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Protein

Hsp70-binding protein 1

Gene

Hspbp1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Inhibits HSPA1A chaperone activity by changing the conformation of the ATP-binding domain of HSPA1A and interfering with ATP binding. Interferes with ubiquitination mediated by STUB1 and inhibits chaperone-assisted degradation of target proteins (By similarity).By similarity1 Publication

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Hsp70-binding protein 1
Short name:
HspBP1
Alternative name(s):
Heat shock protein-binding protein 1
Hsp70-interacting protein 1
Gene namesi
Name:Hspbp1
Synonyms:Hspbp
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi628677. Hspbp1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 357357Hsp70-binding protein 1PRO_0000084038Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei349 – 3491PhosphoserineCombined sources
Modified residuei354 – 3541PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ6IMX7.
PRIDEiQ6IMX7.

PTM databases

iPTMnetiQ6IMX7.

Expressioni

Tissue specificityi

Ubiquitous.1 Publication

Gene expression databases

GenevisibleiQ6IMX7. RN.

Interactioni

Subunit structurei

Interacts with the ATP-binding domain of HSPA1A. Detected in a ternary complex containing STUB1, HSPA1A and HSPBP1 (By similarity).By similarity

Protein-protein interaction databases

IntActiQ6IMX7. 1 interaction.
STRINGi10116.ENSRNOP00000024251.

Structurei

3D structure databases

ProteinModelPortaliQ6IMX7.
SMRiQ6IMX7. Positions 82-348.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati130 – 17243ARM 1Add
BLAST
Repeati175 – 21541ARM 2Add
BLAST
Repeati218 – 25740ARM 3Add
BLAST
Repeati260 – 29940ARM 4Add
BLAST

Sequence similaritiesi

Contains 4 ARM repeats.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG2160. Eukaryota.
ENOG410Y90B. LUCA.
GeneTreeiENSGT00510000048482.
HOGENOMiHOG000007740.
HOVERGENiHBG053282.
InParanoidiQ6IMX7.
KOiK09562.
OMAiCCLVEDC.
OrthoDBiEOG7N37D8.
PhylomeDBiQ6IMX7.
TreeFamiTF324307.

Family and domain databases

Gene3Di1.25.10.10. 1 hit.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR013918. Nucleotide_exch_fac_Fes1.
[Graphical view]
PfamiPF08609. Fes1. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6IMX7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADKGSGGSR LPLALPPASQ GCSSGSSGSS AGGSGNPRLP RNLQGLLQMA
60 70 80 90 100
ITAGSEEPDP PPEPMSEERR QWLQEAMSAA FRGQREEVEQ MKNCLRVLSQ
110 120 130 140 150
ATPPTAGEAE LATDQQEREG ALELLADLCE NMDNAADFCQ LSGMHLLVGR
160 170 180 190 200
YLEAGAAGLR WRAAQLIGTC SQNVAAIQEQ VLGLGALRKL LRLLDRDSCD
210 220 230 240 250
TVRVKALFAI SCLVREQEAG LLQFLRLDGF SVLMRAMQQQ VQKLKVKSAF
260 270 280 290 300
LLQNLLVGHP EHKGTLCSMG MVQQLVALVR TEHSPFHEHV LGALCSLVTD
310 320 330 340 350
FPQGVRECRE PELGLEELLR HRCQLLQQHE EYQEELEFCE KLLQTCFSSP

TDDSMDR
Length:357
Mass (Da):39,191
Last modified:July 5, 2004 - v1
Checksum:i9DF1A7EE6E88AE7C
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti205 – 2051K → N in AAF35834 (PubMed:10786638).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF187860 mRNA. Translation: AAF35834.1.
BC072541 mRNA. Translation: AAH72541.1.
RefSeqiNP_640354.1. NM_139261.1.
XP_006228310.1. XM_006228248.1.
XP_006228311.1. XM_006228249.2.
XP_006228312.1. XM_006228250.2.
UniGeneiRn.4297.

Genome annotation databases

EnsembliENSRNOT00000024251; ENSRNOP00000024251; ENSRNOG00000017795.
GeneIDi246146.
KEGGirno:246146.
UCSCiRGD:628677. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF187860 mRNA. Translation: AAF35834.1.
BC072541 mRNA. Translation: AAH72541.1.
RefSeqiNP_640354.1. NM_139261.1.
XP_006228310.1. XM_006228248.1.
XP_006228311.1. XM_006228249.2.
XP_006228312.1. XM_006228250.2.
UniGeneiRn.4297.

3D structure databases

ProteinModelPortaliQ6IMX7.
SMRiQ6IMX7. Positions 82-348.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ6IMX7. 1 interaction.
STRINGi10116.ENSRNOP00000024251.

PTM databases

iPTMnetiQ6IMX7.

Proteomic databases

PaxDbiQ6IMX7.
PRIDEiQ6IMX7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000024251; ENSRNOP00000024251; ENSRNOG00000017795.
GeneIDi246146.
KEGGirno:246146.
UCSCiRGD:628677. rat.

Organism-specific databases

CTDi23640.
RGDi628677. Hspbp1.

Phylogenomic databases

eggNOGiKOG2160. Eukaryota.
ENOG410Y90B. LUCA.
GeneTreeiENSGT00510000048482.
HOGENOMiHOG000007740.
HOVERGENiHBG053282.
InParanoidiQ6IMX7.
KOiK09562.
OMAiCCLVEDC.
OrthoDBiEOG7N37D8.
PhylomeDBiQ6IMX7.
TreeFamiTF324307.

Miscellaneous databases

PROiQ6IMX7.

Gene expression databases

GenevisibleiQ6IMX7. RN.

Family and domain databases

Gene3Di1.25.10.10. 1 hit.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR013918. Nucleotide_exch_fac_Fes1.
[Graphical view]
PfamiPF08609. Fes1. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation and characterization of isoforms of HspBP1, inhibitors of Hsp70."
    Guerriero V. Jr., Raynes D.A.
    Biochim. Biophys. Acta 1490:203-207(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Heart.
  3. "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues."
    Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C., Olsen J.V.
    Nat. Commun. 3:876-876(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-349, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiHPBP1_RAT
AccessioniPrimary (citable) accession number: Q6IMX7
Secondary accession number(s): Q9JLF4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 25, 2005
Last sequence update: July 5, 2004
Last modified: June 8, 2016
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.