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Q6IMN6

- CAPR2_HUMAN

UniProt

Q6IMN6 - CAPR2_HUMAN

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Protein

Caprin-2

Gene

CAPRIN2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

May regulate the transport and translation of mRNAs, modulating for instance the expression of proteins involved in synaptic plasticity in neurons. Involved in regulation of growth as erythroblasts shift from a highly proliferative state towards their terminal phase of differentiation. May be involved in apoptosis.1 Publication

GO - Molecular functioni

  1. receptor binding Source: BHF-UCL
  2. RNA binding Source: UniProtKB-KW

GO - Biological processi

  1. negative regulation of cell growth Source: UniProtKB
  2. negative regulation of translation Source: UniProtKB-KW
  3. positive regulation of canonical Wnt signaling pathway Source: BHF-UCL
  4. positive regulation of dendrite morphogenesis Source: UniProtKB
  5. positive regulation of dendritic spine morphogenesis Source: UniProtKB
  6. positive regulation of peptidyl-serine phosphorylation Source: BHF-UCL
  7. positive regulation of protein binding Source: BHF-UCL
  8. positive regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
Complete GO annotation...

Keywords - Molecular functioni

Protein synthesis inhibitor

Keywords - Biological processi

Differentiation, Growth regulation

Keywords - Ligandi

RNA-binding

Enzyme and pathway databases

SignaLinkiQ6IMN6.

Names & Taxonomyi

Protein namesi
Recommended name:
Caprin-2
Alternative name(s):
C1q domain-containing protein 1
Cytoplasmic activation/proliferation-associated protein 2
Gastric cancer multidrug resistance-associated protein
Protein EEG-1
RNA granule protein 140
Gene namesi
Name:CAPRIN2Imported
Synonyms:C1QDC1, EEG1Imported, KIAA1873, RNG140
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 12

Organism-specific databases

HGNCiHGNC:21259. CAPRIN2.

Subcellular locationi

Isoform 2 : Mitochondrion. Cytoplasm
Note: Expressed throughout the cytoplasm.
Isoform 5 : Mitochondrion
Note: Colocalizes with aggregated mitochondria.

GO - Cellular componenti

  1. centrosome Source: HPA
  2. cytoplasm Source: UniProtKB
  3. mitochondrion Source: UniProtKB
  4. nucleus Source: HPA
  5. receptor complex Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Mitochondrion

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162381044.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11271127Caprin-2PRO_0000302082Add
BLAST

Proteomic databases

MaxQBiQ6IMN6.
PaxDbiQ6IMN6.
PRIDEiQ6IMN6.

PTM databases

PhosphoSiteiQ6IMN6.

Expressioni

Tissue specificityi

Detected in all tissues tested with highest levels of expression in brain and spleen.1 Publication

Developmental stagei

Expression is highly regulated during erythroid development with increased expression at the stage of differentiation associated with the onset of global nuclear condensation and reduced cell proliferation.1 Publication

Gene expression databases

BgeeiQ6IMN6.
ExpressionAtlasiQ6IMN6. baseline and differential.
GenevestigatoriQ6IMN6.

Organism-specific databases

HPAiHPA039746.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
LRP5O751973EBI-6918449,EBI-2466421

Protein-protein interaction databases

BioGridi122431. 3 interactions.
IntActiQ6IMN6. 2 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ6IMN6.
SMRiQ6IMN6. Positions 999-1125.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini993 – 1127135C1qPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili129 – 15628Sequence AnalysisAdd
BLAST
Coiled coili194 – 21623Sequence AnalysisAdd
BLAST

Sequence similaritiesi

Belongs to the caprin family.Curated
Contains 1 C1q domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG41180.
GeneTreeiENSGT00760000119052.
HOGENOMiHOG000082543.
HOVERGENiHBG057777.
InParanoidiQ6IMN6.
OMAiAGWSDSS.
PhylomeDBiQ6IMN6.
TreeFamiTF329471.

Family and domain databases

Gene3Di2.60.120.40. 1 hit.
InterProiIPR001073. C1q.
IPR028816. Caprin.
IPR022070. Caprin-1_C.
IPR008983. Tumour_necrosis_fac-like_dom.
[Graphical view]
PANTHERiPTHR22922. PTHR22922. 1 hit.
PfamiPF00386. C1q. 1 hit.
PF12287. Caprin-1_C. 1 hit.
[Graphical view]
PRINTSiPR00007. COMPLEMNTC1Q.
SMARTiSM00110. C1Q. 1 hit.
[Graphical view]
SUPFAMiSSF49842. SSF49842. 1 hit.
PROSITEiPS50871. C1Q. 1 hit.
[Graphical view]

Sequences (9)i

Sequence statusi: Complete.

This entry describes 9 isoformsi produced by alternative splicing. Align

Isoform 11 Publication (identifier: Q6IMN6-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEVQVSQASL GFELTSVEKS LREWSRLSRE VIAWLCPSSP NFILNFPPPP
60 70 80 90 100
SASSVSMVQL FSSPFGYQSP SGHSEEEREG NMKSAKPQVN HSQHGESQRA
110 120 130 140 150
LSPLQSTLSS AASPSQAYET YIENGLICLK HKIRNIEKKK LKLEDYKDRL
160 170 180 190 200
KSGEHLNPDQ LEAVEKYEEV LHNLEFAKEL QKTFSGLSLD LLKAQKKAQR
210 220 230 240 250
REHMLKLEAE KKKLRTILQV QYVLQNLTQE HVQKDFKGGL NGAVYLPSKE
260 270 280 290 300
LDYLIKFSKL TCPERNESLS VEDQMEQSSL YFWDLLEGSE KAVVGTTYKH
310 320 330 340 350
LKDLLSKLLN SGYFESIPVP KNAKEKEVPL EEEMLIQSEK KTQLSKTESV
360 370 380 390 400
KESESLMEFA QPEIQPQEFL NRRYMTEVDY SNKQGEEQPW EADYARKPNL
410 420 430 440 450
PKRWDMLTEP DGQEKKQESF KSWEASGKHQ EVSKPAVSLE QRKQDTSKLR
460 470 480 490 500
STLPEEQKKQ EISKSKPSPS QWKQDTPKSK AGYVQEEQKK QETPKLWPVQ
510 520 530 540 550
LQKEQDPKKQ TPKSWTPSMQ SEQNTTKSWT TPMCEEQDSK QPETPKSWEN
560 570 580 590 600
NVESQKHSLT SQSQISPKSW GVATASLIPN DQLLPRKLNT EPKDVPKPVH
610 620 630 640 650
QPVGSSSTLP KDPVLRKEKL QDLMTQIQGT CNFMQESVLD FDKPSSAIPT
660 670 680 690 700
SQPPSATPGS PVASKEQNLS SQSDFLQEPL QATSSPVTCS SNACLVTTDQ
710 720 730 740 750
ASSGSETEFM TSETPEAAIP PGKQPSSLAS PNPPMAKGSE QGFQSPPASS
760 770 780 790 800
SSVTINTAPF QAMQTVFNVN APLPPRKEQE IKESPYSPGY NQSFTTASTQ
810 820 830 840 850
TPPQCQLPSI HVEQTVHSQE TAANYHPDGT IQVSNGSLAF YPAQTNVFPR
860 870 880 890 900
PTQPFVNSRG SVRGCTRGGR LITNSYRSPG GYKGFDTYRG LPSISNGNYS
910 920 930 940 950
QLQFQAREYS GAPYSQRDNF QQCYKRGGTS GGPRANSRAG WSDSSQVSSP
960 970 980 990 1000
ERDNETFNSG DSGQGDSRSM TPVDVPVTNP AATILPVHVY PLPQQMRVAF
1010 1020 1030 1040 1050
SAARTSNLAP GTLDQPIVFD LLLNNLGETF DLQLGRFNCP VNGTYVFIFH
1060 1070 1080 1090 1100
MLKLAVNVPL YVNLMKNEEV LVSAYANDGA PDHETASNHA ILQLFQGDQI
1110 1120
WLRLHRGAIY GSSWKYSTFS GYLLYQD

Note: No experimental confirmation available.Curated

Length:1,127
Mass (Da):125,925
Last modified:July 5, 2004 - v1
Checksum:iD74D1D284B69FA0F
GO
Isoform 21 Publication (identifier: Q6IMN6-2) [UniParc]FASTAAdd to Basket

Also known as: EEG-1L1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     717-765: Missing.
     823-823: Missing.

Show »
Length:1,077
Mass (Da):120,974
Checksum:i2B88BF3C47D032D6
GO
Isoform 31 Publication (identifier: Q6IMN6-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     823-823: Missing.
     940-961: GWSDSSQVSSPERDNETFNSGD → NCFIMRNSLLLIKQQGGVILLR
     962-1127: Missing.

Note: No experimental confirmation available.Curated

Show »
Length:960
Mass (Da):107,601
Checksum:i6FE365832F2D366A
GO
Isoform 41 Publication (identifier: Q6IMN6-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-333: Missing.

Note: No experimental confirmation available.Curated

Show »
Length:794
Mass (Da):88,029
Checksum:iF275265D8CF45DAB
GO
Isoform 51 Publication (identifier: Q6IMN6-5) [UniParc]FASTAAdd to Basket

Also known as: EEG-1S1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     270-278: SVEDQMEQS → RQTLEGSTV
     279-1127: Missing.

Show »
Length:278
Mass (Da):31,586
Checksum:i2AC3F3676C6B9930
GO
Isoform 61 Publication (identifier: Q6IMN6-6) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     596-596: P → S
     597-1127: Missing.

Show »
Length:596
Mass (Da):68,429
Checksum:iDD750EAA52CEF4BE
GO
Isoform 7 (identifier: Q6IMN6-7) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     823-843: Missing.
     940-961: GWSDSSQVSSPERDNETFNSGD → NCFIMRNSLLLIKQQGGVILLR
     962-1127: Missing.

Note: No experimental confirmation available.Curated

Show »
Length:940
Mass (Da):105,467
Checksum:i04796A2E02988C6E
GO
Isoform 9 (identifier: Q6IMN6-9) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     823-823: Missing.

Note: No experimental confirmation available.

Show »
Length:1,126
Mass (Da):125,854
Checksum:i735B40BA2213669A
GO
Isoform 10 (identifier: Q6IMN6-10) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     682-716: Missing.
     823-843: Missing.
     940-961: GWSDSSQVSSPERDNETFNSGD → NCFIMRNSLLLIKQQGGVILLR
     962-1127: Missing.

Note: No experimental confirmation available.Curated

Show »
Length:905
Mass (Da):101,929
Checksum:i3F69E619920528F5
GO

Sequence cautioni

The sequence AAK83153.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti298 – 2981Y → D in BAB13830. (PubMed:14702039)Curated
Sequence conflicti320 – 3201P → S in AAK83153. 1 PublicationCurated
Sequence conflicti595 – 5951V → A in BAB13830. (PubMed:14702039)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti114 – 1141P → S.
Corresponds to variant rs17688567 [ dbSNP | Ensembl ].
VAR_048445
Natural varianti237 – 2371K → R.
Corresponds to variant rs12146709 [ dbSNP | Ensembl ].
VAR_048446
Natural varianti519 – 5191M → V.1 Publication
Corresponds to variant rs2304630 [ dbSNP | Ensembl ].
VAR_034939
Natural varianti655 – 6551S → L.
Corresponds to variant rs2304628 [ dbSNP | Ensembl ].
VAR_048447

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 333333Missing in isoform 4. 1 PublicationVSP_052531Add
BLAST
Alternative sequencei270 – 2789SVEDQMEQS → RQTLEGSTV in isoform 5. 1 PublicationVSP_052532
Alternative sequencei279 – 1127849Missing in isoform 5. 1 PublicationVSP_052533Add
BLAST
Alternative sequencei596 – 5961P → S in isoform 6. 1 PublicationVSP_052534
Alternative sequencei597 – 1127531Missing in isoform 6. 1 PublicationVSP_052535Add
BLAST
Alternative sequencei682 – 71635Missing in isoform 10. 1 PublicationVSP_043293Add
BLAST
Alternative sequencei717 – 76549Missing in isoform 2. 1 PublicationVSP_052536Add
BLAST
Alternative sequencei823 – 84321Missing in isoform 7 and isoform 10. 2 PublicationsVSP_052537Add
BLAST
Alternative sequencei823 – 8231Missing in isoform 2, isoform 3 and isoform 9. 2 PublicationsVSP_027920
Alternative sequencei940 – 96122GWSDS…FNSGD → NCFIMRNSLLLIKQQGGVIL LR in isoform 3, isoform 7 and isoform 10. 2 PublicationsVSP_052538Add
BLAST
Alternative sequencei962 – 1127166Missing in isoform 3, isoform 7 and isoform 10. 2 PublicationsVSP_052539Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY074490 mRNA. Translation: AAL71549.1.
AY074491 mRNA. Translation: AAL71550.1.
AC010198 Genomic DNA. No translation available.
BC066295 mRNA. Translation: AAH66295.1.
BC111007 mRNA. Translation: AAI11008.1.
BC117672 mRNA. Translation: AAI17673.1.
BC117673 mRNA. Translation: AAI17674.1.
AK021453 mRNA. Translation: BAB13830.1.
AK026222 mRNA. Translation: BAB15398.1.
AF326778 mRNA. Translation: AAK83153.1. Different initiation.
BX538080 mRNA. Translation: CAD98004.1.
BK001102 mRNA. Translation: DAA01119.1.
BK001103 mRNA. Translation: DAA01120.1.
BR000870 mRNA. Translation: FAA00695.1.
CCDSiCCDS41766.2. [Q6IMN6-3]
CCDS55816.1. [Q6IMN6-10]
CCDS8720.1. [Q6IMN6-2]
RefSeqiNP_001002259.1. NM_001002259.2. [Q6IMN6-1]
NP_001193785.1. NM_001206856.2. [Q6IMN6-10]
NP_076414.2. NM_023925.4. [Q6IMN6-2]
NP_115532.3. NM_032156.4. [Q6IMN6-3]
XP_006719200.1. XM_006719137.1. [Q6IMN6-9]
XP_006719210.1. XM_006719147.1. [Q6IMN6-7]
XP_006719211.1. XM_006719148.1. [Q6IMN6-4]
UniGeneiHs.234355.

Genome annotation databases

EnsembliENST00000298892; ENSP00000298892; ENSG00000110888. [Q6IMN6-2]
ENST00000395805; ENSP00000379150; ENSG00000110888. [Q6IMN6-10]
ENST00000417045; ENSP00000391479; ENSG00000110888. [Q6IMN6-3]
ENST00000454014; ENSP00000403876; ENSG00000110888. [Q6IMN6-5]
GeneIDi65981.
KEGGihsa:65981.
UCSCiuc001rjf.1. human. [Q6IMN6-3]
uc001rjg.1. human. [Q6IMN6-1]
uc001rjh.1. human. [Q6IMN6-2]
uc001rjl.4. human. [Q6IMN6-10]

Polymorphism databases

DMDMi74748798.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY074490 mRNA. Translation: AAL71549.1 .
AY074491 mRNA. Translation: AAL71550.1 .
AC010198 Genomic DNA. No translation available.
BC066295 mRNA. Translation: AAH66295.1 .
BC111007 mRNA. Translation: AAI11008.1 .
BC117672 mRNA. Translation: AAI17673.1 .
BC117673 mRNA. Translation: AAI17674.1 .
AK021453 mRNA. Translation: BAB13830.1 .
AK026222 mRNA. Translation: BAB15398.1 .
AF326778 mRNA. Translation: AAK83153.1 . Different initiation.
BX538080 mRNA. Translation: CAD98004.1 .
BK001102 mRNA. Translation: DAA01119.1 .
BK001103 mRNA. Translation: DAA01120.1 .
BR000870 mRNA. Translation: FAA00695.1 .
CCDSi CCDS41766.2. [Q6IMN6-3 ]
CCDS55816.1. [Q6IMN6-10 ]
CCDS8720.1. [Q6IMN6-2 ]
RefSeqi NP_001002259.1. NM_001002259.2. [Q6IMN6-1 ]
NP_001193785.1. NM_001206856.2. [Q6IMN6-10 ]
NP_076414.2. NM_023925.4. [Q6IMN6-2 ]
NP_115532.3. NM_032156.4. [Q6IMN6-3 ]
XP_006719200.1. XM_006719137.1. [Q6IMN6-9 ]
XP_006719210.1. XM_006719147.1. [Q6IMN6-7 ]
XP_006719211.1. XM_006719148.1. [Q6IMN6-4 ]
UniGenei Hs.234355.

3D structure databases

ProteinModelPortali Q6IMN6.
SMRi Q6IMN6. Positions 999-1125.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 122431. 3 interactions.
IntActi Q6IMN6. 2 interactions.

PTM databases

PhosphoSitei Q6IMN6.

Polymorphism databases

DMDMi 74748798.

Proteomic databases

MaxQBi Q6IMN6.
PaxDbi Q6IMN6.
PRIDEi Q6IMN6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000298892 ; ENSP00000298892 ; ENSG00000110888 . [Q6IMN6-2 ]
ENST00000395805 ; ENSP00000379150 ; ENSG00000110888 . [Q6IMN6-10 ]
ENST00000417045 ; ENSP00000391479 ; ENSG00000110888 . [Q6IMN6-3 ]
ENST00000454014 ; ENSP00000403876 ; ENSG00000110888 . [Q6IMN6-5 ]
GeneIDi 65981.
KEGGi hsa:65981.
UCSCi uc001rjf.1. human. [Q6IMN6-3 ]
uc001rjg.1. human. [Q6IMN6-1 ]
uc001rjh.1. human. [Q6IMN6-2 ]
uc001rjl.4. human. [Q6IMN6-10 ]

Organism-specific databases

CTDi 65981.
GeneCardsi GC12M030862.
HGNCi HGNC:21259. CAPRIN2.
HPAi HPA039746.
MIMi 610375. gene.
neXtProti NX_Q6IMN6.
PharmGKBi PA162381044.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG41180.
GeneTreei ENSGT00760000119052.
HOGENOMi HOG000082543.
HOVERGENi HBG057777.
InParanoidi Q6IMN6.
OMAi AGWSDSS.
PhylomeDBi Q6IMN6.
TreeFami TF329471.

Enzyme and pathway databases

SignaLinki Q6IMN6.

Miscellaneous databases

ChiTaRSi CAPRIN2. human.
GeneWikii CAPRIN2.
GenomeRNAii 65981.
NextBioi 67435.
PROi Q6IMN6.
SOURCEi Search...

Gene expression databases

Bgeei Q6IMN6.
ExpressionAtlasi Q6IMN6. baseline and differential.
Genevestigatori Q6IMN6.

Family and domain databases

Gene3Di 2.60.120.40. 1 hit.
InterProi IPR001073. C1q.
IPR028816. Caprin.
IPR022070. Caprin-1_C.
IPR008983. Tumour_necrosis_fac-like_dom.
[Graphical view ]
PANTHERi PTHR22922. PTHR22922. 1 hit.
Pfami PF00386. C1q. 1 hit.
PF12287. Caprin-1_C. 1 hit.
[Graphical view ]
PRINTSi PR00007. COMPLEMNTC1Q.
SMARTi SM00110. C1Q. 1 hit.
[Graphical view ]
SUPFAMi SSF49842. SSF49842. 1 hit.
PROSITEi PS50871. C1Q. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and characterization of a gene expressed during terminal differentiation that encodes a novel inhibitor of growth."
    Aerbajinai W., Lee Y.T., Wojda U., Barr V.A., Miller J.L.
    J. Biol. Chem. 279:1916-1921(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2 AND 5), FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
    Tissue: ErythroblastImported.
  2. "The finished DNA sequence of human chromosome 12."
    Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.
    , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
    Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3 AND 10), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 844-1127 (ISOFORMS 1/2/4).
    Tissue: BrainImported and Uterus.
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 298-776 (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-776 (ISOFORM 4), VARIANT VAL-519.
    Tissue: EmbryoImported and Small intestineImported.
  5. "Isolation and functional characterization of a novel gene associated with gastric cancer multidrug resistance."
    Shi Y.-Q., Zhai H.-H., Han Y., Wang X., Wu H.-P., Fan D.-M.
    Submitted (DEC-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 319-1127 (ISOFORM 6).
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 766-1127 (ISOFORM 7).
    Tissue: Cerebellum.
  7. "Activation/division of lymphocytes results in increased levels of cytoplasmic activation/proliferation-associated protein-1: prototype of a new family of proteins."
    Grill B., Wilson G.M., Zhang K.-X., Wang B., Doyonnas R., Quadroni M., Schrader J.W.
    J. Immunol. 172:2389-2400(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION (ISOFORM 9).
  8. "RNA granule protein 140 (RNG140), a paralog of RNG105 localized to distinct RNA granules in neuronal dendrites in the adult vertebrate brain."
    Shiina N., Tokunaga M.
    J. Biol. Chem. 285:24260-24269(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiCAPR2_HUMAN
AccessioniPrimary (citable) accession number: Q6IMN6
Secondary accession number(s): E4NKG2
, Q149P6, Q149P7, Q6IMN5, Q7Z371, Q8TE70, Q8TE71, Q96RN6, Q9H667, Q9HAL4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: July 5, 2004
Last modified: October 29, 2014
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3