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Protein

Ras-like protein family member 11A

Gene

Rasl11a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Regulator of rDNA transcription. Acts in cooperation UBF/UBTF and positively regulates RNA polymerase I transcription.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi34 – 418GTPBy similarity
Nucleotide bindingi81 – 888GTPBy similarity
Nucleotide bindingi147 – 1504GTPBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-like protein family member 11A
Gene namesi
Name:Rasl11aImported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1916145. Rasl11a.

Subcellular locationi

  • Nucleusnucleolus 1 Publication

  • Note: Associates with rDNA transcription unit throughout the cell cycle.

GO - Cellular componenti

  • membrane Source: InterPro
  • nucleolus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 242242Ras-like protein family member 11APRO_0000308361Add
BLAST

Proteomic databases

MaxQBiQ6IMB1.
PaxDbiQ6IMB1.
PRIDEiQ6IMB1.

PTM databases

iPTMnetiQ6IMB1.
PhosphoSiteiQ6IMB1.

Expressioni

Gene expression databases

BgeeiQ6IMB1.
CleanExiMM_RASL11A.
GenevisibleiQ6IMB1. MM.

Interactioni

Subunit structurei

Interacts with UBF/UBTF.1 Publication

Protein-protein interaction databases

IntActiQ6IMB1. 4 interactions.
STRINGi10090.ENSMUSP00000031646.

Structurei

3D structure databases

ProteinModelPortaliQ6IMB1.
SMRiQ6IMB1. Positions 27-196.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni17 – 241225Small GTPase-likeAdd
BLAST

Sequence similaritiesi

Belongs to the small GTPase superfamily. Ras family.Sequence analysis

Phylogenomic databases

eggNOGiKOG0395. Eukaryota.
COG1100. LUCA.
GeneTreeiENSGT00780000121877.
HOGENOMiHOG000233973.
HOVERGENiHBG108422.
InParanoidiQ6IMB1.
KOiK07852.
OMAiYLCKEVS.
OrthoDBiEOG70W3F5.
PhylomeDBiQ6IMB1.
TreeFamiTF318030.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR020849. Small_GTPase_Ras.
[Graphical view]
PANTHERiPTHR24070. PTHR24070. 1 hit.
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51421. RAS. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 11 Publication (identifier: Q6IMB1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRPLTMSGHF LLAPIPESSS DYLLPKDIKL AVLGAGCVGK SAMIVRFLTK
60 70 80 90 100
RFIGDYEPNT GKLYSRLVYV EGDQLSLQIQ DTPGGIQAQD SLSQMVDSLT
110 120 130 140 150
KSVHWAEGFL LVYSITDYES YQSIRPLYQH IRKVHPDGKA PIFIVGNKGD
160 170 180 190 200
LLHARQVQTH EGLQLANELG SLFLEISTSE NYEDVCDVFQ HLCKEVIKVH
210 220 230 240
RLGGERRRAS VIPRPRSPNM QDLKRRFRQA LSSKAKASSA LG
Length:242
Mass (Da):27,067
Last modified:July 5, 2004 - v1
Checksum:iC2A97D12904DA251
GO
Isoform 21 Publication (identifier: Q6IMB1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-42: Missing.

Note: No experimental confirmation available.Curated
Show »
Length:200
Mass (Da):22,700
Checksum:i326647736C44046C
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 4242Missing in isoform 2. 1 PublicationVSP_052584Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK004371 mRNA. Translation: BAE43176.1.
AC124828 Genomic DNA. No translation available.
BC118009 mRNA. Translation: AAI18010.1.
BK001706 mRNA. Translation: DAA02248.1.
CCDSiCCDS39396.1. [Q6IMB1-1]
RefSeqiNP_081140.1. NM_026864.1. [Q6IMB1-1]
UniGeneiMm.266978.

Genome annotation databases

EnsembliENSMUST00000031646; ENSMUSP00000031646; ENSMUSG00000029641. [Q6IMB1-1]
GeneIDi68895.
KEGGimmu:68895.
UCSCiuc009anm.1. mouse. [Q6IMB1-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK004371 mRNA. Translation: BAE43176.1.
AC124828 Genomic DNA. No translation available.
BC118009 mRNA. Translation: AAI18010.1.
BK001706 mRNA. Translation: DAA02248.1.
CCDSiCCDS39396.1. [Q6IMB1-1]
RefSeqiNP_081140.1. NM_026864.1. [Q6IMB1-1]
UniGeneiMm.266978.

3D structure databases

ProteinModelPortaliQ6IMB1.
SMRiQ6IMB1. Positions 27-196.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ6IMB1. 4 interactions.
STRINGi10090.ENSMUSP00000031646.

PTM databases

iPTMnetiQ6IMB1.
PhosphoSiteiQ6IMB1.

Proteomic databases

MaxQBiQ6IMB1.
PaxDbiQ6IMB1.
PRIDEiQ6IMB1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000031646; ENSMUSP00000031646; ENSMUSG00000029641. [Q6IMB1-1]
GeneIDi68895.
KEGGimmu:68895.
UCSCiuc009anm.1. mouse. [Q6IMB1-1]

Organism-specific databases

CTDi387496.
MGIiMGI:1916145. Rasl11a.

Phylogenomic databases

eggNOGiKOG0395. Eukaryota.
COG1100. LUCA.
GeneTreeiENSGT00780000121877.
HOGENOMiHOG000233973.
HOVERGENiHBG108422.
InParanoidiQ6IMB1.
KOiK07852.
OMAiYLCKEVS.
OrthoDBiEOG70W3F5.
PhylomeDBiQ6IMB1.
TreeFamiTF318030.

Miscellaneous databases

PROiQ6IMB1.
SOURCEiSearch...

Gene expression databases

BgeeiQ6IMB1.
CleanExiMM_RASL11A.
GenevisibleiQ6IMB1. MM.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR020849. Small_GTPase_Ras.
[Graphical view]
PANTHERiPTHR24070. PTHR24070. 1 hit.
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51421. RAS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: C57BL/6JImported.
    Tissue: EmbryoImported.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
  4. "Rasl11a, member of a novel small monomeric GTPase gene family, is differentially expressed in prostate tumors."
    Louro R., Nakaya H.I., Paquola A.C.M., Martins E.A.L., da Silva A.M., Verjovski-Almeida S., Reis E.M.
    Biochem. Biophys. Res. Commun. 316:618-627(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION (ISOFORM 1).
  5. "Chromatin association and regulation of rDNA transcription by the Ras-family protein RasL11a."
    Pistoni M., Verrecchia A., Doni M., Guccione E., Amati B.
    EMBO J. 29:1215-1224(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH UBTF.

Entry informationi

Entry nameiRSLBA_MOUSE
AccessioniPrimary (citable) accession number: Q6IMB1
Secondary accession number(s): Q148R6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: July 5, 2004
Last modified: July 6, 2016
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Caution

Although highly related to the Ras family, lacks the conserved prenylation motif at the C-terminus, which serves to target Ras proteins to membrane compartments.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.