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Protein

Keratin, type II cytoskeletal 2 epidermal

Gene

Krt2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Probably contributes to terminal cornification. Associated with keratinocyte activation, proliferation and keratinization (By similarity). Plays a role in the establishment of the epidermal barrier on plantar skin (By similarity).By similarity

Miscellaneous

There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).Curated

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei449StutterSequence analysis1

GO - Molecular functioni

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin, type II cytoskeletal 2 epidermal
Alternative name(s):
Cytokeratin-2e
Short name:
CK-2e
Epithelial keratin-2e
Keratin-2 epidermis
Keratin-2e
Short name:
K2e
Type-II keratin Kb2
Gene namesi
Name:Krt2By similarity
Synonyms:Kb2Imported, Krt2aBy similarity
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1303297 Krt2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Intermediate filament, Keratin

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002837641 – 685Keratin, type II cytoskeletal 2 epidermalAdd BLAST685

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei22Asymmetric dimethylarginineBy similarity1
Modified residuei25PhosphoserineBy similarity1
Modified residuei28PhosphoserineBy similarity1
Modified residuei52Omega-N-methylarginineBy similarity1
Modified residuei64PhosphoserineBy similarity1
Modified residuei554Omega-N-methylarginineBy similarity1
Modified residuei588Omega-N-methylarginineBy similarity1
Modified residuei603Omega-N-methylarginineBy similarity1
Modified residuei653Omega-N-methylarginineBy similarity1

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

PaxDbiQ6IG02
PRIDEiQ6IG02

PTM databases

iPTMnetiQ6IG02
PhosphoSitePlusiQ6IG02

Interactioni

Subunit structurei

Heterotetramer of two type I and two type II keratins. Associates with KRT10 (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000050471

Structurei

3D structure databases

ProteinModelPortaliQ6IG02
SMRiQ6IG02
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini197 – 511IF rodPROSITE-ProRule annotationAdd BLAST315

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 196HeadSequence analysisAdd BLAST196
Regioni197 – 232Coil 1ASequence analysisAdd BLAST36
Regioni233 – 251Linker 1Sequence analysisAdd BLAST19
Regioni252 – 343Coil 1BSequence analysisAdd BLAST92
Regioni344 – 367Linker 12Sequence analysisAdd BLAST24
Regioni368 – 507Coil 2Sequence analysisAdd BLAST140
Regioni508 – 685TailSequence analysisAdd BLAST178

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi12 – 168Gly-richSequence analysisAdd BLAST157
Compositional biasi537 – 679Gly-richSequence analysisAdd BLAST143

Sequence similaritiesi

Belongs to the intermediate filament family.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IJPR Eukaryota
ENOG410XWGZ LUCA
HOVERGENiHBG013015
InParanoidiQ6IG02
KOiK07605
OrthoDBiEOG091G09KR
PhylomeDBiQ6IG02

Family and domain databases

InterProiView protein in InterPro
IPR001664 IF
IPR018039 IF_conserved
IPR039008 IF_rod_dom
IPR032444 Keratin_2_head
IPR003054 Keratin_II
PANTHERiPTHR23239 PTHR23239, 5 hits
PfamiView protein in Pfam
PF00038 Filament, 1 hit
PF16208 Keratin_2_head, 1 hit
PRINTSiPR01276 TYPE2KERATIN
SMARTiView protein in SMART
SM01391 Filament, 1 hit
PROSITEiView protein in PROSITE
PS00226 IF_ROD_1, 1 hit
PS51842 IF_ROD_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q6IG02-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSCQISCKSR RGGGGGGGGG FRGFSSGSAV VSGGSRRSTS GFSCLSRHGG
60 70 80 90 100
GRGGSGGGGF GSQSLVGLGG YKSISSSVAG YGGGFGGRSY GGFGGGSGFG
110 120 130 140 150
GSGGFGGGSG FGGGRGFGGG SGFGGGSGFG GGSGFGGGSG FGGGGFGGGR
160 170 180 190 200
FGGGPGGFGG PGGFPGGGIH EVSVNQSLLQ PLDVKVDPEI QNVKSQEREQ
210 220 230 240 250
IKTLNNKFAS FIDTVRFLEQ QNQVLHTKWE LLQQLDVGTR TTNLDPVFQA
260 270 280 290 300
YIGILKKQVD RLTAERNSQD SELNNMQDLV EDFKKKYEDE INKRTSAEND
310 320 330 340 350
FVTIKKDVDS CYMDKTELQA KMEMLTQEVD FLRTLYDTEL SQLQQNVTDT
360 370 380 390 400
NVILSMDNNR NLDLDSIIAE VQSQYEIIAH KSKAESEELY HSKANEELQV
410 420 430 440 450
TAVKHGDSLK EIKMEISELN RTIQRLQGEI SHVKKQCKGV QDSIADAEQR
460 470 480 490 500
GEHAIKDARG KLTDLEEALQ QGRENLARLL RDYQELMNVK LALDVEIATY
510 520 530 540 550
RKLLEGEECR MSGDFSDNVS VSVTSSTISS SVASKAGFGS GGQSSGGRGS
560 570 580 590 600
YGGRGGGSTY GSGGRSSGVR GSGSGSGGGG YSSGGGSRGG SGGGGYSTGG
610 620 630 640 650
GSRGGSSSGG GGYSSGGGSR GDSSSGGGSR GGSGGGSRGG SGGGGYSSGG
660 670 680
GSRGGSSSGG AVSGSERGGS GSGEGCGSGV TFSFR
Length:685
Mass (Da):69,127
Last modified:July 5, 2004 - v1
Checksum:iF6F8C0D770C6DF01
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR03055962 Genomic DNA No translation available.
BK003983 mRNA Translation: DAA02228.1
RefSeqiNP_001008899.1, NM_001008899.1
UniGeneiRn.143274

Genome annotation databases

GeneIDi406228
KEGGirno:406228
UCSCiRGD:1303297 rat

Similar proteinsi

Entry informationi

Entry nameiK22E_RAT
AccessioniPrimary (citable) accession number: Q6IG02
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: July 5, 2004
Last modified: May 23, 2018
This is version 88 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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