Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Keratin, type II cytoskeletal 72

Gene

Krt72

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Has a role in hair formation. Specific component of keratin intermediate filaments in the inner root sheath (IRS) of the hair follicle (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei385Stutter1

GO - Molecular functioni

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-RNO-6805567. Keratinization.
R-RNO-6809371. Formation of the cornified envelope.

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin, type II cytoskeletal 72
Alternative name(s):
Cytokeratin-72
Short name:
CK-72
Keratin-72
Short name:
K72
Type II inner root sheath-specific keratin-K6irs2
Type-II keratin Kb35
Gene namesi
Name:Krt72
Synonyms:Kb35
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 7

Organism-specific databases

RGDi1303216. Krt72.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Intermediate filament, Keratin

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003148791 – 520Keratin, type II cytoskeletal 72Add BLAST520

Proteomic databases

PaxDbiQ6IG04.
PRIDEiQ6IG04.

PTM databases

iPTMnetiQ6IG04.
PhosphoSitePlusiQ6IG04.

Expressioni

Gene expression databases

BgeeiENSRNOG00000030876.
ExpressionAtlasiQ6IG04. differential.

Interactioni

Subunit structurei

Heterotetramer of two type I and two type II keratins.

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000035371.

Structurei

3D structure databases

ProteinModelPortaliQ6IG04.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 133HeadAdd BLAST133
Regioni134 – 443RodAdd BLAST310
Regioni134 – 169Coil 1AAdd BLAST36
Regioni170 – 188Linker 1Add BLAST19
Regioni189 – 280Coil 1BAdd BLAST92
Regioni281 – 304Linker 12Add BLAST24
Regioni305 – 443Coil 2Add BLAST139
Regioni444 – 520TailAdd BLAST77

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi10 – 105Gly-richAdd BLAST96

Sequence similaritiesi

Belongs to the intermediate filament family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IQKP. Eukaryota.
ENOG4111AD7. LUCA.
GeneTreeiENSGT00760000118796.
HOGENOMiHOG000230976.
HOVERGENiHBG013015.
InParanoidiQ6IG04.
KOiK07605.
PhylomeDBiQ6IG04.
TreeFamiTF317854.

Family and domain databases

InterProiIPR001664. IF.
IPR018039. Intermediate_filament_CS.
IPR032444. Keratin_2_head.
IPR003054. Keratin_II.
[Graphical view]
PANTHERiPTHR23239. PTHR23239. 1 hit.
PfamiPF00038. Filament. 1 hit.
PF16208. Keratin_2_head. 1 hit.
[Graphical view]
PRINTSiPR01276. TYPE2KERATIN.
SMARTiSM01391. Filament. 1 hit.
[Graphical view]
PROSITEiPS00226. IF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6IG04-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRQLTLYPG AERLGFSGCS AVISGRFSGS HASVRAGVKG AAFGSRSLFC
60 70 80 90 100
VGGGRRLALS SGGRSGGFTL GHGGASGGRP GGFVGTVFGS AGLGPTCPSV
110 120 130 140 150
CPPGGIPQVV VNKSLLAPLN VELDPEIQKV RAQEREQIKA LNNKFASFID
160 170 180 190 200
KVRFLEQQNQ VLETKWELLQ QLDQNNSRRS LEPVHESYIS NLQKQLEILS
210 220 230 240 250
GDRVRLDSEL RNMREVVEDC KKRYEVEINR RTAAENEFVV LKKDVDAAYM
260 270 280 290 300
NKVELQAKVD SMTDDIKFFK VLFEGEIAQM QSHISDTSVI LSMDNNRQLD
310 320 330 340 350
LDSILAEVRA QYEEIAVKSK AETENMYQCK IQELQATAGQ HGDDLKLTKS
360 370 380 390 400
EITEINRLIQ RIHSEIGNMK KQCSNLETAI ADAEQRGDCA LKDARAKLDQ
410 420 430 440 450
LEGVLQQSKE ELARMLREHQ ELMNVKLALD MEIATYRKLL ESEESRMAGE
460 470 480 490 500
YPSSVSISVV SSTNAGPGGA GFSVGFGASS NYNYRPLALE VKTKGSCGSE
510 520
LKDPPAKTSA SSCVSKKASR
Length:520
Mass (Da):56,851
Last modified:January 15, 2008 - v2
Checksum:i3A7B068F826DC968
GO

Sequence cautioni

The sequence DAA02226 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR03055962 Genomic DNA. No translation available.
BK003981 mRNA. Translation: DAA02226.1. Sequence problems.
RefSeqiNP_001008809.1. NM_001008809.1.
XP_017450521.1. XM_017595032.1.
UniGeneiRn.143276.

Genome annotation databases

EnsembliENSRNOT00000038105; ENSRNOP00000035371; ENSRNOG00000030876.
GeneIDi406227.
KEGGirno:406227.
UCSCiRGD:1303216. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR03055962 Genomic DNA. No translation available.
BK003981 mRNA. Translation: DAA02226.1. Sequence problems.
RefSeqiNP_001008809.1. NM_001008809.1.
XP_017450521.1. XM_017595032.1.
UniGeneiRn.143276.

3D structure databases

ProteinModelPortaliQ6IG04.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000035371.

PTM databases

iPTMnetiQ6IG04.
PhosphoSitePlusiQ6IG04.

Proteomic databases

PaxDbiQ6IG04.
PRIDEiQ6IG04.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000038105; ENSRNOP00000035371; ENSRNOG00000030876.
GeneIDi406227.
KEGGirno:406227.
UCSCiRGD:1303216. rat.

Organism-specific databases

CTDi140807.
RGDi1303216. Krt72.

Phylogenomic databases

eggNOGiENOG410IQKP. Eukaryota.
ENOG4111AD7. LUCA.
GeneTreeiENSGT00760000118796.
HOGENOMiHOG000230976.
HOVERGENiHBG013015.
InParanoidiQ6IG04.
KOiK07605.
PhylomeDBiQ6IG04.
TreeFamiTF317854.

Enzyme and pathway databases

ReactomeiR-RNO-6805567. Keratinization.
R-RNO-6809371. Formation of the cornified envelope.

Miscellaneous databases

PROiQ6IG04.

Gene expression databases

BgeeiENSRNOG00000030876.
ExpressionAtlasiQ6IG04. differential.

Family and domain databases

InterProiIPR001664. IF.
IPR018039. Intermediate_filament_CS.
IPR032444. Keratin_2_head.
IPR003054. Keratin_II.
[Graphical view]
PANTHERiPTHR23239. PTHR23239. 1 hit.
PfamiPF00038. Filament. 1 hit.
PF16208. Keratin_2_head. 1 hit.
[Graphical view]
PRINTSiPR01276. TYPE2KERATIN.
SMARTiSM01391. Filament. 1 hit.
[Graphical view]
PROSITEiPS00226. IF. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiK2C72_RAT
AccessioniPrimary (citable) accession number: Q6IG04
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 15, 2008
Last modified: November 30, 2016
This is version 86 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

There are two types of cytoskeletal and microfibrillar keratin, I (acidic) and II (neutral to basic) (40-55 and 56-70 kDa, respectively).

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.