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Q6IMF0

- KRT83_MOUSE

UniProt

Q6IMF0 - KRT83_MOUSE

Protein

Keratin, type II cuticular Hb3

Gene

Krt83

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 83 (01 Oct 2014)
      Sequence version 2 (10 Feb 2009)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. structural molecule activity Source: InterPro

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Keratin, type II cuticular Hb3By similarity
    Alternative name(s):
    Keratin-83Imported
    Short name:
    K83
    Type II hair keratin Hb3
    Type-II keratin Kb23
    Gene namesi
    Name:Krt83Imported
    Synonyms:Kb23, Krt2-25Imported
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 15

    Organism-specific databases

    MGIiMGI:3665486. Krt83.

    Subcellular locationi

    GO - Cellular componenti

    1. keratin filament Source: InterPro

    Keywords - Cellular componenti

    Intermediate filament, Keratin

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 495495Keratin, type II cuticular Hb3PRO_0000361692Add
    BLAST

    Proteomic databases

    PaxDbiQ6IMF0.
    PRIDEiQ6IMF0.

    PTM databases

    PhosphoSiteiQ6IMF0.

    Expressioni

    Gene expression databases

    BgeeiQ6IMF0.
    GenevestigatoriQ6IMF0.

    Interactioni

    Subunit structurei

    Heterotetramer of two type I and two type II keratins.Curated

    Structurei

    3D structure databases

    ProteinModelPortaliQ6IMF0.
    SMRiQ6IMF0. Positions 111-259, 277-417.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 111111HeadSequence AnalysisAdd
    BLAST
    Regioni112 – 418307RodSequence AnalysisAdd
    BLAST
    Regioni112 – 14635Coil 1ASequence AnalysisAdd
    BLAST
    Regioni147 – 15610Linker 1Sequence Analysis
    Regioni157 – 257101Coil 1BSequence AnalysisAdd
    BLAST
    Regioni258 – 27417Linker 12Sequence AnalysisAdd
    BLAST
    Regioni275 – 418144Coil 2Sequence AnalysisAdd
    BLAST
    Regioni419 – 49476TailSequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Belongs to the intermediate filament family.Sequence Analysis

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiNOG149039.
    GeneTreeiENSGT00670000097789.
    HOGENOMiHOG000230976.
    HOVERGENiHBG013015.
    InParanoidiB2RTF5.
    KOiK07605.
    OMAiCAPCNSI.
    OrthoDBiEOG7B05CW.
    PhylomeDBiQ6IMF0.
    TreeFamiTF317854.

    Family and domain databases

    InterProiIPR001664. IF.
    IPR018039. Intermediate_filament_CS.
    IPR003054. Keratin_II.
    [Graphical view]
    PANTHERiPTHR23239. PTHR23239. 1 hit.
    PfamiPF00038. Filament. 1 hit.
    [Graphical view]
    PRINTSiPR01276. TYPE2KERATIN.
    PROSITEiPS00226. IF. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q6IMF0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSCFSSRLGA SCGVRAFSCA SACGPRPGRC CISAAPYRGI SCYRGLSGGF    50
    GSRSVCGPFR SGSCGRSFGY RSGGVCGPSP PCITTVSVNE SLLTPLNLEI 100
    DPNAQCVKHE EKEQIKCLNS KFAAFIDKVR FLEQQNKLLE TKWQFYQNRK 150
    CCESNMEPLF EGYIEALRRE AECVEADSGR LAAELNHVQE SMEGYKKRYE 200
    EEVALRATSE NEFVALKKDV DCAYLRKSDL EANAEALTQE TDFLRQLYEE 250
    ETRLLHSHIS DTSVVVKMDN SRDLNMDCVV AEIKAQYDDI ASRSRAEAES 300
    WYRTKCEEMK ATVIRHGETL RRTREEINEL NRMIQRLTAE IENAKCQNTK 350
    LEAAVTQSEQ QGEAALTDAR CKLAELEGAL QKAKQDMACL LKEYQEVMNS 400
    KLGLDVEIIT YRRLLEGEEQ RLCEGVGSVN VCVSSSRGGV TCGGLTYGTT 450
    PGRQIASGPS VTGGSITVMA PDSCSPCQPR ASSFTCGSSR SVRFA 495
    Length:495
    Mass (Da):54,629
    Last modified:February 10, 2009 - v2
    Checksum:i9523A541F0EF7231
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti456 – 4561A → V(PubMed:19468303)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CAAA01196873 Genomic DNA. No translation available.
    CH466550 Genomic DNA. Translation: EDL04045.1.
    BC139321 mRNA. Translation: AAI39322.1.
    BC139322 mRNA. Translation: AAI39323.1.
    BK001583 mRNA. Translation: DAA02058.1.
    CCDSiCCDS27852.1.
    RefSeqiNP_001003668.2. NM_001003668.2.
    UniGeneiMm.347934.

    Genome annotation databases

    EnsembliENSMUST00000081945; ENSMUSP00000080613; ENSMUSG00000047641.
    GeneIDi406219.
    KEGGimmu:406219.
    UCSCiuc007xte.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CAAA01196873 Genomic DNA. No translation available.
    CH466550 Genomic DNA. Translation: EDL04045.1 .
    BC139321 mRNA. Translation: AAI39322.1 .
    BC139322 mRNA. Translation: AAI39323.1 .
    BK001583 mRNA. Translation: DAA02058.1 .
    CCDSi CCDS27852.1.
    RefSeqi NP_001003668.2. NM_001003668.2.
    UniGenei Mm.347934.

    3D structure databases

    ProteinModelPortali Q6IMF0.
    SMRi Q6IMF0. Positions 111-259, 277-417.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q6IMF0.

    Proteomic databases

    PaxDbi Q6IMF0.
    PRIDEi Q6IMF0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000081945 ; ENSMUSP00000080613 ; ENSMUSG00000047641 .
    GeneIDi 406219.
    KEGGi mmu:406219.
    UCSCi uc007xte.2. mouse.

    Organism-specific databases

    CTDi 3889.
    MGIi MGI:3665486. Krt83.

    Phylogenomic databases

    eggNOGi NOG149039.
    GeneTreei ENSGT00670000097789.
    HOGENOMi HOG000230976.
    HOVERGENi HBG013015.
    InParanoidi B2RTF5.
    KOi K07605.
    OMAi CAPCNSI.
    OrthoDBi EOG7B05CW.
    PhylomeDBi Q6IMF0.
    TreeFami TF317854.

    Miscellaneous databases

    NextBioi 407151.
    PROi Q6IMF0.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q6IMF0.
    Genevestigatori Q6IMF0.

    Family and domain databases

    InterProi IPR001664. IF.
    IPR018039. Intermediate_filament_CS.
    IPR003054. Keratin_II.
    [Graphical view ]
    PANTHERi PTHR23239. PTHR23239. 1 hit.
    Pfami PF00038. Filament. 1 hit.
    [Graphical view ]
    PRINTSi PR01276. TYPE2KERATIN.
    PROSITEi PS00226. IF. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    2. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: BrainImported.
    4. "Comprehensive analysis of keratin gene clusters in humans and rodents."
      Hesse M., Zimek A., Weber K., Magin T.M.
      Eur. J. Cell Biol. 83:19-26(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION.

    Entry informationi

    Entry nameiKRT83_MOUSE
    AccessioniPrimary (citable) accession number: Q6IMF0
    Secondary accession number(s): B2RTF5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 10, 2009
    Last sequence update: February 10, 2009
    Last modified: October 1, 2014
    This is version 83 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    There are two types of hair/microfibrillar keratin, I (acidic) and II (neutral to basic).Curated

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3