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Protein

Keratin, type II cytoskeletal 72

Gene

Krt72

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Has a role in hair formation. Specific component of keratin intermediate filaments in the inner root sheath (IRS) of the hair follicle (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei385 – 3851Stutter

GO - Molecular functioni

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin, type II cytoskeletal 72
Alternative name(s):
Cytokeratin-72
Short name:
CK-72
Keratin-72
Short name:
K72
Type II inner root sheath-specific keratin-K6irs2
Type-II keratin Kb35
Gene namesi
Name:Krt72
Synonyms:Kb35, Krt72-ps
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:2146034. Krt72.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Intermediate filament, Keratin

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 520520Keratin, type II cytoskeletal 72PRO_0000314878Add
BLAST

Proteomic databases

MaxQBiQ6IME9.
PaxDbiQ6IME9.
PRIDEiQ6IME9.

PTM databases

iPTMnetiQ6IME9.
PhosphoSiteiQ6IME9.

Expressioni

Gene expression databases

BgeeiQ6IME9.
CleanExiMM_KRT72.
GenevisibleiQ6IME9. MM.

Interactioni

Subunit structurei

Heterotetramer of two type I and two type II keratins.

Protein-protein interaction databases

BioGridi222940. 1 interaction.
STRINGi10090.ENSMUSP00000065922.

Structurei

3D structure databases

ProteinModelPortaliQ6IME9.
SMRiQ6IME9. Positions 131-284, 300-441.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 133133HeadAdd
BLAST
Regioni134 – 443310RodAdd
BLAST
Regioni134 – 16936Coil 1AAdd
BLAST
Regioni170 – 18819Linker 1Add
BLAST
Regioni189 – 28092Coil 1BAdd
BLAST
Regioni281 – 30424Linker 12Add
BLAST
Regioni305 – 443139Coil 2Add
BLAST
Regioni444 – 52077TailAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi10 – 10596Gly-richAdd
BLAST

Sequence similaritiesi

Belongs to the intermediate filament family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IQKP. Eukaryota.
ENOG4111AD7. LUCA.
GeneTreeiENSGT00760000118796.
HOGENOMiHOG000230976.
HOVERGENiHBG013015.
InParanoidiQ6IME9.
KOiK07605.
OMAiSYSYKTA.
OrthoDBiEOG7P2XRX.
PhylomeDBiQ6IME9.
TreeFamiTF317854.

Family and domain databases

InterProiIPR001664. IF.
IPR018039. Intermediate_filament_CS.
IPR032444. Keratin_2_head.
IPR003054. Keratin_II.
[Graphical view]
PANTHERiPTHR23239. PTHR23239. 1 hit.
PfamiPF00038. Filament. 1 hit.
PF16208. Keratin_2_head. 1 hit.
[Graphical view]
PRINTSiPR01276. TYPE2KERATIN.
SMARTiSM01391. Filament. 1 hit.
[Graphical view]
PROSITEiPS00226. IF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6IME9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRQLTLYPG AERLGFSGCS AVISGRLSGS HASVRAGVKG AAFGSRSLFC
60 70 80 90 100
VGGGRRLALS SAGRSGGFTL GHGGASGGRP GGFVGTVFGS AGLGPTCPSV
110 120 130 140 150
CPPGGIPQVV VNKSLLAPLN VELDPEIQKV RAQEREQIKA LNNKFASFID
160 170 180 190 200
KVRFLEQQNQ VLETKWELLQ QLDLNNSKRS LEPVHESYIS NLQKQLEILS
210 220 230 240 250
GDRVRLDSEL RNMREVVEDC KKRYEVEINR RTAAENEFVV LKKDVDAAYM
260 270 280 290 300
NKVELQAKVD SLTDDIKFFK VLFEGEIAQM QSHISDTSVI LSMDNNRQLD
310 320 330 340 350
LDSILAEVRA QYEEIAVKSK AETENMYQCK IQELQATAGQ HGDDLKHTKS
360 370 380 390 400
EITEINRLIQ RIHSEIGNMK KQCSNLETAI ADAEQRGDCA LKDARAKLDQ
410 420 430 440 450
LEGALQQAKE ELARMLREHQ ELMNVKLALD MEIATYRKLL ESEESRMAGE
460 470 480 490 500
YPNSVSISVI SSTNAGPGGA GFSVGFGASS SYNYRPLALE VKTKGSCGSE
510 520
LKDPPAKTSG SSGTTKKTSR
Length:520
Mass (Da):56,750
Last modified:July 5, 2004 - v1
Checksum:iBC19F6823BC58B2C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC104862 Genomic DNA. No translation available.
BK001584 mRNA. Translation: DAA02059.1.
CCDSiCCDS27863.1.
RefSeqiNP_998893.1. NM_213728.1.
UniGeneiMm.298210.

Genome annotation databases

EnsembliENSMUST00000071104; ENSMUSP00000065922; ENSMUSG00000056605.
GeneIDi105866.
KEGGimmu:105866.
UCSCiuc007xtz.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC104862 Genomic DNA. No translation available.
BK001584 mRNA. Translation: DAA02059.1.
CCDSiCCDS27863.1.
RefSeqiNP_998893.1. NM_213728.1.
UniGeneiMm.298210.

3D structure databases

ProteinModelPortaliQ6IME9.
SMRiQ6IME9. Positions 131-284, 300-441.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi222940. 1 interaction.
STRINGi10090.ENSMUSP00000065922.

PTM databases

iPTMnetiQ6IME9.
PhosphoSiteiQ6IME9.

Proteomic databases

MaxQBiQ6IME9.
PaxDbiQ6IME9.
PRIDEiQ6IME9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000071104; ENSMUSP00000065922; ENSMUSG00000056605.
GeneIDi105866.
KEGGimmu:105866.
UCSCiuc007xtz.1. mouse.

Organism-specific databases

CTDi140807.
MGIiMGI:2146034. Krt72.

Phylogenomic databases

eggNOGiENOG410IQKP. Eukaryota.
ENOG4111AD7. LUCA.
GeneTreeiENSGT00760000118796.
HOGENOMiHOG000230976.
HOVERGENiHBG013015.
InParanoidiQ6IME9.
KOiK07605.
OMAiSYSYKTA.
OrthoDBiEOG7P2XRX.
PhylomeDBiQ6IME9.
TreeFamiTF317854.

Miscellaneous databases

NextBioi357946.
PROiQ6IME9.
SOURCEiSearch...

Gene expression databases

BgeeiQ6IME9.
CleanExiMM_KRT72.
GenevisibleiQ6IME9. MM.

Family and domain databases

InterProiIPR001664. IF.
IPR018039. Intermediate_filament_CS.
IPR032444. Keratin_2_head.
IPR003054. Keratin_II.
[Graphical view]
PANTHERiPTHR23239. PTHR23239. 1 hit.
PfamiPF00038. Filament. 1 hit.
PF16208. Keratin_2_head. 1 hit.
[Graphical view]
PRINTSiPR01276. TYPE2KERATIN.
SMARTiSM01391. Filament. 1 hit.
[Graphical view]
PROSITEiPS00226. IF. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  2. "Comprehensive analysis of keratin gene clusters in humans and rodents."
    Hesse M., Zimek A., Weber K., Magin T.M.
    Eur. J. Cell Biol. 83:19-26(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiK2C72_MOUSE
AccessioniPrimary (citable) accession number: Q6IME9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: July 5, 2004
Last modified: May 11, 2016
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

There are two types of cytoskeletal and microfibrillar keratin, I (acidic) and II (neutral to basic) (40-55 and 56-70 kDa, respectively).

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.