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Q6IMN6 (CAPR2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 81. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Caprin-2
Alternative name(s):
C1q domain-containing protein 1
Cytoplasmic activation/proliferation-associated protein 2
Gastric cancer multidrug resistance-associated protein
Protein EEG-1
RNA granule protein 140
Gene names
Name:CAPRIN2
Synonyms:C1QDC1, EEG1, KIAA1873, RNG140
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length1127 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May regulate the transport and translation of mRNAs, modulating for instance the expression of proteins involved in synaptic plasticity in neurons. Involved in regulation of growth as erythroblasts shift from a highly proliferative state towards their terminal phase of differentiation. May be involved in apoptosis. Ref.1

Subcellular location

Isoform 1: Cytoplasm.

Isoform 2: Mitochondrion. Cytoplasm. Note: Expressed throughout the cytoplasm. Ref.1

Isoform 5: Mitochondrion. Note: Colocalizes with aggregated mitochondria. Ref.1

Tissue specificity

Detected in all tissues tested with highest levels of expression in brain and spleen. Ref.1

Developmental stage

Expression is highly regulated during erythroid development with increased expression at the stage of differentiation associated with the onset of global nuclear condensation and reduced cell proliferation. Ref.1

Sequence similarities

Belongs to the caprin family.

Contains 1 C1q domain.

Sequence caution

The sequence AAK83153.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Ontologies

Keywords
   Biological processDifferentiation
Growth regulation
   Cellular componentCytoplasm
Mitochondrion
   Coding sequence diversityAlternative splicing
Polymorphism
   DomainCoiled coil
   LigandRNA-binding
   Molecular functionProtein synthesis inhibitor
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processnegative regulation of cell growth

Inferred from direct assay Ref.1. Source: UniProtKB

negative regulation of translation

Inferred from electronic annotation. Source: UniProtKB-KW

positive regulation of canonical Wnt signaling pathway

Inferred from direct assay PubMed 18762581. Source: BHF-UCL

positive regulation of dendrite morphogenesis

Inferred from sequence or structural similarity. Source: UniProtKB

positive regulation of dendritic spine morphogenesis

Inferred from sequence or structural similarity. Source: UniProtKB

positive regulation of peptidyl-serine phosphorylation

Inferred from direct assay PubMed 18762581. Source: BHF-UCL

positive regulation of protein binding

Inferred from direct assay PubMed 18762581. Source: BHF-UCL

positive regulation of transcription from RNA polymerase II promoter

Inferred from direct assay PubMed 18762581. Source: BHF-UCL

   Cellular_componentcentrosome

Inferred from direct assay. Source: HPA

cytoplasm

Inferred from direct assay Ref.1. Source: UniProtKB

mitochondrion

Inferred from direct assay Ref.1. Source: UniProtKB

nucleus

Inferred from direct assay. Source: HPA

receptor complex

Inferred from direct assay PubMed 18762581. Source: BHF-UCL

   Molecular_functionRNA binding

Inferred from electronic annotation. Source: UniProtKB-KW

receptor binding

Inferred from physical interaction PubMed 18762581. Source: BHF-UCL

Complete GO annotation...

Binary interactions

With

Entry

#Exp.

IntAct

Notes

LRP5O751973EBI-6918449,EBI-2466421

Alternative products

This entry describes 9 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 Ref.2 (identifier: Q6IMN6-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Note: No experimental confirmation available.
Isoform 2 Ref.1 (identifier: Q6IMN6-2)

Also known as: EEG-1L;

The sequence of this isoform differs from the canonical sequence as follows:
     717-765: Missing.
     823-823: Missing.
Isoform 3 Ref.3 (identifier: Q6IMN6-3)

The sequence of this isoform differs from the canonical sequence as follows:
     823-823: Missing.
     940-961: GWSDSSQVSSPERDNETFNSGD → NCFIMRNSLLLIKQQGGVILLR
     962-1127: Missing.
Note: No experimental confirmation available.
Isoform 4 Ref.4 (identifier: Q6IMN6-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1-333: Missing.
Note: No experimental confirmation available.
Isoform 5 Ref.1 (identifier: Q6IMN6-5)

Also known as: EEG-1S;

The sequence of this isoform differs from the canonical sequence as follows:
     270-278: SVEDQMEQS → RQTLEGSTV
     279-1127: Missing.
Isoform 6 Ref.5 (identifier: Q6IMN6-6)

The sequence of this isoform differs from the canonical sequence as follows:
     596-596: P → S
     597-1127: Missing.
Isoform 7 Ref.6 (identifier: Q6IMN6-7)

The sequence of this isoform differs from the canonical sequence as follows:
     823-843: Missing.
     940-961: GWSDSSQVSSPERDNETFNSGD → NCFIMRNSLLLIKQQGGVILLR
     962-1127: Missing.
Note: No experimental confirmation available.
Isoform 9 (identifier: Q6IMN6-9)

The sequence of this isoform differs from the canonical sequence as follows:
     823-823: Missing.
Note: No experimental confirmation available.
Isoform 10 (identifier: Q6IMN6-10)

The sequence of this isoform differs from the canonical sequence as follows:
     682-716: Missing.
     823-843: Missing.
     940-961: GWSDSSQVSSPERDNETFNSGD → NCFIMRNSLLLIKQQGGVILLR
     962-1127: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 11271127Caprin-2
PRO_0000302082

Regions

Domain993 – 1127135C1q
Coiled coil129 – 15628 Potential
Coiled coil194 – 21623 Potential

Natural variations

Alternative sequence1 – 333333Missing in isoform 4. Ref.4
VSP_052531
Alternative sequence270 – 2789SVEDQMEQS → RQTLEGSTV in isoform 5. Ref.1
VSP_052532
Alternative sequence279 – 1127849Missing in isoform 5. Ref.1
VSP_052533
Alternative sequence5961P → S in isoform 6. Ref.5
VSP_052534
Alternative sequence597 – 1127531Missing in isoform 6. Ref.5
VSP_052535
Alternative sequence682 – 71635Missing in isoform 10.
VSP_043293
Alternative sequence717 – 76549Missing in isoform 2. Ref.1
VSP_052536
Alternative sequence823 – 84321Missing in isoform 7 and isoform 10. Ref.6
VSP_052537
Alternative sequence8231Missing in isoform 2, isoform 3 and isoform 9.
VSP_027920
Alternative sequence940 – 96122GWSDS…FNSGD → NCFIMRNSLLLIKQQGGVIL LR in isoform 3, isoform 7 and isoform 10. Ref.3 Ref.6
VSP_052538
Alternative sequence962 – 1127166Missing in isoform 3, isoform 7 and isoform 10. Ref.3 Ref.6
VSP_052539
Natural variant1141P → S.
Corresponds to variant rs17688567 [ dbSNP | Ensembl ].
VAR_048445
Natural variant2371K → R.
Corresponds to variant rs12146709 [ dbSNP | Ensembl ].
VAR_048446
Natural variant5191M → V. Ref.4
Corresponds to variant rs2304630 [ dbSNP | Ensembl ].
VAR_034939
Natural variant6551S → L.
Corresponds to variant rs2304628 [ dbSNP | Ensembl ].
VAR_048447

Experimental info

Sequence conflict2981Y → D in BAB13830. Ref.4
Sequence conflict3201P → S in AAK83153. Ref.5
Sequence conflict5951V → A in BAB13830. Ref.4

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: D74D1D284B69FA0F

FASTA1,127125,925
        10         20         30         40         50         60 
MEVQVSQASL GFELTSVEKS LREWSRLSRE VIAWLCPSSP NFILNFPPPP SASSVSMVQL 

        70         80         90        100        110        120 
FSSPFGYQSP SGHSEEEREG NMKSAKPQVN HSQHGESQRA LSPLQSTLSS AASPSQAYET 

       130        140        150        160        170        180 
YIENGLICLK HKIRNIEKKK LKLEDYKDRL KSGEHLNPDQ LEAVEKYEEV LHNLEFAKEL 

       190        200        210        220        230        240 
QKTFSGLSLD LLKAQKKAQR REHMLKLEAE KKKLRTILQV QYVLQNLTQE HVQKDFKGGL 

       250        260        270        280        290        300 
NGAVYLPSKE LDYLIKFSKL TCPERNESLS VEDQMEQSSL YFWDLLEGSE KAVVGTTYKH 

       310        320        330        340        350        360 
LKDLLSKLLN SGYFESIPVP KNAKEKEVPL EEEMLIQSEK KTQLSKTESV KESESLMEFA 

       370        380        390        400        410        420 
QPEIQPQEFL NRRYMTEVDY SNKQGEEQPW EADYARKPNL PKRWDMLTEP DGQEKKQESF 

       430        440        450        460        470        480 
KSWEASGKHQ EVSKPAVSLE QRKQDTSKLR STLPEEQKKQ EISKSKPSPS QWKQDTPKSK 

       490        500        510        520        530        540 
AGYVQEEQKK QETPKLWPVQ LQKEQDPKKQ TPKSWTPSMQ SEQNTTKSWT TPMCEEQDSK 

       550        560        570        580        590        600 
QPETPKSWEN NVESQKHSLT SQSQISPKSW GVATASLIPN DQLLPRKLNT EPKDVPKPVH 

       610        620        630        640        650        660 
QPVGSSSTLP KDPVLRKEKL QDLMTQIQGT CNFMQESVLD FDKPSSAIPT SQPPSATPGS 

       670        680        690        700        710        720 
PVASKEQNLS SQSDFLQEPL QATSSPVTCS SNACLVTTDQ ASSGSETEFM TSETPEAAIP 

       730        740        750        760        770        780 
PGKQPSSLAS PNPPMAKGSE QGFQSPPASS SSVTINTAPF QAMQTVFNVN APLPPRKEQE 

       790        800        810        820        830        840 
IKESPYSPGY NQSFTTASTQ TPPQCQLPSI HVEQTVHSQE TAANYHPDGT IQVSNGSLAF 

       850        860        870        880        890        900 
YPAQTNVFPR PTQPFVNSRG SVRGCTRGGR LITNSYRSPG GYKGFDTYRG LPSISNGNYS 

       910        920        930        940        950        960 
QLQFQAREYS GAPYSQRDNF QQCYKRGGTS GGPRANSRAG WSDSSQVSSP ERDNETFNSG 

       970        980        990       1000       1010       1020 
DSGQGDSRSM TPVDVPVTNP AATILPVHVY PLPQQMRVAF SAARTSNLAP GTLDQPIVFD 

      1030       1040       1050       1060       1070       1080 
LLLNNLGETF DLQLGRFNCP VNGTYVFIFH MLKLAVNVPL YVNLMKNEEV LVSAYANDGA 

      1090       1100       1110       1120 
PDHETASNHA ILQLFQGDQI WLRLHRGAIY GSSWKYSTFS GYLLYQD 

« Hide

Isoform 2 (EEG-1L) [UniParc].

Checksum: 2B88BF3C47D032D6
Show »

FASTA1,077120,974
Isoform 3 [UniParc].

Checksum: 6FE365832F2D366A
Show »

FASTA960107,601
Isoform 4 [UniParc].

Checksum: F275265D8CF45DAB
Show »

FASTA79488,029
Isoform 5 (EEG-1S) [UniParc].

Checksum: 2AC3F3676C6B9930
Show »

FASTA27831,586
Isoform 6 [UniParc].

Checksum: DD750EAA52CEF4BE
Show »

FASTA59668,429
Isoform 7 [UniParc].

Checksum: 04796A2E02988C6E
Show »

FASTA940105,467
Isoform 9 [UniParc].

Checksum: 735B40BA2213669A
Show »

FASTA1,126125,854
Isoform 10 [UniParc].

Checksum: 3F69E619920528F5
Show »

FASTA905101,929

References

« Hide 'large scale' references
[1]"Cloning and characterization of a gene expressed during terminal differentiation that encodes a novel inhibitor of growth."
Aerbajinai W., Lee Y.T., Wojda U., Barr V.A., Miller J.L.
J. Biol. Chem. 279:1916-1921(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2 AND 5), FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
Tissue: Erythroblast.
[2]"The finished DNA sequence of human chromosome 12."
Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R. expand/collapse author list , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3 AND 10), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 844-1127 (ISOFORMS 1/2/4).
Tissue: Brain and Uterus.
[4]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 298-776 (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-776 (ISOFORM 4), VARIANT VAL-519.
Tissue: Embryo and Small intestine.
[5]"Isolation and functional characterization of a novel gene associated with gastric cancer multidrug resistance."
Shi Y.-Q., Zhai H.-H., Han Y., Wang X., Wu H.-P., Fan D.-M.
Submitted (DEC-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 319-1127 (ISOFORM 6).
[6]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 766-1127 (ISOFORM 7).
Tissue: Cerebellum.
[7]"Activation/division of lymphocytes results in increased levels of cytoplasmic activation/proliferation-associated protein-1: prototype of a new family of proteins."
Grill B., Wilson G.M., Zhang K.-X., Wang B., Doyonnas R., Quadroni M., Schrader J.W.
J. Immunol. 172:2389-2400(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION (ISOFORM 9).
[8]"RNA granule protein 140 (RNG140), a paralog of RNG105 localized to distinct RNA granules in neuronal dendrites in the adult vertebrate brain."
Shiina N., Tokunaga M.
J. Biol. Chem. 285:24260-24269(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY074490 mRNA. Translation: AAL71549.1.
AY074491 mRNA. Translation: AAL71550.1.
AC010198 Genomic DNA. No translation available.
BC066295 mRNA. Translation: AAH66295.1.
BC111007 mRNA. Translation: AAI11008.1.
BC117672 mRNA. Translation: AAI17673.1.
BC117673 mRNA. Translation: AAI17674.1.
AK021453 mRNA. Translation: BAB13830.1.
AK026222 mRNA. Translation: BAB15398.1.
AF326778 mRNA. Translation: AAK83153.1. Different initiation.
BX538080 mRNA. Translation: CAD98004.1.
BK001102 mRNA. Translation: DAA01119.1.
BK001103 mRNA. Translation: DAA01120.1.
BR000870 mRNA. Translation: FAA00695.1.
RefSeqNP_001002259.1. NM_001002259.2.
NP_001193785.1. NM_001206856.2.
NP_076414.2. NM_023925.4.
NP_115532.3. NM_032156.4.
UniGeneHs.234355.

3D structure databases

ProteinModelPortalQ6IMN6.
SMRQ6IMN6. Positions 997-1127.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid122431. 3 interactions.
IntActQ6IMN6. 2 interactions.

PTM databases

PhosphoSiteQ6IMN6.

Polymorphism databases

DMDM74748798.

Proteomic databases

PaxDbQ6IMN6.
PRIDEQ6IMN6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000251071; ENSP00000251071; ENSG00000110888. [Q6IMN6-1]
ENST00000298892; ENSP00000298892; ENSG00000110888. [Q6IMN6-2]
ENST00000395805; ENSP00000379150; ENSG00000110888. [Q6IMN6-10]
ENST00000417045; ENSP00000391479; ENSG00000110888. [Q6IMN6-3]
ENST00000454014; ENSP00000403876; ENSG00000110888. [Q6IMN6-5]
GeneID65981.
KEGGhsa:65981.
UCSCuc001rjf.1. human. [Q6IMN6-3]
uc001rjg.1. human. [Q6IMN6-1]
uc001rjh.1. human. [Q6IMN6-2]
uc001rjl.4. human. [Q6IMN6-10]

Organism-specific databases

CTD65981.
GeneCardsGC12M030862.
HGNCHGNC:21259. CAPRIN2.
HPAHPA039746.
MIM610375. gene.
neXtProtNX_Q6IMN6.
PharmGKBPA162381044.
HUGESearch...
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG41180.
HOGENOMHOG000082543.
HOVERGENHBG057777.
InParanoidQ6IMN6.
OMAAGWSDSS.
PhylomeDBQ6IMN6.
TreeFamTF329471.

Enzyme and pathway databases

SignaLinkQ6IMN6.

Gene expression databases

ArrayExpressQ6IMN6.
BgeeQ6IMN6.
GenevestigatorQ6IMN6.

Family and domain databases

Gene3D2.60.120.40. 1 hit.
InterProIPR001073. C1q.
IPR028816. Caprin.
IPR022070. Caprin-1_C.
IPR008983. Tumour_necrosis_fac-like_dom.
[Graphical view]
PANTHERPTHR22922. PTHR22922. 1 hit.
PfamPF00386. C1q. 1 hit.
PF12287. Caprin-1_C. 1 hit.
[Graphical view]
PRINTSPR00007. COMPLEMNTC1Q.
SMARTSM00110. C1Q. 1 hit.
[Graphical view]
SUPFAMSSF49842. SSF49842. 1 hit.
PROSITEPS50871. C1Q. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSCAPRIN2. human.
GeneWikiCAPRIN2.
GenomeRNAi65981.
NextBio67435.
PROQ6IMN6.
SOURCESearch...

Entry information

Entry nameCAPR2_HUMAN
AccessionPrimary (citable) accession number: Q6IMN6
Secondary accession number(s): E4NKG2 expand/collapse secondary AC list , Q149P6, Q149P7, Q6IMN5, Q7Z371, Q8TE70, Q8TE71, Q96RN6, Q9H667, Q9HAL4
Entry history
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: July 5, 2004
Last modified: April 16, 2014
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 12

Human chromosome 12: entries, gene names and cross-references to MIM