ID Q6IN42_RAT Unreviewed; 511 AA. AC Q6IN42; DT 05-JUL-2004, integrated into UniProtKB/TrEMBL. DT 05-JUL-2004, sequence version 1. DT 22-FEB-2023, entry version 82. DE SubName: Full=Grn protein {ECO:0000313|EMBL:AAH72469.1}; GN Name=Grn {ECO:0000313|EMBL:AAH72469.1, ECO:0000313|RGD:61983}; OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; OC Murinae; Rattus. OX NCBI_TaxID=10116 {ECO:0000313|EMBL:AAH72469.1}; RN [1] {ECO:0000313|EMBL:AAH72469.1} RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Lung {ECO:0000313|EMBL:AAH72469.1}; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RA Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., RA Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., RA Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M., RA Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., RA Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., RA Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., RA Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., RA Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., RA Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., RA Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., RA Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., RA Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., RA Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., RA Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., RA Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., RA Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., RA Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., RA Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., RA Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., RA Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.; RT "The status, quality, and expansion of the NIH full-length cDNA project: RT the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}. CC -!- SIMILARITY: Belongs to the granulin family. CC {ECO:0000256|ARBA:ARBA00010093}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; BC072469; AAH72469.1; -; mRNA. DR RefSeq; NP_001139314.1; NM_001145842.1. DR RefSeq; NP_058809.2; NM_017113.2. DR AlphaFoldDB; Q6IN42; -. DR GeneID; 29143; -. DR KEGG; rno:29143; -. DR CTD; 2896; -. DR RGD; 61983; Grn. DR OrthoDB; 11342at2759; -. DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell. DR Gene3D; 2.10.25.160; Granulin; 6. DR InterPro; IPR000118; Granulin. DR InterPro; IPR039036; Granulin_fam. DR InterPro; IPR037277; Granulin_sf. DR PANTHER; PTHR12274; GRANULIN; 1. DR PANTHER; PTHR12274:SF3; PROGRANULIN; 1. DR Pfam; PF00396; Granulin; 6. DR SMART; SM00277; GRAN; 6. DR SUPFAM; SSF57277; Granulin repeat; 5. DR PROSITE; PS00799; GRANULINS; 6. DR Genevisible; Q6IN42; RN. PE 2: Evidence at transcript level; KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, KW ECO:0000256|PIRSR:PIRSR639036-50}; KW Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1..17 FT /evidence="ECO:0000256|SAM:SignalP" FT CHAIN 18..511 FT /evidence="ECO:0000256|SAM:SignalP" FT /id="PRO_5004275879" FT DOMAIN 92..105 FT /note="Granulins" FT /evidence="ECO:0000259|PROSITE:PS00799" FT DOMAIN 157..170 FT /note="Granulins" FT /evidence="ECO:0000259|PROSITE:PS00799" FT DOMAIN 239..252 FT /note="Granulins" FT /evidence="ECO:0000259|PROSITE:PS00799" FT DOMAIN 313..326 FT /note="Granulins" FT /evidence="ECO:0000259|PROSITE:PS00799" FT DOMAIN 395..408 FT /note="Granulins" FT /evidence="ECO:0000259|PROSITE:PS00799" FT DOMAIN 470..483 FT /note="Granulins" FT /evidence="ECO:0000259|PROSITE:PS00799" FT DISULFID 125..138 FT /evidence="ECO:0000256|PIRSR:PIRSR639036-50" FT DISULFID 132..148 FT /evidence="ECO:0000256|PIRSR:PIRSR639036-50" FT DISULFID 282..294 FT /evidence="ECO:0000256|PIRSR:PIRSR639036-50" FT DISULFID 288..304 FT /evidence="ECO:0000256|PIRSR:PIRSR639036-50" FT DISULFID 295..312 FT /evidence="ECO:0000256|PIRSR:PIRSR639036-50" FT DISULFID 305..319 FT /evidence="ECO:0000256|PIRSR:PIRSR639036-50" FT DISULFID 313..326 FT /evidence="ECO:0000256|PIRSR:PIRSR639036-50" FT DISULFID 320..333 FT /evidence="ECO:0000256|PIRSR:PIRSR639036-50" FT DISULFID 364..376 FT /evidence="ECO:0000256|PIRSR:PIRSR639036-50" FT DISULFID 370..386 FT /evidence="ECO:0000256|PIRSR:PIRSR639036-50" FT DISULFID 395..408 FT /evidence="ECO:0000256|PIRSR:PIRSR639036-50" FT DISULFID 402..415 FT /evidence="ECO:0000256|PIRSR:PIRSR639036-50" SQ SEQUENCE 511 AA; 55030 MW; 56E112233F2FC75F CRC64; MWILVSWLAL VARLVAGTQC PDGQFCPVAC CLDQGGANYS CCNPLLDTWP IITSRRLDGS CQIRDHCPDG YSCLLTVSGT SSCCPFSEGV SCDDGQHCCP RGFHCSVDGK SCSQISDSLL GAVQCPGSQF ECPDSATCCI MIDGSWGCCP MPQASCCEDR VHCCPHGASC DLVHTRCISP TGTHPLLKKF PAQRTNRAVA FPFSVVCPDA KTQCPDDSTC CELPTGKYGC CPMPNAICCS DHLHCCPQDT VCDLIQSKCI SKDYTTDLMT KLPGYPVNEV KCDLEVSCPD GYTCCRLNTG AWGCCPFTKA VCCEDHIHCC PAGFQCHTET GTCELGVLQV PWMKKVTASL SLPDPQILKN DVPCDDFSSC PSNNTCCRLS SGDWGCCPIP EAVCCEDRQH CCPAGYTCNV KARTCEKDAG SVQPSMDLTF GSKVGNVECG AGHFCHDNQS CCKDSQGGWA CCPYVKGVCC RDGRHCCPIG FHCSAKGTKC LRKKTPRWDI LLRDPAPRPL L //