ref.10
Subcellular location	Cytoplasm. Cytoplasm › cytoskeleton › centrosome. Nucleus. Note: In interphase localized in the cytoplasm and in the nucleus (with higher levels). During metaphase located in pericentriolar regions. Ref.9
Sequence similarities	Belongs to the SMEK family. Contains 1 WH1 domain.
Sequence caution	The sequence AAG39284.1 differs from that shown. Reason: Erroneous translation. Wrong choice of frame. The sequence BAA91960.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended. The sequence BAA91960.1 differs from that shown. Reason: Probable intron retention. The sequence BAB14877.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended. The sequence BAC23106.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Ontologies

Keywords
Cellular component	Cytoplasm Cytoskeleton Nucleus
Coding sequence diversity	Alternative splicing
PTM	Acetylation Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	positive regulation of gluconeogenesis Inferred from electronic annotation. Source: Compara protein dephosphorylation Inferred from electronic annotation. Source: Compara
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell microtubule organizing center Inferred from electronic annotation. Source: UniProtKB-SubCell nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell protein phosphatase 4 complex Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q6IN85-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Note: No experimental confirmation available.

Isoform 2 (identifier: Q6IN85-2)

The sequence of this isoform differs from the canonical sequence as follows:
     410-422: Missing.

Note: No experimental confirmation available.

Isoform 4 (identifier: Q6IN85-4)

The sequence of this isoform differs from the canonical sequence as follows:
     67-305: Missing.

Note: No experimental confirmation available.

Isoform 5 (identifier: Q6IN85-5)

The sequence of this isoform differs from the canonical sequence as follows:
     410-422: Missing.
     554-833: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 833	833	Serine/threonine-protein phosphatase 4 regulatory subunit 3A		PRO_0000254598
Regions
	Domain	1 – 100	100	WH1
Amino acid modifications
	Modified residue	117	1	Phosphoserine Ref.11
	Modified residue	655	1	N6-acetyllysine Ref.13
	Modified residue	741	1	Phosphoserine Ref.15
	Modified residue	771	1	Phosphoserine Ref.11 Ref.12
	Modified residue	774	1	Phosphoserine Ref.12
	Modified residue	777	1	Phosphoserine Ref.12
Natural variations
	Alternative sequence	67 – 305	239	Missing in isoform 4.		VSP_021252
	Alternative sequence	410 – 422	13	Missing in isoform 2 and isoform 5.		VSP_021253
	Alternative sequence	554 – 833	280	Missing in isoform 5.		VSP_021256

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: EDDB4E1F47197A94	FASTA	833	95,368
	10 20 30 40 50 60 MTDTRRRVKV YTLNEDRQWD DRGTGHVSSG YVERLKGMSL LVRAESDGSL LLESKINPNT 70 80 90 100 110 120 AYQKQQDTLI VWSEAENYDL ALSFQEKAGC DEIWEKICQV QGKDPSVDIT QDLVDESEEE 130 140 150 160 170 180 RFDDMSSPGL ELPSCELSRL EEIAELVASS LPSPLRREKL ALALENEGYI KKLLELFHVC 190 200 210 220 230 240 EDLENIEGLH HLYEIIKGIF LLNRTALFEV MFSEECIMDV IGCLEYDPAL SQPRKHREFL 250 260 270 280 290 300 TKTAKFKEVI PISDPELKQK IHQTYRVQYI QDMVLPTPSV FEENMLSTLH SFIFFNKVEI 310 320 330 340 350 360 VGMLQEDEKF LTDLFAQLTD EATDEEKRQE LVNFLKEFCA FSQTLQPQNR DAFFKTLSNM 370 380 390 400 410 420 GILPALEVIL GMDDTQVRSA ATDIFSYLVE YNPSMVREFV MQEAQQNDDV SKKLTEQKIT 430 440 450 460 470 480 SKDILLINLI IEHMICDTDP ELGGAVQLMG LLRTLVDPEN MLATANKTEK TEFLGFFYKH 490 500 510 520 530 540 CMHVLTAPLL ANTTEDKPSK DDFQTAQLLA LVLELLTFCV EHHTYHIKNY IINKDILRRV 550 560 570 580 590 600 LVLMASKHAF LALCALRFKR KIIGLKDEFY NRYIMKSFLF EPVVKAFLNN GSRYNLMNSA 610 620 630 640 650 660 IIEMFEFIRV EDIKSLTAHV IENYWKALED VDYVQTFKGL KLRFEQQRER QDNPKLDSMR 670 680 690 700 710 720 SILRNHRYRR DARTLEDEEE MWFNTDEDDM EDGEAVVSPS DKTKNDDDIM DPISKFMERK 730 740 750 760 770 780 KLKESEEKEV LLKTNLSGRQ SPSFKLSLSS GTKTNLTSQS STTNLPGSPG SPGSPGSPGS 790 800 810 820 830 PGSVPKNTSQ TAAITTKGGL VGLVDYPDDD EDDDEDEDKE DTLPLSKKAK FDS
	Isoform 2 [UniParc]. Checksum: B87BA2CA6C7121C4	FASTA	820	93,897
	10 20 30 40 50 60 MTDTRRRVKV YTLNEDRQWD DRGTGHVSSG YVERLKGMSL LVRAESDGSL LLESKINPNT 70 80 90 100 110 120 AYQKQQDTLI VWSEAENYDL ALSFQEKAGC DEIWEKICQV QGKDPSVDIT QDLVDESEEE 130 140 150 160 170 180 RFDDMSSPGL ELPSCELSRL EEIAELVASS LPSPLRREKL ALALENEGYI KKLLELFHVC 190 200 210 220 230 240 EDLENIEGLH HLYEIIKGIF LLNRTALFEV MFSEECIMDV IGCLEYDPAL SQPRKHREFL 250 260 270 280 290 300 TKTAKFKEVI PISDPELKQK IHQTYRVQYI QDMVLPTPSV FEENMLSTLH SFIFFNKVEI 310 320 330 340 350 360 VGMLQEDEKF LTDLFAQLTD EATDEEKRQE LVNFLKEFCA FSQTLQPQNR DAFFKTLSNM 370 380 390 400 410 420 GILPALEVIL GMDDTQVRSA ATDIFSYLVE YNPSMVREFV MQEAQQNDDD ILLINLIIEH 430 440 450 460 470 480 MICDTDPELG GAVQLMGLLR TLVDPENMLA TANKTEKTEF LGFFYKHCMH VLTAPLLANT 490 500 510 520 530 540 TEDKPSKDDF QTAQLLALVL ELLTFCVEHH TYHIKNYIIN KDILRRVLVL MASKHAFLAL 550 560 570 580 590 600 CALRFKRKII GLKDEFYNRY IMKSFLFEPV VKAFLNNGSR YNLMNSAIIE MFEFIRVEDI 610 620 630 640 650 660 KSLTAHVIEN YWKALEDVDY VQTFKGLKLR FEQQRERQDN PKLDSMRSIL RNHRYRRDAR 670 680 690 700 710 720 TLEDEEEMWF NTDEDDMEDG EAVVSPSDKT KNDDDIMDPI SKFMERKKLK ESEEKEVLLK 730 740 750 760 770 780 TNLSGRQSPS FKLSLSSGTK TNLTSQSSTT NLPGSPGSPG SPGSPGSPGS VPKNTSQTAA 790 800 810 820 ITTKGGLVGL VDYPDDDEDD DEDEDKEDTL PLSKKAKFDS
	Isoform 4 [UniParc]. Checksum: 571E51214496F24F	FASTA	594	67,812
	10 20 30 40 50 60 MTDTRRRVKV YTLNEDRQWD DRGTGHVSSG YVERLKGMSL LVRAESDGSL LLESKINPNT 70 80 90 100 110 120 AYQKQQEDEK FLTDLFAQLT DEATDEEKRQ ELVNFLKEFC AFSQTLQPQN RDAFFKTLSN 130 140 150 160 170 180 MGILPALEVI LGMDDTQVRS AATDIFSYLV EYNPSMVREF VMQEAQQNDD VSKKLTEQKI 190 200 210 220 230 240 TSKDILLINL IIEHMICDTD PELGGAVQLM GLLRTLVDPE NMLATANKTE KTEFLGFFYK 250 260 270 280 290 300 HCMHVLTAPL LANTTEDKPS KDDFQTAQLL ALVLELLTFC VEHHTYHIKN YIINKDILRR 310 320 330 340 350 360 VLVLMASKHA FLALCALRFK RKIIGLKDEF YNRYIMKSFL FEPVVKAFLN NGSRYNLMNS 370 380 390 400 410 420 AIIEMFEFIR VEDIKSLTAH VIENYWKALE DVDYVQTFKG LKLRFEQQRE RQDNPKLDSM 430 440 450 460 470 480 RSILRNHRYR RDARTLEDEE EMWFNTDEDD MEDGEAVVSP SDKTKNDDDI MDPISKFMER 490 500 510 520 530 540 KKLKESEEKE VLLKTNLSGR QSPSFKLSLS SGTKTNLTSQ SSTTNLPGSP GSPGSPGSPG 550 560 570 580 590 SPGSVPKNTS QTAAITTKGG LVGLVDYPDD DEDDDEDEDK EDTLPLSKKA KFDS
	Isoform 5 [UniParc]. Checksum: 0C55DF4DB36B8908	FASTA	540	62,020
	10 20 30 40 50 60 MTDTRRRVKV YTLNEDRQWD DRGTGHVSSG YVERLKGMSL LVRAESDGSL LLESKINPNT 70 80 90 100 110 120 AYQKQQDTLI VWSEAENYDL ALSFQEKAGC DEIWEKICQV QGKDPSVDIT QDLVDESEEE 130 140 150 160 170 180 RFDDMSSPGL ELPSCELSRL EEIAELVASS LPSPLRREKL ALALENEGYI KKLLELFHVC 190 200 210 220 230 240 EDLENIEGLH HLYEIIKGIF LLNRTALFEV MFSEECIMDV IGCLEYDPAL SQPRKHREFL 250 260 270 280 290 300 TKTAKFKEVI PISDPELKQK IHQTYRVQYI QDMVLPTPSV FEENMLSTLH SFIFFNKVEI 310 320 330 340 350 360 VGMLQEDEKF LTDLFAQLTD EATDEEKRQE LVNFLKEFCA FSQTLQPQNR DAFFKTLSNM 370 380 390 400 410 420 GILPALEVIL GMDDTQVRSA ATDIFSYLVE YNPSMVREFV MQEAQQNDDD ILLINLIIEH 430 440 450 460 470 480 MICDTDPELG GAVQLMGLLR TLVDPENMLA TANKTEKTEF LGFFYKHCMH VLTAPLLANT 490 500 510 520 530 540 TEDKPSKDDF QTAQLLALVL ELLTFCVEHH TYHIKNYIIN KDILRRVLVL MASKHAFLAL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The nucleotide sequence of a long cDNA clone isolated from human." Nagase T., Kikuno R., Ohara O. Submitted (NOV-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Brain.
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 98-833 (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 165-422 (ISOFORM 1). Tissue: Ileal mucosa and Placenta.
[3]	"The DNA sequence and analysis of human chromosome 14." Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H. , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J. Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 4). Tissue: Eye.
[5]	"Full-length cDNA libraries and normalization." Li W.B., Gruber C., Jessee J., Polayes D. Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 238-833. Tissue: Neuroblastoma.
[6]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 667-833. Tissue: Melanoma.
[7]	Liu B., Liu Y.Q., Wang X.Y., Zhao B., Sheng H., Zhao X.W., Liu S., Xu Y.Y., Ye J., Song L., Gao Y., Zhang C.L., Zhang J., Wei Y.J., Cao H.Q., Zhao Y., Liu L.S., Ding J.F. , Gao R.L., Wu Q.Y., Qiang B.Q., Yuan J.G., Liew C.C., Zhao M.S., Hui R.T. Submitted (DEC-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 808-833. Tissue: Aorta.
[8]	"A novel, evolutionarily conserved protein phosphatase complex involved in cisplatin sensitivity." Gingras A.-C., Caballero M., Zarske M., Sanchez A., Hazbun T.R., Fields S., Sonenberg N., Hafen E., Raught B., Aebersold R. Mol. Cell. Proteomics 4:1725-1740(2005) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION IN THE PPP4C-PPP4R2-PPP4R3A COMPLEX, INTERACTION WITH PPP4C, MASS SPECTROMETRY.
[9]	"Depletion of protein phosphatase 4 in human cells reveals essential roles in centrosome maturation, cell migration and the regulation of Rho GTPases." Martin-Granados C., Philp A., Oxenham S.K., Prescott A.R., Cohen P.T.W. Int. J. Biochem. Cell Biol. 40:2315-2332(2008) [PubMed] [Europe PMC] [Abstract] Cited for: SUBCELLULAR LOCATION.
[10]	"A PP4-phosphatase complex dephosphorylates gamma-H2AX generated during DNA replication." Chowdhury D., Xu X., Zhong X., Ahmed F., Zhong J., Liao J., Dykxhoorn D.M., Weinstock D.M., Pfeifer G.P., Lieberman J. Mol. Cell 31:33-46(2008) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION IN THE PPP4C-PPP4R2-PPP4R3A COMPLEX, FUNCTION OF THE PPP4C-PPP4R2-PPP4R3A COMPLEX.
[11]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-117 AND SER-771, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[12]	"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-771; SER-774 AND SER-777, MASS SPECTROMETRY. Tissue: Leukemic T-cell.
[13]	"Lysine acetylation targets protein complexes and co-regulates major cellular functions." Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M. Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract] Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-655, MASS SPECTROMETRY.
[14]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[15]	"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation." Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B. Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-741, MASS SPECTROMETRY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB095930 mRNA. Translation: BAC23106.1. Different initiation. AK000714 mRNA. Translation: BAA91338.1. AK001885 mRNA. Translation: BAA91960.1. Sequence problems. AK024297 mRNA. Translation: BAB14877.1. Different initiation. AL133153 Genomic DNA. No translation available. BC038932 mRNA. Translation: AAH38932.1. BC072409 mRNA. Translation: AAH72409.1. BX248247 mRNA. Translation: CAD62575.1. AL832921 mRNA. Translation: CAH10634.1. AF113213 mRNA. Translation: AAG39284.1. Sequence problems.
IPI	IPI00017290. IPI00217013. IPI00384714. IPI00479778.
RefSeq	NP_115949.3. NM_032560.4.
UniGene	Hs.533887.
3D structure databases
ProteinModelPortal	Q6IN85.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q6IN85. 4 interactions.
PTM databases
PhosphoSite	Q6IN85.
Polymorphism databases
DMDM	74736507.
Proteomic databases
PaxDb	Q6IN85.
PRIDE	Q6IN85.
Protocols and materials databases
DNASU	55671.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000337238; ENSP00000337125; ENSG00000100796. ENST00000428424; ENSP00000392704; ENSG00000100796. ENST00000554684; ENSP00000450864; ENSG00000100796. ENST00000554943; ENSP00000450883; ENSG00000100796. ENST00000555462; ENSP00000450891; ENSG00000100796.
GeneID	55671.
KEGG	hsa:55671.
UCSC	uc001xzm.3. human. uc001xzn.3. human. uc001xzq.1. human. uc010atz.3. human.
Organism-specific databases
CTD	55671.
GeneCards	GC14M091923.
H-InvDB	HIX0202046.
HGNC	HGNC:20219. SMEK1.
HPA	HPA002568.
MIM	610351. gene.
neXtProt	NX_Q6IN85.
PharmGKB	PA162403940.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG314899.
HOVERGEN	HBG056624.
InParanoid	Q6IN85.
OMA	LRFMRKI.
Gene expression databases
ArrayExpress	Q6IN85.
Bgee	Q6IN85.
Genevestigator	Q6IN85.
GermOnline	ENSG00000100796. Homo sapiens.
Family and domain databases
Gene3D	2.30.29.30. 1 hit.
InterPro	IPR016024. ARM-type_fold. IPR006887. DUF625. IPR011993. PH_like_dom. [Graphical view]
Pfam	PF04802. SMK-1. 1 hit. [Graphical view]
SUPFAM	SSF48371. ARM-type_fold. 1 hit.
PROSITE	PS50229. WH1. False negative. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	SMEK1. human.
GenomeRNAi	55671.
NextBio	60444.
SOURCE	Search...

Entry information

Entry name

P4R3A_HUMAN

Accession

Primary (citable) accession number: Q6IN85
Secondary accession number(s): Q69YK6 , Q86U23, Q86YI7, Q8IVG1, Q9H3F1, Q9H7U8, Q9NV01, Q9NWP1

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 31, 2006
Last sequence update:	July 5, 2004
Last modified:	April 3, 2013
This is version 88 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.