Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Ras-like protein family member 11A

Gene

Rasl11a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regulator of rDNA transcription. Acts in cooperation UBF/UBTF and positively regulates RNA polymerase I transcription.1 Publication

Caution

Although highly related to the Ras family, lacks the conserved prenylation motif at the C-terminus, which serves to target Ras proteins to membrane compartments.Curated

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi34 – 41GTPBy similarity8
Nucleotide bindingi81 – 88GTPBy similarity8
Nucleotide bindingi147 – 150GTPBy similarity4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processTranscription, Transcription regulation
LigandGTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-like protein family member 11A
Gene namesi
Name:Rasl11aImported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1916145 Rasl11a

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003083611 – 242Ras-like protein family member 11AAdd BLAST242

Proteomic databases

PaxDbiQ6IMB1
PRIDEiQ6IMB1

PTM databases

iPTMnetiQ6IMB1
PhosphoSitePlusiQ6IMB1

Expressioni

Gene expression databases

BgeeiENSMUSG00000029641
CleanExiMM_RASL11A
GenevisibleiQ6IMB1 MM

Interactioni

Subunit structurei

Interacts with UBF/UBTF.1 Publication

Protein-protein interaction databases

IntActiQ6IMB1, 4 interactors
MINTiQ6IMB1
STRINGi10090.ENSMUSP00000031646

Structurei

3D structure databases

ProteinModelPortaliQ6IMB1
SMRiQ6IMB1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni17 – 241Small GTPase-likeAdd BLAST225

Sequence similaritiesi

Belongs to the small GTPase superfamily. Ras family.Sequence analysis

Phylogenomic databases

eggNOGiKOG0395 Eukaryota
COG1100 LUCA
GeneTreeiENSGT00860000133696
HOGENOMiHOG000233973
HOVERGENiHBG108422
InParanoidiQ6IMB1
KOiK07852
OMAiQDTPGCI
OrthoDBiEOG091G0M6D
PhylomeDBiQ6IMB1
TreeFamiTF318030

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR001806 Small_GTPase
IPR020849 Small_GTPase_Ras-type
PANTHERiPTHR24070 PTHR24070, 1 hit
PfamiView protein in Pfam
PF00071 Ras, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51421 RAS, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 11 Publication (identifier: Q6IMB1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRPLTMSGHF LLAPIPESSS DYLLPKDIKL AVLGAGCVGK SAMIVRFLTK
60 70 80 90 100
RFIGDYEPNT GKLYSRLVYV EGDQLSLQIQ DTPGGIQAQD SLSQMVDSLT
110 120 130 140 150
KSVHWAEGFL LVYSITDYES YQSIRPLYQH IRKVHPDGKA PIFIVGNKGD
160 170 180 190 200
LLHARQVQTH EGLQLANELG SLFLEISTSE NYEDVCDVFQ HLCKEVIKVH
210 220 230 240
RLGGERRRAS VIPRPRSPNM QDLKRRFRQA LSSKAKASSA LG
Length:242
Mass (Da):27,067
Last modified:July 5, 2004 - v1
Checksum:iC2A97D12904DA251
GO
Isoform 21 Publication (identifier: Q6IMB1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-42: Missing.

Note: No experimental confirmation available.Curated
Show »
Length:200
Mass (Da):22,700
Checksum:i326647736C44046C
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0525841 – 42Missing in isoform 2. 1 PublicationAdd BLAST42

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK004371 mRNA Translation: BAE43176.1
AC124828 Genomic DNA No translation available.
BC118009 mRNA Translation: AAI18010.1
BK001706 mRNA Translation: DAA02248.1
CCDSiCCDS39396.1 [Q6IMB1-1]
RefSeqiNP_081140.1, NM_026864.1 [Q6IMB1-1]
UniGeneiMm.266978

Genome annotation databases

EnsembliENSMUST00000031646; ENSMUSP00000031646; ENSMUSG00000029641 [Q6IMB1-1]
GeneIDi68895
KEGGimmu:68895
UCSCiuc009anm.1 mouse [Q6IMB1-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiRSLBA_MOUSE
AccessioniPrimary (citable) accession number: Q6IMB1
Secondary accession number(s): Q148R6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: July 5, 2004
Last modified: May 23, 2018
This is version 122 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health