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Protein

Calcipressin-1

Gene

Rcan1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A. Could play a role during central nervous system development (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

  • calcineurin-NFAT signaling cascade Source: InterPro
  • negative regulation of smooth muscle cell differentiation Source: RGD
  • regulation of calcineurin-NFAT signaling cascade Source: GO_Central
  • response to estrogen Source: RGD
  • response to mechanical stimulus Source: RGD
  • signal transduction Source: RGD
  • skeletal muscle tissue development Source: RGD
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Calcipressin-1
Alternative name(s):
Down syndrome critical region protein 1 homolog
Myocyte-enriched calcineurin-interacting protein 1
Short name:
MCIP1
Regulator of calcineurin 1
Gene namesi
Name:Rcan1
Synonyms:Dscr1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 11

Organism-specific databases

RGDi631338. Rcan1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 199199Calcipressin-1PRO_0000295267Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei163 – 1631PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ6IN33.

PTM databases

iPTMnetiQ6IN33.
PhosphoSiteiQ6IN33.

Expressioni

Gene expression databases

BgeeiENSRNOG00000001979.
GenevisibleiQ6IN33. RN.

Interactioni

Subunit structurei

Interacts with RAF1.By similarity

GO - Molecular functioni

  • protein phosphatase 2B binding Source: RGD

Protein-protein interaction databases

IntActiQ6IN33. 1 interaction.
STRINGi10116.ENSRNOP00000002715.

Structurei

3D structure databases

ProteinModelPortaliQ6IN33.
SMRiQ6IN33. Positions 11-103.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the RCAN family.Curated

Phylogenomic databases

eggNOGiKOG4019. Eukaryota.
ENOG4111I50. LUCA.
GeneTreeiENSGT00400000022053.
HOGENOMiHOG000254788.
HOVERGENiHBG018932.
InParanoidiQ6IN33.
KOiK17901.
OMAiVHPCETP.
OrthoDBiEOG091G0OZ7.

Family and domain databases

InterProiIPR006931. Calcipressin.
IPR012677. Nucleotide-bd_a/b_plait.
IPR031271. RCAN1.
[Graphical view]
PANTHERiPTHR10300. PTHR10300. 1 hit.
PTHR10300:SF4. PTHR10300:SF4. 1 hit.
PfamiPF04847. Calcipressin. 1 hit.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6IN33-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHFRDFNYNF SSLIACVANG DVFSESETRA KFESLFRTYD KDITFQYFKS
60 70 80 90 100
FKRVRINFSN PLSAADARLQ LHKTEFLGKE MKLYFAQTLH IGSSHLAPPN
110 120 130 140 150
PDKQFLISPP ASPPVGWKQV EDATPVINYD LLYAISKLGP GEKYELHAAT
160 170 180 190
DTTPSVVVHV CESDQEEEEE EEEEMERMKR PKPKIIQTRR PEYTPIHLS
Length:199
Mass (Da):22,948
Last modified:July 5, 2004 - v1
Checksum:i3BA20EE4BD59F0BB
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti70 – 701Q → R in BAC06443 (Ref. 1) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB075973 mRNA. Translation: BAC06443.1.
BC072478 mRNA. Translation: AAH72478.1.
RefSeqiNP_714946.2. NM_153724.2.
UniGeneiRn.12942.

Genome annotation databases

EnsembliENSRNOT00000002715; ENSRNOP00000002715; ENSRNOG00000001979.
GeneIDi266766.
KEGGirno:266766.
UCSCiRGD:631338. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB075973 mRNA. Translation: BAC06443.1.
BC072478 mRNA. Translation: AAH72478.1.
RefSeqiNP_714946.2. NM_153724.2.
UniGeneiRn.12942.

3D structure databases

ProteinModelPortaliQ6IN33.
SMRiQ6IN33. Positions 11-103.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ6IN33. 1 interaction.
STRINGi10116.ENSRNOP00000002715.

PTM databases

iPTMnetiQ6IN33.
PhosphoSiteiQ6IN33.

Proteomic databases

PaxDbiQ6IN33.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000002715; ENSRNOP00000002715; ENSRNOG00000001979.
GeneIDi266766.
KEGGirno:266766.
UCSCiRGD:631338. rat.

Organism-specific databases

CTDi1827.
RGDi631338. Rcan1.

Phylogenomic databases

eggNOGiKOG4019. Eukaryota.
ENOG4111I50. LUCA.
GeneTreeiENSGT00400000022053.
HOGENOMiHOG000254788.
HOVERGENiHBG018932.
InParanoidiQ6IN33.
KOiK17901.
OMAiVHPCETP.
OrthoDBiEOG091G0OZ7.

Miscellaneous databases

PROiQ6IN33.

Gene expression databases

BgeeiENSRNOG00000001979.
GenevisibleiQ6IN33. RN.

Family and domain databases

InterProiIPR006931. Calcipressin.
IPR012677. Nucleotide-bd_a/b_plait.
IPR031271. RCAN1.
[Graphical view]
PANTHERiPTHR10300. PTHR10300. 1 hit.
PTHR10300:SF4. PTHR10300:SF4. 1 hit.
PfamiPF04847. Calcipressin. 1 hit.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiRCAN1_RAT
AccessioniPrimary (citable) accession number: Q6IN33
Secondary accession number(s): Q8K4S2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: July 5, 2004
Last modified: September 7, 2016
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.