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Protein

Keratin, type II cytoskeletal 72

Gene

Krt72

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Has a role in hair formation. Specific component of keratin intermediate filaments in the inner root sheath (IRS) of the hair follicle (By similarity).By similarity

Miscellaneous

There are two types of cytoskeletal and microfibrillar keratin, I (acidic) and II (neutral to basic) (40-55 and 56-70 kDa, respectively).

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei385Stutter1

GO - Molecular functioni

Enzyme and pathway databases

ReactomeiR-MMU-6805567 Keratinization
R-MMU-6809371 Formation of the cornified envelope

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin, type II cytoskeletal 72
Alternative name(s):
Cytokeratin-72
Short name:
CK-72
Keratin-72
Short name:
K72
Type II inner root sheath-specific keratin-K6irs2
Type-II keratin Kb35
Gene namesi
Name:Krt72
Synonyms:Kb35, Krt72-ps
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:2146034 Krt72

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Intermediate filament, Keratin

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003148781 – 520Keratin, type II cytoskeletal 72Add BLAST520

Proteomic databases

PaxDbiQ6IME9
PeptideAtlasiQ6IME9
PRIDEiQ6IME9

PTM databases

iPTMnetiQ6IME9
PhosphoSitePlusiQ6IME9

Expressioni

Gene expression databases

BgeeiENSMUSG00000056605
CleanExiMM_KRT72
GenevisibleiQ6IME9 MM

Interactioni

Subunit structurei

Heterotetramer of two type I and two type II keratins.

Protein-protein interaction databases

BioGridi222940, 1 interactor
STRINGi10090.ENSMUSP00000065922

Structurei

3D structure databases

ProteinModelPortaliQ6IME9
SMRiQ6IME9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini134 – 447IF rodPROSITE-ProRule annotationAdd BLAST314

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 133HeadAdd BLAST133
Regioni134 – 169Coil 1AAdd BLAST36
Regioni170 – 188Linker 1Add BLAST19
Regioni189 – 280Coil 1BAdd BLAST92
Regioni281 – 304Linker 12Add BLAST24
Regioni305 – 443Coil 2Add BLAST139
Regioni444 – 520TailAdd BLAST77

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi10 – 105Gly-richAdd BLAST96

Sequence similaritiesi

Belongs to the intermediate filament family.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IQKP Eukaryota
ENOG4111AD7 LUCA
GeneTreeiENSGT00910000144006
HOGENOMiHOG000230976
HOVERGENiHBG013015
InParanoidiQ6IME9
KOiK07605
OMAiSYSYKTA
OrthoDBiEOG091G09KR
PhylomeDBiQ6IME9
TreeFamiTF317854

Family and domain databases

InterProiView protein in InterPro
IPR001664 IF
IPR018039 IF_conserved
IPR039008 IF_rod_dom
IPR032444 Keratin_2_head
IPR003054 Keratin_II
PANTHERiPTHR23239 PTHR23239, 1 hit
PfamiView protein in Pfam
PF00038 Filament, 1 hit
PF16208 Keratin_2_head, 1 hit
PRINTSiPR01276 TYPE2KERATIN
SMARTiView protein in SMART
SM01391 Filament, 1 hit
PROSITEiView protein in PROSITE
PS00226 IF_ROD_1, 1 hit
PS51842 IF_ROD_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q6IME9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRQLTLYPG AERLGFSGCS AVISGRLSGS HASVRAGVKG AAFGSRSLFC
60 70 80 90 100
VGGGRRLALS SAGRSGGFTL GHGGASGGRP GGFVGTVFGS AGLGPTCPSV
110 120 130 140 150
CPPGGIPQVV VNKSLLAPLN VELDPEIQKV RAQEREQIKA LNNKFASFID
160 170 180 190 200
KVRFLEQQNQ VLETKWELLQ QLDLNNSKRS LEPVHESYIS NLQKQLEILS
210 220 230 240 250
GDRVRLDSEL RNMREVVEDC KKRYEVEINR RTAAENEFVV LKKDVDAAYM
260 270 280 290 300
NKVELQAKVD SLTDDIKFFK VLFEGEIAQM QSHISDTSVI LSMDNNRQLD
310 320 330 340 350
LDSILAEVRA QYEEIAVKSK AETENMYQCK IQELQATAGQ HGDDLKHTKS
360 370 380 390 400
EITEINRLIQ RIHSEIGNMK KQCSNLETAI ADAEQRGDCA LKDARAKLDQ
410 420 430 440 450
LEGALQQAKE ELARMLREHQ ELMNVKLALD MEIATYRKLL ESEESRMAGE
460 470 480 490 500
YPNSVSISVI SSTNAGPGGA GFSVGFGASS SYNYRPLALE VKTKGSCGSE
510 520
LKDPPAKTSG SSGTTKKTSR
Length:520
Mass (Da):56,750
Last modified:July 5, 2004 - v1
Checksum:iBC19F6823BC58B2C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC104862 Genomic DNA No translation available.
BK001584 mRNA Translation: DAA02059.1
CCDSiCCDS27863.1
RefSeqiNP_998893.1, NM_213728.1
UniGeneiMm.298210

Genome annotation databases

EnsembliENSMUST00000071104; ENSMUSP00000065922; ENSMUSG00000056605
GeneIDi105866
KEGGimmu:105866
UCSCiuc007xtz.1 mouse

Similar proteinsi

Entry informationi

Entry nameiK2C72_MOUSE
AccessioniPrimary (citable) accession number: Q6IME9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: July 5, 2004
Last modified: May 23, 2018
This is version 102 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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