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Protein

Microtubule-associated tumor suppressor 1 homolog

Gene

Mtus1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Cooperates with AGTR2 to inhibit ERK2 activation and cell proliferation. May be required for AGTR2 cell surface expression. Together with PTPN6, induces UBE2V2 expression upon angiotensin-II stimulation (By similarity).By similarity

GO - Biological processi

  • cell cycle Source: UniProtKB-KW
  • cellular response to peptide hormone stimulus Source: RGD
Complete GO annotation...

Keywords - Biological processi

Cell cycle

Names & Taxonomyi

Protein namesi
Recommended name:
Microtubule-associated tumor suppressor 1 homolog
Alternative name(s):
Angiotensin-II type 2 receptor-interacting protein
Mitochondrial tumor suppressor 1 homolog
Gene namesi
Name:Mtus1
Synonyms:Atip, Mtsg1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 16

Organism-specific databases

RGDi631381. Mtus1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Golgi apparatus, Membrane, Mitochondrion, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 440440Microtubule-associated tumor suppressor 1 homologPRO_0000305200Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei373 – 3731PhosphoserineCombined sources
Modified residuei394 – 3941PhosphoserineCombined sources
Modified residuei415 – 4151PhosphoserineBy similarity
Modified residuei425 – 4251PhosphoserineBy similarity
Modified residuei429 – 4291PhosphoserineCombined sources
Modified residuei431 – 4311PhosphoserineCombined sources
Modified residuei433 – 4331PhosphoserineBy similarity
Modified residuei434 – 4341PhosphoserineCombined sources
Modified residuei438 – 4381PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ6IMY1.
PRIDEiQ6IMY1.

PTM databases

PhosphoSiteiQ6IMY1.

Expressioni

Tissue specificityi

Present in neurons (at protein level).1 Publication

Gene expression databases

ExpressionAtlasiQ6IMY1. baseline and differential.
GenevisibleiQ6IMY1. RN.

Interactioni

Subunit structurei

Homodimer. Interacts with AGTR2. Interacts with PTPN6 (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000030995.

Structurei

3D structure databases

ProteinModelPortaliQ6IMY1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili106 – 401296Sequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the MTUS1 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IEXM. Eukaryota.
ENOG41118DX. LUCA.
GeneTreeiENSGT00390000006245.
HOGENOMiHOG000013016.
HOVERGENiHBG104120.
InParanoidiQ6IMY1.
OMAiKARMDRH.
OrthoDBiEOG76X5Z9.
PhylomeDBiQ6IMY1.

Family and domain databases

InterProiIPR029786. MTUS1.
[Graphical view]
PANTHERiPTHR24200:SF7. PTHR24200:SF7. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6IMY1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLLSPKFSLS TIHVRLTAKG LLRNLRLPSG LRKNTVIFHT VEKGRQKNPR
60 70 80 90 100
SLCIQTQTAP DVLSTERTLE LADYKTKCEN QSGFILHLKQ LLSCGNTKFE
110 120 130 140 150
ALTVVIQHLL SEREEALKQH KTLSQELVSL RGELVAASST CEKLEKARND
160 170 180 190 200
LQTAYEGFVQ KLNQQHQTDQ TELENRLKEF YTAECEKLQS IYIEEAEKYK
210 220 230 240 250
TQLQEQFDNL NAAHETTKLE IEASHSEKVE LLKKTYETSL SEIKKSHEME
260 270 280 290 300
KKLLENLLNE KQESLEKQIN DLKSENDALN ERLKSEEQKQ LSREKANSKN
310 320 330 340 350
PQVMYLEQEL ESLKAVLEIK NEKLHQQDLK LMKMEKLVDN NTTLVDKLTR
360 370 380 390 400
FQQENEELKA RMDRHMAISR QLSTEQAALQ ESLEKESKVN KRLSMENEEL
410 420 430 440
LWKLHNGDLC SPKRSPTSSA IPFQSPRNSG SFSSPSISPR
Length:440
Mass (Da):50,745
Last modified:July 5, 2004 - v1
Checksum:iA20F08D74ECCE902
GO
Isoform 2 (identifier: Q6IMY1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-94: Missing.
     95-112: GNTKFEALTVVIQHLLSE → MGCPSSKMCLSPPQAAAR

Show »
Length:346
Mass (Da):39,952
Checksum:i6882F2F87429B34D
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti73 – 731D → Q in AAO60217 (Ref. 1) Curated
Sequence conflicti343 – 3431T → A in AAO60218 (Ref. 1) Curated
Sequence conflicti343 – 3431T → A in AAO60217 (Ref. 1) Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 9494Missing in isoform 2. 1 PublicationVSP_028284Add
BLAST
Alternative sequencei95 – 11218GNTKF…HLLSE → MGCPSSKMCLSPPQAAAR in isoform 2. 1 PublicationVSP_028285Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY208916 mRNA. Translation: AAO60218.1.
AY208915 mRNA. Translation: AAO60217.1.
BC072537 mRNA. Translation: AAH72537.1.
RefSeqiNP_835194.2. NM_178093.2. [Q6IMY1-1]
UniGeneiRn.95344.

Genome annotation databases

EnsembliENSRNOT00000037685; ENSRNOP00000030995; ENSRNOG00000010748. [Q6IMY1-1]
ENSRNOT00000047314; ENSRNOP00000042990; ENSRNOG00000010748. [Q6IMY1-2]
GeneIDi306487.
KEGGirno:306487.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY208916 mRNA. Translation: AAO60218.1.
AY208915 mRNA. Translation: AAO60217.1.
BC072537 mRNA. Translation: AAH72537.1.
RefSeqiNP_835194.2. NM_178093.2. [Q6IMY1-1]
UniGeneiRn.95344.

3D structure databases

ProteinModelPortaliQ6IMY1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000030995.

PTM databases

PhosphoSiteiQ6IMY1.

Proteomic databases

PaxDbiQ6IMY1.
PRIDEiQ6IMY1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000037685; ENSRNOP00000030995; ENSRNOG00000010748. [Q6IMY1-1]
ENSRNOT00000047314; ENSRNOP00000042990; ENSRNOG00000010748. [Q6IMY1-2]
GeneIDi306487.
KEGGirno:306487.

Organism-specific databases

CTDi57509.
RGDi631381. Mtus1.

Phylogenomic databases

eggNOGiENOG410IEXM. Eukaryota.
ENOG41118DX. LUCA.
GeneTreeiENSGT00390000006245.
HOGENOMiHOG000013016.
HOVERGENiHBG104120.
InParanoidiQ6IMY1.
OMAiKARMDRH.
OrthoDBiEOG76X5Z9.
PhylomeDBiQ6IMY1.

Miscellaneous databases

NextBioi656098.
PROiQ6IMY1.

Gene expression databases

ExpressionAtlasiQ6IMY1. baseline and differential.
GenevisibleiQ6IMY1. RN.

Family and domain databases

InterProiIPR029786. MTUS1.
[Graphical view]
PANTHERiPTHR24200:SF7. PTHR24200:SF7. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and characterization of rat MTSG1."
    Seibold S., Wanner C., Galle J.
    Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
    Strain: Wistar.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Heart.
  3. "Angiotensin II-induced neural differentiation via angiotensin II type 2 (AT2) receptor-MMS2 cascade involving interaction between AT2 receptor-interacting protein and Src homology 2 domain-containing protein-tyrosine phosphatase 1."
    Li J.-M., Mogi M., Tsukuda K., Tomochika H., Iwanami J., Min L.-J., Nahmias C., Iwai M., Horiuchi M.
    Mol. Endocrinol. 21:499-511(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  4. "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues."
    Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C., Olsen J.V.
    Nat. Commun. 3:876-876(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-373; SER-394; SER-429; SER-431; SER-434 AND SER-438, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiMTUS1_RAT
AccessioniPrimary (citable) accession number: Q6IMY1
Secondary accession number(s): Q6XUU5, Q80Z99
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: July 5, 2004
Last modified: May 11, 2016
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.