Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q6IMF1

- K2C80_RAT

UniProt

Q6IMF1 - K2C80_RAT

Protein

Keratin, type II cytoskeletal 80

Gene

Krt80

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 71 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei334 – 3341Stutter

    GO - Molecular functioni

    1. structural molecule activity Source: InterPro

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Keratin, type II cytoskeletal 80
    Alternative name(s):
    Cytokeratin-80
    Short name:
    CK-80
    Keratin-80
    Short name:
    K80
    Type-II keratin Kb20
    Gene namesi
    Name:Krt80
    Synonyms:Kb20
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 7

    Organism-specific databases

    RGDi1359177. Krt80.

    Subcellular locationi

    GO - Cellular componenti

    1. keratin filament Source: InterPro

    Keywords - Cellular componenti

    Intermediate filament, Keratin

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 452452Keratin, type II cytoskeletal 80PRO_0000314898Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei45 – 451PhosphoserineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiQ6IMF1.
    PRIDEiQ6IMF1.

    Expressioni

    Gene expression databases

    GenevestigatoriQ6IMF1.

    Interactioni

    Subunit structurei

    Heterotetramer of two type I and two type II keratins.

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000038848.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6IMF1.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 8282HeadAdd
    BLAST
    Regioni82 – 11837Coil 1AAdd
    BLAST
    Regioni83 – 390308RodAdd
    BLAST
    Regioni119 – 13517Linker 1Add
    BLAST
    Regioni136 – 22792Coil 1BAdd
    BLAST
    Regioni228 – 25124Linker 12Add
    BLAST
    Regioni252 – 390139Coil 2Add
    BLAST
    Regioni391 – 45262TailAdd
    BLAST

    Sequence similaritiesi

    Belongs to the intermediate filament family.Curated

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiNOG147372.
    GeneTreeiENSGT00730000110415.
    HOGENOMiHOG000230976.
    HOVERGENiHBG013015.
    InParanoidiQ6IMF1.
    KOiK07605.
    OMAiSCEVTPV.
    OrthoDBiEOG7FV3Q8.
    PhylomeDBiQ6IMF1.
    TreeFamiTF317854.

    Family and domain databases

    InterProiIPR001664. IF.
    IPR003054. Keratin_II.
    [Graphical view]
    PANTHERiPTHR23239. PTHR23239. 1 hit.
    PfamiPF00038. Filament. 1 hit.
    [Graphical view]
    PRINTSiPR01276. TYPE2KERATIN.

    Sequencei

    Sequence statusi: Complete.

    Q6IMF1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAYRSCVVGF SSHSGCEVTP AGSSQPGTSG WGSCGLPGPG FSSRSLTSCR    50
    PAGVIPKVTV NPSLLVPLDL KVDPAVQQQK NQEKEEMKVL NDKFASLIGK 100
    VQALEQRNQL LETRWGFLQG QGSATFDLSH HYETFQGRLQ EELRKVSQER 150
    GQLEASLLQV LEKVEEFRVR YEDEISKRTD LEFTFVQLKK DLDAECLRRT 200
    ELETKLKGLQ GFVELMRTVY EQELKDLTAQ VKDVSVTVGL DSRCHIDLSG 250
    IVEEVKAQYD AIAARSLEEA EAYSRSQLEE RAARSAEFGN SLQSSRCEIA 300
    DLNVRIQKLR SQIVSVKSHC LKLEENIKVA EEQGELAFQD AKDKMAQLEA 350
    ALQKAKQDMA RQLREYQDLM NTKLALDIEI ATYHKLMEGE ESRMDLPSTT 400
    VVSAVQSRCR TTASKSGLSK TPSRKKKNRG GPVIKITEMS EKYLSQESEA 450
    SE 452
    Length:452
    Mass (Da):50,550
    Last modified:July 5, 2004 - v1
    Checksum:iFEDBE9145CA03721
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AABR03055900 Genomic DNA. No translation available.
    AABR03056151 Genomic DNA. No translation available.
    BK001581 mRNA. Translation: DAA02056.1.
    BK001582 mRNA. Translation: DAA02057.1.
    RefSeqiNP_001008815.1. NM_001008815.1.
    UniGeneiRn.103689.

    Genome annotation databases

    EnsembliENSRNOT00000029697; ENSRNOP00000038848; ENSRNOG00000025994.
    GeneIDi315318.
    KEGGirno:315318.
    UCSCiRGD:1359177. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AABR03055900 Genomic DNA. No translation available.
    AABR03056151 Genomic DNA. No translation available.
    BK001581 mRNA. Translation: DAA02056.1 .
    BK001582 mRNA. Translation: DAA02057.1 .
    RefSeqi NP_001008815.1. NM_001008815.1.
    UniGenei Rn.103689.

    3D structure databases

    ProteinModelPortali Q6IMF1.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000038848.

    Proteomic databases

    PaxDbi Q6IMF1.
    PRIDEi Q6IMF1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000029697 ; ENSRNOP00000038848 ; ENSRNOG00000025994 .
    GeneIDi 315318.
    KEGGi rno:315318.
    UCSCi RGD:1359177. rat.

    Organism-specific databases

    CTDi 144501.
    RGDi 1359177. Krt80.

    Phylogenomic databases

    eggNOGi NOG147372.
    GeneTreei ENSGT00730000110415.
    HOGENOMi HOG000230976.
    HOVERGENi HBG013015.
    InParanoidi Q6IMF1.
    KOi K07605.
    OMAi SCEVTPV.
    OrthoDBi EOG7FV3Q8.
    PhylomeDBi Q6IMF1.
    TreeFami TF317854.

    Miscellaneous databases

    NextBioi 669051.
    PROi Q6IMF1.

    Gene expression databases

    Genevestigatori Q6IMF1.

    Family and domain databases

    InterProi IPR001664. IF.
    IPR003054. Keratin_II.
    [Graphical view ]
    PANTHERi PTHR23239. PTHR23239. 1 hit.
    Pfami PF00038. Filament. 1 hit.
    [Graphical view ]
    PRINTSi PR01276. TYPE2KERATIN.
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
      Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
      , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
      Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Brown Norway.
    2. "Comprehensive analysis of keratin gene clusters in humans and rodents."
      Hesse M., Zimek A., Weber K., Magin T.M.
      Eur. J. Cell Biol. 83:19-26(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION.

    Entry informationi

    Entry nameiK2C80_RAT
    AccessioniPrimary (citable) accession number: Q6IMF1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 71 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    There are two types of cytoskeletal and microfibrillar keratin, I (acidic) and II (neutral to basic) (40-55 and 56-70 kDa, respectively).

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3