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Q6IN85

- P4R3A_HUMAN

UniProt

Q6IN85 - P4R3A_HUMAN

Protein

Serine/threonine-protein phosphatase 4 regulatory subunit 3A

Gene

SMEK1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 100 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    Regulatory subunit of serine/threonine-protein phosphatase 4. May regulate the activity of PPP4C at centrosomal microtubule organizing centers. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AFX phosphorylated on 'Ser-140' (gamma-H2AFX) generated during DNA replication and required for DNA DSB repair.1 Publication

    GO - Biological processi

    1. positive regulation of gluconeogenesis Source: Ensembl
    2. protein dephosphorylation Source: Ensembl

    Enzyme and pathway databases

    SignaLinkiQ6IN85.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Serine/threonine-protein phosphatase 4 regulatory subunit 3A
    Alternative name(s):
    SMEK homolog 1
    Gene namesi
    Name:SMEK1
    Synonyms:KIAA2010, PP4R3A, PPP4R3A
    ORF Names:MSTP033
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 14

    Organism-specific databases

    HGNCiHGNC:20219. SMEK1.

    Subcellular locationi

    Cytoplasm 1 Publication. Cytoplasmcytoskeletonmicrotubule organizing centercentrosome 1 Publication. Nucleus 1 Publication
    Note: In interphase localized in the cytoplasm and in the nucleus (with higher levels). During metaphase located in pericentriolar regions.

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. microtubule organizing center Source: UniProtKB-SubCell
    3. nucleus Source: UniProtKB-SubCell
    4. protein phosphatase 4 complex Source: Ensembl

    Keywords - Cellular componenti

    Cytoplasm, Cytoskeleton, Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA162403940.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 833833Serine/threonine-protein phosphatase 4 regulatory subunit 3APRO_0000254598Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei117 – 1171Phosphoserine1 Publication
    Modified residuei655 – 6551N6-acetyllysine1 Publication
    Modified residuei741 – 7411Phosphoserine1 Publication
    Modified residuei771 – 7711Phosphoserine2 Publications
    Modified residuei774 – 7741Phosphoserine1 Publication
    Modified residuei777 – 7771Phosphoserine1 Publication

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiQ6IN85.
    PaxDbiQ6IN85.
    PRIDEiQ6IN85.

    PTM databases

    PhosphoSiteiQ6IN85.

    Expressioni

    Gene expression databases

    ArrayExpressiQ6IN85.
    BgeeiQ6IN85.
    GenevestigatoriQ6IN85.

    Organism-specific databases

    HPAiHPA002568.

    Interactioni

    Subunit structurei

    Serine/threonine-protein phosphatase 4 (PP4) occurs in different assemblies of the catalytic and one or more regulatory subunits. Component of the PP4 complex PPP4C-PPP4R2-PPP4R3A. Interacts with PPP4C; the interaction requires PPP4R2.2 Publications

    Protein-protein interaction databases

    BioGridi120803. 20 interactions.
    IntActiQ6IN85. 6 interactions.
    MINTiMINT-4827313.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6IN85.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini1 – 100100WH1Add
    BLAST

    Sequence similaritiesi

    Belongs to the SMEK family.Curated
    Contains 1 WH1 domain.Curated

    Phylogenomic databases

    eggNOGiNOG314899.
    HOVERGENiHBG056624.
    InParanoidiQ6IN85.
    KOiK17491.
    OMAiIEMFEYV.
    OrthoDBiEOG7ZSHS7.
    PhylomeDBiQ6IN85.
    TreeFamiTF315190.

    Family and domain databases

    Gene3Di2.30.29.30. 1 hit.
    InterProiIPR016024. ARM-type_fold.
    IPR006887. DUF625.
    IPR011993. PH_like_dom.
    [Graphical view]
    PfamiPF04802. SMK-1. 1 hit.
    [Graphical view]
    SUPFAMiSSF48371. SSF48371. 1 hit.

    Sequences (4)i

    Sequence statusi: Complete.

    This entry describes 4 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q6IN85-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MTDTRRRVKV YTLNEDRQWD DRGTGHVSSG YVERLKGMSL LVRAESDGSL    50
    LLESKINPNT AYQKQQDTLI VWSEAENYDL ALSFQEKAGC DEIWEKICQV 100
    QGKDPSVDIT QDLVDESEEE RFDDMSSPGL ELPSCELSRL EEIAELVASS 150
    LPSPLRREKL ALALENEGYI KKLLELFHVC EDLENIEGLH HLYEIIKGIF 200
    LLNRTALFEV MFSEECIMDV IGCLEYDPAL SQPRKHREFL TKTAKFKEVI 250
    PISDPELKQK IHQTYRVQYI QDMVLPTPSV FEENMLSTLH SFIFFNKVEI 300
    VGMLQEDEKF LTDLFAQLTD EATDEEKRQE LVNFLKEFCA FSQTLQPQNR 350
    DAFFKTLSNM GILPALEVIL GMDDTQVRSA ATDIFSYLVE YNPSMVREFV 400
    MQEAQQNDDV SKKLTEQKIT SKDILLINLI IEHMICDTDP ELGGAVQLMG 450
    LLRTLVDPEN MLATANKTEK TEFLGFFYKH CMHVLTAPLL ANTTEDKPSK 500
    DDFQTAQLLA LVLELLTFCV EHHTYHIKNY IINKDILRRV LVLMASKHAF 550
    LALCALRFKR KIIGLKDEFY NRYIMKSFLF EPVVKAFLNN GSRYNLMNSA 600
    IIEMFEFIRV EDIKSLTAHV IENYWKALED VDYVQTFKGL KLRFEQQRER 650
    QDNPKLDSMR SILRNHRYRR DARTLEDEEE MWFNTDEDDM EDGEAVVSPS 700
    DKTKNDDDIM DPISKFMERK KLKESEEKEV LLKTNLSGRQ SPSFKLSLSS 750
    GTKTNLTSQS STTNLPGSPG SPGSPGSPGS PGSVPKNTSQ TAAITTKGGL 800
    VGLVDYPDDD EDDDEDEDKE DTLPLSKKAK FDS 833

    Note: No experimental confirmation available.

    Length:833
    Mass (Da):95,368
    Last modified:July 5, 2004 - v1
    Checksum:iEDDB4E1F47197A94
    GO
    Isoform 2 (identifier: Q6IN85-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         410-422: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:820
    Mass (Da):93,897
    Checksum:iB87BA2CA6C7121C4
    GO
    Isoform 4 (identifier: Q6IN85-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         67-305: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:594
    Mass (Da):67,812
    Checksum:i571E51214496F24F
    GO
    Isoform 5 (identifier: Q6IN85-5) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         410-422: Missing.
         554-833: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:540
    Mass (Da):62,020
    Checksum:i0C55DF4DB36B8908
    GO

    Sequence cautioni

    The sequence BAA91960.1 differs from that shown. Reason: Probable intron retention.
    The sequence BAA91960.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
    The sequence BAB14877.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
    The sequence BAC23106.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei67 – 305239Missing in isoform 4. 1 PublicationVSP_021252Add
    BLAST
    Alternative sequencei410 – 42213Missing in isoform 2 and isoform 5. 2 PublicationsVSP_021253Add
    BLAST
    Alternative sequencei554 – 833280Missing in isoform 5. 1 PublicationVSP_021256Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB095930 mRNA. Translation: BAC23106.1. Different initiation.
    AK000714 mRNA. Translation: BAA91338.1.
    AK001885 mRNA. Translation: BAA91960.1. Sequence problems.
    AK024297 mRNA. Translation: BAB14877.1. Different initiation.
    AL133153 Genomic DNA. No translation available.
    BC038932 mRNA. Translation: AAH38932.1.
    BC072409 mRNA. Translation: AAH72409.1.
    BX248247 mRNA. Translation: CAD62575.1.
    AL832921 mRNA. Translation: CAH10634.1.
    AF113213 mRNA. Translation: AAG39284.1. Sequence problems.
    CCDSiCCDS61532.1. [Q6IN85-4]
    CCDS9895.1. [Q6IN85-2]
    RefSeqiNP_001271209.1. NM_001284280.1. [Q6IN85-2]
    NP_001271210.1. NM_001284281.1. [Q6IN85-4]
    XP_005267899.1. XM_005267842.1. [Q6IN85-1]
    XP_006720257.1. XM_006720194.1. [Q6IN85-1]
    UniGeneiHs.533887.

    Genome annotation databases

    EnsembliENST00000554684; ENSP00000450864; ENSG00000100796. [Q6IN85-2]
    ENST00000554943; ENSP00000450883; ENSG00000100796. [Q6IN85-1]
    ENST00000555462; ENSP00000450891; ENSG00000100796. [Q6IN85-4]
    GeneIDi55671.
    KEGGihsa:55671.
    UCSCiuc001xzm.3. human. [Q6IN85-2]
    uc001xzn.3. human. [Q6IN85-1]
    uc001xzq.1. human. [Q6IN85-5]
    uc010atz.3. human. [Q6IN85-4]

    Polymorphism databases

    DMDMi74736507.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB095930 mRNA. Translation: BAC23106.1 . Different initiation.
    AK000714 mRNA. Translation: BAA91338.1 .
    AK001885 mRNA. Translation: BAA91960.1 . Sequence problems.
    AK024297 mRNA. Translation: BAB14877.1 . Different initiation.
    AL133153 Genomic DNA. No translation available.
    BC038932 mRNA. Translation: AAH38932.1 .
    BC072409 mRNA. Translation: AAH72409.1 .
    BX248247 mRNA. Translation: CAD62575.1 .
    AL832921 mRNA. Translation: CAH10634.1 .
    AF113213 mRNA. Translation: AAG39284.1 . Sequence problems.
    CCDSi CCDS61532.1. [Q6IN85-4 ]
    CCDS9895.1. [Q6IN85-2 ]
    RefSeqi NP_001271209.1. NM_001284280.1. [Q6IN85-2 ]
    NP_001271210.1. NM_001284281.1. [Q6IN85-4 ]
    XP_005267899.1. XM_005267842.1. [Q6IN85-1 ]
    XP_006720257.1. XM_006720194.1. [Q6IN85-1 ]
    UniGenei Hs.533887.

    3D structure databases

    ProteinModelPortali Q6IN85.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 120803. 20 interactions.
    IntActi Q6IN85. 6 interactions.
    MINTi MINT-4827313.

    PTM databases

    PhosphoSitei Q6IN85.

    Polymorphism databases

    DMDMi 74736507.

    Proteomic databases

    MaxQBi Q6IN85.
    PaxDbi Q6IN85.
    PRIDEi Q6IN85.

    Protocols and materials databases

    DNASUi 55671.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000554684 ; ENSP00000450864 ; ENSG00000100796 . [Q6IN85-2 ]
    ENST00000554943 ; ENSP00000450883 ; ENSG00000100796 . [Q6IN85-1 ]
    ENST00000555462 ; ENSP00000450891 ; ENSG00000100796 . [Q6IN85-4 ]
    GeneIDi 55671.
    KEGGi hsa:55671.
    UCSCi uc001xzm.3. human. [Q6IN85-2 ]
    uc001xzn.3. human. [Q6IN85-1 ]
    uc001xzq.1. human. [Q6IN85-5 ]
    uc010atz.3. human. [Q6IN85-4 ]

    Organism-specific databases

    CTDi 55671.
    GeneCardsi GC14M091923.
    H-InvDB HIX0202046.
    HGNCi HGNC:20219. SMEK1.
    HPAi HPA002568.
    MIMi 610351. gene.
    neXtProti NX_Q6IN85.
    PharmGKBi PA162403940.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG314899.
    HOVERGENi HBG056624.
    InParanoidi Q6IN85.
    KOi K17491.
    OMAi IEMFEYV.
    OrthoDBi EOG7ZSHS7.
    PhylomeDBi Q6IN85.
    TreeFami TF315190.

    Enzyme and pathway databases

    SignaLinki Q6IN85.

    Miscellaneous databases

    ChiTaRSi SMEK1. human.
    GenomeRNAii 55671.
    NextBioi 60444.
    PROi Q6IN85.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q6IN85.
    Bgeei Q6IN85.
    Genevestigatori Q6IN85.

    Family and domain databases

    Gene3Di 2.30.29.30. 1 hit.
    InterProi IPR016024. ARM-type_fold.
    IPR006887. DUF625.
    IPR011993. PH_like_dom.
    [Graphical view ]
    Pfami PF04802. SMK-1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48371. SSF48371. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The nucleotide sequence of a long cDNA clone isolated from human."
      Nagase T., Kikuno R., Ohara O.
      Submitted (NOV-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Brain.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 98-833 (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 165-422 (ISOFORM 1).
      Tissue: Ileal mucosa and Placenta.
    3. "The DNA sequence and analysis of human chromosome 14."
      Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H.
      , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J.
      Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 4).
      Tissue: Eye.
    5. "Full-length cDNA libraries and normalization."
      Li W.B., Gruber C., Jessee J., Polayes D.
      Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 238-833.
      Tissue: Neuroblastoma.
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 667-833.
      Tissue: Melanoma.
    7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 808-833.
      Tissue: Aorta.
    8. "A novel, evolutionarily conserved protein phosphatase complex involved in cisplatin sensitivity."
      Gingras A.-C., Caballero M., Zarske M., Sanchez A., Hazbun T.R., Fields S., Sonenberg N., Hafen E., Raught B., Aebersold R.
      Mol. Cell. Proteomics 4:1725-1740(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION IN THE PPP4C-PPP4R2-PPP4R3A COMPLEX, INTERACTION WITH PPP4C, IDENTIFICATION BY MASS SPECTROMETRY.
    9. "Depletion of protein phosphatase 4 in human cells reveals essential roles in centrosome maturation, cell migration and the regulation of Rho GTPases."
      Martin-Granados C., Philp A., Oxenham S.K., Prescott A.R., Cohen P.T.W.
      Int. J. Biochem. Cell Biol. 40:2315-2332(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION.
    10. "A PP4-phosphatase complex dephosphorylates gamma-H2AX generated during DNA replication."
      Chowdhury D., Xu X., Zhong X., Ahmed F., Zhong J., Liao J., Dykxhoorn D.M., Weinstock D.M., Pfeifer G.P., Lieberman J.
      Mol. Cell 31:33-46(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION IN THE PPP4C-PPP4R2-PPP4R3A COMPLEX, FUNCTION OF THE PPP4C-PPP4R2-PPP4R3A COMPLEX.
    11. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-117 AND SER-771, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    12. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    13. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-771; SER-774 AND SER-777, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    14. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
      Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
      Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-655, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    15. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    16. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-741, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiP4R3A_HUMAN
    AccessioniPrimary (citable) accession number: Q6IN85
    Secondary accession number(s): Q69YK6
    , Q86U23, Q86YI7, Q8IVG1, Q9H3F1, Q9H7U8, Q9NV01, Q9NWP1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 31, 2006
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 100 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 14
      Human chromosome 14: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

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