Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Calcipressin-1

Gene

Rcan1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A. Could play a role during central nervous system development.By similarity

GO - Molecular functioni

GO - Biological processi

  • calcineurin-NFAT signaling cascade Source: InterPro
  • negative regulation of calcineurin-NFAT signaling cascade Source: UniProtKB
  • negative regulation of smooth muscle cell differentiation Source: RGD
  • regulation of calcineurin-NFAT signaling cascade Source: GO_Central
  • response to estrogen Source: RGD
  • response to mechanical stimulus Source: RGD
  • signal transduction Source: RGD
  • skeletal muscle tissue development Source: RGD

Names & Taxonomyi

Protein namesi
Recommended name:
Calcipressin-1
Alternative name(s):
Down syndrome critical region protein 1 homolog
Myocyte-enriched calcineurin-interacting protein 1
Short name:
MCIP1
Regulator of calcineurin 1
Gene namesi
Name:Rcan1
Synonyms:Dscr1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 11

Organism-specific databases

RGDi631338 Rcan1

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002952671 – 199Calcipressin-1Add BLAST199

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei108PhosphoserineBy similarity1
Modified residuei112PhosphoserineBy similarity1
Modified residuei163PhosphoserineBy similarity1

Post-translational modificationi

Phosphorylation increases its ability to inhibit calcineurin and decreases protein half-life.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ6IN33
PRIDEiQ6IN33

PTM databases

iPTMnetiQ6IN33
PhosphoSitePlusiQ6IN33

Expressioni

Gene expression databases

BgeeiENSRNOG00000001979
GenevisibleiQ6IN33 RN

Interactioni

Subunit structurei

Interacts with RAF1, PPP3R1 and PPP3CA.By similarity

GO - Molecular functioni

  • protein phosphatase 2B binding Source: RGD

Protein-protein interaction databases

IntActiQ6IN33, 1 interactor
STRINGi10116.ENSRNOP00000002715

Structurei

3D structure databases

ProteinModelPortaliQ6IN33
SMRiQ6IN33
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the RCAN family.Curated

Phylogenomic databases

eggNOGiKOG4019 Eukaryota
ENOG4111I50 LUCA
GeneTreeiENSGT00400000022053
HOGENOMiHOG000254788
HOVERGENiHBG018932
InParanoidiQ6IN33
KOiK17901
OMAiVQFQYFR
OrthoDBiEOG091G0OZ7

Family and domain databases

CDDicd12708 RRM_RCAN1, 1 hit
Gene3Di3.30.70.330, 1 hit
InterProiView protein in InterPro
IPR006931 Calcipressin
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR031271 RCAN1
IPR034906 RCAN1_RRM
PANTHERiPTHR10300 PTHR10300, 1 hit
PTHR10300:SF4 PTHR10300:SF4, 1 hit
PfamiView protein in Pfam
PF04847 Calcipressin, 1 hit
SUPFAMiSSF54928 SSF54928, 1 hit

Sequencei

Sequence statusi: Complete.

Q6IN33-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHFRDFNYNF SSLIACVANG DVFSESETRA KFESLFRTYD KDITFQYFKS
60 70 80 90 100
FKRVRINFSN PLSAADARLQ LHKTEFLGKE MKLYFAQTLH IGSSHLAPPN
110 120 130 140 150
PDKQFLISPP ASPPVGWKQV EDATPVINYD LLYAISKLGP GEKYELHAAT
160 170 180 190
DTTPSVVVHV CESDQEEEEE EEEEMERMKR PKPKIIQTRR PEYTPIHLS
Length:199
Mass (Da):22,948
Last modified:July 5, 2004 - v1
Checksum:i3BA20EE4BD59F0BB
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti70Q → R in BAC06443 (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB075973 mRNA Translation: BAC06443.1
BC072478 mRNA Translation: AAH72478.1
RefSeqiNP_714946.2, NM_153724.2
UniGeneiRn.12942

Genome annotation databases

EnsembliENSRNOT00000002715; ENSRNOP00000002715; ENSRNOG00000001979
GeneIDi266766
KEGGirno:266766
UCSCiRGD:631338 rat

Similar proteinsi

Entry informationi

Entry nameiRCAN1_RAT
AccessioniPrimary (citable) accession number: Q6IN33
Secondary accession number(s): Q8K4S2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: July 5, 2004
Last modified: May 23, 2018
This is version 94 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health