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Q6IMF1

- K2C80_RAT

UniProt

Q6IMF1 - K2C80_RAT

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Protein

Keratin, type II cytoskeletal 80

Gene

Krt80

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei334 – 3341Stutter

GO - Molecular functioni

  1. structural molecule activity Source: InterPro
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin, type II cytoskeletal 80
Alternative name(s):
Cytokeratin-80
Short name:
CK-80
Keratin-80
Short name:
K80
Type-II keratin Kb20
Gene namesi
Name:Krt80
Synonyms:Kb20
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 7

Organism-specific databases

RGDi1359177. Krt80.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: Ensembl
  2. keratin filament Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Intermediate filament, Keratin

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 452452Keratin, type II cytoskeletal 80PRO_0000314898Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei45 – 451PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ6IMF1.
PRIDEiQ6IMF1.

Expressioni

Gene expression databases

GenevestigatoriQ6IMF1.

Interactioni

Subunit structurei

Heterotetramer of two type I and two type II keratins.

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000038848.

Structurei

3D structure databases

ProteinModelPortaliQ6IMF1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 8282HeadAdd
BLAST
Regioni82 – 11837Coil 1AAdd
BLAST
Regioni83 – 390308RodAdd
BLAST
Regioni119 – 13517Linker 1Add
BLAST
Regioni136 – 22792Coil 1BAdd
BLAST
Regioni228 – 25124Linker 12Add
BLAST
Regioni252 – 390139Coil 2Add
BLAST
Regioni391 – 45262TailAdd
BLAST

Sequence similaritiesi

Belongs to the intermediate filament family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG147372.
GeneTreeiENSGT00730000110415.
HOGENOMiHOG000230976.
HOVERGENiHBG013015.
InParanoidiQ6IMF1.
KOiK07605.
OMAiSCEVTPV.
OrthoDBiEOG7FV3Q8.
PhylomeDBiQ6IMF1.
TreeFamiTF317854.

Family and domain databases

InterProiIPR001664. IF.
IPR003054. Keratin_II.
[Graphical view]
PANTHERiPTHR23239. PTHR23239. 1 hit.
PfamiPF00038. Filament. 1 hit.
[Graphical view]
PRINTSiPR01276. TYPE2KERATIN.

Sequencei

Sequence statusi: Complete.

Q6IMF1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAYRSCVVGF SSHSGCEVTP AGSSQPGTSG WGSCGLPGPG FSSRSLTSCR
60 70 80 90 100
PAGVIPKVTV NPSLLVPLDL KVDPAVQQQK NQEKEEMKVL NDKFASLIGK
110 120 130 140 150
VQALEQRNQL LETRWGFLQG QGSATFDLSH HYETFQGRLQ EELRKVSQER
160 170 180 190 200
GQLEASLLQV LEKVEEFRVR YEDEISKRTD LEFTFVQLKK DLDAECLRRT
210 220 230 240 250
ELETKLKGLQ GFVELMRTVY EQELKDLTAQ VKDVSVTVGL DSRCHIDLSG
260 270 280 290 300
IVEEVKAQYD AIAARSLEEA EAYSRSQLEE RAARSAEFGN SLQSSRCEIA
310 320 330 340 350
DLNVRIQKLR SQIVSVKSHC LKLEENIKVA EEQGELAFQD AKDKMAQLEA
360 370 380 390 400
ALQKAKQDMA RQLREYQDLM NTKLALDIEI ATYHKLMEGE ESRMDLPSTT
410 420 430 440 450
VVSAVQSRCR TTASKSGLSK TPSRKKKNRG GPVIKITEMS EKYLSQESEA

SE
Length:452
Mass (Da):50,550
Last modified:July 5, 2004 - v1
Checksum:iFEDBE9145CA03721
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR03055900 Genomic DNA. No translation available.
AABR03056151 Genomic DNA. No translation available.
BK001581 mRNA. Translation: DAA02056.1.
BK001582 mRNA. Translation: DAA02057.1.
RefSeqiNP_001008815.1. NM_001008815.1.
UniGeneiRn.103689.

Genome annotation databases

EnsembliENSRNOT00000029697; ENSRNOP00000038848; ENSRNOG00000025994.
GeneIDi315318.
KEGGirno:315318.
UCSCiRGD:1359177. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR03055900 Genomic DNA. No translation available.
AABR03056151 Genomic DNA. No translation available.
BK001581 mRNA. Translation: DAA02056.1 .
BK001582 mRNA. Translation: DAA02057.1 .
RefSeqi NP_001008815.1. NM_001008815.1.
UniGenei Rn.103689.

3D structure databases

ProteinModelPortali Q6IMF1.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000038848.

Proteomic databases

PaxDbi Q6IMF1.
PRIDEi Q6IMF1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000029697 ; ENSRNOP00000038848 ; ENSRNOG00000025994 .
GeneIDi 315318.
KEGGi rno:315318.
UCSCi RGD:1359177. rat.

Organism-specific databases

CTDi 144501.
RGDi 1359177. Krt80.

Phylogenomic databases

eggNOGi NOG147372.
GeneTreei ENSGT00730000110415.
HOGENOMi HOG000230976.
HOVERGENi HBG013015.
InParanoidi Q6IMF1.
KOi K07605.
OMAi SCEVTPV.
OrthoDBi EOG7FV3Q8.
PhylomeDBi Q6IMF1.
TreeFami TF317854.

Miscellaneous databases

NextBioi 669051.
PROi Q6IMF1.

Gene expression databases

Genevestigatori Q6IMF1.

Family and domain databases

InterProi IPR001664. IF.
IPR003054. Keratin_II.
[Graphical view ]
PANTHERi PTHR23239. PTHR23239. 1 hit.
Pfami PF00038. Filament. 1 hit.
[Graphical view ]
PRINTSi PR01276. TYPE2KERATIN.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
    Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
    , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
    Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Brown Norway.
  2. "Comprehensive analysis of keratin gene clusters in humans and rodents."
    Hesse M., Zimek A., Weber K., Magin T.M.
    Eur. J. Cell Biol. 83:19-26(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiK2C80_RAT
AccessioniPrimary (citable) accession number: Q6IMF1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: July 5, 2004
Last modified: October 29, 2014
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

There are two types of cytoskeletal and microfibrillar keratin, I (acidic) and II (neutral to basic) (40-55 and 56-70 kDa, respectively).

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3