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Protein

Sulfotransferase 1C3

Gene

SULT1C3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor and has low sulphotransferase activity towards various substrates with alcohol groups (in vitro). May catalyze the sulfate conjugation of xenobiotic compounds and endogenous substrates.2 Publications

Catalytic activityi

3'-phosphoadenylyl sulfate + an alcohol = adenosine 3',5'-bisphosphate + an alkyl sulfate.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei117 – 1171Proton acceptorBy similarity
Binding sitei139 – 1391PAPS
Binding sitei147 – 1471PAPS
Binding sitei202 – 2021PAPS

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi56 – 616PAPS
Nucleotide bindingi236 – 2416PAPS
Nucleotide bindingi264 – 2685PAPS

GO - Molecular functioni

  • alcohol sulfotransferase activity Source: UniProtKB
  • aryl sulfotransferase activity Source: Ensembl

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Sulfotransferase 1C3 (EC:2.8.2.2)
Short name:
ST1C3
Gene namesi
Name:SULT1C3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:33543. SULT1C3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162405069.

Polymorphism and mutation databases

BioMutaiSULT1C3.
DMDMi74724707.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 304304Sulfotransferase 1C3PRO_0000249887Add
BLAST

Proteomic databases

PaxDbiQ6IMI6.
PeptideAtlasiQ6IMI6.
PRIDEiQ6IMI6.

PTM databases

iPTMnetiQ6IMI6.
PhosphoSiteiQ6IMI6.

Expressioni

Tissue specificityi

Isoform 1 is not detectable in any of the tissues tested. Isoform 2 is expressed in the small intestine.2 Publications

Gene expression databases

BgeeiQ6IMI6.
CleanExiHS_SULT1C3.

Organism-specific databases

HPAiHPA060368.

Interactioni

Protein-protein interaction databases

BioGridi137954. 5 interactions.

Structurei

Secondary structure

1
304
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi21 – 233Combined sources
Turni24 – 274Combined sources
Beta strandi28 – 303Combined sources
Helixi32 – 398Combined sources
Beta strandi49 – 535Combined sources
Helixi59 – 7012Combined sources
Beta strandi113 – 1164Combined sources
Helixi120 – 1223Combined sources
Helixi125 – 1295Combined sources
Beta strandi133 – 1386Combined sources
Helixi141 – 15414Combined sources
Helixi164 – 17310Combined sources
Helixi181 – 19111Combined sources
Turni192 – 1943Combined sources
Beta strandi197 – 2015Combined sources
Helixi202 – 2076Combined sources
Helixi209 – 22012Combined sources
Helixi226 – 23510Combined sources
Helixi238 – 2425Combined sources
Turni245 – 2473Combined sources
Turni254 – 2563Combined sources
Turni259 – 2613Combined sources
Helixi272 – 2754Combined sources
Helixi279 – 29214Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2H8KX-ray3.20A/B1-304[»]
2REOX-ray2.65A1-304[»]
ProteinModelPortaliQ6IMI6.
SMRiQ6IMI6. Positions 18-302.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ6IMI6.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni115 – 1173Substrate bindingBy similarity

Sequence similaritiesi

Belongs to the sulfotransferase 1 family.Curated

Phylogenomic databases

eggNOGiKOG1584. Eukaryota.
ENOG4111H56. LUCA.
GeneTreeiENSGT00760000118932.
HOGENOMiHOG000037209.
HOVERGENiHBG001195.
InParanoidiQ6IMI6.
KOiK01025.
OMAiAPTMEKK.
OrthoDBiEOG7V49ZK.
PhylomeDBiQ6IMI6.
TreeFamiTF321745.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR000863. Sulfotransferase_dom.
[Graphical view]
PfamiPF00685. Sulfotransfer_1. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Note: The SULT1C3 gene contains duplicated exons that could give rise to 4 potential isoforms. So far, it is not known which isoforms are expressed.

Isoform 1 (identifier: Q6IMI6-1) [UniParc]FASTAAdd to basket

Also known as: D, SULT1C3d

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAKIEKNAPT MEKKPELFNI MEVDGVPTLI LSKEWWEKVC NFQAKPDDLI
60 70 80 90 100
LATYPKSGTT WMHEILDMIL NDGDVEKCKR AQTLDRHAFL ELKFPHKEKP
110 120 130 140 150
DLEFVLEMSS PQLIKTHLPS HLIPPSIWKE NCKIVYVARN PKDCLVSYYH
160 170 180 190 200
FHRMASFMPD PQNLEEFYEK FMSGKVVGGS WFDHVKGWWA AKDMHRILYL
210 220 230 240 250
FYEDIKKDPK REIEKILKFL EKDISEEILN KIIYHTSFDV MKQNPMTNYT
260 270 280 290 300
TLPTSIMDHS ISPFMRKGMP GDWKNYFTVA QNEEFDKDYQ KKMAGSTLTF

RTEI
Length:304
Mass (Da):35,889
Last modified:July 5, 2004 - v1
Checksum:i5510C869578BB70C
GO
Isoform 2 (identifier: Q6IMI6-2) [UniParc]FASTAAdd to basket

Also known as: A, SULT1C3a

The sequence of this isoform differs from the canonical sequence as follows:
     208-304: DPKREIEKIL...GSTLTFRTEI → NPKHEIHKVL...GSTLNFCLEI

Show »
Length:304
Mass (Da):35,674
Checksum:i398CB6FF9792FFD9
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti88 – 881A → T.
Corresponds to variant rs11903659 [ dbSNP | Ensembl ].
VAR_052519
Natural varianti148 – 1481Y → C.
Corresponds to variant rs17035911 [ dbSNP | Ensembl ].
VAR_033732
Natural varianti179 – 1791G → R.
Corresponds to variant rs2219078 [ dbSNP | Ensembl ].
VAR_033733
Natural varianti194 – 1941M → T.
Corresponds to variant rs6722745 [ dbSNP | Ensembl ].
VAR_033734

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei208 – 30497DPKRE…FRTEI → NPKHEIHKVLEFLEKTWSGD VINKIVHHTSFDVMKDNPMA NHTAVPAHIFNHSISKFMRK GMPGDWKNHFTVALNENFDK HYEKKMAGSTLNFCLEI in isoform 2. CuratedVSP_020583Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC019100 Genomic DNA. No translation available.
BK001432 Genomic DNA. Translation: DAA01770.1.
BK001432 Genomic DNA. Translation: DAA01771.1.
CCDSiCCDS33267.1. [Q6IMI6-1]
RefSeqiNP_001008743.1. NM_001008743.2. [Q6IMI6-1]
NP_001307807.1. NM_001320878.1. [Q6IMI6-2]
XP_011509512.1. XM_011511210.1. [Q6IMI6-2]
XP_011509513.1. XM_011511211.1. [Q6IMI6-2]

Genome annotation databases

EnsembliENST00000329106; ENSP00000333310; ENSG00000196228. [Q6IMI6-1]
GeneIDi442038.
KEGGihsa:442038.
UCSCiuc010ywo.2. human. [Q6IMI6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC019100 Genomic DNA. No translation available.
BK001432 Genomic DNA. Translation: DAA01770.1.
BK001432 Genomic DNA. Translation: DAA01771.1.
CCDSiCCDS33267.1. [Q6IMI6-1]
RefSeqiNP_001008743.1. NM_001008743.2. [Q6IMI6-1]
NP_001307807.1. NM_001320878.1. [Q6IMI6-2]
XP_011509512.1. XM_011511210.1. [Q6IMI6-2]
XP_011509513.1. XM_011511211.1. [Q6IMI6-2]

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2H8KX-ray3.20A/B1-304[»]
2REOX-ray2.65A1-304[»]
ProteinModelPortaliQ6IMI6.
SMRiQ6IMI6. Positions 18-302.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi137954. 5 interactions.

PTM databases

iPTMnetiQ6IMI6.
PhosphoSiteiQ6IMI6.

Polymorphism and mutation databases

BioMutaiSULT1C3.
DMDMi74724707.

Proteomic databases

PaxDbiQ6IMI6.
PeptideAtlasiQ6IMI6.
PRIDEiQ6IMI6.

Protocols and materials databases

DNASUi442038.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000329106; ENSP00000333310; ENSG00000196228. [Q6IMI6-1]
GeneIDi442038.
KEGGihsa:442038.
UCSCiuc010ywo.2. human. [Q6IMI6-1]

Organism-specific databases

CTDi442038.
GeneCardsiSULT1C3.
HGNCiHGNC:33543. SULT1C3.
HPAiHPA060368.
neXtProtiNX_Q6IMI6.
PharmGKBiPA162405069.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1584. Eukaryota.
ENOG4111H56. LUCA.
GeneTreeiENSGT00760000118932.
HOGENOMiHOG000037209.
HOVERGENiHBG001195.
InParanoidiQ6IMI6.
KOiK01025.
OMAiAPTMEKK.
OrthoDBiEOG7V49ZK.
PhylomeDBiQ6IMI6.
TreeFamiTF321745.

Miscellaneous databases

EvolutionaryTraceiQ6IMI6.
GeneWikiiSULT1C3.
GenomeRNAii442038.
PROiQ6IMI6.

Gene expression databases

BgeeiQ6IMI6.
CleanExiHS_SULT1C3.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR000863. Sulfotransferase_dom.
[Graphical view]
PfamiPF00685. Sulfotransfer_1. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "Human cytosolic sulfotransferase database mining: identification of seven novel genes and pseudogenes."
    Freimuth R.R., Wiepert M., Chute C.G., Wieben E.D., Weinshilboum R.M.
    Pharmacogenomics J. 4:54-65(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION, TISSUE SPECIFICITY, ALTERNATIVE SPLICING.
  3. "SULT1C3, an orphan sequence of the human genome, encodes an enzyme activating various promutagens."
    Meinl W., Donath C., Schneider H., Sommer Y., Glatt H.
    Food Chem. Toxicol. 46:1249-1256(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  4. "Expression of the orphan cytosolic sulfotransferase SULT1C3 in human intestine: characterization of the transcript variant and implications for function."
    Duniec-Dmuchowski Z., Rondini E.A., Tibbs Z.E., Falany C.N., Runge-Morris M., Kocarek T.A.
    Drug Metab. Dispos. 42:352-360(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: ALTERNATIVE SPLICING, TISSUE SPECIFICITY.
  5. Cited for: X-RAY CRYSTALLOGRAPHY (3.20 ANGSTROMS) IN COMPLEX WITH ADENOSINE-3'-5'-DIPHOSPHATE (PAP), CATALYTIC ACTIVITY, FUNCTION.
  6. "Crystal structure of human sulfotransferase 1C3 (SULT1C3) in complex with PAP."
    Structural genomics consortium (SGC)
    Submitted (FEB-2009) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (2.65 ANGSTROMS) IN COMPLEX WITH ADENOSINE-3'-5'-DIPHOSPHATE (PAP).

Entry informationi

Entry nameiST1C3_HUMAN
AccessioniPrimary (citable) accession number: Q6IMI6
Secondary accession number(s): Q6IMI5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2006
Last sequence update: July 5, 2004
Last modified: July 6, 2016
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.