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Protein

Keratin, type II cytoskeletal 75

Gene

Krt75

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Plays a central role in hair and nail formation. Essential component of keratin intermediate filaments in the companion layer of the hair follicle (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei391 – 3911Stutter

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin, type II cytoskeletal 75
Alternative name(s):
Cytokeratin-75
Short name:
CK-75
Keratin-6 hair follicle
Keratin-75
Short name:
K75
Type II keratin-K6hf
Type-II keratin Kb18
Gene namesi
Name:Krt75
Synonyms:Kb18
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 7

Organism-specific databases

RGDi1359576. Krt75.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Intermediate filament, Keratin

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 542542Keratin, type II cytoskeletal 75PRO_0000314889Add
BLAST

Proteomic databases

PaxDbiQ6IG05.
PRIDEiQ6IG05.

PTM databases

iPTMnetiQ6IG05.
PhosphoSiteiQ6IG05.

Expressioni

Gene expression databases

ExpressionAtlasiQ6IG05. baseline and differential.
GenevisibleiQ6IG05. RN.

Interactioni

Subunit structurei

Heterodimer of a type I and a type II keratin. May associate with KRT17.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000012640.

Structurei

3D structure databases

ProteinModelPortaliQ6IG05.
SMRiQ6IG05. Positions 139-175.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 139139HeadAdd
BLAST
Regioni140 – 449310RodAdd
BLAST
Regioni140 – 17536Coil 1AAdd
BLAST
Regioni176 – 19419Linker 1Add
BLAST
Regioni195 – 28793Coil 1BAdd
BLAST
Regioni288 – 31023Linker 12Add
BLAST
Regioni311 – 449139Coil 2Add
BLAST
Regioni450 – 54293TailAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi39 – 11173Gly-richAdd
BLAST

Sequence similaritiesi

Belongs to the intermediate filament family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IG4R. Eukaryota.
ENOG410YY6B. LUCA.
GeneTreeiENSGT00760000118796.
HOGENOMiHOG000230976.
HOVERGENiHBG013015.
InParanoidiQ6IG05.
KOiK07605.
OMAiRQSTITF.
OrthoDBiEOG7FV3Q8.
PhylomeDBiQ6IG05.
TreeFamiTF317854.

Family and domain databases

InterProiIPR001664. IF.
IPR018039. Intermediate_filament_CS.
IPR032444. Keratin_2_head.
IPR003054. Keratin_II.
[Graphical view]
PANTHERiPTHR23239. PTHR23239. 1 hit.
PfamiPF00038. Filament. 1 hit.
PF16208. Keratin_2_head. 2 hits.
[Graphical view]
PRINTSiPR01276. TYPE2KERATIN.
SMARTiSM01391. Filament. 1 hit.
[Graphical view]
PROSITEiPS00226. IF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6IG05-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRQSTVTFH SGSRRGFSTA SATTPTAGRS RFSSVSVARS SGNSGGLGRI
60 70 80 90 100
SGIGSGFGSR SLYNLGATRP VSVGGCAGSG FRSGFGGRAS SSFGYGGGFG
110 120 130 140 150
GPGFPVCPSG SIQEVTVNQS LLTPLNLQID PTIQRVRKEE REQIKTLNNK
160 170 180 190 200
FASFIDKVRF LEQQNKVLET KWNLLQEQGS RTVRQNLEPF FDAYVNDLRR
210 220 230 240 250
QLDSVTAERG RLDAELRHMQ EVVEDFKVRY EDEINKRAAA ENEFVGLKKD
260 270 280 290 300
VDGAYMNKVE LEAKVDSLTD QINFYRMVYE AELSQMQNQV SDTSVVLSMD
310 320 330 340 350
NNRSLDLDSI IAEVKAQYED IANRSRAEAE SWYQTKYEEL QVTAGRHGDD
360 370 380 390 400
LRNTKQEISE MNRMIQRLRS EIDAVKKQCS SLQTAISDTE QRGELALKDA
410 420 430 440 450
RAKLVELEDA LQKAKQDMAR LLREYQELMN VKLALDVEIA TYRKLLEGEE
460 470 480 490 500
CRLSGEGVSP VNISVVTSTV SSGYGGGTNI GGGSLGLGGN SGYSFTTTGG
510 520 530 540
HSLGTGLGGS GFTTSSSRGP VGSGSSIKFV SSTSSSRKSY KH
Length:542
Mass (Da):59,027
Last modified:January 15, 2008 - v2
Checksum:i5600853834F37EFC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR03056237 Genomic DNA. No translation available.
BK003980 mRNA. Translation: DAA02225.1.
RefSeqiNP_001008828.1. NM_001008828.1.
XP_006242387.1. XM_006242325.2.
UniGeneiRn.229344.

Genome annotation databases

EnsembliENSRNOT00000088923; ENSRNOP00000070762; ENSRNOG00000043203.
GeneIDi300247.
KEGGirno:300247.
UCSCiRGD:1359576. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR03056237 Genomic DNA. No translation available.
BK003980 mRNA. Translation: DAA02225.1.
RefSeqiNP_001008828.1. NM_001008828.1.
XP_006242387.1. XM_006242325.2.
UniGeneiRn.229344.

3D structure databases

ProteinModelPortaliQ6IG05.
SMRiQ6IG05. Positions 139-175.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000012640.

PTM databases

iPTMnetiQ6IG05.
PhosphoSiteiQ6IG05.

Proteomic databases

PaxDbiQ6IG05.
PRIDEiQ6IG05.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000088923; ENSRNOP00000070762; ENSRNOG00000043203.
GeneIDi300247.
KEGGirno:300247.
UCSCiRGD:1359576. rat.

Organism-specific databases

CTDi9119.
RGDi1359576. Krt75.

Phylogenomic databases

eggNOGiENOG410IG4R. Eukaryota.
ENOG410YY6B. LUCA.
GeneTreeiENSGT00760000118796.
HOGENOMiHOG000230976.
HOVERGENiHBG013015.
InParanoidiQ6IG05.
KOiK07605.
OMAiRQSTITF.
OrthoDBiEOG7FV3Q8.
PhylomeDBiQ6IG05.
TreeFamiTF317854.

Miscellaneous databases

NextBioi646629.
PROiQ6IG05.

Gene expression databases

ExpressionAtlasiQ6IG05. baseline and differential.
GenevisibleiQ6IG05. RN.

Family and domain databases

InterProiIPR001664. IF.
IPR018039. Intermediate_filament_CS.
IPR032444. Keratin_2_head.
IPR003054. Keratin_II.
[Graphical view]
PANTHERiPTHR23239. PTHR23239. 1 hit.
PfamiPF00038. Filament. 1 hit.
PF16208. Keratin_2_head. 2 hits.
[Graphical view]
PRINTSiPR01276. TYPE2KERATIN.
SMARTiSM01391. Filament. 1 hit.
[Graphical view]
PROSITEiPS00226. IF. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
    Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
    , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
    Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Brown Norway.
  2. "Comprehensive analysis of keratin gene clusters in humans and rodents."
    Hesse M., Zimek A., Weber K., Magin T.M.
    Eur. J. Cell Biol. 83:19-26(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiK2C75_RAT
AccessioniPrimary (citable) accession number: Q6IG05
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 15, 2008
Last modified: May 11, 2016
This is version 79 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

There are two types of cytoskeletal and microfibrillar keratin, I (acidic) and II (neutral to basic) (40-55 and 56-70 kDa, respectively).

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.