Q6IMF1 (K2C80_RAT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Keratin, type II cytoskeletal 80

Alternative name(s):
Cytokeratin-80
Short name=CK-80
Keratin-80
Short name=K80
Type-II keratin Kb20

Gene names

Name:	Krt80
Synonyms:	Kb20

Organism

Rattus norvegicus (Rat) [Reference proteome]

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	452 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Subunit structure	Heterotetramer of two type I and two type II keratins.
Miscellaneous	There are two types of cytoskeletal and microfibrillar keratin, I (acidic) and II (neutral to basic) (40-55 and 56-70 kDa, respectively).
Sequence similarities	Belongs to the intermediate filament family.

Ontologies

Keywords
Cellular component	Intermediate filament Keratin
Domain	Coiled coil
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	keratin filament Inferred from electronic annotation. Source: InterPro
Molecular_function	structural molecule activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 452	452	Keratin, type II cytoskeletal 80		PRO_0000314898
Regions
	Region	1 – 82	82	Head
	Region	82 – 118	37	Coil 1A
	Region	83 – 390	308	Rod
	Region	119 – 135	17	Linker 1
	Region	136 – 227	92	Coil 1B
	Region	228 – 251	24	Linker 12
	Region	252 – 390	139	Coil 2
	Region	391 – 452	62	Tail
Sites
	Site	334	1	Stutter
Amino acid modifications
	Modified residue	45	1	Phosphoserine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q6IMF1 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: FEDBE9145CA03721	FASTA	452	50,550
	10 20 30 40 50 60 MAYRSCVVGF SSHSGCEVTP AGSSQPGTSG WGSCGLPGPG FSSRSLTSCR PAGVIPKVTV 70 80 90 100 110 120 NPSLLVPLDL KVDPAVQQQK NQEKEEMKVL NDKFASLIGK VQALEQRNQL LETRWGFLQG 130 140 150 160 170 180 QGSATFDLSH HYETFQGRLQ EELRKVSQER GQLEASLLQV LEKVEEFRVR YEDEISKRTD 190 200 210 220 230 240 LEFTFVQLKK DLDAECLRRT ELETKLKGLQ GFVELMRTVY EQELKDLTAQ VKDVSVTVGL 250 260 270 280 290 300 DSRCHIDLSG IVEEVKAQYD AIAARSLEEA EAYSRSQLEE RAARSAEFGN SLQSSRCEIA 310 320 330 340 350 360 DLNVRIQKLR SQIVSVKSHC LKLEENIKVA EEQGELAFQD AKDKMAQLEA ALQKAKQDMA 370 380 390 400 410 420 RQLREYQDLM NTKLALDIEI ATYHKLMEGE ESRMDLPSTT VVSAVQSRCR TTASKSGLSK 430 440 450 TPSRKKKNRG GPVIKITEMS EKYLSQESEA SE

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Genome sequence of the Brown Norway rat yields insights into mammalian evolution." Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M. , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S. Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Brown Norway.
[2]	"Comprehensive analysis of keratin gene clusters in humans and rodents." Hesse M., Zimek A., Weber K., Magin T.M. Eur. J. Cell Biol. 83:19-26(2004) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AABR03055900 Genomic DNA. No translation available. AABR03056151 Genomic DNA. No translation available. BK001581 mRNA. Translation: DAA02056.1. BK001582 mRNA. Translation: DAA02057.1.
IPI	IPI00361747.
RefSeq	NP_001008815.1. NM_001008815.1.
UniGene	Rn.103689.
3D structure databases
HSSP	HSSP built from PDB template 1GK4 based on UniProtKB P08670.
ProteinModelPortal	Q6IMF1.
ModBase	Search...
Protein-protein interaction databases
STRING	10116.ENSRNOP00000038848.
Proteomic databases
PaxDb	Q6IMF1.
PRIDE	Q6IMF1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSRNOT00000029697; ENSRNOP00000038848; ENSRNOG00000025994.
GeneID	315318.
KEGG	rno:315318.
UCSC	RGD:1359177. rat.
Organism-specific databases
CTD	144501.
RGD	1359177. Krt80.
Phylogenomic databases
eggNOG	NOG147372.
GeneTree	ENSGT00690000102295.
HOGENOM	HOG000230976.
HOVERGEN	HBG013015.
InParanoid	Q6IMF1.
KO	K07605.
OMA	NQEKEEM.
OrthoDB	EOG49GKGM.
Gene expression databases
ArrayExpress	Q6IMF1.
Genevestigator	Q6IMF1.
Family and domain databases
InterPro	IPR016044. F. IPR001664. IF. IPR003054. Keratin_II. [Graphical view]
PANTHER	PTHR23239. PTHR23239. 1 hit. PTHR23239:SF18. PTHR23239:SF18. 1 hit.
Pfam	PF00038. Filament. 1 hit. [Graphical view]
PRINTS	PR01276. TYPE2KERATIN.
PROSITE	PS00226. IF. False negative. [Graphical view]
ProtoNet	Search...
Other
NextBio	669051.

Entry information

Entry name

K2C80_RAT

Accession

Primary (citable) accession number: Q6IMF1

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	July 5, 2004
Last modified:	April 3, 2013
This is version 62 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program