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Q6IMF0 (KRT83_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 82. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Keratin, type II cuticular Hb3
Alternative name(s):
Keratin-83
Short name=K83
Type II hair keratin Hb3
Type-II keratin Kb23
Gene names
Name:Krt83
Synonyms:Kb23, Krt2-25
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length495 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Subunit structure

Heterotetramer of two type I and two type II keratins.

Miscellaneous

There are two types of hair/microfibrillar keratin, I (acidic) and II (neutral to basic).

Sequence similarities

Belongs to the intermediate filament family.

Ontologies

Keywords
   Cellular componentIntermediate filament
Keratin
   DomainCoiled coil
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentkeratin filament

Inferred from electronic annotation. Source: InterPro

   Molecular_functionstructural molecule activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 495495Keratin, type II cuticular Hb3
PRO_0000361692

Regions

Region1 – 111111Head
Region112 – 418307Rod
Region112 – 14635Coil 1A
Region147 – 15610Linker 1
Region157 – 257101Coil 1B
Region258 – 27417Linker 12
Region275 – 418144Coil 2
Region419 – 49476Tail

Experimental info

Sequence conflict4561A → V Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q6IMF0 [UniParc].

Last modified February 10, 2009. Version 2.
Checksum: 9523A541F0EF7231

FASTA49554,629
        10         20         30         40         50         60 
MSCFSSRLGA SCGVRAFSCA SACGPRPGRC CISAAPYRGI SCYRGLSGGF GSRSVCGPFR 

        70         80         90        100        110        120 
SGSCGRSFGY RSGGVCGPSP PCITTVSVNE SLLTPLNLEI DPNAQCVKHE EKEQIKCLNS 

       130        140        150        160        170        180 
KFAAFIDKVR FLEQQNKLLE TKWQFYQNRK CCESNMEPLF EGYIEALRRE AECVEADSGR 

       190        200        210        220        230        240 
LAAELNHVQE SMEGYKKRYE EEVALRATSE NEFVALKKDV DCAYLRKSDL EANAEALTQE 

       250        260        270        280        290        300 
TDFLRQLYEE ETRLLHSHIS DTSVVVKMDN SRDLNMDCVV AEIKAQYDDI ASRSRAEAES 

       310        320        330        340        350        360 
WYRTKCEEMK ATVIRHGETL RRTREEINEL NRMIQRLTAE IENAKCQNTK LEAAVTQSEQ 

       370        380        390        400        410        420 
QGEAALTDAR CKLAELEGAL QKAKQDMACL LKEYQEVMNS KLGLDVEIIT YRRLLEGEEQ 

       430        440        450        460        470        480 
RLCEGVGSVN VCVSSSRGGV TCGGLTYGTT PGRQIASGPS VTGGSITVMA PDSCSPCQPR 

       490 
ASSFTCGSSR SVRFA 

« Hide

References

« Hide 'large scale' references
[1]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
[2]Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
[4]"Comprehensive analysis of keratin gene clusters in humans and rodents."
Hesse M., Zimek A., Weber K., Magin T.M.
Eur. J. Cell Biol. 83:19-26(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CAAA01196873 Genomic DNA. No translation available.
CH466550 Genomic DNA. Translation: EDL04045.1.
BC139321 mRNA. Translation: AAI39322.1.
BC139322 mRNA. Translation: AAI39323.1.
BK001583 mRNA. Translation: DAA02058.1.
CCDSCCDS27852.1.
RefSeqNP_001003668.2. NM_001003668.2.
UniGeneMm.347934.

3D structure databases

ProteinModelPortalQ6IMF0.
SMRQ6IMF0. Positions 111-259, 277-417.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteQ6IMF0.

Proteomic databases

PaxDbQ6IMF0.
PRIDEQ6IMF0.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000081945; ENSMUSP00000080613; ENSMUSG00000047641.
GeneID406219.
KEGGmmu:406219.
UCSCuc007xte.2. mouse.

Organism-specific databases

CTD3889.
MGIMGI:3665486. Krt83.

Phylogenomic databases

eggNOGNOG149039.
GeneTreeENSGT00670000097789.
HOGENOMHOG000230976.
HOVERGENHBG013015.
InParanoidB2RTF5.
KOK07605.
OMACAPCNSI.
OrthoDBEOG7B05CW.
PhylomeDBQ6IMF0.
TreeFamTF317854.

Gene expression databases

BgeeQ6IMF0.
GenevestigatorQ6IMF0.

Family and domain databases

InterProIPR001664. IF.
IPR018039. Intermediate_filament_CS.
IPR003054. Keratin_II.
[Graphical view]
PANTHERPTHR23239. PTHR23239. 1 hit.
PfamPF00038. Filament. 1 hit.
[Graphical view]
PRINTSPR01276. TYPE2KERATIN.
PROSITEPS00226. IF. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio407151.
PROQ6IMF0.
SOURCESearch...

Entry information

Entry nameKRT83_MOUSE
AccessionPrimary (citable) accession number: Q6IMF0
Secondary accession number(s): B2RTF5
Entry history
Integrated into UniProtKB/Swiss-Prot: February 10, 2009
Last sequence update: February 10, 2009
Last modified: July 9, 2014
This is version 82 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot