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Protein

Wnt inhibitory factor 1

Gene

Wif1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Binds to WNT proteins and inhibits their activities. May be involved in mesoderm segmentation.

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein
Biological processWnt signaling pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Wnt inhibitory factor 1
Short name:
WIF-1
Gene namesi
Name:Wif1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 7

Organism-specific databases

RGDi619774 Wif1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 28Sequence analysisAdd BLAST28
ChainiPRO_000000777729 – 379Wnt inhibitory factor 1Add BLAST351

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi88N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi140 ↔ 177By similarity
Disulfide bondi182 ↔ 192By similarity
Disulfide bondi186 ↔ 198By similarity
Disulfide bondi200 ↔ 209By similarity
Disulfide bondi214 ↔ 224By similarity
Disulfide bondi218 ↔ 230By similarity
Disulfide bondi232 ↔ 241By similarity
Glycosylationi245N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi246 ↔ 256By similarity
Disulfide bondi250 ↔ 262By similarity
Disulfide bondi264 ↔ 273By similarity
Disulfide bondi278 ↔ 288By similarity
Disulfide bondi282 ↔ 294By similarity
Disulfide bondi296 ↔ 305By similarity
Disulfide bondi310 ↔ 320By similarity
Disulfide bondi314 ↔ 326By similarity
Disulfide bondi328 ↔ 337By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ6IN38

PTM databases

PhosphoSitePlusiQ6IN38

Expressioni

Inductioni

Induced during the differentiation of CG-4 cells.1 Publication

Gene expression databases

BgeeiENSRNOG00000004476
GenevisibleiQ6IN38 RN

Interactioni

Subunit structurei

Interacts with MYOC.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000006426

Structurei

3D structure databases

ProteinModelPortaliQ6IN38
SMRiQ6IN38
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini38 – 177WIFPROSITE-ProRule annotationAdd BLAST140
Domaini178 – 210EGF-like 1PROSITE-ProRule annotationAdd BLAST33
Domaini211 – 242EGF-like 2PROSITE-ProRule annotationAdd BLAST32
Domaini243 – 274EGF-like 3PROSITE-ProRule annotationAdd BLAST32
Domaini274 – 306EGF-like 4PROSITE-ProRule annotationAdd BLAST33
Domaini307 – 338EGF-like 5PROSITE-ProRule annotationAdd BLAST32

Keywords - Domaini

EGF-like domain, Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IQQ0 Eukaryota
ENOG41104IN LUCA
GeneTreeiENSGT00760000119131
HOGENOMiHOG000015769
HOVERGENiHBG017335
InParanoidiQ6IN38
KOiK01691
OMAiDKGIMAD
OrthoDBiEOG091G08T8
PhylomeDBiQ6IN38

Family and domain databases

Gene3Di2.60.40.2170, 1 hit
InterProiView protein in InterPro
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR003306 WIF
IPR038677 WIF_sf
IPR013309 Wnt-inh
PfamiView protein in Pfam
PF12661 hEGF, 3 hits
PF02019 WIF, 1 hit
PRINTSiPR01901 WIFPROTEIN
ProDomiView protein in ProDom or Entries sharing at least one domain
PD013948 WIF, 1 hit
SMARTiView protein in SMART
SM00181 EGF, 5 hits
SM00469 WIF, 1 hit
PROSITEiView protein in PROSITE
PS00022 EGF_1, 5 hits
PS01186 EGF_2, 4 hits
PS50026 EGF_3, 5 hits
PS50814 WIF, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6IN38-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MARRRAFPAF VLRLWSILPC LLLLRADAGQ PPEESLYLWI DAHQARVLIG
60 70 80 90 100
FEEDILIVSE GKMAPFTHDF RKAQQRMPAI PVNIHSMNFT WQASGQAEYF
110 120 130 140 150
YEFLSLRSLD KGIMADPTVN VPRLGTVPHK ASVVQVGFPC LGKQDGVAAF
160 170 180 190 200
EVNVIVMNSE GNPILRTPQN AIFFKTCQQA ECPGGCRNGG FCNERRVCEC
210 220 230 240 250
PDGFYGPHCE KALCIPRCMN GGLCVTPGFC ICPPGFYGVN CDKANCSATC
260 270 280 290 300
FNGGTCFYPG KCICPPGLEG EQCELSKCPQ PCRNGGKCIG KSKCKCPKGY
310 320 330 340 350
QGDLCSKPVC EPGCGAHGTC HEPNKCQCRE GWHGRHCNKR YGASLMHAPR
360 370
PAGAGLERHT PSLKKAEGRR DPPESNYIW
Length:379
Mass (Da):41,585
Last modified:July 5, 2004 - v1
Checksum:i55229F6FDCC1021C
GO
Isoform 2 (identifier: Q6IN38-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     293-308: KCKCPKGYQGDLCSKP → KS

Show »
Length:365
Mass (Da):40,063
Checksum:i0DA55C1B1CF543BE
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_013172293 – 308KCKCP…LCSKP → KS in isoform 2. 1 PublicationAdd BLAST16

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY030278 mRNA Translation: AAK51134.1
BC072473 mRNA Translation: AAH72473.1
RefSeqiNP_446190.1, NM_053738.1 [Q6IN38-2]
XP_006241457.1, XM_006241395.3 [Q6IN38-1]
UniGeneiRn.74256

Genome annotation databases

EnsembliENSRNOT00000006426; ENSRNOP00000006426; ENSRNOG00000004476 [Q6IN38-1]
GeneIDi114557
KEGGirno:114557

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiWIF1_RAT
AccessioniPrimary (citable) accession number: Q6IN38
Secondary accession number(s): Q924Y6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: July 5, 2004
Last modified: May 23, 2018
This is version 101 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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