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Q6IMN6

- CAPR2_HUMAN

UniProt

Q6IMN6 - CAPR2_HUMAN

Protein

Caprin-2

Gene

CAPRIN2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
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    • History
      Entry version 85 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    May regulate the transport and translation of mRNAs, modulating for instance the expression of proteins involved in synaptic plasticity in neurons. Involved in regulation of growth as erythroblasts shift from a highly proliferative state towards their terminal phase of differentiation. May be involved in apoptosis.1 Publication

    GO - Molecular functioni

    1. protein binding Source: IntAct
    2. receptor binding Source: BHF-UCL
    3. RNA binding Source: UniProtKB-KW

    GO - Biological processi

    1. negative regulation of cell growth Source: UniProtKB
    2. negative regulation of translation Source: UniProtKB-KW
    3. positive regulation of canonical Wnt signaling pathway Source: BHF-UCL
    4. positive regulation of dendrite morphogenesis Source: UniProtKB
    5. positive regulation of dendritic spine morphogenesis Source: UniProtKB
    6. positive regulation of peptidyl-serine phosphorylation Source: BHF-UCL
    7. positive regulation of protein binding Source: BHF-UCL
    8. positive regulation of transcription from RNA polymerase II promoter Source: BHF-UCL

    Keywords - Molecular functioni

    Protein synthesis inhibitor

    Keywords - Biological processi

    Differentiation, Growth regulation

    Keywords - Ligandi

    RNA-binding

    Enzyme and pathway databases

    SignaLinkiQ6IMN6.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Caprin-2
    Alternative name(s):
    C1q domain-containing protein 1
    Cytoplasmic activation/proliferation-associated protein 2
    Gastric cancer multidrug resistance-associated protein
    Protein EEG-1
    RNA granule protein 140
    Gene namesi
    Name:CAPRIN2Imported
    Synonyms:C1QDC1, EEG1Imported, KIAA1873, RNG140
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 12

    Organism-specific databases

    HGNCiHGNC:21259. CAPRIN2.

    Subcellular locationi

    Isoform 2 : Mitochondrion. Cytoplasm
    Note: Expressed throughout the cytoplasm.
    Isoform 5 : Mitochondrion
    Note: Colocalizes with aggregated mitochondria.

    GO - Cellular componenti

    1. centrosome Source: HPA
    2. cytoplasm Source: UniProtKB
    3. mitochondrion Source: UniProtKB
    4. nucleus Source: HPA
    5. receptor complex Source: BHF-UCL

    Keywords - Cellular componenti

    Cytoplasm, Mitochondrion

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA162381044.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 11271127Caprin-2PRO_0000302082Add
    BLAST

    Proteomic databases

    MaxQBiQ6IMN6.
    PaxDbiQ6IMN6.
    PRIDEiQ6IMN6.

    PTM databases

    PhosphoSiteiQ6IMN6.

    Expressioni

    Tissue specificityi

    Detected in all tissues tested with highest levels of expression in brain and spleen.1 Publication

    Developmental stagei

    Expression is highly regulated during erythroid development with increased expression at the stage of differentiation associated with the onset of global nuclear condensation and reduced cell proliferation.1 Publication

    Gene expression databases

    ArrayExpressiQ6IMN6.
    BgeeiQ6IMN6.
    GenevestigatoriQ6IMN6.

    Organism-specific databases

    HPAiHPA039746.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    LRP5O751973EBI-6918449,EBI-2466421

    Protein-protein interaction databases

    BioGridi122431. 3 interactions.
    IntActiQ6IMN6. 2 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6IMN6.
    SMRiQ6IMN6. Positions 999-1125.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini993 – 1127135C1qPROSITE-ProRule annotationAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili129 – 15628Sequence AnalysisAdd
    BLAST
    Coiled coili194 – 21623Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Belongs to the caprin family.Curated
    Contains 1 C1q domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiNOG41180.
    HOGENOMiHOG000082543.
    HOVERGENiHBG057777.
    InParanoidiQ6IMN6.
    OMAiAGWSDSS.
    PhylomeDBiQ6IMN6.
    TreeFamiTF329471.

    Family and domain databases

    Gene3Di2.60.120.40. 1 hit.
    InterProiIPR001073. C1q.
    IPR028816. Caprin.
    IPR022070. Caprin-1_C.
    IPR008983. Tumour_necrosis_fac-like_dom.
    [Graphical view]
    PANTHERiPTHR22922. PTHR22922. 1 hit.
    PfamiPF00386. C1q. 1 hit.
    PF12287. Caprin-1_C. 1 hit.
    [Graphical view]
    PRINTSiPR00007. COMPLEMNTC1Q.
    SMARTiSM00110. C1Q. 1 hit.
    [Graphical view]
    SUPFAMiSSF49842. SSF49842. 1 hit.
    PROSITEiPS50871. C1Q. 1 hit.
    [Graphical view]

    Sequences (9)i

    Sequence statusi: Complete.

    This entry describes 9 isoformsi produced by alternative splicing. Align

    Isoform 11 Publication (identifier: Q6IMN6-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MEVQVSQASL GFELTSVEKS LREWSRLSRE VIAWLCPSSP NFILNFPPPP     50
    SASSVSMVQL FSSPFGYQSP SGHSEEEREG NMKSAKPQVN HSQHGESQRA 100
    LSPLQSTLSS AASPSQAYET YIENGLICLK HKIRNIEKKK LKLEDYKDRL 150
    KSGEHLNPDQ LEAVEKYEEV LHNLEFAKEL QKTFSGLSLD LLKAQKKAQR 200
    REHMLKLEAE KKKLRTILQV QYVLQNLTQE HVQKDFKGGL NGAVYLPSKE 250
    LDYLIKFSKL TCPERNESLS VEDQMEQSSL YFWDLLEGSE KAVVGTTYKH 300
    LKDLLSKLLN SGYFESIPVP KNAKEKEVPL EEEMLIQSEK KTQLSKTESV 350
    KESESLMEFA QPEIQPQEFL NRRYMTEVDY SNKQGEEQPW EADYARKPNL 400
    PKRWDMLTEP DGQEKKQESF KSWEASGKHQ EVSKPAVSLE QRKQDTSKLR 450
    STLPEEQKKQ EISKSKPSPS QWKQDTPKSK AGYVQEEQKK QETPKLWPVQ 500
    LQKEQDPKKQ TPKSWTPSMQ SEQNTTKSWT TPMCEEQDSK QPETPKSWEN 550
    NVESQKHSLT SQSQISPKSW GVATASLIPN DQLLPRKLNT EPKDVPKPVH 600
    QPVGSSSTLP KDPVLRKEKL QDLMTQIQGT CNFMQESVLD FDKPSSAIPT 650
    SQPPSATPGS PVASKEQNLS SQSDFLQEPL QATSSPVTCS SNACLVTTDQ 700
    ASSGSETEFM TSETPEAAIP PGKQPSSLAS PNPPMAKGSE QGFQSPPASS 750
    SSVTINTAPF QAMQTVFNVN APLPPRKEQE IKESPYSPGY NQSFTTASTQ 800
    TPPQCQLPSI HVEQTVHSQE TAANYHPDGT IQVSNGSLAF YPAQTNVFPR 850
    PTQPFVNSRG SVRGCTRGGR LITNSYRSPG GYKGFDTYRG LPSISNGNYS 900
    QLQFQAREYS GAPYSQRDNF QQCYKRGGTS GGPRANSRAG WSDSSQVSSP 950
    ERDNETFNSG DSGQGDSRSM TPVDVPVTNP AATILPVHVY PLPQQMRVAF 1000
    SAARTSNLAP GTLDQPIVFD LLLNNLGETF DLQLGRFNCP VNGTYVFIFH 1050
    MLKLAVNVPL YVNLMKNEEV LVSAYANDGA PDHETASNHA ILQLFQGDQI 1100
    WLRLHRGAIY GSSWKYSTFS GYLLYQD 1127

    Note: No experimental confirmation available.Curated

    Length:1,127
    Mass (Da):125,925
    Last modified:July 5, 2004 - v1
    Checksum:iD74D1D284B69FA0F
    GO
    Isoform 21 Publication (identifier: Q6IMN6-2) [UniParc]FASTAAdd to Basket

    Also known as: EEG-1L1 Publication

    The sequence of this isoform differs from the canonical sequence as follows:
         717-765: Missing.
         823-823: Missing.

    Show »
    Length:1,077
    Mass (Da):120,974
    Checksum:i2B88BF3C47D032D6
    GO
    Isoform 31 Publication (identifier: Q6IMN6-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         823-823: Missing.
         940-961: GWSDSSQVSSPERDNETFNSGD → NCFIMRNSLLLIKQQGGVILLR
         962-1127: Missing.

    Note: No experimental confirmation available.Curated

    Show »
    Length:960
    Mass (Da):107,601
    Checksum:i6FE365832F2D366A
    GO
    Isoform 41 Publication (identifier: Q6IMN6-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-333: Missing.

    Note: No experimental confirmation available.Curated

    Show »
    Length:794
    Mass (Da):88,029
    Checksum:iF275265D8CF45DAB
    GO
    Isoform 51 Publication (identifier: Q6IMN6-5) [UniParc]FASTAAdd to Basket

    Also known as: EEG-1S1 Publication

    The sequence of this isoform differs from the canonical sequence as follows:
         270-278: SVEDQMEQS → RQTLEGSTV
         279-1127: Missing.

    Show »
    Length:278
    Mass (Da):31,586
    Checksum:i2AC3F3676C6B9930
    GO
    Isoform 61 Publication (identifier: Q6IMN6-6) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         596-596: P → S
         597-1127: Missing.

    Show »
    Length:596
    Mass (Da):68,429
    Checksum:iDD750EAA52CEF4BE
    GO
    Isoform 7 (identifier: Q6IMN6-7) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         823-843: Missing.
         940-961: GWSDSSQVSSPERDNETFNSGD → NCFIMRNSLLLIKQQGGVILLR
         962-1127: Missing.

    Note: No experimental confirmation available.Curated

    Show »
    Length:940
    Mass (Da):105,467
    Checksum:i04796A2E02988C6E
    GO
    Isoform 9 (identifier: Q6IMN6-9) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         823-823: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:1,126
    Mass (Da):125,854
    Checksum:i735B40BA2213669A
    GO
    Isoform 10 (identifier: Q6IMN6-10) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         682-716: Missing.
         823-843: Missing.
         940-961: GWSDSSQVSSPERDNETFNSGD → NCFIMRNSLLLIKQQGGVILLR
         962-1127: Missing.

    Note: No experimental confirmation available.Curated

    Show »
    Length:905
    Mass (Da):101,929
    Checksum:i3F69E619920528F5
    GO

    Sequence cautioni

    The sequence AAK83153.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti298 – 2981Y → D in BAB13830. (PubMed:14702039)Curated
    Sequence conflicti320 – 3201P → S in AAK83153. 1 PublicationCurated
    Sequence conflicti595 – 5951V → A in BAB13830. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti114 – 1141P → S.
    Corresponds to variant rs17688567 [ dbSNP | Ensembl ].
    VAR_048445
    Natural varianti237 – 2371K → R.
    Corresponds to variant rs12146709 [ dbSNP | Ensembl ].
    VAR_048446
    Natural varianti519 – 5191M → V.1 Publication
    Corresponds to variant rs2304630 [ dbSNP | Ensembl ].
    VAR_034939
    Natural varianti655 – 6551S → L.
    Corresponds to variant rs2304628 [ dbSNP | Ensembl ].
    VAR_048447

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 333333Missing in isoform 4. 1 PublicationVSP_052531Add
    BLAST
    Alternative sequencei270 – 2789SVEDQMEQS → RQTLEGSTV in isoform 5. 1 PublicationVSP_052532
    Alternative sequencei279 – 1127849Missing in isoform 5. 1 PublicationVSP_052533Add
    BLAST
    Alternative sequencei596 – 5961P → S in isoform 6. 1 PublicationVSP_052534
    Alternative sequencei597 – 1127531Missing in isoform 6. 1 PublicationVSP_052535Add
    BLAST
    Alternative sequencei682 – 71635Missing in isoform 10. 1 PublicationVSP_043293Add
    BLAST
    Alternative sequencei717 – 76549Missing in isoform 2. 1 PublicationVSP_052536Add
    BLAST
    Alternative sequencei823 – 84321Missing in isoform 7 and isoform 10. 2 PublicationsVSP_052537Add
    BLAST
    Alternative sequencei823 – 8231Missing in isoform 2, isoform 3 and isoform 9. 2 PublicationsVSP_027920
    Alternative sequencei940 – 96122GWSDS…FNSGD → NCFIMRNSLLLIKQQGGVIL LR in isoform 3, isoform 7 and isoform 10. 2 PublicationsVSP_052538Add
    BLAST
    Alternative sequencei962 – 1127166Missing in isoform 3, isoform 7 and isoform 10. 2 PublicationsVSP_052539Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY074490 mRNA. Translation: AAL71549.1.
    AY074491 mRNA. Translation: AAL71550.1.
    AC010198 Genomic DNA. No translation available.
    BC066295 mRNA. Translation: AAH66295.1.
    BC111007 mRNA. Translation: AAI11008.1.
    BC117672 mRNA. Translation: AAI17673.1.
    BC117673 mRNA. Translation: AAI17674.1.
    AK021453 mRNA. Translation: BAB13830.1.
    AK026222 mRNA. Translation: BAB15398.1.
    AF326778 mRNA. Translation: AAK83153.1. Different initiation.
    BX538080 mRNA. Translation: CAD98004.1.
    BK001102 mRNA. Translation: DAA01119.1.
    BK001103 mRNA. Translation: DAA01120.1.
    BR000870 mRNA. Translation: FAA00695.1.
    CCDSiCCDS41766.2. [Q6IMN6-3]
    CCDS55816.1. [Q6IMN6-10]
    CCDS8720.1. [Q6IMN6-2]
    RefSeqiNP_001002259.1. NM_001002259.2. [Q6IMN6-1]
    NP_001193785.1. NM_001206856.2. [Q6IMN6-10]
    NP_076414.2. NM_023925.4. [Q6IMN6-2]
    NP_115532.3. NM_032156.4. [Q6IMN6-3]
    XP_006719200.1. XM_006719137.1. [Q6IMN6-9]
    XP_006719210.1. XM_006719147.1. [Q6IMN6-7]
    XP_006719211.1. XM_006719148.1. [Q6IMN6-4]
    UniGeneiHs.234355.

    Genome annotation databases

    EnsembliENST00000298892; ENSP00000298892; ENSG00000110888. [Q6IMN6-2]
    ENST00000395805; ENSP00000379150; ENSG00000110888. [Q6IMN6-10]
    ENST00000417045; ENSP00000391479; ENSG00000110888. [Q6IMN6-3]
    ENST00000454014; ENSP00000403876; ENSG00000110888. [Q6IMN6-5]
    GeneIDi65981.
    KEGGihsa:65981.
    UCSCiuc001rjf.1. human. [Q6IMN6-3]
    uc001rjg.1. human. [Q6IMN6-1]
    uc001rjh.1. human. [Q6IMN6-2]
    uc001rjl.4. human. [Q6IMN6-10]

    Polymorphism databases

    DMDMi74748798.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY074490 mRNA. Translation: AAL71549.1 .
    AY074491 mRNA. Translation: AAL71550.1 .
    AC010198 Genomic DNA. No translation available.
    BC066295 mRNA. Translation: AAH66295.1 .
    BC111007 mRNA. Translation: AAI11008.1 .
    BC117672 mRNA. Translation: AAI17673.1 .
    BC117673 mRNA. Translation: AAI17674.1 .
    AK021453 mRNA. Translation: BAB13830.1 .
    AK026222 mRNA. Translation: BAB15398.1 .
    AF326778 mRNA. Translation: AAK83153.1 . Different initiation.
    BX538080 mRNA. Translation: CAD98004.1 .
    BK001102 mRNA. Translation: DAA01119.1 .
    BK001103 mRNA. Translation: DAA01120.1 .
    BR000870 mRNA. Translation: FAA00695.1 .
    CCDSi CCDS41766.2. [Q6IMN6-3 ]
    CCDS55816.1. [Q6IMN6-10 ]
    CCDS8720.1. [Q6IMN6-2 ]
    RefSeqi NP_001002259.1. NM_001002259.2. [Q6IMN6-1 ]
    NP_001193785.1. NM_001206856.2. [Q6IMN6-10 ]
    NP_076414.2. NM_023925.4. [Q6IMN6-2 ]
    NP_115532.3. NM_032156.4. [Q6IMN6-3 ]
    XP_006719200.1. XM_006719137.1. [Q6IMN6-9 ]
    XP_006719210.1. XM_006719147.1. [Q6IMN6-7 ]
    XP_006719211.1. XM_006719148.1. [Q6IMN6-4 ]
    UniGenei Hs.234355.

    3D structure databases

    ProteinModelPortali Q6IMN6.
    SMRi Q6IMN6. Positions 999-1125.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 122431. 3 interactions.
    IntActi Q6IMN6. 2 interactions.

    PTM databases

    PhosphoSitei Q6IMN6.

    Polymorphism databases

    DMDMi 74748798.

    Proteomic databases

    MaxQBi Q6IMN6.
    PaxDbi Q6IMN6.
    PRIDEi Q6IMN6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000298892 ; ENSP00000298892 ; ENSG00000110888 . [Q6IMN6-2 ]
    ENST00000395805 ; ENSP00000379150 ; ENSG00000110888 . [Q6IMN6-10 ]
    ENST00000417045 ; ENSP00000391479 ; ENSG00000110888 . [Q6IMN6-3 ]
    ENST00000454014 ; ENSP00000403876 ; ENSG00000110888 . [Q6IMN6-5 ]
    GeneIDi 65981.
    KEGGi hsa:65981.
    UCSCi uc001rjf.1. human. [Q6IMN6-3 ]
    uc001rjg.1. human. [Q6IMN6-1 ]
    uc001rjh.1. human. [Q6IMN6-2 ]
    uc001rjl.4. human. [Q6IMN6-10 ]

    Organism-specific databases

    CTDi 65981.
    GeneCardsi GC12M030862.
    HGNCi HGNC:21259. CAPRIN2.
    HPAi HPA039746.
    MIMi 610375. gene.
    neXtProti NX_Q6IMN6.
    PharmGKBi PA162381044.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG41180.
    HOGENOMi HOG000082543.
    HOVERGENi HBG057777.
    InParanoidi Q6IMN6.
    OMAi AGWSDSS.
    PhylomeDBi Q6IMN6.
    TreeFami TF329471.

    Enzyme and pathway databases

    SignaLinki Q6IMN6.

    Miscellaneous databases

    ChiTaRSi CAPRIN2. human.
    GeneWikii CAPRIN2.
    GenomeRNAii 65981.
    NextBioi 67435.
    PROi Q6IMN6.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q6IMN6.
    Bgeei Q6IMN6.
    Genevestigatori Q6IMN6.

    Family and domain databases

    Gene3Di 2.60.120.40. 1 hit.
    InterProi IPR001073. C1q.
    IPR028816. Caprin.
    IPR022070. Caprin-1_C.
    IPR008983. Tumour_necrosis_fac-like_dom.
    [Graphical view ]
    PANTHERi PTHR22922. PTHR22922. 1 hit.
    Pfami PF00386. C1q. 1 hit.
    PF12287. Caprin-1_C. 1 hit.
    [Graphical view ]
    PRINTSi PR00007. COMPLEMNTC1Q.
    SMARTi SM00110. C1Q. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49842. SSF49842. 1 hit.
    PROSITEi PS50871. C1Q. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and characterization of a gene expressed during terminal differentiation that encodes a novel inhibitor of growth."
      Aerbajinai W., Lee Y.T., Wojda U., Barr V.A., Miller J.L.
      J. Biol. Chem. 279:1916-1921(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2 AND 5), FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
      Tissue: ErythroblastImported.
    2. "The finished DNA sequence of human chromosome 12."
      Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.
      , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
      Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3 AND 10), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 844-1127 (ISOFORMS 1/2/4).
      Tissue: BrainImported and Uterus.
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 298-776 (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-776 (ISOFORM 4), VARIANT VAL-519.
      Tissue: EmbryoImported and Small intestineImported.
    5. "Isolation and functional characterization of a novel gene associated with gastric cancer multidrug resistance."
      Shi Y.-Q., Zhai H.-H., Han Y., Wang X., Wu H.-P., Fan D.-M.
      Submitted (DEC-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 319-1127 (ISOFORM 6).
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 766-1127 (ISOFORM 7).
      Tissue: Cerebellum.
    7. "Activation/division of lymphocytes results in increased levels of cytoplasmic activation/proliferation-associated protein-1: prototype of a new family of proteins."
      Grill B., Wilson G.M., Zhang K.-X., Wang B., Doyonnas R., Quadroni M., Schrader J.W.
      J. Immunol. 172:2389-2400(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION (ISOFORM 9).
    8. "RNA granule protein 140 (RNG140), a paralog of RNG105 localized to distinct RNA granules in neuronal dendrites in the adult vertebrate brain."
      Shiina N., Tokunaga M.
      J. Biol. Chem. 285:24260-24269(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION.

    Entry informationi

    Entry nameiCAPR2_HUMAN
    AccessioniPrimary (citable) accession number: Q6IMN6
    Secondary accession number(s): E4NKG2
    , Q149P6, Q149P7, Q6IMN5, Q7Z371, Q8TE70, Q8TE71, Q96RN6, Q9H667, Q9HAL4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 11, 2007
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 85 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 12
      Human chromosome 12: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3