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Protein

Keratin, type II cytoskeletal 80

Gene

Krt80

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Miscellaneous

There are two types of cytoskeletal and microfibrillar keratin, I (acidic) and II (neutral to basic) (40-55 and 56-70 kDa, respectively).

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei334Stutter1

GO - Molecular functioni

Enzyme and pathway databases

ReactomeiR-RNO-6805567 Keratinization
R-RNO-6809371 Formation of the cornified envelope

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin, type II cytoskeletal 80
Alternative name(s):
Cytokeratin-80
Short name:
CK-80
Keratin-80
Short name:
K80
Type-II keratin Kb20
Gene namesi
Name:Krt80
Synonyms:Kb20
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 7

Organism-specific databases

RGDi1359177 Krt80

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Intermediate filament, Keratin

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003148981 – 452Keratin, type II cytoskeletal 80Add BLAST452

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei45PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ6IMF1
PRIDEiQ6IMF1

PTM databases

iPTMnetiQ6IMF1
PhosphoSitePlusiQ6IMF1

Expressioni

Gene expression databases

BgeeiENSRNOG00000025994
GenevisibleiQ6IMF1 RN

Interactioni

Subunit structurei

Heterotetramer of two type I and two type II keratins.

Structurei

3D structure databases

ProteinModelPortaliQ6IMF1
SMRiQ6IMF1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini83 – 394IF rodPROSITE-ProRule annotationAdd BLAST312

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 82HeadAdd BLAST82
Regioni82 – 118Coil 1AAdd BLAST37
Regioni119 – 135Linker 1Add BLAST17
Regioni136 – 227Coil 1BAdd BLAST92
Regioni228 – 251Linker 12Add BLAST24
Regioni252 – 390Coil 2Add BLAST139
Regioni391 – 452TailAdd BLAST62

Sequence similaritiesi

Belongs to the intermediate filament family.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IGH5 Eukaryota
ENOG411183I LUCA
GeneTreeiENSGT00910000144169
HOGENOMiHOG000230976
HOVERGENiHBG013015
InParanoidiQ6IMF1
KOiK07605
OMAiMACRSCV
OrthoDBiEOG091G0AOP
PhylomeDBiQ6IMF1
TreeFamiTF317854

Family and domain databases

InterProiView protein in InterPro
IPR001664 IF
IPR039008 IF_rod_dom
IPR032444 Keratin_2_head
IPR003054 Keratin_II
PANTHERiPTHR23239 PTHR23239, 1 hit
PfamiView protein in Pfam
PF00038 Filament, 1 hit
PF16208 Keratin_2_head, 1 hit
PRINTSiPR01276 TYPE2KERATIN
SMARTiView protein in SMART
SM01391 Filament, 1 hit
PROSITEiView protein in PROSITE
PS51842 IF_ROD_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q6IMF1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAYRSCVVGF SSHSGCEVTP AGSSQPGTSG WGSCGLPGPG FSSRSLTSCR
60 70 80 90 100
PAGVIPKVTV NPSLLVPLDL KVDPAVQQQK NQEKEEMKVL NDKFASLIGK
110 120 130 140 150
VQALEQRNQL LETRWGFLQG QGSATFDLSH HYETFQGRLQ EELRKVSQER
160 170 180 190 200
GQLEASLLQV LEKVEEFRVR YEDEISKRTD LEFTFVQLKK DLDAECLRRT
210 220 230 240 250
ELETKLKGLQ GFVELMRTVY EQELKDLTAQ VKDVSVTVGL DSRCHIDLSG
260 270 280 290 300
IVEEVKAQYD AIAARSLEEA EAYSRSQLEE RAARSAEFGN SLQSSRCEIA
310 320 330 340 350
DLNVRIQKLR SQIVSVKSHC LKLEENIKVA EEQGELAFQD AKDKMAQLEA
360 370 380 390 400
ALQKAKQDMA RQLREYQDLM NTKLALDIEI ATYHKLMEGE ESRMDLPSTT
410 420 430 440 450
VVSAVQSRCR TTASKSGLSK TPSRKKKNRG GPVIKITEMS EKYLSQESEA

SE
Length:452
Mass (Da):50,550
Last modified:July 5, 2004 - v1
Checksum:iFEDBE9145CA03721
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR03055900 Genomic DNA No translation available.
AABR03056151 Genomic DNA No translation available.
BK001581 mRNA Translation: DAA02056.1
BK001582 mRNA Translation: DAA02057.1
RefSeqiNP_001008815.1, NM_001008815.1
UniGeneiRn.103689

Genome annotation databases

EnsembliENSRNOT00000029697; ENSRNOP00000038848; ENSRNOG00000025994
GeneIDi315318
KEGGirno:315318
UCSCiRGD:1359177 rat

Similar proteinsi

Entry informationi

Entry nameiK2C80_RAT
AccessioniPrimary (citable) accession number: Q6IMF1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: July 5, 2004
Last modified: May 23, 2018
This is version 92 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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