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Protein

Microtubule-associated tumor suppressor 1 homolog

Gene

Mtus1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Cooperates with AGTR2 to inhibit ERK2 activation and cell proliferation. May be required for AGTR2 cell surface expression. Together with PTPN6, induces UBE2V2 expression upon angiotensin-II stimulation (By similarity).By similarity

GO - Biological processi

  • cell cycle Source: UniProtKB-KW
  • cellular response to peptide hormone stimulus Source: RGD

Keywordsi

Biological processCell cycle

Names & Taxonomyi

Protein namesi
Recommended name:
Microtubule-associated tumor suppressor 1 homolog
Alternative name(s):
Angiotensin-II type 2 receptor-interacting protein
Mitochondrial tumor suppressor 1 homolog
Gene namesi
Name:Mtus1
Synonyms:Atip, Mtsg1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 16

Organism-specific databases

RGDi631381 Mtus1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Golgi apparatus, Membrane, Mitochondrion, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003052001 – 440Microtubule-associated tumor suppressor 1 homologAdd BLAST440

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei373PhosphoserineCombined sources1
Modified residuei394PhosphoserineCombined sources1
Modified residuei415PhosphoserineBy similarity1
Modified residuei425PhosphoserineBy similarity1
Modified residuei429PhosphoserineCombined sources1
Modified residuei431PhosphoserineCombined sources1
Modified residuei433PhosphoserineBy similarity1
Modified residuei434PhosphoserineCombined sources1
Modified residuei438PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ6IMY1
PRIDEiQ6IMY1

PTM databases

iPTMnetiQ6IMY1
PhosphoSitePlusiQ6IMY1

Expressioni

Tissue specificityi

Present in neurons (at protein level).1 Publication

Gene expression databases

BgeeiENSRNOG00000010748
ExpressionAtlasiQ6IMY1 baseline and differential
GenevisibleiQ6IMY1 RN

Interactioni

Subunit structurei

Homodimer. Interacts with AGTR2. Interacts with PTPN6 (By similarity).By similarity

Structurei

3D structure databases

ProteinModelPortaliQ6IMY1
SMRiQ6IMY1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili106 – 401Sequence analysisAdd BLAST296

Sequence similaritiesi

Belongs to the MTUS1 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IEXM Eukaryota
ENOG41118DX LUCA
GeneTreeiENSGT00390000006245
HOGENOMiHOG000013016
HOVERGENiHBG104120
InParanoidiQ6IMY1
PhylomeDBiQ6IMY1

Family and domain databases

InterProiView protein in InterPro
IPR029786 MTUS1
PANTHERiPTHR24200:SF7 PTHR24200:SF7, 2 hits

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6IMY1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLLSPKFSLS TIHVRLTAKG LLRNLRLPSG LRKNTVIFHT VEKGRQKNPR
60 70 80 90 100
SLCIQTQTAP DVLSTERTLE LADYKTKCEN QSGFILHLKQ LLSCGNTKFE
110 120 130 140 150
ALTVVIQHLL SEREEALKQH KTLSQELVSL RGELVAASST CEKLEKARND
160 170 180 190 200
LQTAYEGFVQ KLNQQHQTDQ TELENRLKEF YTAECEKLQS IYIEEAEKYK
210 220 230 240 250
TQLQEQFDNL NAAHETTKLE IEASHSEKVE LLKKTYETSL SEIKKSHEME
260 270 280 290 300
KKLLENLLNE KQESLEKQIN DLKSENDALN ERLKSEEQKQ LSREKANSKN
310 320 330 340 350
PQVMYLEQEL ESLKAVLEIK NEKLHQQDLK LMKMEKLVDN NTTLVDKLTR
360 370 380 390 400
FQQENEELKA RMDRHMAISR QLSTEQAALQ ESLEKESKVN KRLSMENEEL
410 420 430 440
LWKLHNGDLC SPKRSPTSSA IPFQSPRNSG SFSSPSISPR
Length:440
Mass (Da):50,745
Last modified:July 5, 2004 - v1
Checksum:iA20F08D74ECCE902
GO
Isoform 2 (identifier: Q6IMY1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-94: Missing.
     95-112: GNTKFEALTVVIQHLLSE → MGCPSSKMCLSPPQAAAR

Show »
Length:346
Mass (Da):39,952
Checksum:i6882F2F87429B34D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti73D → Q in AAO60217 (Ref. 1) Curated1
Sequence conflicti343T → A in AAO60218 (Ref. 1) Curated1
Sequence conflicti343T → A in AAO60217 (Ref. 1) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0282841 – 94Missing in isoform 2. 1 PublicationAdd BLAST94
Alternative sequenceiVSP_02828595 – 112GNTKF…HLLSE → MGCPSSKMCLSPPQAAAR in isoform 2. 1 PublicationAdd BLAST18

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY208916 mRNA Translation: AAO60218.1
AY208915 mRNA Translation: AAO60217.1
BC072537 mRNA Translation: AAH72537.1
RefSeqiNP_835194.2, NM_178093.2 [Q6IMY1-1]
UniGeneiRn.95344

Genome annotation databases

EnsembliENSRNOT00000037685; ENSRNOP00000030995; ENSRNOG00000010748 [Q6IMY1-1]
ENSRNOT00000047314; ENSRNOP00000042990; ENSRNOG00000010748 [Q6IMY1-2]
GeneIDi306487
KEGGirno:306487

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiMTUS1_RAT
AccessioniPrimary (citable) accession number: Q6IMY1
Secondary accession number(s): Q6XUU5, Q80Z99
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: July 5, 2004
Last modified: May 23, 2018
This is version 79 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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