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Protein

Caprin-2

Gene

CAPRIN2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May regulate the transport and translation of mRNAs, modulating for instance the expression of proteins involved in synaptic plasticity in neurons. Involved in regulation of growth as erythroblasts shift from a highly proliferative state towards their terminal phase of differentiation. May be involved in apoptosis.1 Publication

GO - Molecular functioni

  • receptor binding Source: BHF-UCL
  • RNA binding Source: UniProtKB-KW

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Protein synthesis inhibitor

Keywords - Biological processi

Differentiation, Growth regulation

Keywords - Ligandi

RNA-binding

Enzyme and pathway databases

SignaLinkiQ6IMN6.
SIGNORiQ6IMN6.

Names & Taxonomyi

Protein namesi
Recommended name:
Caprin-2
Alternative name(s):
C1q domain-containing protein 1
Cytoplasmic activation/proliferation-associated protein 2
Gastric cancer multidrug resistance-associated protein
Protein EEG-1
RNA granule protein 140
Gene namesi
Name:CAPRIN2Imported
Synonyms:C1QDC1, EEG1Imported, KIAA1873, RNG140
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:21259. CAPRIN2.

Subcellular locationi

Isoform 2 :
Isoform 5 :

GO - Cellular componenti

  • centrosome Source: HPA
  • cytoplasm Source: UniProtKB
  • mitochondrion Source: UniProtKB
  • nucleus Source: HPA
  • receptor complex Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Mitochondrion

Pathology & Biotechi

Organism-specific databases

DisGeNETi65981.
OpenTargetsiENSG00000110888.
PharmGKBiPA162381044.

Polymorphism and mutation databases

BioMutaiCAPRIN2.
DMDMi74748798.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003020821 – 1127Caprin-2Add BLAST1127

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei948PhosphoserineBy similarity1
Modified residuei949PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ6IMN6.
MaxQBiQ6IMN6.
PeptideAtlasiQ6IMN6.
PRIDEiQ6IMN6.

PTM databases

iPTMnetiQ6IMN6.
PhosphoSitePlusiQ6IMN6.

Expressioni

Tissue specificityi

Detected in all tissues tested with highest levels of expression in brain and spleen.1 Publication

Developmental stagei

Expression is highly regulated during erythroid development with increased expression at the stage of differentiation associated with the onset of global nuclear condensation and reduced cell proliferation.1 Publication

Gene expression databases

BgeeiENSG00000110888.
ExpressionAtlasiQ6IMN6. baseline and differential.
GenevisibleiQ6IMN6. HS.

Organism-specific databases

HPAiHPA039746.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
LRP5O751973EBI-6918449,EBI-2466421
PEX5P505423EBI-6918449,EBI-597835

GO - Molecular functioni

  • receptor binding Source: BHF-UCL

Protein-protein interaction databases

BioGridi122431. 6 interactors.
IntActiQ6IMN6. 4 interactors.

Structurei

Secondary structure

11127
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi999 – 1004Combined sources6
Beta strandi1011 – 1016Combined sources6
Beta strandi1020 – 1026Combined sources7
Turni1032 – 1035Combined sources4
Beta strandi1036 – 1038Combined sources3
Beta strandi1041 – 1053Combined sources13
Beta strandi1055 – 1058Combined sources4
Beta strandi1060 – 1066Combined sources7
Beta strandi1069 – 1076Combined sources8
Beta strandi1079 – 1082Combined sources4
Beta strandi1085 – 1094Combined sources10
Beta strandi1099 – 1107Combined sources9
Beta strandi1117 – 1126Combined sources10

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4OULX-ray1.95A/B/C/D/E/F996-1127[»]
4OUMX-ray1.49A996-1127[»]
ProteinModelPortaliQ6IMN6.
SMRiQ6IMN6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini993 – 1127C1qPROSITE-ProRule annotationAdd BLAST135

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili129 – 156Sequence analysisAdd BLAST28
Coiled coili194 – 216Sequence analysisAdd BLAST23

Sequence similaritiesi

Belongs to the caprin family.Curated
Contains 1 C1q domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

GeneTreeiENSGT00760000119052.
HOGENOMiHOG000082543.
HOVERGENiHBG057777.
InParanoidiQ6IMN6.
KOiK18744.
OMAiQAYETYI.
OrthoDBiEOG091G0UOF.
PhylomeDBiQ6IMN6.
TreeFamiTF329471.

Family and domain databases

Gene3Di2.60.120.40. 1 hit.
InterProiIPR001073. C1q_dom.
IPR028816. Caprin.
IPR022070. Caprin-1_C.
IPR008983. Tumour_necrosis_fac-like_dom.
[Graphical view]
PANTHERiPTHR22922. PTHR22922. 3 hits.
PfamiPF00386. C1q. 1 hit.
PF12287. Caprin-1_C. 1 hit.
[Graphical view]
PRINTSiPR00007. COMPLEMNTC1Q.
SMARTiSM00110. C1Q. 1 hit.
[Graphical view]
SUPFAMiSSF49842. SSF49842. 1 hit.
PROSITEiPS50871. C1Q. 1 hit.
[Graphical view]

Sequences (9)i

Sequence statusi: Complete.

This entry describes 9 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 11 Publication (identifier: Q6IMN6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEVQVSQASL GFELTSVEKS LREWSRLSRE VIAWLCPSSP NFILNFPPPP
60 70 80 90 100
SASSVSMVQL FSSPFGYQSP SGHSEEEREG NMKSAKPQVN HSQHGESQRA
110 120 130 140 150
LSPLQSTLSS AASPSQAYET YIENGLICLK HKIRNIEKKK LKLEDYKDRL
160 170 180 190 200
KSGEHLNPDQ LEAVEKYEEV LHNLEFAKEL QKTFSGLSLD LLKAQKKAQR
210 220 230 240 250
REHMLKLEAE KKKLRTILQV QYVLQNLTQE HVQKDFKGGL NGAVYLPSKE
260 270 280 290 300
LDYLIKFSKL TCPERNESLS VEDQMEQSSL YFWDLLEGSE KAVVGTTYKH
310 320 330 340 350
LKDLLSKLLN SGYFESIPVP KNAKEKEVPL EEEMLIQSEK KTQLSKTESV
360 370 380 390 400
KESESLMEFA QPEIQPQEFL NRRYMTEVDY SNKQGEEQPW EADYARKPNL
410 420 430 440 450
PKRWDMLTEP DGQEKKQESF KSWEASGKHQ EVSKPAVSLE QRKQDTSKLR
460 470 480 490 500
STLPEEQKKQ EISKSKPSPS QWKQDTPKSK AGYVQEEQKK QETPKLWPVQ
510 520 530 540 550
LQKEQDPKKQ TPKSWTPSMQ SEQNTTKSWT TPMCEEQDSK QPETPKSWEN
560 570 580 590 600
NVESQKHSLT SQSQISPKSW GVATASLIPN DQLLPRKLNT EPKDVPKPVH
610 620 630 640 650
QPVGSSSTLP KDPVLRKEKL QDLMTQIQGT CNFMQESVLD FDKPSSAIPT
660 670 680 690 700
SQPPSATPGS PVASKEQNLS SQSDFLQEPL QATSSPVTCS SNACLVTTDQ
710 720 730 740 750
ASSGSETEFM TSETPEAAIP PGKQPSSLAS PNPPMAKGSE QGFQSPPASS
760 770 780 790 800
SSVTINTAPF QAMQTVFNVN APLPPRKEQE IKESPYSPGY NQSFTTASTQ
810 820 830 840 850
TPPQCQLPSI HVEQTVHSQE TAANYHPDGT IQVSNGSLAF YPAQTNVFPR
860 870 880 890 900
PTQPFVNSRG SVRGCTRGGR LITNSYRSPG GYKGFDTYRG LPSISNGNYS
910 920 930 940 950
QLQFQAREYS GAPYSQRDNF QQCYKRGGTS GGPRANSRAG WSDSSQVSSP
960 970 980 990 1000
ERDNETFNSG DSGQGDSRSM TPVDVPVTNP AATILPVHVY PLPQQMRVAF
1010 1020 1030 1040 1050
SAARTSNLAP GTLDQPIVFD LLLNNLGETF DLQLGRFNCP VNGTYVFIFH
1060 1070 1080 1090 1100
MLKLAVNVPL YVNLMKNEEV LVSAYANDGA PDHETASNHA ILQLFQGDQI
1110 1120
WLRLHRGAIY GSSWKYSTFS GYLLYQD
Note: No experimental confirmation available.Curated
Length:1,127
Mass (Da):125,925
Last modified:July 5, 2004 - v1
Checksum:iD74D1D284B69FA0F
GO
Isoform 21 Publication (identifier: Q6IMN6-2) [UniParc]FASTAAdd to basket
Also known as: EEG-1L1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     717-765: Missing.
     823-823: Missing.

Show »
Length:1,077
Mass (Da):120,974
Checksum:i2B88BF3C47D032D6
GO
Isoform 31 Publication (identifier: Q6IMN6-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     823-823: Missing.
     940-961: GWSDSSQVSSPERDNETFNSGD → NCFIMRNSLLLIKQQGGVILLR
     962-1127: Missing.

Note: No experimental confirmation available.Curated
Show »
Length:960
Mass (Da):107,601
Checksum:i6FE365832F2D366A
GO
Isoform 41 Publication (identifier: Q6IMN6-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-333: Missing.

Note: No experimental confirmation available.Curated
Show »
Length:794
Mass (Da):88,029
Checksum:iF275265D8CF45DAB
GO
Isoform 51 Publication (identifier: Q6IMN6-5) [UniParc]FASTAAdd to basket
Also known as: EEG-1S1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     270-278: SVEDQMEQS → RQTLEGSTV
     279-1127: Missing.

Show »
Length:278
Mass (Da):31,586
Checksum:i2AC3F3676C6B9930
GO
Isoform 61 Publication (identifier: Q6IMN6-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     596-596: P → S
     597-1127: Missing.

Show »
Length:596
Mass (Da):68,429
Checksum:iDD750EAA52CEF4BE
GO
Isoform 7 (identifier: Q6IMN6-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     823-843: Missing.
     940-961: GWSDSSQVSSPERDNETFNSGD → NCFIMRNSLLLIKQQGGVILLR
     962-1127: Missing.

Note: No experimental confirmation available.Curated
Show »
Length:940
Mass (Da):105,467
Checksum:i04796A2E02988C6E
GO
Isoform 9 (identifier: Q6IMN6-9) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     823-823: Missing.

Note: No experimental confirmation available.
Show »
Length:1,126
Mass (Da):125,854
Checksum:i735B40BA2213669A
GO
Isoform 10 (identifier: Q6IMN6-10) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     682-716: Missing.
     823-843: Missing.
     940-961: GWSDSSQVSSPERDNETFNSGD → NCFIMRNSLLLIKQQGGVILLR
     962-1127: Missing.

Note: No experimental confirmation available.Curated
Show »
Length:905
Mass (Da):101,929
Checksum:i3F69E619920528F5
GO

Sequence cautioni

The sequence AAK83153 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti298Y → D in BAB13830 (PubMed:14702039).Curated1
Sequence conflicti320P → S in AAK83153 (Ref. 5) Curated1
Sequence conflicti595V → A in BAB13830 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_048445114P → S.Corresponds to variant rs17688567dbSNPEnsembl.1
Natural variantiVAR_048446237K → R.Corresponds to variant rs12146709dbSNPEnsembl.1
Natural variantiVAR_034939519M → V.1 PublicationCorresponds to variant rs2304630dbSNPEnsembl.1
Natural variantiVAR_048447655S → L.Corresponds to variant rs2304628dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0525311 – 333Missing in isoform 4. 1 PublicationAdd BLAST333
Alternative sequenceiVSP_052532270 – 278SVEDQMEQS → RQTLEGSTV in isoform 5. 1 Publication9
Alternative sequenceiVSP_052533279 – 1127Missing in isoform 5. 1 PublicationAdd BLAST849
Alternative sequenceiVSP_052534596P → S in isoform 6. 1 Publication1
Alternative sequenceiVSP_052535597 – 1127Missing in isoform 6. 1 PublicationAdd BLAST531
Alternative sequenceiVSP_043293682 – 716Missing in isoform 10. 1 PublicationAdd BLAST35
Alternative sequenceiVSP_052536717 – 765Missing in isoform 2. 1 PublicationAdd BLAST49
Alternative sequenceiVSP_052537823 – 843Missing in isoform 7 and isoform 10. 2 PublicationsAdd BLAST21
Alternative sequenceiVSP_027920823Missing in isoform 2, isoform 3 and isoform 9. 2 Publications1
Alternative sequenceiVSP_052538940 – 961GWSDS…FNSGD → NCFIMRNSLLLIKQQGGVIL LR in isoform 3, isoform 7 and isoform 10. 2 PublicationsAdd BLAST22
Alternative sequenceiVSP_052539962 – 1127Missing in isoform 3, isoform 7 and isoform 10. 2 PublicationsAdd BLAST166

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY074490 mRNA. Translation: AAL71549.1.
AY074491 mRNA. Translation: AAL71550.1.
AC010198 Genomic DNA. No translation available.
BC066295 mRNA. Translation: AAH66295.1.
BC111007 mRNA. Translation: AAI11008.1.
BC117672 mRNA. Translation: AAI17673.1.
BC117673 mRNA. Translation: AAI17674.1.
AK021453 mRNA. Translation: BAB13830.1.
AK026222 mRNA. Translation: BAB15398.1.
AF326778 mRNA. Translation: AAK83153.1. Different initiation.
BX538080 mRNA. Translation: CAD98004.1.
BK001102 mRNA. Translation: DAA01119.1.
BK001103 mRNA. Translation: DAA01120.1.
BR000870 mRNA. Translation: FAA00695.1.
CCDSiCCDS41766.2. [Q6IMN6-3]
CCDS55816.1. [Q6IMN6-10]
CCDS8720.1. [Q6IMN6-2]
RefSeqiNP_001002259.1. NM_001002259.2. [Q6IMN6-1]
NP_001193785.1. NM_001206856.2. [Q6IMN6-10]
NP_001306771.1. NM_001319842.1.
NP_001306772.1. NM_001319843.1. [Q6IMN6-9]
NP_076414.2. NM_023925.4. [Q6IMN6-2]
NP_115532.3. NM_032156.4. [Q6IMN6-3]
XP_006719210.1. XM_006719147.3. [Q6IMN6-7]
UniGeneiHs.234355.

Genome annotation databases

EnsembliENST00000298892; ENSP00000298892; ENSG00000110888. [Q6IMN6-2]
ENST00000395805; ENSP00000379150; ENSG00000110888. [Q6IMN6-10]
ENST00000417045; ENSP00000391479; ENSG00000110888. [Q6IMN6-3]
ENST00000454014; ENSP00000403876; ENSG00000110888. [Q6IMN6-5]
GeneIDi65981.
KEGGihsa:65981.
UCSCiuc001rjh.2. human. [Q6IMN6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY074490 mRNA. Translation: AAL71549.1.
AY074491 mRNA. Translation: AAL71550.1.
AC010198 Genomic DNA. No translation available.
BC066295 mRNA. Translation: AAH66295.1.
BC111007 mRNA. Translation: AAI11008.1.
BC117672 mRNA. Translation: AAI17673.1.
BC117673 mRNA. Translation: AAI17674.1.
AK021453 mRNA. Translation: BAB13830.1.
AK026222 mRNA. Translation: BAB15398.1.
AF326778 mRNA. Translation: AAK83153.1. Different initiation.
BX538080 mRNA. Translation: CAD98004.1.
BK001102 mRNA. Translation: DAA01119.1.
BK001103 mRNA. Translation: DAA01120.1.
BR000870 mRNA. Translation: FAA00695.1.
CCDSiCCDS41766.2. [Q6IMN6-3]
CCDS55816.1. [Q6IMN6-10]
CCDS8720.1. [Q6IMN6-2]
RefSeqiNP_001002259.1. NM_001002259.2. [Q6IMN6-1]
NP_001193785.1. NM_001206856.2. [Q6IMN6-10]
NP_001306771.1. NM_001319842.1.
NP_001306772.1. NM_001319843.1. [Q6IMN6-9]
NP_076414.2. NM_023925.4. [Q6IMN6-2]
NP_115532.3. NM_032156.4. [Q6IMN6-3]
XP_006719210.1. XM_006719147.3. [Q6IMN6-7]
UniGeneiHs.234355.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4OULX-ray1.95A/B/C/D/E/F996-1127[»]
4OUMX-ray1.49A996-1127[»]
ProteinModelPortaliQ6IMN6.
SMRiQ6IMN6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122431. 6 interactors.
IntActiQ6IMN6. 4 interactors.

PTM databases

iPTMnetiQ6IMN6.
PhosphoSitePlusiQ6IMN6.

Polymorphism and mutation databases

BioMutaiCAPRIN2.
DMDMi74748798.

Proteomic databases

EPDiQ6IMN6.
MaxQBiQ6IMN6.
PeptideAtlasiQ6IMN6.
PRIDEiQ6IMN6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000298892; ENSP00000298892; ENSG00000110888. [Q6IMN6-2]
ENST00000395805; ENSP00000379150; ENSG00000110888. [Q6IMN6-10]
ENST00000417045; ENSP00000391479; ENSG00000110888. [Q6IMN6-3]
ENST00000454014; ENSP00000403876; ENSG00000110888. [Q6IMN6-5]
GeneIDi65981.
KEGGihsa:65981.
UCSCiuc001rjh.2. human. [Q6IMN6-1]

Organism-specific databases

CTDi65981.
DisGeNETi65981.
GeneCardsiCAPRIN2.
HGNCiHGNC:21259. CAPRIN2.
HPAiHPA039746.
MIMi610375. gene.
neXtProtiNX_Q6IMN6.
OpenTargetsiENSG00000110888.
PharmGKBiPA162381044.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00760000119052.
HOGENOMiHOG000082543.
HOVERGENiHBG057777.
InParanoidiQ6IMN6.
KOiK18744.
OMAiQAYETYI.
OrthoDBiEOG091G0UOF.
PhylomeDBiQ6IMN6.
TreeFamiTF329471.

Enzyme and pathway databases

SignaLinkiQ6IMN6.
SIGNORiQ6IMN6.

Miscellaneous databases

ChiTaRSiCAPRIN2. human.
GeneWikiiCAPRIN2.
GenomeRNAii65981.
PROiQ6IMN6.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000110888.
ExpressionAtlasiQ6IMN6. baseline and differential.
GenevisibleiQ6IMN6. HS.

Family and domain databases

Gene3Di2.60.120.40. 1 hit.
InterProiIPR001073. C1q_dom.
IPR028816. Caprin.
IPR022070. Caprin-1_C.
IPR008983. Tumour_necrosis_fac-like_dom.
[Graphical view]
PANTHERiPTHR22922. PTHR22922. 3 hits.
PfamiPF00386. C1q. 1 hit.
PF12287. Caprin-1_C. 1 hit.
[Graphical view]
PRINTSiPR00007. COMPLEMNTC1Q.
SMARTiSM00110. C1Q. 1 hit.
[Graphical view]
SUPFAMiSSF49842. SSF49842. 1 hit.
PROSITEiPS50871. C1Q. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCAPR2_HUMAN
AccessioniPrimary (citable) accession number: Q6IMN6
Secondary accession number(s): E4NKG2
, Q149P6, Q149P7, Q6IMN5, Q7Z371, Q8TE70, Q8TE71, Q96RN6, Q9H667, Q9HAL4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: July 5, 2004
Last modified: November 30, 2016
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.