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Protein

Keratin, type II cuticular 87

Gene

Krt87

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-MMU-6805567. Keratinization.
R-MMU-6809371. Formation of the cornified envelope.

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin, type II cuticular 87
Alternative name(s):
Keratin-87Imported
Short name:
K87Curated
Gene namesi
Name:Krt87Imported
Synonyms:Kb251 Publication, Krt2-25Imported, Krt83Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:3665486. Krt87.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Intermediate filament, Keratin

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003616921 – 495Keratin, type II cuticular 87Add BLAST495

Proteomic databases

MaxQBiQ6IMF0.
PaxDbiQ6IMF0.
PeptideAtlasiQ6IMF0.
PRIDEiQ6IMF0.

PTM databases

iPTMnetiQ6IMF0.
PhosphoSitePlusiQ6IMF0.

Expressioni

Gene expression databases

BgeeiENSMUSG00000047641.
GenevisibleiQ6IMF0. MM.

Interactioni

Subunit structurei

Heterotetramer of two type I and two type II keratins.Curated

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000080613.

Structurei

3D structure databases

ProteinModelPortaliQ6IMF0.
SMRiQ6IMF0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 111HeadSequence analysisAdd BLAST111
Regioni112 – 418RodSequence analysisAdd BLAST307
Regioni112 – 146Coil 1ASequence analysisAdd BLAST35
Regioni147 – 156Linker 1Sequence analysis10
Regioni157 – 257Coil 1BSequence analysisAdd BLAST101
Regioni258 – 274Linker 12Sequence analysisAdd BLAST17
Regioni275 – 418Coil 2Sequence analysisAdd BLAST144
Regioni419 – 494TailSequence analysisAdd BLAST76

Sequence similaritiesi

Belongs to the intermediate filament family.Sequence analysis

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IH1H. Eukaryota.
ENOG41113GZ. LUCA.
GeneTreeiENSGT00830000128228.
HOGENOMiHOG000230976.
HOVERGENiHBG013015.
InParanoidiQ6IMF0.
KOiK07605.
OMAiCAPCNSI.
OrthoDBiEOG091G06FG.
PhylomeDBiQ6IMF0.
TreeFamiTF317854.

Family and domain databases

InterProiIPR001664. IF.
IPR018039. Intermediate_filament_CS.
IPR032444. Keratin_2_head.
IPR003054. Keratin_II.
[Graphical view]
PANTHERiPTHR23239. PTHR23239. 1 hit.
PfamiPF00038. Filament. 1 hit.
PF16208. Keratin_2_head. 1 hit.
[Graphical view]
PRINTSiPR01276. TYPE2KERATIN.
SMARTiSM01391. Filament. 1 hit.
[Graphical view]
PROSITEiPS00226. IF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6IMF0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSCFSSRLGA SCGVRAFSCA SACGPRPGRC CISAAPYRGI SCYRGLSGGF
60 70 80 90 100
GSRSVCGPFR SGSCGRSFGY RSGGVCGPSP PCITTVSVNE SLLTPLNLEI
110 120 130 140 150
DPNAQCVKHE EKEQIKCLNS KFAAFIDKVR FLEQQNKLLE TKWQFYQNRK
160 170 180 190 200
CCESNMEPLF EGYIEALRRE AECVEADSGR LAAELNHVQE SMEGYKKRYE
210 220 230 240 250
EEVALRATSE NEFVALKKDV DCAYLRKSDL EANAEALTQE TDFLRQLYEE
260 270 280 290 300
ETRLLHSHIS DTSVVVKMDN SRDLNMDCVV AEIKAQYDDI ASRSRAEAES
310 320 330 340 350
WYRTKCEEMK ATVIRHGETL RRTREEINEL NRMIQRLTAE IENAKCQNTK
360 370 380 390 400
LEAAVTQSEQ QGEAALTDAR CKLAELEGAL QKAKQDMACL LKEYQEVMNS
410 420 430 440 450
KLGLDVEIIT YRRLLEGEEQ RLCEGVGSVN VCVSSSRGGV TCGGLTYGTT
460 470 480 490
PGRQIASGPS VTGGSITVMA PDSCSPCQPR ASSFTCGSSR SVRFA
Length:495
Mass (Da):54,629
Last modified:February 10, 2009 - v2
Checksum:i9523A541F0EF7231
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti456A → V (PubMed:19468303).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CAAA01196873 Genomic DNA. No translation available.
CH466550 Genomic DNA. Translation: EDL04045.1.
BC139321 mRNA. Translation: AAI39322.1.
BC139322 mRNA. Translation: AAI39323.1.
BK001583 mRNA. Translation: DAA02058.1.
CCDSiCCDS27852.1.
RefSeqiNP_001003668.2. NM_001003668.2.
UniGeneiMm.347934.

Genome annotation databases

EnsembliENSMUST00000081945; ENSMUSP00000080613; ENSMUSG00000047641.
GeneIDi406219.
KEGGimmu:406219.
UCSCiuc007xte.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CAAA01196873 Genomic DNA. No translation available.
CH466550 Genomic DNA. Translation: EDL04045.1.
BC139321 mRNA. Translation: AAI39322.1.
BC139322 mRNA. Translation: AAI39323.1.
BK001583 mRNA. Translation: DAA02058.1.
CCDSiCCDS27852.1.
RefSeqiNP_001003668.2. NM_001003668.2.
UniGeneiMm.347934.

3D structure databases

ProteinModelPortaliQ6IMF0.
SMRiQ6IMF0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000080613.

PTM databases

iPTMnetiQ6IMF0.
PhosphoSitePlusiQ6IMF0.

Proteomic databases

MaxQBiQ6IMF0.
PaxDbiQ6IMF0.
PeptideAtlasiQ6IMF0.
PRIDEiQ6IMF0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000081945; ENSMUSP00000080613; ENSMUSG00000047641.
GeneIDi406219.
KEGGimmu:406219.
UCSCiuc007xte.2. mouse.

Organism-specific databases

CTDi406219.
MGIiMGI:3665486. Krt87.

Phylogenomic databases

eggNOGiENOG410IH1H. Eukaryota.
ENOG41113GZ. LUCA.
GeneTreeiENSGT00830000128228.
HOGENOMiHOG000230976.
HOVERGENiHBG013015.
InParanoidiQ6IMF0.
KOiK07605.
OMAiCAPCNSI.
OrthoDBiEOG091G06FG.
PhylomeDBiQ6IMF0.
TreeFamiTF317854.

Enzyme and pathway databases

ReactomeiR-MMU-6805567. Keratinization.
R-MMU-6809371. Formation of the cornified envelope.

Miscellaneous databases

PROiQ6IMF0.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000047641.
GenevisibleiQ6IMF0. MM.

Family and domain databases

InterProiIPR001664. IF.
IPR018039. Intermediate_filament_CS.
IPR032444. Keratin_2_head.
IPR003054. Keratin_II.
[Graphical view]
PANTHERiPTHR23239. PTHR23239. 1 hit.
PfamiPF00038. Filament. 1 hit.
PF16208. Keratin_2_head. 1 hit.
[Graphical view]
PRINTSiPR01276. TYPE2KERATIN.
SMARTiSM01391. Filament. 1 hit.
[Graphical view]
PROSITEiPS00226. IF. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKRT87_MOUSE
AccessioniPrimary (citable) accession number: Q6IMF0
Secondary accession number(s): B2RTF5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 10, 2009
Last sequence update: February 10, 2009
Last modified: November 30, 2016
This is version 96 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

There are two types of hair/microfibrillar keratin, I (acidic) and II (neutral to basic).Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.