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Protein

rRNA methyltransferase 1, mitochondrial

Gene

MRM1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

S-adenosyl-L-methionine-dependent 2'-O-ribose methyltransferase that catalyzes the formation of 2'-O-methylguanosine at position 1145 (Gm1145) in the 16S mitochondrial large subunit ribosomal RNA (mtLSU rRNA), a universally conserved modification in the peptidyl transferase domain of the mtLSU rRNA.1 Publication

Catalytic activityi

S-adenosyl-L-methionine + guanosine(1145) in 16S rRNA = S-adenosyl-L-homocysteine + 2'-O-methylguanosine(1145) in 16S rRNA.1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

rRNA processing

Keywords - Ligandi

S-adenosyl-L-methionine

Names & Taxonomyi

Protein namesi
Recommended name:
rRNA methyltransferase 1, mitochondrial1 Publication (EC:2.1.1.-1 Publication)
Alternative name(s):
16S rRNA (guanosine(1145)-2'-O)-methyltransferase1 Publication
16S rRNA [Gm1145] 2'-O-methyltransferase1 Publication
Gene namesi
Name:MRM11 Publication
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:26202. MRM1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142671338.

Polymorphism and mutation databases

BioMutaiMRM1.
DMDMi74736506.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 2020MitochondrionSequence analysisAdd
BLAST
Chaini21 – 353333rRNA methyltransferase 1, mitochondrialPRO_0000273202Add
BLAST

Proteomic databases

EPDiQ6IN84.
MaxQBiQ6IN84.
PaxDbiQ6IN84.
PeptideAtlasiQ6IN84.
PRIDEiQ6IN84.

PTM databases

iPTMnetiQ6IN84.
PhosphoSiteiQ6IN84.

Expressioni

Gene expression databases

BgeeiQ6IN84.
CleanExiHS_MRM1.
ExpressionAtlasiQ6IN84. baseline and differential.
GenevisibleiQ6IN84. HS.

Organism-specific databases

HPAiHPA021598.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
AGTRAPQ6RW133EBI-5454865,EBI-741181

Protein-protein interaction databases

BioGridi122999. 43 interactions.
IntActiQ6IN84. 13 interactions.
STRINGi9606.ENSP00000250156.

Structurei

3D structure databases

ProteinModelPortaliQ6IN84.
SMRiQ6IN84. Positions 137-299.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG0838. Eukaryota.
COG0566. LUCA.
GeneTreeiENSGT00390000018761.
HOGENOMiHOG000004826.
HOVERGENiHBG081986.
InParanoidiQ6IN84.
KOiK15507.
OMAiWVEGVHQ.
PhylomeDBiQ6IN84.
TreeFamiTF315167.

Family and domain databases

Gene3Di3.30.1330.30. 1 hit.
3.40.1280.10. 1 hit.
InterProiIPR029028. Alpha/beta_knot_MTases.
IPR029064. L30e-like.
IPR004441. rRNA_MeTrfase_TrmH.
IPR001537. SpoU_MeTrfase.
IPR013123. SpoU_subst-bd.
IPR029026. tRNA_m1G_MTases_N.
[Graphical view]
PfamiPF00588. SpoU_methylase. 1 hit.
PF08032. SpoU_sub_bind. 1 hit.
[Graphical view]
SMARTiSM00967. SpoU_sub_bind. 1 hit.
[Graphical view]
SUPFAMiSSF55315. SSF55315. 1 hit.
SSF75217. SSF75217. 1 hit.
TIGRFAMsiTIGR00186. rRNA_methyl_3. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6IN84-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MALLSTVRGA TWGRLVTRHF SHAARHGERP GGEELSRLLL DDLVPTSRLE
60 70 80 90 100
LLFGMTPCLL ALQAARRSVA RLLLQAGKAG LQGKRAELLR MAEARDIPVL
110 120 130 140 150
RPRRQKLDTM CRYQVHQGVC MEVSPLRPRP WREAGEASPG DDPQQLWLVL
160 170 180 190 200
DGIQDPRNFG AVLRSAHFLG VDKVITSRRN SCPLTPVVSK SSAGAMEVMD
210 220 230 240 250
VFSTDDLTGF LQTKAQQGWL VAGTVGCPST EDPQSSEIPI MSCLEFLWER
260 270 280 290 300
PTLLVLGNEG SGLSQEVQAS CQLLLTILPR RQLPPGLESL NVSVAAGILL
310 320 330 340 350
HSICSQRKGF PTEGERRQLL QDPQEPSARS EGLSMAQHPG LSSGPEKERQ

NEG
Length:353
Mass (Da):38,638
Last modified:July 5, 2004 - v1
Checksum:iD47B4B147523D07D
GO
Isoform 2 (identifier: Q6IN84-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-198: Missing.

Show »
Length:155
Mass (Da):16,770
Checksum:i22EB6F2DE004386D
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti98 – 981P → S.
Corresponds to variant rs60978234 [ dbSNP | Ensembl ].
VAR_061906

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 198198Missing in isoform 2. 3 PublicationsVSP_022494Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK026231 mRNA. Translation: BAB15401.1.
AK292307 mRNA. Translation: BAF84996.1.
CR457357 mRNA. Translation: CAG33638.1.
CH471199 Genomic DNA. Translation: EAW57571.1.
BC009416 mRNA. Translation: AAH09416.2.
BC072411 mRNA. Translation: AAH72411.1.
CCDSiCCDS32631.1. [Q6IN84-1]
RefSeqiNP_079140.2. NM_024864.4. [Q6IN84-1]
UniGeneiHs.194864.

Genome annotation databases

EnsembliENST00000611231; ENSP00000478520; ENSG00000274853. [Q6IN84-1]
ENST00000614766; ENSP00000481559; ENSG00000278619. [Q6IN84-1]
GeneIDi79922.
KEGGihsa:79922.
UCSCiuc002hne.4. human. [Q6IN84-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK026231 mRNA. Translation: BAB15401.1.
AK292307 mRNA. Translation: BAF84996.1.
CR457357 mRNA. Translation: CAG33638.1.
CH471199 Genomic DNA. Translation: EAW57571.1.
BC009416 mRNA. Translation: AAH09416.2.
BC072411 mRNA. Translation: AAH72411.1.
CCDSiCCDS32631.1. [Q6IN84-1]
RefSeqiNP_079140.2. NM_024864.4. [Q6IN84-1]
UniGeneiHs.194864.

3D structure databases

ProteinModelPortaliQ6IN84.
SMRiQ6IN84. Positions 137-299.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122999. 43 interactions.
IntActiQ6IN84. 13 interactions.
STRINGi9606.ENSP00000250156.

PTM databases

iPTMnetiQ6IN84.
PhosphoSiteiQ6IN84.

Polymorphism and mutation databases

BioMutaiMRM1.
DMDMi74736506.

Proteomic databases

EPDiQ6IN84.
MaxQBiQ6IN84.
PaxDbiQ6IN84.
PeptideAtlasiQ6IN84.
PRIDEiQ6IN84.

Protocols and materials databases

DNASUi79922.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000611231; ENSP00000478520; ENSG00000274853. [Q6IN84-1]
ENST00000614766; ENSP00000481559; ENSG00000278619. [Q6IN84-1]
GeneIDi79922.
KEGGihsa:79922.
UCSCiuc002hne.4. human. [Q6IN84-1]

Organism-specific databases

CTDi79922.
GeneCardsiMRM1.
H-InvDBHIX0202428.
HGNCiHGNC:26202. MRM1.
HPAiHPA021598.
neXtProtiNX_Q6IN84.
PharmGKBiPA142671338.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0838. Eukaryota.
COG0566. LUCA.
GeneTreeiENSGT00390000018761.
HOGENOMiHOG000004826.
HOVERGENiHBG081986.
InParanoidiQ6IN84.
KOiK15507.
OMAiWVEGVHQ.
PhylomeDBiQ6IN84.
TreeFamiTF315167.

Miscellaneous databases

GenomeRNAii79922.
PROiQ6IN84.

Gene expression databases

BgeeiQ6IN84.
CleanExiHS_MRM1.
ExpressionAtlasiQ6IN84. baseline and differential.
GenevisibleiQ6IN84. HS.

Family and domain databases

Gene3Di3.30.1330.30. 1 hit.
3.40.1280.10. 1 hit.
InterProiIPR029028. Alpha/beta_knot_MTases.
IPR029064. L30e-like.
IPR004441. rRNA_MeTrfase_TrmH.
IPR001537. SpoU_MeTrfase.
IPR013123. SpoU_subst-bd.
IPR029026. tRNA_m1G_MTases_N.
[Graphical view]
PfamiPF00588. SpoU_methylase. 1 hit.
PF08032. SpoU_sub_bind. 1 hit.
[Graphical view]
SMARTiSM00967. SpoU_sub_bind. 1 hit.
[Graphical view]
SUPFAMiSSF55315. SSF55315. 1 hit.
SSF75217. SSF75217. 1 hit.
TIGRFAMsiTIGR00186. rRNA_methyl_3. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Small intestine and Testis.
  2. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Kidney and Skin.
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  6. "Mitochondrial ribosomal RNA (rRNA) methyltransferase family members are positioned to modify nascent rRNA in foci near the mitochondrial DNA nucleoid."
    Lee K.W., Okot-Kotber C., LaComb J.F., Bogenhagen D.F.
    J. Biol. Chem. 288:31386-31399(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.
  7. "Assignment of 2'-O-methyltransferases to modification sites on the mammalian mitochondrial large subunit 16S rRNA."
    Lee K.W., Bogenhagen D.F.
    J. Biol. Chem. 289:24936-24942(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  8. "MRM2 and MRM3 are involved in biogenesis of the large subunit of the mitochondrial ribosome."
    Rorbach J., Boesch P., Gammage P.A., Nicholls T.J., Pearce S.F., Patel D., Hauser A., Perocchi F., Minczuk M.
    Mol. Biol. Cell 25:2542-2555(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.
  9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiMRM1_HUMAN
AccessioniPrimary (citable) accession number: Q6IN84
Secondary accession number(s): A8K8E2, Q96GK2, Q9H664
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2007
Last sequence update: July 5, 2004
Last modified: July 6, 2016
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.