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Protein

Developmental pluripotency-associated protein 3

Gene

Dppa3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Primordial germ cell (PGCs)-specific protein involved in epigenetic chromatin reprogramming in the zygote following fertilization. In zygotes, DNA demethylation occurs selectively in the paternal pronucleus before the first cell division, while the adjacent maternal pronucleus and certain paternally-imprinted loci are protected from this process. Participates in protection of DNA methylation in the maternal pronucleus by preventing conversion of 5mC to 5hmC: specifically recognizes and binds histone H3 dimethylated at 'Lys-9' (H3K9me2) on maternal genome, and protects maternal genome from TET3-mediated conversion to 5hmC and subsequent DNA demethylation. Does not bind paternal chromatin, which is mainly packed into protamine and does not contain much H3K9me2 mark. Also protects imprinted loci that are marked with H3K9me2 in mature sperm from DNA demethylation in early embryogenesis. May be important for the totipotent/pluripotent states continuing through preimplantation development. Also involved in chromatin condensation in oocytogenesis (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulator, Developmental protein

Names & Taxonomyi

Protein namesi
Recommended name:
Developmental pluripotency-associated protein 3
Gene namesi
Name:Dppa3
Synonyms:Stella
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componentsi: Chromosome 3, Chromosome 4, Chromosome 5

Organism-specific databases

RGDi1310932. Dppa3.

Subcellular locationi

  • Nucleus By similarity
  • Cytoplasm By similarity

  • Note: Mainly localizes in the female pronucleus, localization to the male pronucleus in much weaker.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 158158Developmental pluripotency-associated protein 3PRO_0000239267Add
BLAST

Proteomic databases

PaxDbiQ6IMK0.
PRIDEiQ6IMK0.

Expressioni

Gene expression databases

GenevisibleiQ6IMK0. RN.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000036033.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi62 – 13372Arg-richAdd
BLAST

Domaini

Mediates binding to H3K9me2 via N-terminal region, while ability to exclude TET3 from the maternal pronucleus requires the C-terminal part.By similarity

Phylogenomic databases

eggNOGiENOG410JJNY. Eukaryota.
ENOG41115BI. LUCA.
GeneTreeiENSGT00800000124303.
HOGENOMiHOG000293369.
HOVERGENiHBG081463.
InParanoidiQ6IMK0.
OrthoDBiEOG7J448M.
PhylomeDBiQ6IMK0.
TreeFamiTF338511.

Family and domain databases

InterProiIPR029096. Dppa3.
[Graphical view]
PANTHERiPTHR31577. PTHR31577. 1 hit.
PfamiPF15549. PGC7_Stella. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6IMK0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDEPSEKVDP VVNPETQMYD GSQREDEGDS PDDSEILQPE TLVKVMKKLT
60 70 80 90 100
LNPSAKPTKY HRRQRVRLQV KSQPVENRSE RIMREVQSAF PRRRVRTLLS
110 120 130 140 150
VLKDPIARMR RFVRIEQRQR QLEGNERRDE PFRCLCTFCH YQRWDPSENA

KIGQNQKN
Length:158
Mass (Da):18,834
Last modified:July 5, 2004 - v1
Checksum:i0D7928CE627AF761
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BK001414 mRNA. Translation: DAA01452.1.
RefSeqiNP_001041329.1. NM_001047864.1.
UniGeneiRn.79056.

Genome annotation databases

EnsembliENSRNOT00000031353; ENSRNOP00000036033; ENSRNOG00000022950.
ENSRNOT00000043677; ENSRNOP00000070027; ENSRNOG00000031161.
ENSRNOT00000049192; ENSRNOP00000070289; ENSRNOG00000031344.
GeneIDi297576.
KEGGirno:297576.
UCSCiRGD:1310932. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BK001414 mRNA. Translation: DAA01452.1.
RefSeqiNP_001041329.1. NM_001047864.1.
UniGeneiRn.79056.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000036033.

Proteomic databases

PaxDbiQ6IMK0.
PRIDEiQ6IMK0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000031353; ENSRNOP00000036033; ENSRNOG00000022950.
ENSRNOT00000043677; ENSRNOP00000070027; ENSRNOG00000031161.
ENSRNOT00000049192; ENSRNOP00000070289; ENSRNOG00000031344.
GeneIDi297576.
KEGGirno:297576.
UCSCiRGD:1310932. rat.

Organism-specific databases

CTDi359787.
RGDi1310932. Dppa3.

Phylogenomic databases

eggNOGiENOG410JJNY. Eukaryota.
ENOG41115BI. LUCA.
GeneTreeiENSGT00800000124303.
HOGENOMiHOG000293369.
HOVERGENiHBG081463.
InParanoidiQ6IMK0.
OrthoDBiEOG7J448M.
PhylomeDBiQ6IMK0.
TreeFamiTF338511.

Miscellaneous databases

PROiQ6IMK0.

Gene expression databases

GenevisibleiQ6IMK0. RN.

Family and domain databases

InterProiIPR029096. Dppa3.
[Graphical view]
PANTHERiPTHR31577. PTHR31577. 1 hit.
PfamiPF15549. PGC7_Stella. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Stella is a maternal effect gene required for normal early development in mice."
    Payer B., Saitou M., Barton S.C., Thresher R., Dixon J.P., Zahn D., Colledge W.H., Carlton M.B., Nakano T., Surani M.A.
    Curr. Biol. 13:2110-2117(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiDPPA3_RAT
AccessioniPrimary (citable) accession number: Q6IMK0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: July 5, 2004
Last modified: June 8, 2016
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.