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Protein

Keratin, type II cuticular 87

Gene

Krt87

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Miscellaneous

There are two types of hair/microfibrillar keratin, I (acidic) and II (neutral to basic).Curated

GO - Molecular functioni

Enzyme and pathway databases

ReactomeiR-MMU-6805567 Keratinization
R-MMU-6809371 Formation of the cornified envelope

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin, type II cuticular 87
Alternative name(s):
Keratin-87Imported
Short name:
K87Curated
Gene namesi
Name:Krt87Imported
Synonyms:Kb251 Publication, Krt2-25Imported, Krt83Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi

Organism-specific databases

MGIiMGI:3665486 Krt87

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Intermediate filament, Keratin

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003616921 – 495Keratin, type II cuticular 87Add BLAST495

Proteomic databases

MaxQBiQ6IMF0
PaxDbiQ6IMF0
PeptideAtlasiQ6IMF0
PRIDEiQ6IMF0

PTM databases

iPTMnetiQ6IMF0
PhosphoSitePlusiQ6IMF0

Expressioni

Gene expression databases

BgeeiENSMUSG00000047641
GenevisibleiQ6IMF0 MM

Interactioni

Subunit structurei

Heterotetramer of two type I and two type II keratins.Curated

Protein-protein interaction databases

BioGridi240429, 1 interactor
STRINGi10090.ENSMUSP00000080613

Structurei

3D structure databases

ProteinModelPortaliQ6IMF0
SMRiQ6IMF0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini111 – 422IF rodPROSITE-ProRule annotationAdd BLAST312

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 111HeadSequence analysisAdd BLAST111
Regioni112 – 146Coil 1ASequence analysisAdd BLAST35
Regioni147 – 156Linker 1Sequence analysis10
Regioni157 – 257Coil 1BSequence analysisAdd BLAST101
Regioni258 – 274Linker 12Sequence analysisAdd BLAST17
Regioni275 – 418Coil 2Sequence analysisAdd BLAST144
Regioni419 – 494TailSequence analysisAdd BLAST76

Sequence similaritiesi

Belongs to the intermediate filament family.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IH1H Eukaryota
ENOG41113GZ LUCA
GeneTreeiENSGT00910000144006
HOGENOMiHOG000230976
HOVERGENiHBG013015
InParanoidiQ6IMF0
KOiK07605
OMAiGLCKPCG
OrthoDBiEOG091G06FG
PhylomeDBiQ6IMF0
TreeFamiTF317854

Family and domain databases

InterProiView protein in InterPro
IPR001664 IF
IPR018039 IF_conserved
IPR039008 IF_rod_dom
IPR032444 Keratin_2_head
IPR003054 Keratin_II
PANTHERiPTHR23239 PTHR23239, 1 hit
PfamiView protein in Pfam
PF00038 Filament, 1 hit
PF16208 Keratin_2_head, 1 hit
PRINTSiPR01276 TYPE2KERATIN
SMARTiView protein in SMART
SM01391 Filament, 1 hit
PROSITEiView protein in PROSITE
PS00226 IF_ROD_1, 1 hit
PS51842 IF_ROD_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q6IMF0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSCFSSRLGA SCGVRAFSCA SACGPRPGRC CISAAPYRGI SCYRGLSGGF
60 70 80 90 100
GSRSVCGPFR SGSCGRSFGY RSGGVCGPSP PCITTVSVNE SLLTPLNLEI
110 120 130 140 150
DPNAQCVKHE EKEQIKCLNS KFAAFIDKVR FLEQQNKLLE TKWQFYQNRK
160 170 180 190 200
CCESNMEPLF EGYIEALRRE AECVEADSGR LAAELNHVQE SMEGYKKRYE
210 220 230 240 250
EEVALRATSE NEFVALKKDV DCAYLRKSDL EANAEALTQE TDFLRQLYEE
260 270 280 290 300
ETRLLHSHIS DTSVVVKMDN SRDLNMDCVV AEIKAQYDDI ASRSRAEAES
310 320 330 340 350
WYRTKCEEMK ATVIRHGETL RRTREEINEL NRMIQRLTAE IENAKCQNTK
360 370 380 390 400
LEAAVTQSEQ QGEAALTDAR CKLAELEGAL QKAKQDMACL LKEYQEVMNS
410 420 430 440 450
KLGLDVEIIT YRRLLEGEEQ RLCEGVGSVN VCVSSSRGGV TCGGLTYGTT
460 470 480 490
PGRQIASGPS VTGGSITVMA PDSCSPCQPR ASSFTCGSSR SVRFA
Length:495
Mass (Da):54,629
Last modified:February 10, 2009 - v2
Checksum:i9523A541F0EF7231
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti456A → V (PubMed:19468303).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CAAA01196873 Genomic DNA No translation available.
CH466550 Genomic DNA Translation: EDL04045.1
BC139321 mRNA Translation: AAI39322.1
BC139322 mRNA Translation: AAI39323.1
BK001583 mRNA Translation: DAA02058.1
CCDSiCCDS27852.1
RefSeqiNP_001003668.2, NM_001003668.2
UniGeneiMm.347934

Genome annotation databases

EnsembliENSMUST00000081945; ENSMUSP00000080613; ENSMUSG00000047641
GeneIDi406219
KEGGimmu:406219
UCSCiuc007xte.2 mouse

Similar proteinsi

Entry informationi

Entry nameiKRT87_MOUSE
AccessioniPrimary (citable) accession number: Q6IMF0
Secondary accession number(s): B2RTF5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 10, 2009
Last sequence update: February 10, 2009
Last modified: May 23, 2018
This is version 104 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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