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Protein

Keratin, type II cuticular Hb3

Gene

Krt83

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. structural molecule activity Source: InterPro
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin, type II cuticular Hb3By similarity
Alternative name(s):
Keratin-83Imported
Short name:
K83
Type II hair keratin Hb3
Type-II keratin Kb23
Gene namesi
Name:Krt83Imported
Synonyms:Kb23, Krt2-25Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:3665486. Krt83.

Subcellular locationi

GO - Cellular componenti

  1. keratin filament Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Intermediate filament, Keratin

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 495495Keratin, type II cuticular Hb3PRO_0000361692Add
BLAST

Proteomic databases

PaxDbiQ6IMF0.
PRIDEiQ6IMF0.

PTM databases

PhosphoSiteiQ6IMF0.

Expressioni

Gene expression databases

BgeeiQ6IMF0.
GenevestigatoriQ6IMF0.

Interactioni

Subunit structurei

Heterotetramer of two type I and two type II keratins.Curated

Structurei

3D structure databases

ProteinModelPortaliQ6IMF0.
SMRiQ6IMF0. Positions 111-259, 277-417.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 111111HeadSequence AnalysisAdd
BLAST
Regioni112 – 418307RodSequence AnalysisAdd
BLAST
Regioni112 – 14635Coil 1ASequence AnalysisAdd
BLAST
Regioni147 – 15610Linker 1Sequence Analysis
Regioni157 – 257101Coil 1BSequence AnalysisAdd
BLAST
Regioni258 – 27417Linker 12Sequence AnalysisAdd
BLAST
Regioni275 – 418144Coil 2Sequence AnalysisAdd
BLAST
Regioni419 – 49476TailSequence AnalysisAdd
BLAST

Sequence similaritiesi

Belongs to the intermediate filament family.Sequence Analysis

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG149039.
GeneTreeiENSGT00760000118796.
HOGENOMiHOG000230976.
HOVERGENiHBG013015.
InParanoidiQ6IMF0.
KOiK07605.
OMAiCAPCNSI.
OrthoDBiEOG7B05CW.
PhylomeDBiQ6IMF0.
TreeFamiTF317854.

Family and domain databases

InterProiIPR001664. IF.
IPR018039. Intermediate_filament_CS.
IPR003054. Keratin_II.
[Graphical view]
PANTHERiPTHR23239. PTHR23239. 1 hit.
PfamiPF00038. Filament. 1 hit.
[Graphical view]
PRINTSiPR01276. TYPE2KERATIN.
PROSITEiPS00226. IF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6IMF0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSCFSSRLGA SCGVRAFSCA SACGPRPGRC CISAAPYRGI SCYRGLSGGF
60 70 80 90 100
GSRSVCGPFR SGSCGRSFGY RSGGVCGPSP PCITTVSVNE SLLTPLNLEI
110 120 130 140 150
DPNAQCVKHE EKEQIKCLNS KFAAFIDKVR FLEQQNKLLE TKWQFYQNRK
160 170 180 190 200
CCESNMEPLF EGYIEALRRE AECVEADSGR LAAELNHVQE SMEGYKKRYE
210 220 230 240 250
EEVALRATSE NEFVALKKDV DCAYLRKSDL EANAEALTQE TDFLRQLYEE
260 270 280 290 300
ETRLLHSHIS DTSVVVKMDN SRDLNMDCVV AEIKAQYDDI ASRSRAEAES
310 320 330 340 350
WYRTKCEEMK ATVIRHGETL RRTREEINEL NRMIQRLTAE IENAKCQNTK
360 370 380 390 400
LEAAVTQSEQ QGEAALTDAR CKLAELEGAL QKAKQDMACL LKEYQEVMNS
410 420 430 440 450
KLGLDVEIIT YRRLLEGEEQ RLCEGVGSVN VCVSSSRGGV TCGGLTYGTT
460 470 480 490
PGRQIASGPS VTGGSITVMA PDSCSPCQPR ASSFTCGSSR SVRFA
Length:495
Mass (Da):54,629
Last modified:February 10, 2009 - v2
Checksum:i9523A541F0EF7231
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti456 – 4561A → V (PubMed:19468303).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CAAA01196873 Genomic DNA. No translation available.
CH466550 Genomic DNA. Translation: EDL04045.1.
BC139321 mRNA. Translation: AAI39322.1.
BC139322 mRNA. Translation: AAI39323.1.
BK001583 mRNA. Translation: DAA02058.1.
CCDSiCCDS27852.1.
RefSeqiNP_001003668.2. NM_001003668.2.
UniGeneiMm.347934.

Genome annotation databases

EnsembliENSMUST00000081945; ENSMUSP00000080613; ENSMUSG00000047641.
GeneIDi406219.
KEGGimmu:406219.
UCSCiuc007xte.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CAAA01196873 Genomic DNA. No translation available.
CH466550 Genomic DNA. Translation: EDL04045.1.
BC139321 mRNA. Translation: AAI39322.1.
BC139322 mRNA. Translation: AAI39323.1.
BK001583 mRNA. Translation: DAA02058.1.
CCDSiCCDS27852.1.
RefSeqiNP_001003668.2. NM_001003668.2.
UniGeneiMm.347934.

3D structure databases

ProteinModelPortaliQ6IMF0.
SMRiQ6IMF0. Positions 111-259, 277-417.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

PhosphoSiteiQ6IMF0.

Proteomic databases

PaxDbiQ6IMF0.
PRIDEiQ6IMF0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000081945; ENSMUSP00000080613; ENSMUSG00000047641.
GeneIDi406219.
KEGGimmu:406219.
UCSCiuc007xte.2. mouse.

Organism-specific databases

CTDi3889.
MGIiMGI:3665486. Krt83.

Phylogenomic databases

eggNOGiNOG149039.
GeneTreeiENSGT00760000118796.
HOGENOMiHOG000230976.
HOVERGENiHBG013015.
InParanoidiQ6IMF0.
KOiK07605.
OMAiCAPCNSI.
OrthoDBiEOG7B05CW.
PhylomeDBiQ6IMF0.
TreeFamiTF317854.

Miscellaneous databases

NextBioi407151.
PROiQ6IMF0.
SOURCEiSearch...

Gene expression databases

BgeeiQ6IMF0.
GenevestigatoriQ6IMF0.

Family and domain databases

InterProiIPR001664. IF.
IPR018039. Intermediate_filament_CS.
IPR003054. Keratin_II.
[Graphical view]
PANTHERiPTHR23239. PTHR23239. 1 hit.
PfamiPF00038. Filament. 1 hit.
[Graphical view]
PRINTSiPR01276. TYPE2KERATIN.
PROSITEiPS00226. IF. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  2. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: BrainImported.
  4. "Comprehensive analysis of keratin gene clusters in humans and rodents."
    Hesse M., Zimek A., Weber K., Magin T.M.
    Eur. J. Cell Biol. 83:19-26(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiKRT83_MOUSE
AccessioniPrimary (citable) accession number: Q6IMF0
Secondary accession number(s): B2RTF5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 10, 2009
Last sequence update: February 10, 2009
Last modified: January 7, 2015
This is version 85 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

There are two types of hair/microfibrillar keratin, I (acidic) and II (neutral to basic).Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.