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Protein

Sulfotransferase 1C3

Gene

SULT1C3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor and has low sulphotransferase activity towards various substrates with alcohol groups (in vitro). May catalyze the sulfate conjugation of xenobiotic compounds and endogenous substrates.2 Publications

Catalytic activityi

3'-phosphoadenylyl sulfate + an alcohol = adenosine 3',5'-bisphosphate + an alkyl sulfate.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei117Proton acceptorBy similarity1
Binding sitei139PAPS1
Binding sitei147PAPS1
Binding sitei202PAPS1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi56 – 61PAPS6
Nucleotide bindingi236 – 241PAPS6
Nucleotide bindingi264 – 268PAPS5

GO - Molecular functioni

  • alcohol sulfotransferase activity Source: UniProtKB
  • aryl sulfotransferase activity Source: Ensembl

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Transferase

Enzyme and pathway databases

BioCyciZFISH:G66-33247-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Sulfotransferase 1C3 (EC:2.8.2.2)
Short name:
ST1C3
Gene namesi
Name:SULT1C3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:33543. SULT1C3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi442038.
OpenTargetsiENSG00000196228.
PharmGKBiPA162405069.

Polymorphism and mutation databases

BioMutaiSULT1C3.
DMDMi74724707.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002498871 – 304Sulfotransferase 1C3Add BLAST304

Proteomic databases

PaxDbiQ6IMI6.
PeptideAtlasiQ6IMI6.
PRIDEiQ6IMI6.

PTM databases

iPTMnetiQ6IMI6.
PhosphoSitePlusiQ6IMI6.

Expressioni

Tissue specificityi

Isoform 1 is not detectable in any of the tissues tested. Isoform 2 is expressed in the small intestine.2 Publications

Gene expression databases

CleanExiHS_SULT1C3.

Organism-specific databases

HPAiHPA060368.

Interactioni

Protein-protein interaction databases

BioGridi137954. 5 interactors.

Structurei

Secondary structure

1304
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi21 – 23Combined sources3
Turni24 – 27Combined sources4
Beta strandi28 – 30Combined sources3
Helixi32 – 39Combined sources8
Beta strandi49 – 53Combined sources5
Helixi59 – 70Combined sources12
Beta strandi113 – 116Combined sources4
Helixi120 – 122Combined sources3
Helixi125 – 129Combined sources5
Beta strandi133 – 138Combined sources6
Helixi141 – 154Combined sources14
Helixi164 – 173Combined sources10
Helixi181 – 191Combined sources11
Turni192 – 194Combined sources3
Beta strandi197 – 201Combined sources5
Helixi202 – 207Combined sources6
Helixi209 – 220Combined sources12
Helixi226 – 235Combined sources10
Helixi238 – 242Combined sources5
Turni245 – 247Combined sources3
Turni254 – 256Combined sources3
Turni259 – 261Combined sources3
Helixi272 – 275Combined sources4
Helixi279 – 292Combined sources14

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2H8KX-ray3.20A/B1-304[»]
2REOX-ray2.65A1-304[»]
ProteinModelPortaliQ6IMI6.
SMRiQ6IMI6.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ6IMI6.

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni115 – 117Substrate bindingBy similarity3

Sequence similaritiesi

Belongs to the sulfotransferase 1 family.Curated

Phylogenomic databases

eggNOGiKOG1584. Eukaryota.
ENOG4111H56. LUCA.
GeneTreeiENSGT00760000118932.
HOGENOMiHOG000037209.
HOVERGENiHBG001195.
InParanoidiQ6IMI6.
KOiK01025.
OMAiAPTMEKK.
OrthoDBiEOG091G0D5F.
PhylomeDBiQ6IMI6.
TreeFamiTF321745.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR000863. Sulfotransferase_dom.
[Graphical view]
PfamiPF00685. Sulfotransfer_1. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Note: The SULT1C3 gene contains duplicated exons that could give rise to 4 potential isoforms. So far, it is not known which isoforms are expressed.
Isoform 1 (identifier: Q6IMI6-1) [UniParc]FASTAAdd to basket
Also known as: D, SULT1C3d

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAKIEKNAPT MEKKPELFNI MEVDGVPTLI LSKEWWEKVC NFQAKPDDLI
60 70 80 90 100
LATYPKSGTT WMHEILDMIL NDGDVEKCKR AQTLDRHAFL ELKFPHKEKP
110 120 130 140 150
DLEFVLEMSS PQLIKTHLPS HLIPPSIWKE NCKIVYVARN PKDCLVSYYH
160 170 180 190 200
FHRMASFMPD PQNLEEFYEK FMSGKVVGGS WFDHVKGWWA AKDMHRILYL
210 220 230 240 250
FYEDIKKDPK REIEKILKFL EKDISEEILN KIIYHTSFDV MKQNPMTNYT
260 270 280 290 300
TLPTSIMDHS ISPFMRKGMP GDWKNYFTVA QNEEFDKDYQ KKMAGSTLTF

RTEI
Length:304
Mass (Da):35,889
Last modified:July 5, 2004 - v1
Checksum:i5510C869578BB70C
GO
Isoform 2 (identifier: Q6IMI6-2) [UniParc]FASTAAdd to basket
Also known as: A, SULT1C3a

The sequence of this isoform differs from the canonical sequence as follows:
     208-304: DPKREIEKIL...GSTLTFRTEI → NPKHEIHKVL...GSTLNFCLEI

Show »
Length:304
Mass (Da):35,674
Checksum:i398CB6FF9792FFD9
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05251988A → T.Corresponds to variant rs11903659dbSNPEnsembl.1
Natural variantiVAR_033732148Y → C.Corresponds to variant rs17035911dbSNPEnsembl.1
Natural variantiVAR_033733179G → R.Corresponds to variant rs2219078dbSNPEnsembl.1
Natural variantiVAR_033734194M → T.Corresponds to variant rs6722745dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_020583208 – 304DPKRE…FRTEI → NPKHEIHKVLEFLEKTWSGD VINKIVHHTSFDVMKDNPMA NHTAVPAHIFNHSISKFMRK GMPGDWKNHFTVALNENFDK HYEKKMAGSTLNFCLEI in isoform 2. CuratedAdd BLAST97

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC019100 Genomic DNA. No translation available.
BK001432 Genomic DNA. Translation: DAA01770.1.
BK001432 Genomic DNA. Translation: DAA01771.1.
CCDSiCCDS33267.1. [Q6IMI6-1]
RefSeqiNP_001008743.1. NM_001008743.2. [Q6IMI6-1]
NP_001307807.1. NM_001320878.1. [Q6IMI6-2]

Genome annotation databases

EnsembliENST00000329106; ENSP00000333310; ENSG00000196228. [Q6IMI6-1]
GeneIDi442038.
KEGGihsa:442038.
UCSCiuc010ywo.2. human. [Q6IMI6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC019100 Genomic DNA. No translation available.
BK001432 Genomic DNA. Translation: DAA01770.1.
BK001432 Genomic DNA. Translation: DAA01771.1.
CCDSiCCDS33267.1. [Q6IMI6-1]
RefSeqiNP_001008743.1. NM_001008743.2. [Q6IMI6-1]
NP_001307807.1. NM_001320878.1. [Q6IMI6-2]

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2H8KX-ray3.20A/B1-304[»]
2REOX-ray2.65A1-304[»]
ProteinModelPortaliQ6IMI6.
SMRiQ6IMI6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi137954. 5 interactors.

PTM databases

iPTMnetiQ6IMI6.
PhosphoSitePlusiQ6IMI6.

Polymorphism and mutation databases

BioMutaiSULT1C3.
DMDMi74724707.

Proteomic databases

PaxDbiQ6IMI6.
PeptideAtlasiQ6IMI6.
PRIDEiQ6IMI6.

Protocols and materials databases

DNASUi442038.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000329106; ENSP00000333310; ENSG00000196228. [Q6IMI6-1]
GeneIDi442038.
KEGGihsa:442038.
UCSCiuc010ywo.2. human. [Q6IMI6-1]

Organism-specific databases

CTDi442038.
DisGeNETi442038.
GeneCardsiSULT1C3.
HGNCiHGNC:33543. SULT1C3.
HPAiHPA060368.
neXtProtiNX_Q6IMI6.
OpenTargetsiENSG00000196228.
PharmGKBiPA162405069.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1584. Eukaryota.
ENOG4111H56. LUCA.
GeneTreeiENSGT00760000118932.
HOGENOMiHOG000037209.
HOVERGENiHBG001195.
InParanoidiQ6IMI6.
KOiK01025.
OMAiAPTMEKK.
OrthoDBiEOG091G0D5F.
PhylomeDBiQ6IMI6.
TreeFamiTF321745.

Enzyme and pathway databases

BioCyciZFISH:G66-33247-MONOMER.

Miscellaneous databases

EvolutionaryTraceiQ6IMI6.
GeneWikiiSULT1C3.
GenomeRNAii442038.
PROiQ6IMI6.

Gene expression databases

CleanExiHS_SULT1C3.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR000863. Sulfotransferase_dom.
[Graphical view]
PfamiPF00685. Sulfotransfer_1. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiST1C3_HUMAN
AccessioniPrimary (citable) accession number: Q6IMI6
Secondary accession number(s): Q6IMI5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2006
Last sequence update: July 5, 2004
Last modified: November 2, 2016
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.