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Q6IMN6

- CAPR2_HUMAN

UniProt

Q6IMN6 - CAPR2_HUMAN

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Protein
Caprin-2
Gene
CAPRIN2, C1QDC1, EEG1, KIAA1873, RNG140
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

May regulate the transport and translation of mRNAs, modulating for instance the expression of proteins involved in synaptic plasticity in neurons. Involved in regulation of growth as erythroblasts shift from a highly proliferative state towards their terminal phase of differentiation. May be involved in apoptosis.1 Publication

GO - Molecular functioni

  1. RNA binding Source: UniProtKB-KW
  2. protein binding Source: IntAct
  3. receptor binding Source: BHF-UCL
Complete GO annotation...

GO - Biological processi

  1. negative regulation of cell growth Source: UniProtKB
  2. negative regulation of translation Source: UniProtKB-KW
  3. positive regulation of canonical Wnt signaling pathway Source: BHF-UCL
  4. positive regulation of dendrite morphogenesis Source: UniProtKB
  5. positive regulation of dendritic spine morphogenesis Source: UniProtKB
  6. positive regulation of peptidyl-serine phosphorylation Source: BHF-UCL
  7. positive regulation of protein binding Source: BHF-UCL
  8. positive regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
Complete GO annotation...

Keywords - Molecular functioni

Protein synthesis inhibitor

Keywords - Biological processi

Differentiation, Growth regulation

Keywords - Ligandi

RNA-binding

Enzyme and pathway databases

SignaLinkiQ6IMN6.

Names & Taxonomyi

Protein namesi
Recommended name:
Caprin-2
Alternative name(s):
C1q domain-containing protein 1
Cytoplasmic activation/proliferation-associated protein 2
Gastric cancer multidrug resistance-associated protein
Protein EEG-1
RNA granule protein 140
Gene namesi
Name:CAPRIN2
Synonyms:C1QDC1, EEG1, KIAA1873, RNG140
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 12

Organism-specific databases

HGNCiHGNC:21259. CAPRIN2.

Subcellular locationi

Isoform 1 : Cytoplasm 1 Publication
Isoform 2 : Mitochondrion. Cytoplasm
Note: Expressed throughout the cytoplasm.1 Publication
Isoform 5 : Mitochondrion
Note: Colocalizes with aggregated mitochondria.1 Publication

GO - Cellular componenti

  1. centrosome Source: HPA
  2. cytoplasm Source: UniProtKB
  3. mitochondrion Source: UniProtKB
  4. nucleus Source: HPA
  5. receptor complex Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Mitochondrion

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162381044.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11271127Caprin-2
PRO_0000302082Add
BLAST

Proteomic databases

MaxQBiQ6IMN6.
PaxDbiQ6IMN6.
PRIDEiQ6IMN6.

PTM databases

PhosphoSiteiQ6IMN6.

Expressioni

Tissue specificityi

Detected in all tissues tested with highest levels of expression in brain and spleen.1 Publication

Developmental stagei

Expression is highly regulated during erythroid development with increased expression at the stage of differentiation associated with the onset of global nuclear condensation and reduced cell proliferation.1 Publication

Gene expression databases

ArrayExpressiQ6IMN6.
BgeeiQ6IMN6.
GenevestigatoriQ6IMN6.

Organism-specific databases

HPAiHPA039746.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
LRP5O751973EBI-6918449,EBI-2466421

Protein-protein interaction databases

BioGridi122431. 3 interactions.
IntActiQ6IMN6. 2 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ6IMN6.
SMRiQ6IMN6. Positions 999-1125.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini993 – 1127135C1q
Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili129 – 15628 Reviewed prediction
Add
BLAST
Coiled coili194 – 21623 Reviewed prediction
Add
BLAST

Sequence similaritiesi

Belongs to the caprin family.
Contains 1 C1q domain.

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG41180.
HOGENOMiHOG000082543.
HOVERGENiHBG057777.
InParanoidiQ6IMN6.
OMAiAGWSDSS.
PhylomeDBiQ6IMN6.
TreeFamiTF329471.

Family and domain databases

Gene3Di2.60.120.40. 1 hit.
InterProiIPR001073. C1q.
IPR028816. Caprin.
IPR022070. Caprin-1_C.
IPR008983. Tumour_necrosis_fac-like_dom.
[Graphical view]
PANTHERiPTHR22922. PTHR22922. 1 hit.
PfamiPF00386. C1q. 1 hit.
PF12287. Caprin-1_C. 1 hit.
[Graphical view]
PRINTSiPR00007. COMPLEMNTC1Q.
SMARTiSM00110. C1Q. 1 hit.
[Graphical view]
SUPFAMiSSF49842. SSF49842. 1 hit.
PROSITEiPS50871. C1Q. 1 hit.
[Graphical view]

Sequences (9)i

Sequence statusi: Complete.

This entry describes 9 isoformsi produced by alternative splicing. Align

Isoform 11 Publication (identifier: Q6IMN6-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MEVQVSQASL GFELTSVEKS LREWSRLSRE VIAWLCPSSP NFILNFPPPP     50
SASSVSMVQL FSSPFGYQSP SGHSEEEREG NMKSAKPQVN HSQHGESQRA 100
LSPLQSTLSS AASPSQAYET YIENGLICLK HKIRNIEKKK LKLEDYKDRL 150
KSGEHLNPDQ LEAVEKYEEV LHNLEFAKEL QKTFSGLSLD LLKAQKKAQR 200
REHMLKLEAE KKKLRTILQV QYVLQNLTQE HVQKDFKGGL NGAVYLPSKE 250
LDYLIKFSKL TCPERNESLS VEDQMEQSSL YFWDLLEGSE KAVVGTTYKH 300
LKDLLSKLLN SGYFESIPVP KNAKEKEVPL EEEMLIQSEK KTQLSKTESV 350
KESESLMEFA QPEIQPQEFL NRRYMTEVDY SNKQGEEQPW EADYARKPNL 400
PKRWDMLTEP DGQEKKQESF KSWEASGKHQ EVSKPAVSLE QRKQDTSKLR 450
STLPEEQKKQ EISKSKPSPS QWKQDTPKSK AGYVQEEQKK QETPKLWPVQ 500
LQKEQDPKKQ TPKSWTPSMQ SEQNTTKSWT TPMCEEQDSK QPETPKSWEN 550
NVESQKHSLT SQSQISPKSW GVATASLIPN DQLLPRKLNT EPKDVPKPVH 600
QPVGSSSTLP KDPVLRKEKL QDLMTQIQGT CNFMQESVLD FDKPSSAIPT 650
SQPPSATPGS PVASKEQNLS SQSDFLQEPL QATSSPVTCS SNACLVTTDQ 700
ASSGSETEFM TSETPEAAIP PGKQPSSLAS PNPPMAKGSE QGFQSPPASS 750
SSVTINTAPF QAMQTVFNVN APLPPRKEQE IKESPYSPGY NQSFTTASTQ 800
TPPQCQLPSI HVEQTVHSQE TAANYHPDGT IQVSNGSLAF YPAQTNVFPR 850
PTQPFVNSRG SVRGCTRGGR LITNSYRSPG GYKGFDTYRG LPSISNGNYS 900
QLQFQAREYS GAPYSQRDNF QQCYKRGGTS GGPRANSRAG WSDSSQVSSP 950
ERDNETFNSG DSGQGDSRSM TPVDVPVTNP AATILPVHVY PLPQQMRVAF 1000
SAARTSNLAP GTLDQPIVFD LLLNNLGETF DLQLGRFNCP VNGTYVFIFH 1050
MLKLAVNVPL YVNLMKNEEV LVSAYANDGA PDHETASNHA ILQLFQGDQI 1100
WLRLHRGAIY GSSWKYSTFS GYLLYQD 1127

Note: No experimental confirmation available.

Length:1,127
Mass (Da):125,925
Last modified:July 5, 2004 - v1
Checksum:iD74D1D284B69FA0F
GO
Isoform 21 Publication (identifier: Q6IMN6-2) [UniParc]FASTAAdd to Basket

Also known as: EEG-1L

The sequence of this isoform differs from the canonical sequence as follows:
     717-765: Missing.
     823-823: Missing.

Show »
Length:1,077
Mass (Da):120,974
Checksum:i2B88BF3C47D032D6
GO
Isoform 31 Publication (identifier: Q6IMN6-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     823-823: Missing.
     940-961: GWSDSSQVSSPERDNETFNSGD → NCFIMRNSLLLIKQQGGVILLR
     962-1127: Missing.

Note: No experimental confirmation available.

Show »
Length:960
Mass (Da):107,601
Checksum:i6FE365832F2D366A
GO
Isoform 41 Publication (identifier: Q6IMN6-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-333: Missing.

Note: No experimental confirmation available.

Show »
Length:794
Mass (Da):88,029
Checksum:iF275265D8CF45DAB
GO
Isoform 51 Publication (identifier: Q6IMN6-5) [UniParc]FASTAAdd to Basket

Also known as: EEG-1S

The sequence of this isoform differs from the canonical sequence as follows:
     270-278: SVEDQMEQS → RQTLEGSTV
     279-1127: Missing.

Show »
Length:278
Mass (Da):31,586
Checksum:i2AC3F3676C6B9930
GO
Isoform 61 Publication (identifier: Q6IMN6-6) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     596-596: P → S
     597-1127: Missing.

Show »
Length:596
Mass (Da):68,429
Checksum:iDD750EAA52CEF4BE
GO
Isoform 71 Publication (identifier: Q6IMN6-7) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     823-843: Missing.
     940-961: GWSDSSQVSSPERDNETFNSGD → NCFIMRNSLLLIKQQGGVILLR
     962-1127: Missing.

Note: No experimental confirmation available.

Show »
Length:940
Mass (Da):105,467
Checksum:i04796A2E02988C6E
GO
Isoform 9 (identifier: Q6IMN6-9) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     823-823: Missing.

Note: No experimental confirmation available.

Show »
Length:1,126
Mass (Da):125,854
Checksum:i735B40BA2213669A
GO
Isoform 10 (identifier: Q6IMN6-10) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     682-716: Missing.
     823-843: Missing.
     940-961: GWSDSSQVSSPERDNETFNSGD → NCFIMRNSLLLIKQQGGVILLR
     962-1127: Missing.

Note: No experimental confirmation available.

Show »
Length:905
Mass (Da):101,929
Checksum:i3F69E619920528F5
GO

Sequence cautioni

The sequence AAK83153.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti114 – 1141P → S.
Corresponds to variant rs17688567 [ dbSNP | Ensembl ].
VAR_048445
Natural varianti237 – 2371K → R.
Corresponds to variant rs12146709 [ dbSNP | Ensembl ].
VAR_048446
Natural varianti519 – 5191M → V.1 Publication
Corresponds to variant rs2304630 [ dbSNP | Ensembl ].
VAR_034939
Natural varianti655 – 6551S → L.
Corresponds to variant rs2304628 [ dbSNP | Ensembl ].
VAR_048447

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 333333Missing in isoform 4. 1 Publication
VSP_052531Add
BLAST
Alternative sequencei270 – 2789SVEDQMEQS → RQTLEGSTV in isoform 5. 1 Publication
VSP_052532
Alternative sequencei279 – 1127849Missing in isoform 5. 1 Publication
VSP_052533Add
BLAST
Alternative sequencei596 – 5961P → S in isoform 6. 1 Publication
VSP_052534
Alternative sequencei597 – 1127531Missing in isoform 6. 1 Publication
VSP_052535Add
BLAST
Alternative sequencei682 – 71635Missing in isoform 10.
VSP_043293Add
BLAST
Alternative sequencei717 – 76549Missing in isoform 2. 1 Publication
VSP_052536Add
BLAST
Alternative sequencei823 – 84321Missing in isoform 7 and isoform 10. 1 Publication
VSP_052537Add
BLAST
Alternative sequencei823 – 8231Missing in isoform 2, isoform 3 and isoform 9.
VSP_027920
Alternative sequencei940 – 96122GWSDS…FNSGD → NCFIMRNSLLLIKQQGGVIL LR in isoform 3, isoform 7 and isoform 10. 2 Publications
VSP_052538Add
BLAST
Alternative sequencei962 – 1127166Missing in isoform 3, isoform 7 and isoform 10. 2 Publications
VSP_052539Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti298 – 2981Y → D in BAB13830. 1 Publication
Sequence conflicti320 – 3201P → S in AAK83153. 1 Publication
Sequence conflicti595 – 5951V → A in BAB13830. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY074490 mRNA. Translation: AAL71549.1.
AY074491 mRNA. Translation: AAL71550.1.
AC010198 Genomic DNA. No translation available.
BC066295 mRNA. Translation: AAH66295.1.
BC111007 mRNA. Translation: AAI11008.1.
BC117672 mRNA. Translation: AAI17673.1.
BC117673 mRNA. Translation: AAI17674.1.
AK021453 mRNA. Translation: BAB13830.1.
AK026222 mRNA. Translation: BAB15398.1.
AF326778 mRNA. Translation: AAK83153.1. Different initiation.
BX538080 mRNA. Translation: CAD98004.1.
BK001102 mRNA. Translation: DAA01119.1.
BK001103 mRNA. Translation: DAA01120.1.
BR000870 mRNA. Translation: FAA00695.1.
CCDSiCCDS41766.2. [Q6IMN6-3]
CCDS55816.1. [Q6IMN6-10]
CCDS8720.1. [Q6IMN6-2]
RefSeqiNP_001002259.1. NM_001002259.2. [Q6IMN6-1]
NP_001193785.1. NM_001206856.2. [Q6IMN6-10]
NP_076414.2. NM_023925.4. [Q6IMN6-2]
NP_115532.3. NM_032156.4. [Q6IMN6-3]
XP_006719200.1. XM_006719137.1. [Q6IMN6-9]
XP_006719210.1. XM_006719147.1. [Q6IMN6-7]
XP_006719211.1. XM_006719148.1. [Q6IMN6-4]
UniGeneiHs.234355.

Genome annotation databases

EnsembliENST00000251071; ENSP00000251071; ENSG00000110888. [Q6IMN6-1]
ENST00000298892; ENSP00000298892; ENSG00000110888. [Q6IMN6-2]
ENST00000395805; ENSP00000379150; ENSG00000110888. [Q6IMN6-10]
ENST00000417045; ENSP00000391479; ENSG00000110888. [Q6IMN6-3]
ENST00000454014; ENSP00000403876; ENSG00000110888. [Q6IMN6-5]
GeneIDi65981.
KEGGihsa:65981.
UCSCiuc001rjf.1. human. [Q6IMN6-3]
uc001rjg.1. human. [Q6IMN6-1]
uc001rjh.1. human. [Q6IMN6-2]
uc001rjl.4. human. [Q6IMN6-10]

Polymorphism databases

DMDMi74748798.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY074490 mRNA. Translation: AAL71549.1 .
AY074491 mRNA. Translation: AAL71550.1 .
AC010198 Genomic DNA. No translation available.
BC066295 mRNA. Translation: AAH66295.1 .
BC111007 mRNA. Translation: AAI11008.1 .
BC117672 mRNA. Translation: AAI17673.1 .
BC117673 mRNA. Translation: AAI17674.1 .
AK021453 mRNA. Translation: BAB13830.1 .
AK026222 mRNA. Translation: BAB15398.1 .
AF326778 mRNA. Translation: AAK83153.1 . Different initiation.
BX538080 mRNA. Translation: CAD98004.1 .
BK001102 mRNA. Translation: DAA01119.1 .
BK001103 mRNA. Translation: DAA01120.1 .
BR000870 mRNA. Translation: FAA00695.1 .
CCDSi CCDS41766.2. [Q6IMN6-3 ]
CCDS55816.1. [Q6IMN6-10 ]
CCDS8720.1. [Q6IMN6-2 ]
RefSeqi NP_001002259.1. NM_001002259.2. [Q6IMN6-1 ]
NP_001193785.1. NM_001206856.2. [Q6IMN6-10 ]
NP_076414.2. NM_023925.4. [Q6IMN6-2 ]
NP_115532.3. NM_032156.4. [Q6IMN6-3 ]
XP_006719200.1. XM_006719137.1. [Q6IMN6-9 ]
XP_006719210.1. XM_006719147.1. [Q6IMN6-7 ]
XP_006719211.1. XM_006719148.1. [Q6IMN6-4 ]
UniGenei Hs.234355.

3D structure databases

ProteinModelPortali Q6IMN6.
SMRi Q6IMN6. Positions 999-1125.
ModBasei Search...

Protein-protein interaction databases

BioGridi 122431. 3 interactions.
IntActi Q6IMN6. 2 interactions.

PTM databases

PhosphoSitei Q6IMN6.

Polymorphism databases

DMDMi 74748798.

Proteomic databases

MaxQBi Q6IMN6.
PaxDbi Q6IMN6.
PRIDEi Q6IMN6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000251071 ; ENSP00000251071 ; ENSG00000110888 . [Q6IMN6-1 ]
ENST00000298892 ; ENSP00000298892 ; ENSG00000110888 . [Q6IMN6-2 ]
ENST00000395805 ; ENSP00000379150 ; ENSG00000110888 . [Q6IMN6-10 ]
ENST00000417045 ; ENSP00000391479 ; ENSG00000110888 . [Q6IMN6-3 ]
ENST00000454014 ; ENSP00000403876 ; ENSG00000110888 . [Q6IMN6-5 ]
GeneIDi 65981.
KEGGi hsa:65981.
UCSCi uc001rjf.1. human. [Q6IMN6-3 ]
uc001rjg.1. human. [Q6IMN6-1 ]
uc001rjh.1. human. [Q6IMN6-2 ]
uc001rjl.4. human. [Q6IMN6-10 ]

Organism-specific databases

CTDi 65981.
GeneCardsi GC12M030862.
HGNCi HGNC:21259. CAPRIN2.
HPAi HPA039746.
MIMi 610375. gene.
neXtProti NX_Q6IMN6.
PharmGKBi PA162381044.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG41180.
HOGENOMi HOG000082543.
HOVERGENi HBG057777.
InParanoidi Q6IMN6.
OMAi AGWSDSS.
PhylomeDBi Q6IMN6.
TreeFami TF329471.

Enzyme and pathway databases

SignaLinki Q6IMN6.

Miscellaneous databases

ChiTaRSi CAPRIN2. human.
GeneWikii CAPRIN2.
GenomeRNAii 65981.
NextBioi 67435.
PROi Q6IMN6.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q6IMN6.
Bgeei Q6IMN6.
Genevestigatori Q6IMN6.

Family and domain databases

Gene3Di 2.60.120.40. 1 hit.
InterProi IPR001073. C1q.
IPR028816. Caprin.
IPR022070. Caprin-1_C.
IPR008983. Tumour_necrosis_fac-like_dom.
[Graphical view ]
PANTHERi PTHR22922. PTHR22922. 1 hit.
Pfami PF00386. C1q. 1 hit.
PF12287. Caprin-1_C. 1 hit.
[Graphical view ]
PRINTSi PR00007. COMPLEMNTC1Q.
SMARTi SM00110. C1Q. 1 hit.
[Graphical view ]
SUPFAMi SSF49842. SSF49842. 1 hit.
PROSITEi PS50871. C1Q. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and characterization of a gene expressed during terminal differentiation that encodes a novel inhibitor of growth."
    Aerbajinai W., Lee Y.T., Wojda U., Barr V.A., Miller J.L.
    J. Biol. Chem. 279:1916-1921(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2 AND 5), FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
    Tissue: Erythroblast.
  2. "The finished DNA sequence of human chromosome 12."
    Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.
    , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
    Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3 AND 10), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 844-1127 (ISOFORMS 1/2/4).
    Tissue: Brain and Uterus.
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 298-776 (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-776 (ISOFORM 4), VARIANT VAL-519.
    Tissue: Embryo and Small intestine.
  5. "Isolation and functional characterization of a novel gene associated with gastric cancer multidrug resistance."
    Shi Y.-Q., Zhai H.-H., Han Y., Wang X., Wu H.-P., Fan D.-M.
    Submitted (DEC-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 319-1127 (ISOFORM 6).
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 766-1127 (ISOFORM 7).
    Tissue: Cerebellum.
  7. "Activation/division of lymphocytes results in increased levels of cytoplasmic activation/proliferation-associated protein-1: prototype of a new family of proteins."
    Grill B., Wilson G.M., Zhang K.-X., Wang B., Doyonnas R., Quadroni M., Schrader J.W.
    J. Immunol. 172:2389-2400(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION (ISOFORM 9).
  8. "RNA granule protein 140 (RNG140), a paralog of RNG105 localized to distinct RNA granules in neuronal dendrites in the adult vertebrate brain."
    Shiina N., Tokunaga M.
    J. Biol. Chem. 285:24260-24269(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiCAPR2_HUMAN
AccessioniPrimary (citable) accession number: Q6IMN6
Secondary accession number(s): E4NKG2
, Q149P6, Q149P7, Q6IMN5, Q7Z371, Q8TE70, Q8TE71, Q96RN6, Q9H667, Q9HAL4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: July 5, 2004
Last modified: July 9, 2014
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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