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Protein

Keratin, type II cytoskeletal 72

Gene

Krt72

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Has a role in hair formation. Specific component of keratin intermediate filaments in the inner root sheath (IRS) of the hair follicle (By similarity).By similarity

Miscellaneous

There are two types of cytoskeletal and microfibrillar keratin, I (acidic) and II (neutral to basic) (40-55 and 56-70 kDa, respectively).

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei385Stutter1

GO - Molecular functioni

Enzyme and pathway databases

ReactomeiR-RNO-6805567 Keratinization
R-RNO-6809371 Formation of the cornified envelope

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin, type II cytoskeletal 72
Alternative name(s):
Cytokeratin-72
Short name:
CK-72
Keratin-72
Short name:
K72
Type II inner root sheath-specific keratin-K6irs2
Type-II keratin Kb35
Gene namesi
Name:Krt72
Synonyms:Kb35
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 7

Organism-specific databases

RGDi1303216 Krt72

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Intermediate filament, Keratin

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003148791 – 520Keratin, type II cytoskeletal 72Add BLAST520

Proteomic databases

PaxDbiQ6IG04
PRIDEiQ6IG04

PTM databases

iPTMnetiQ6IG04
PhosphoSitePlusiQ6IG04

Expressioni

Gene expression databases

BgeeiENSRNOG00000030876
ExpressionAtlasiQ6IG04 baseline and differential

Interactioni

Subunit structurei

Heterotetramer of two type I and two type II keratins.

Structurei

3D structure databases

ProteinModelPortaliQ6IG04
SMRiQ6IG04
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini134 – 447IF rodPROSITE-ProRule annotationAdd BLAST314

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 133HeadAdd BLAST133
Regioni134 – 169Coil 1AAdd BLAST36
Regioni170 – 188Linker 1Add BLAST19
Regioni189 – 280Coil 1BAdd BLAST92
Regioni281 – 304Linker 12Add BLAST24
Regioni305 – 443Coil 2Add BLAST139
Regioni444 – 520TailAdd BLAST77

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi10 – 105Gly-richAdd BLAST96

Sequence similaritiesi

Belongs to the intermediate filament family.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IQKP Eukaryota
ENOG4111AD7 LUCA
GeneTreeiENSGT00910000144006
HOGENOMiHOG000230976
HOVERGENiHBG013015
InParanoidiQ6IG04
KOiK07605
PhylomeDBiQ6IG04
TreeFamiTF317854

Family and domain databases

InterProiView protein in InterPro
IPR001664 IF
IPR018039 IF_conserved
IPR039008 IF_rod_dom
IPR032444 Keratin_2_head
IPR003054 Keratin_II
PANTHERiPTHR23239 PTHR23239, 1 hit
PfamiView protein in Pfam
PF00038 Filament, 1 hit
PF16208 Keratin_2_head, 1 hit
PRINTSiPR01276 TYPE2KERATIN
SMARTiView protein in SMART
SM01391 Filament, 1 hit
PROSITEiView protein in PROSITE
PS00226 IF_ROD_1, 1 hit
PS51842 IF_ROD_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q6IG04-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRQLTLYPG AERLGFSGCS AVISGRFSGS HASVRAGVKG AAFGSRSLFC
60 70 80 90 100
VGGGRRLALS SGGRSGGFTL GHGGASGGRP GGFVGTVFGS AGLGPTCPSV
110 120 130 140 150
CPPGGIPQVV VNKSLLAPLN VELDPEIQKV RAQEREQIKA LNNKFASFID
160 170 180 190 200
KVRFLEQQNQ VLETKWELLQ QLDQNNSRRS LEPVHESYIS NLQKQLEILS
210 220 230 240 250
GDRVRLDSEL RNMREVVEDC KKRYEVEINR RTAAENEFVV LKKDVDAAYM
260 270 280 290 300
NKVELQAKVD SMTDDIKFFK VLFEGEIAQM QSHISDTSVI LSMDNNRQLD
310 320 330 340 350
LDSILAEVRA QYEEIAVKSK AETENMYQCK IQELQATAGQ HGDDLKLTKS
360 370 380 390 400
EITEINRLIQ RIHSEIGNMK KQCSNLETAI ADAEQRGDCA LKDARAKLDQ
410 420 430 440 450
LEGVLQQSKE ELARMLREHQ ELMNVKLALD MEIATYRKLL ESEESRMAGE
460 470 480 490 500
YPSSVSISVV SSTNAGPGGA GFSVGFGASS NYNYRPLALE VKTKGSCGSE
510 520
LKDPPAKTSA SSCVSKKASR
Length:520
Mass (Da):56,851
Last modified:January 15, 2008 - v2
Checksum:i3A7B068F826DC968
GO

Sequence cautioni

The sequence DAA02226 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR03055962 Genomic DNA No translation available.
BK003981 mRNA Translation: DAA02226.1 Sequence problems.
RefSeqiNP_001008809.1, NM_001008809.1
XP_017450521.1, XM_017595032.1
UniGeneiRn.143276

Genome annotation databases

EnsembliENSRNOT00000038105; ENSRNOP00000035371; ENSRNOG00000030876
GeneIDi406227
KEGGirno:406227
UCSCiRGD:1303216 rat

Similar proteinsi

Entry informationi

Entry nameiK2C72_RAT
AccessioniPrimary (citable) accession number: Q6IG04
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 15, 2008
Last modified: May 23, 2018
This is version 94 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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