Q6IMN6 (CAPR2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Caprin-2

Alternative name(s):
C1q domain-containing protein 1
Cytoplasmic activation/proliferation-associated protein 2
Gastric cancer multidrug resistance-associated protein
Protein EEG-1
RNA granule protein 140

Gene names

Name:	CAPRIN2
Synonyms:	C1QDC1, EEG1, KIAA1873, RNG140

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1127 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	May regulate the transport and translation of mRNAs, modulating for instance the expression of proteins involved in synaptic plasticity in neurons. Involved in regulation of growth as erythroblasts shift from a highly proliferative state towards their terminal phase of differentiation. May be involved in apoptosis. Ref.1
Subcellular location	Isoform 1: Cytoplasm. Isoform 2: Mitochondrion. Cytoplasm. Note: Expressed throughout the cytoplasm. Ref.1 Isoform 5: Mitochondrion. Note: Colocalizes with aggregated mitochondria. Ref.1
Tissue specificity	Detected in all tissues tested with highest levels of expression in brain and spleen. Ref.1
Developmental stage	Expression is highly regulated during erythroid development with increased expression at the stage of differentiation associated with the onset of global nuclear condensation and reduced cell proliferation. Ref.1
Sequence similarities	Belongs to the caprin family. Contains 1 C1q domain.
Sequence caution	The sequence AAK83153.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Ontologies

Keywords
Biological process	Differentiation Growth regulation
Cellular component	Cytoplasm Mitochondrion
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Coiled coil
Ligand	RNA-binding
Molecular function	Protein synthesis inhibitor
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	negative regulation of cell growth Inferred from direct assay Ref.1. Source: UniProtKB negative regulation of translation Inferred from electronic annotation. Source: UniProtKB-KW positive regulation of canonical Wnt receptor signaling pathway Inferred from direct assay PubMed 18762581. Source: BHF-UCL positive regulation of dendrite morphogenesis Inferred from sequence or structural similarity. Source: UniProtKB positive regulation of dendritic spine morphogenesis Inferred from sequence or structural similarity. Source: UniProtKB positive regulation of peptidyl-serine phosphorylation Inferred from direct assay PubMed 18762581. Source: BHF-UCL positive regulation of protein binding Inferred from direct assay PubMed 18762581. Source: BHF-UCL positive regulation of transcription from RNA polymerase II promoter Inferred from direct assay PubMed 18762581. Source: BHF-UCL
Cellular_component	mitochondrion Inferred from direct assay Ref.1. Source: UniProtKB receptor complex Inferred from direct assay PubMed 18762581. Source: BHF-UCL
Molecular_function	RNA binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 9 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 Ref.2 (identifier: Q6IMN6-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Note: No experimental confirmation available.

Isoform 2 Ref.1 (identifier: Q6IMN6-2)

Also known as: EEG-1L;

The sequence of this isoform differs from the canonical sequence as follows:
     717-765: Missing.
     823-823: Missing.

Isoform 3 Ref.3 (identifier: Q6IMN6-3)

The sequence of this isoform differs from the canonical sequence as follows:
     823-823: Missing.
     940-961: GWSDSSQVSSPERDNETFNSGD → NCFIMRNSLLLIKQQGGVILLR
     962-1127: Missing.

Note: No experimental confirmation available.

Isoform 4 Ref.4 (identifier: Q6IMN6-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1-333: Missing.

Note: No experimental confirmation available.

Isoform 5 Ref.1 (identifier: Q6IMN6-5)

Also known as: EEG-1S;

The sequence of this isoform differs from the canonical sequence as follows:
     270-278: SVEDQMEQS → RQTLEGSTV
     279-1127: Missing.

Isoform 6 Ref.5 (identifier: Q6IMN6-6)

The sequence of this isoform differs from the canonical sequence as follows:
     596-596: P → S
     597-1127: Missing.

Isoform 7 Ref.6 (identifier: Q6IMN6-7)

The sequence of this isoform differs from the canonical sequence as follows:
     823-843: Missing.
     940-961: GWSDSSQVSSPERDNETFNSGD → NCFIMRNSLLLIKQQGGVILLR
     962-1127: Missing.

Note: No experimental confirmation available.

Isoform 9 (identifier: Q6IMN6-9)

The sequence of this isoform differs from the canonical sequence as follows:
     823-823: Missing.

Note: No experimental confirmation available.

Isoform 10 (identifier: Q6IMN6-10)

The sequence of this isoform differs from the canonical sequence as follows:
     682-716: Missing.
     823-843: Missing.
     940-961: GWSDSSQVSSPERDNETFNSGD → NCFIMRNSLLLIKQQGGVILLR
     962-1127: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1127	1127	Caprin-2		PRO_0000302082
Regions
	Domain	993 – 1127	135	C1q
	Coiled coil	129 – 156	28	Potential
	Coiled coil	194 – 216	23	Potential
Natural variations
	Alternative sequence	1 – 333	333	Missing in isoform 4. Ref.4		VSP_052531
	Alternative sequence	270 – 278	9	SVEDQMEQS → RQTLEGSTV in isoform 5. Ref.1		VSP_052532
	Alternative sequence	279 – 1127	849	Missing in isoform 5. Ref.1		VSP_052533
	Alternative sequence	596	1	P → S in isoform 6. Ref.5		VSP_052534
	Alternative sequence	597 – 1127	531	Missing in isoform 6. Ref.5		VSP_052535
	Alternative sequence	682 – 716	35	Missing in isoform 10.		VSP_043293
	Alternative sequence	717 – 765	49	Missing in isoform 2. Ref.1		VSP_052536
	Alternative sequence	823 – 843	21	Missing in isoform 7 and isoform 10. Ref.6		VSP_052537
	Alternative sequence	823	1	Missing in isoform 2, isoform 3 and isoform 9.		VSP_027920
	Alternative sequence	940 – 961	22	GWSDS…FNSGD → NCFIMRNSLLLIKQQGGVIL LR in isoform 3, isoform 7 and isoform 10. Ref.3 Ref.6		VSP_052538
	Alternative sequence	962 – 1127	166	Missing in isoform 3, isoform 7 and isoform 10. Ref.3 Ref.6		VSP_052539
	Natural variant	114	1	P → S. Corresponds to variant rs17688567 [ dbSNP | Ensembl ].		VAR_048445
	Natural variant	237	1	K → R. Corresponds to variant rs12146709 [ dbSNP | Ensembl ].		VAR_048446
	Natural variant	519	1	M → V. Ref.4 Corresponds to variant rs2304630 [ dbSNP | Ensembl ].		VAR_034939
	Natural variant	655	1	S → L. Corresponds to variant rs2304628 [ dbSNP | Ensembl ].		VAR_048447
Experimental info
	Sequence conflict	298	1	Y → D in BAB13830. Ref.4
	Sequence conflict	320	1	P → S in AAK83153. Ref.5
	Sequence conflict	595	1	V → A in BAB13830. Ref.4

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: D74D1D284B69FA0F	FASTA	1,127	125,925
	10 20 30 40 50 60 MEVQVSQASL GFELTSVEKS LREWSRLSRE VIAWLCPSSP NFILNFPPPP SASSVSMVQL 70 80 90 100 110 120 FSSPFGYQSP SGHSEEEREG NMKSAKPQVN HSQHGESQRA LSPLQSTLSS AASPSQAYET 130 140 150 160 170 180 YIENGLICLK HKIRNIEKKK LKLEDYKDRL KSGEHLNPDQ LEAVEKYEEV LHNLEFAKEL 190 200 210 220 230 240 QKTFSGLSLD LLKAQKKAQR REHMLKLEAE KKKLRTILQV QYVLQNLTQE HVQKDFKGGL 250 260 270 280 290 300 NGAVYLPSKE LDYLIKFSKL TCPERNESLS VEDQMEQSSL YFWDLLEGSE KAVVGTTYKH 310 320 330 340 350 360 LKDLLSKLLN SGYFESIPVP KNAKEKEVPL EEEMLIQSEK KTQLSKTESV KESESLMEFA 370 380 390 400 410 420 QPEIQPQEFL NRRYMTEVDY SNKQGEEQPW EADYARKPNL PKRWDMLTEP DGQEKKQESF 430 440 450 460 470 480 KSWEASGKHQ EVSKPAVSLE QRKQDTSKLR STLPEEQKKQ EISKSKPSPS QWKQDTPKSK 490 500 510 520 530 540 AGYVQEEQKK QETPKLWPVQ LQKEQDPKKQ TPKSWTPSMQ SEQNTTKSWT TPMCEEQDSK 550 560 570 580 590 600 QPETPKSWEN NVESQKHSLT SQSQISPKSW GVATASLIPN DQLLPRKLNT EPKDVPKPVH 610 620 630 640 650 660 QPVGSSSTLP KDPVLRKEKL QDLMTQIQGT CNFMQESVLD FDKPSSAIPT SQPPSATPGS 670 680 690 700 710 720 PVASKEQNLS SQSDFLQEPL QATSSPVTCS SNACLVTTDQ ASSGSETEFM TSETPEAAIP 730 740 750 760 770 780 PGKQPSSLAS PNPPMAKGSE QGFQSPPASS SSVTINTAPF QAMQTVFNVN APLPPRKEQE 790 800 810 820 830 840 IKESPYSPGY NQSFTTASTQ TPPQCQLPSI HVEQTVHSQE TAANYHPDGT IQVSNGSLAF 850 860 870 880 890 900 YPAQTNVFPR PTQPFVNSRG SVRGCTRGGR LITNSYRSPG GYKGFDTYRG LPSISNGNYS 910 920 930 940 950 960 QLQFQAREYS GAPYSQRDNF QQCYKRGGTS GGPRANSRAG WSDSSQVSSP ERDNETFNSG 970 980 990 1000 1010 1020 DSGQGDSRSM TPVDVPVTNP AATILPVHVY PLPQQMRVAF SAARTSNLAP GTLDQPIVFD 1030 1040 1050 1060 1070 1080 LLLNNLGETF DLQLGRFNCP VNGTYVFIFH MLKLAVNVPL YVNLMKNEEV LVSAYANDGA 1090 1100 1110 1120 PDHETASNHA ILQLFQGDQI WLRLHRGAIY GSSWKYSTFS GYLLYQD
	Isoform 2 (EEG-1L) [UniParc]. Checksum: 2B88BF3C47D032D6	FASTA	1,077	120,974
	10 20 30 40 50 60 MEVQVSQASL GFELTSVEKS LREWSRLSRE VIAWLCPSSP NFILNFPPPP SASSVSMVQL 70 80 90 100 110 120 FSSPFGYQSP SGHSEEEREG NMKSAKPQVN HSQHGESQRA LSPLQSTLSS AASPSQAYET 130 140 150 160 170 180 YIENGLICLK HKIRNIEKKK LKLEDYKDRL KSGEHLNPDQ LEAVEKYEEV LHNLEFAKEL 190 200 210 220 230 240 QKTFSGLSLD LLKAQKKAQR REHMLKLEAE KKKLRTILQV QYVLQNLTQE HVQKDFKGGL 250 260 270 280 290 300 NGAVYLPSKE LDYLIKFSKL TCPERNESLS VEDQMEQSSL YFWDLLEGSE KAVVGTTYKH 310 320 330 340 350 360 LKDLLSKLLN SGYFESIPVP KNAKEKEVPL EEEMLIQSEK KTQLSKTESV KESESLMEFA 370 380 390 400 410 420 QPEIQPQEFL NRRYMTEVDY SNKQGEEQPW EADYARKPNL PKRWDMLTEP DGQEKKQESF 430 440 450 460 470 480 KSWEASGKHQ EVSKPAVSLE QRKQDTSKLR STLPEEQKKQ EISKSKPSPS QWKQDTPKSK 490 500 510 520 530 540 AGYVQEEQKK QETPKLWPVQ LQKEQDPKKQ TPKSWTPSMQ SEQNTTKSWT TPMCEEQDSK 550 560 570 580 590 600 QPETPKSWEN NVESQKHSLT SQSQISPKSW GVATASLIPN DQLLPRKLNT EPKDVPKPVH 610 620 630 640 650 660 QPVGSSSTLP KDPVLRKEKL QDLMTQIQGT CNFMQESVLD FDKPSSAIPT SQPPSATPGS 670 680 690 700 710 720 PVASKEQNLS SQSDFLQEPL QATSSPVTCS SNACLVTTDQ ASSGSETEFM TSETPEVFNV 730 740 750 760 770 780 NAPLPPRKEQ EIKESPYSPG YNQSFTTAST QTPPQCQLPS IHVEQTVHSQ ETANYHPDGT 790 800 810 820 830 840 IQVSNGSLAF YPAQTNVFPR PTQPFVNSRG SVRGCTRGGR LITNSYRSPG GYKGFDTYRG 850 860 870 880 890 900 LPSISNGNYS QLQFQAREYS GAPYSQRDNF QQCYKRGGTS GGPRANSRAG WSDSSQVSSP 910 920 930 940 950 960 ERDNETFNSG DSGQGDSRSM TPVDVPVTNP AATILPVHVY PLPQQMRVAF SAARTSNLAP 970 980 990 1000 1010 1020 GTLDQPIVFD LLLNNLGETF DLQLGRFNCP VNGTYVFIFH MLKLAVNVPL YVNLMKNEEV 1030 1040 1050 1060 1070 LVSAYANDGA PDHETASNHA ILQLFQGDQI WLRLHRGAIY GSSWKYSTFS GYLLYQD
	Isoform 3 [UniParc]. Checksum: 6FE365832F2D366A	FASTA	960	107,601
	10 20 30 40 50 60 MEVQVSQASL GFELTSVEKS LREWSRLSRE VIAWLCPSSP NFILNFPPPP SASSVSMVQL 70 80 90 100 110 120 FSSPFGYQSP SGHSEEEREG NMKSAKPQVN HSQHGESQRA LSPLQSTLSS AASPSQAYET 130 140 150 160 170 180 YIENGLICLK HKIRNIEKKK LKLEDYKDRL KSGEHLNPDQ LEAVEKYEEV LHNLEFAKEL 190 200 210 220 230 240 QKTFSGLSLD LLKAQKKAQR REHMLKLEAE KKKLRTILQV QYVLQNLTQE HVQKDFKGGL 250 260 270 280 290 300 NGAVYLPSKE LDYLIKFSKL TCPERNESLS VEDQMEQSSL YFWDLLEGSE KAVVGTTYKH 310 320 330 340 350 360 LKDLLSKLLN SGYFESIPVP KNAKEKEVPL EEEMLIQSEK KTQLSKTESV KESESLMEFA 370 380 390 400 410 420 QPEIQPQEFL NRRYMTEVDY SNKQGEEQPW EADYARKPNL PKRWDMLTEP DGQEKKQESF 430 440 450 460 470 480 KSWEASGKHQ EVSKPAVSLE QRKQDTSKLR STLPEEQKKQ EISKSKPSPS QWKQDTPKSK 490 500 510 520 530 540 AGYVQEEQKK QETPKLWPVQ LQKEQDPKKQ TPKSWTPSMQ SEQNTTKSWT TPMCEEQDSK 550 560 570 580 590 600 QPETPKSWEN NVESQKHSLT SQSQISPKSW GVATASLIPN DQLLPRKLNT EPKDVPKPVH 610 620 630 640 650 660 QPVGSSSTLP KDPVLRKEKL QDLMTQIQGT CNFMQESVLD FDKPSSAIPT SQPPSATPGS 670 680 690 700 710 720 PVASKEQNLS SQSDFLQEPL QATSSPVTCS SNACLVTTDQ ASSGSETEFM TSETPEAAIP 730 740 750 760 770 780 PGKQPSSLAS PNPPMAKGSE QGFQSPPASS SSVTINTAPF QAMQTVFNVN APLPPRKEQE 790 800 810 820 830 840 IKESPYSPGY NQSFTTASTQ TPPQCQLPSI HVEQTVHSQE TANYHPDGTI QVSNGSLAFY 850 860 870 880 890 900 PAQTNVFPRP TQPFVNSRGS VRGCTRGGRL ITNSYRSPGG YKGFDTYRGL PSISNGNYSQ 910 920 930 940 950 960 LQFQAREYSG APYSQRDNFQ QCYKRGGTSG GPRANSRANC FIMRNSLLLI KQQGGVILLR
	Isoform 4 [UniParc]. Checksum: F275265D8CF45DAB	FASTA	794	88,029
	10 20 30 40 50 60 MLIQSEKKTQ LSKTESVKES ESLMEFAQPE IQPQEFLNRR YMTEVDYSNK QGEEQPWEAD 70 80 90 100 110 120 YARKPNLPKR WDMLTEPDGQ EKKQESFKSW EASGKHQEVS KPAVSLEQRK QDTSKLRSTL 130 140 150 160 170 180 PEEQKKQEIS KSKPSPSQWK QDTPKSKAGY VQEEQKKQET PKLWPVQLQK EQDPKKQTPK 190 200 210 220 230 240 SWTPSMQSEQ NTTKSWTTPM CEEQDSKQPE TPKSWENNVE SQKHSLTSQS QISPKSWGVA 250 260 270 280 290 300 TASLIPNDQL LPRKLNTEPK DVPKPVHQPV GSSSTLPKDP VLRKEKLQDL MTQIQGTCNF 310 320 330 340 350 360 MQESVLDFDK PSSAIPTSQP PSATPGSPVA SKEQNLSSQS DFLQEPLQAT SSPVTCSSNA 370 380 390 400 410 420 CLVTTDQASS GSETEFMTSE TPEAAIPPGK QPSSLASPNP PMAKGSEQGF QSPPASSSSV 430 440 450 460 470 480 TINTAPFQAM QTVFNVNAPL PPRKEQEIKE SPYSPGYNQS FTTASTQTPP QCQLPSIHVE 490 500 510 520 530 540 QTVHSQETAA NYHPDGTIQV SNGSLAFYPA QTNVFPRPTQ PFVNSRGSVR GCTRGGRLIT 550 560 570 580 590 600 NSYRSPGGYK GFDTYRGLPS ISNGNYSQLQ FQAREYSGAP YSQRDNFQQC YKRGGTSGGP 610 620 630 640 650 660 RANSRAGWSD SSQVSSPERD NETFNSGDSG QGDSRSMTPV DVPVTNPAAT ILPVHVYPLP 670 680 690 700 710 720 QQMRVAFSAA RTSNLAPGTL DQPIVFDLLL NNLGETFDLQ LGRFNCPVNG TYVFIFHMLK 730 740 750 760 770 780 LAVNVPLYVN LMKNEEVLVS AYANDGAPDH ETASNHAILQ LFQGDQIWLR LHRGAIYGSS 790 WKYSTFSGYL LYQD
	Isoform 5 (EEG-1S) [UniParc]. Checksum: 2AC3F3676C6B9930	FASTA	278	31,586
	10 20 30 40 50 60 MEVQVSQASL GFELTSVEKS LREWSRLSRE VIAWLCPSSP NFILNFPPPP SASSVSMVQL 70 80 90 100 110 120 FSSPFGYQSP SGHSEEEREG NMKSAKPQVN HSQHGESQRA LSPLQSTLSS AASPSQAYET 130 140 150 160 170 180 YIENGLICLK HKIRNIEKKK LKLEDYKDRL KSGEHLNPDQ LEAVEKYEEV LHNLEFAKEL 190 200 210 220 230 240 QKTFSGLSLD LLKAQKKAQR REHMLKLEAE KKKLRTILQV QYVLQNLTQE HVQKDFKGGL 250 260 270 NGAVYLPSKE LDYLIKFSKL TCPERNESLR QTLEGSTV
	Isoform 6 [UniParc]. Checksum: DD750EAA52CEF4BE	FASTA	596	68,429
	10 20 30 40 50 60 MEVQVSQASL GFELTSVEKS LREWSRLSRE VIAWLCPSSP NFILNFPPPP SASSVSMVQL 70 80 90 100 110 120 FSSPFGYQSP SGHSEEEREG NMKSAKPQVN HSQHGESQRA LSPLQSTLSS AASPSQAYET 130 140 150 160 170 180 YIENGLICLK HKIRNIEKKK LKLEDYKDRL KSGEHLNPDQ LEAVEKYEEV LHNLEFAKEL 190 200 210 220 230 240 QKTFSGLSLD LLKAQKKAQR REHMLKLEAE KKKLRTILQV QYVLQNLTQE HVQKDFKGGL 250 260 270 280 290 300 NGAVYLPSKE LDYLIKFSKL TCPERNESLS VEDQMEQSSL YFWDLLEGSE KAVVGTTYKH 310 320 330 340 350 360 LKDLLSKLLN SGYFESIPVP KNAKEKEVPL EEEMLIQSEK KTQLSKTESV KESESLMEFA 370 380 390 400 410 420 QPEIQPQEFL NRRYMTEVDY SNKQGEEQPW EADYARKPNL PKRWDMLTEP DGQEKKQESF 430 440 450 460 470 480 KSWEASGKHQ EVSKPAVSLE QRKQDTSKLR STLPEEQKKQ EISKSKPSPS QWKQDTPKSK 490 500 510 520 530 540 AGYVQEEQKK QETPKLWPVQ LQKEQDPKKQ TPKSWTPSMQ SEQNTTKSWT TPMCEEQDSK 550 560 570 580 590 QPETPKSWEN NVESQKHSLT SQSQISPKSW GVATASLIPN DQLLPRKLNT EPKDVS
	Isoform 7 [UniParc]. Checksum: 04796A2E02988C6E	FASTA	940	105,467
	10 20 30 40 50 60 MEVQVSQASL GFELTSVEKS LREWSRLSRE VIAWLCPSSP NFILNFPPPP SASSVSMVQL 70 80 90 100 110 120 FSSPFGYQSP SGHSEEEREG NMKSAKPQVN HSQHGESQRA LSPLQSTLSS AASPSQAYET 130 140 150 160 170 180 YIENGLICLK HKIRNIEKKK LKLEDYKDRL KSGEHLNPDQ LEAVEKYEEV LHNLEFAKEL 190 200 210 220 230 240 QKTFSGLSLD LLKAQKKAQR REHMLKLEAE KKKLRTILQV QYVLQNLTQE HVQKDFKGGL 250 260 270 280 290 300 NGAVYLPSKE LDYLIKFSKL TCPERNESLS VEDQMEQSSL YFWDLLEGSE KAVVGTTYKH 310 320 330 340 350 360 LKDLLSKLLN SGYFESIPVP KNAKEKEVPL EEEMLIQSEK KTQLSKTESV KESESLMEFA 370 380 390 400 410 420 QPEIQPQEFL NRRYMTEVDY SNKQGEEQPW EADYARKPNL PKRWDMLTEP DGQEKKQESF 430 440 450 460 470 480 KSWEASGKHQ EVSKPAVSLE QRKQDTSKLR STLPEEQKKQ EISKSKPSPS QWKQDTPKSK 490 500 510 520 530 540 AGYVQEEQKK QETPKLWPVQ LQKEQDPKKQ TPKSWTPSMQ SEQNTTKSWT TPMCEEQDSK 550 560 570 580 590 600 QPETPKSWEN NVESQKHSLT SQSQISPKSW GVATASLIPN DQLLPRKLNT EPKDVPKPVH 610 620 630 640 650 660 QPVGSSSTLP KDPVLRKEKL QDLMTQIQGT CNFMQESVLD FDKPSSAIPT SQPPSATPGS 670 680 690 700 710 720 PVASKEQNLS SQSDFLQEPL QATSSPVTCS SNACLVTTDQ ASSGSETEFM TSETPEAAIP 730 740 750 760 770 780 PGKQPSSLAS PNPPMAKGSE QGFQSPPASS SSVTINTAPF QAMQTVFNVN APLPPRKEQE 790 800 810 820 830 840 IKESPYSPGY NQSFTTASTQ TPPQCQLPSI HVEQTVHSQE TAQTNVFPRP TQPFVNSRGS 850 860 870 880 890 900 VRGCTRGGRL ITNSYRSPGG YKGFDTYRGL PSISNGNYSQ LQFQAREYSG APYSQRDNFQ 910 920 930 940 QCYKRGGTSG GPRANSRANC FIMRNSLLLI KQQGGVILLR
	Isoform 9 [UniParc]. Checksum: 735B40BA2213669A	FASTA	1,126	125,854
	10 20 30 40 50 60 MEVQVSQASL GFELTSVEKS LREWSRLSRE VIAWLCPSSP NFILNFPPPP SASSVSMVQL 70 80 90 100 110 120 FSSPFGYQSP SGHSEEEREG NMKSAKPQVN HSQHGESQRA LSPLQSTLSS AASPSQAYET 130 140 150 160 170 180 YIENGLICLK HKIRNIEKKK LKLEDYKDRL KSGEHLNPDQ LEAVEKYEEV LHNLEFAKEL 190 200 210 220 230 240 QKTFSGLSLD LLKAQKKAQR REHMLKLEAE KKKLRTILQV QYVLQNLTQE HVQKDFKGGL 250 260 270 280 290 300 NGAVYLPSKE LDYLIKFSKL TCPERNESLS VEDQMEQSSL YFWDLLEGSE KAVVGTTYKH 310 320 330 340 350 360 LKDLLSKLLN SGYFESIPVP KNAKEKEVPL EEEMLIQSEK KTQLSKTESV KESESLMEFA 370 380 390 400 410 420 QPEIQPQEFL NRRYMTEVDY SNKQGEEQPW EADYARKPNL PKRWDMLTEP DGQEKKQESF 430 440 450 460 470 480 KSWEASGKHQ EVSKPAVSLE QRKQDTSKLR STLPEEQKKQ EISKSKPSPS QWKQDTPKSK 490 500 510 520 530 540 AGYVQEEQKK QETPKLWPVQ LQKEQDPKKQ TPKSWTPSMQ SEQNTTKSWT TPMCEEQDSK 550 560 570 580 590 600 QPETPKSWEN NVESQKHSLT SQSQISPKSW GVATASLIPN DQLLPRKLNT EPKDVPKPVH 610 620 630 640 650 660 QPVGSSSTLP KDPVLRKEKL QDLMTQIQGT CNFMQESVLD FDKPSSAIPT SQPPSATPGS 670 680 690 700 710 720 PVASKEQNLS SQSDFLQEPL QATSSPVTCS SNACLVTTDQ ASSGSETEFM TSETPEAAIP 730 740 750 760 770 780 PGKQPSSLAS PNPPMAKGSE QGFQSPPASS SSVTINTAPF QAMQTVFNVN APLPPRKEQE 790 800 810 820 830 840 IKESPYSPGY NQSFTTASTQ TPPQCQLPSI HVEQTVHSQE TANYHPDGTI QVSNGSLAFY 850 860 870 880 890 900 PAQTNVFPRP TQPFVNSRGS VRGCTRGGRL ITNSYRSPGG YKGFDTYRGL PSISNGNYSQ 910 920 930 940 950 960 LQFQAREYSG APYSQRDNFQ QCYKRGGTSG GPRANSRAGW SDSSQVSSPE RDNETFNSGD 970 980 990 1000 1010 1020 SGQGDSRSMT PVDVPVTNPA ATILPVHVYP LPQQMRVAFS AARTSNLAPG TLDQPIVFDL 1030 1040 1050 1060 1070 1080 LLNNLGETFD LQLGRFNCPV NGTYVFIFHM LKLAVNVPLY VNLMKNEEVL VSAYANDGAP 1090 1100 1110 1120 DHETASNHAI LQLFQGDQIW LRLHRGAIYG SSWKYSTFSG YLLYQD
	Isoform 10 [UniParc]. Checksum: 3F69E619920528F5	FASTA	905	101,929
	10 20 30 40 50 60 MEVQVSQASL GFELTSVEKS LREWSRLSRE VIAWLCPSSP NFILNFPPPP SASSVSMVQL 70 80 90 100 110 120 FSSPFGYQSP SGHSEEEREG NMKSAKPQVN HSQHGESQRA LSPLQSTLSS AASPSQAYET 130 140 150 160 170 180 YIENGLICLK HKIRNIEKKK LKLEDYKDRL KSGEHLNPDQ LEAVEKYEEV LHNLEFAKEL 190 200 210 220 230 240 QKTFSGLSLD LLKAQKKAQR REHMLKLEAE KKKLRTILQV QYVLQNLTQE HVQKDFKGGL 250 260 270 280 290 300 NGAVYLPSKE LDYLIKFSKL TCPERNESLS VEDQMEQSSL YFWDLLEGSE KAVVGTTYKH 310 320 330 340 350 360 LKDLLSKLLN SGYFESIPVP KNAKEKEVPL EEEMLIQSEK KTQLSKTESV KESESLMEFA 370 380 390 400 410 420 QPEIQPQEFL NRRYMTEVDY SNKQGEEQPW EADYARKPNL PKRWDMLTEP DGQEKKQESF 430 440 450 460 470 480 KSWEASGKHQ EVSKPAVSLE QRKQDTSKLR STLPEEQKKQ EISKSKPSPS QWKQDTPKSK 490 500 510 520 530 540 AGYVQEEQKK QETPKLWPVQ LQKEQDPKKQ TPKSWTPSMQ SEQNTTKSWT TPMCEEQDSK 550 560 570 580 590 600 QPETPKSWEN NVESQKHSLT SQSQISPKSW GVATASLIPN DQLLPRKLNT EPKDVPKPVH 610 620 630 640 650 660 QPVGSSSTLP KDPVLRKEKL QDLMTQIQGT CNFMQESVLD FDKPSSAIPT SQPPSATPGS 670 680 690 700 710 720 PVASKEQNLS SQSDFLQEPL QAAIPPGKQP SSLASPNPPM AKGSEQGFQS PPASSSSVTI 730 740 750 760 770 780 NTAPFQAMQT VFNVNAPLPP RKEQEIKESP YSPGYNQSFT TASTQTPPQC QLPSIHVEQT 790 800 810 820 830 840 VHSQETAQTN VFPRPTQPFV NSRGSVRGCT RGGRLITNSY RSPGGYKGFD TYRGLPSISN 850 860 870 880 890 900 GNYSQLQFQA REYSGAPYSQ RDNFQQCYKR GGTSGGPRAN SRANCFIMRN SLLLIKQQGG VILLR

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning and characterization of a gene expressed during terminal differentiation that encodes a novel inhibitor of growth." Aerbajinai W., Lee Y.T., Wojda U., Barr V.A., Miller J.L. J. Biol. Chem. 279:1916-1921(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2 AND 5), FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE. Tissue: Erythroblast.
[2]	"The finished DNA sequence of human chromosome 12." Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R. , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A. Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3 AND 10), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 844-1127 (ISOFORMS 1/2/4). Tissue: Brain and Uterus.
[4]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 298-776 (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-776 (ISOFORM 4), VARIANT VAL-519. Tissue: Embryo and Small intestine.
[5]	"Isolation and functional characterization of a novel gene associated with gastric cancer multidrug resistance." Shi Y.-Q., Zhai H.-H., Han Y., Wang X., Wu H.-P., Fan D.-M. Submitted (DEC-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 319-1127 (ISOFORM 6).
[6]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 766-1127 (ISOFORM 7). Tissue: Cerebellum.
[7]	"Activation/division of lymphocytes results in increased levels of cytoplasmic activation/proliferation-associated protein-1: prototype of a new family of proteins." Grill B., Wilson G.M., Zhang K.-X., Wang B., Doyonnas R., Quadroni M., Schrader J.W. J. Immunol. 172:2389-2400(2004) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION (ISOFORM 9).
[8]	"RNA granule protein 140 (RNG140), a paralog of RNG105 localized to distinct RNA granules in neuronal dendrites in the adult vertebrate brain." Shiina N., Tokunaga M. J. Biol. Chem. 285:24260-24269(2010) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY074490 mRNA. Translation: AAL71549.1. AY074491 mRNA. Translation: AAL71550.1. AC010198 Genomic DNA. No translation available. BC066295 mRNA. Translation: AAH66295.1. BC111007 mRNA. Translation: AAI11008.1. BC117672 mRNA. Translation: AAI17673.1. BC117673 mRNA. Translation: AAI17674.1. AK021453 mRNA. Translation: BAB13830.1. AK026222 mRNA. Translation: BAB15398.1. AF326778 mRNA. Translation: AAK83153.1. Different initiation. BX538080 mRNA. Translation: CAD98004.1. BK001102 mRNA. Translation: DAA01119.1. BK001103 mRNA. Translation: DAA01120.1. BR000870 mRNA. Translation: FAA00695.1.
IPI	IPI00154829. IPI00744077. IPI00791775. IPI00855828. IPI00855852. IPI00855878. IPI00855955. IPI00855991.
RefSeq	NP_001002259.1. NM_001002259.1. NP_001193785.1. NM_001206856.1. NP_076414.2. NM_023925.3. NP_115532.3. NM_032156.3.
UniGene	Hs.234355.
3D structure databases
ProteinModelPortal	Q6IMN6.
ModBase	Search...
PTM databases
PhosphoSite	Q6IMN6.
Polymorphism databases
DMDM	74748798.
Proteomic databases
PaxDb	Q6IMN6.
PRIDE	Q6IMN6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000251071; ENSP00000251071; ENSG00000110888. ENST00000298892; ENSP00000298892; ENSG00000110888. ENST00000395805; ENSP00000379150; ENSG00000110888. ENST00000417045; ENSP00000391479; ENSG00000110888. ENST00000454014; ENSP00000403876; ENSG00000110888.
GeneID	65981.
KEGG	hsa:65981.
UCSC	uc001rjf.1. human. uc001rjg.1. human. uc001rjh.1. human. uc001rjj.1. human. uc001rjl.4. human.
Organism-specific databases
CTD	65981.
GeneCards	GC12M030862.
HGNC	HGNC:21259. CAPRIN2.
HPA	HPA039746.
MIM	610375. gene.
neXtProt	NX_Q6IMN6.
PharmGKB	PA162381044.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG41180.
HOGENOM	HOG000082543.
HOVERGEN	HBG057777.
InParanoid	Q6IMN6.
OMA	AGWSDSS.
OrthoDB	EOG4W9J33.
Enzyme and pathway databases
SignaLink	Q6IMN6.
Gene expression databases
ArrayExpress	Q6IMN6.
Bgee	Q6IMN6.
Genevestigator	Q6IMN6.
Family and domain databases
Gene3D	2.60.120.40. 1 hit.
InterPro	IPR001073. C1q. IPR022070. Caprin-1_C. IPR008983. Tumour_necrosis_fac-like_dom. [Graphical view]
Pfam	PF00386. C1q. 1 hit. PF12287. Caprin-1_C. 1 hit. [Graphical view]
PRINTS	PR00007. COMPLEMNTC1Q.
SMART	SM00110. C1Q. 1 hit. [Graphical view]
SUPFAM	SSF49842. TNF_like. 1 hit.
PROSITE	PS50871. C1Q. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	CAPRIN2. human.
GenomeRNAi	65981.
NextBio	67435.
SOURCE	Search...

Entry information

Entry name

CAPR2_HUMAN

Accession

Primary (citable) accession number: Q6IMN6
Secondary accession number(s): E4NKG2 , Q149P6, Q149P7, Q6IMN5, Q7Z371, Q8TE70, Q8TE71, Q96RN6, Q9H667, Q9HAL4

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 11, 2007
Last sequence update:	July 5, 2004
Last modified:	May 29, 2013
This is version 73 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.