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Protein

Developmental pluripotency-associated protein 3

Gene

Dppa3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Primordial germ cell (PGCs)-specific protein involved in epigenetic chromatin reprogramming in the zygote following fertilization. In zygotes, DNA demethylation occurs selectively in the paternal pronucleus before the first cell division, while the adjacent maternal pronucleus and certain paternally-imprinted loci are protected from this process. Participates in protection of DNA methylation in the maternal pronucleus by preventing conversion of 5mC to 5hmC: specifically recognizes and binds histone H3 dimethylated at 'Lys-9' (H3K9me2) on maternal genome, and protects maternal genome from TET3-mediated conversion to 5hmC and subsequent DNA demethylation. Does not bind paternal chromatin, which is mainly packed into protamine and does not contain much H3K9me2 mark. Also protects imprinted loci that are marked with H3K9me2 in mature sperm from DNA demethylation in early embryogenesis. May be important for the totipotent/pluripotent states continuing through preimplantation development. Also involved in chromatin condensation in oocytogenesis (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChromatin regulator, Developmental protein

Names & Taxonomyi

Protein namesi
Recommended name:
Developmental pluripotency-associated protein 3
Gene namesi
Name:Dppa3
Synonyms:Stella
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componentsi: Chromosome 3, Chromosome 4

Organism-specific databases

RGDi1310932 Dppa3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002392671 – 158Developmental pluripotency-associated protein 3Add BLAST158

Proteomic databases

PaxDbiQ6IMK0
PRIDEiQ6IMK0

Expressioni

Gene expression databases

BgeeiENSRNOG00000022950
GenevisibleiQ6IMK0 RN

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000036033

Structurei

3D structure databases

SMRiQ6IMK0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi62 – 133Arg-richAdd BLAST72

Domaini

Mediates binding to H3K9me2 via N-terminal region, while ability to exclude TET3 from the maternal pronucleus requires the C-terminal part.By similarity

Phylogenomic databases

eggNOGiENOG410JJNY Eukaryota
ENOG41115BI LUCA
GeneTreeiENSGT00800000124303
HOGENOMiHOG000293369
HOVERGENiHBG081463
InParanoidiQ6IMK0
OrthoDBiEOG091G154N
PhylomeDBiQ6IMK0
TreeFamiTF338511

Family and domain databases

InterProiView protein in InterPro
IPR029096 Dppa3
PANTHERiPTHR31577 PTHR31577, 1 hit
PfamiView protein in Pfam
PF15549 PGC7_Stella, 1 hit

Sequencei

Sequence statusi: Complete.

Q6IMK0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDEPSEKVDP VVNPETQMYD GSQREDEGDS PDDSEILQPE TLVKVMKKLT
60 70 80 90 100
LNPSAKPTKY HRRQRVRLQV KSQPVENRSE RIMREVQSAF PRRRVRTLLS
110 120 130 140 150
VLKDPIARMR RFVRIEQRQR QLEGNERRDE PFRCLCTFCH YQRWDPSENA

KIGQNQKN
Length:158
Mass (Da):18,834
Last modified:July 5, 2004 - v1
Checksum:i0D7928CE627AF761
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BK001414 mRNA Translation: DAA01452.1
RefSeqiNP_001041329.1, NM_001047864.1
UniGeneiRn.79056

Genome annotation databases

EnsembliENSRNOT00000031353; ENSRNOP00000036033; ENSRNOG00000022950
ENSRNOT00000043677; ENSRNOP00000070027; ENSRNOG00000031161
GeneIDi297576
KEGGirno:297576
UCSCiRGD:1310932 rat

Similar proteinsi

Entry informationi

Entry nameiDPPA3_RAT
AccessioniPrimary (citable) accession number: Q6IMK0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: July 5, 2004
Last modified: May 23, 2018
This is version 80 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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